ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)

Gene

• Entrez ID: 9459
• Gene name: Rac/Cdc42 guanine nucleotide exchange factor 6
• Gene symbol: ARHGEF6
• Synonyms (NCBI Gene): COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX
• Chromosome: X
• Chromosome location: Xq26.3
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007134	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT037230	hsa-miR-877-5p	CLASH	23622248
MIRT483456	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT483455	hsa-miR-5197-3p	HITS-CLIP	23824327
MIRT483454	hsa-miR-6758-5p	HITS-CLIP	23824327
MIRT483453	hsa-miR-6856-5p	HITS-CLIP	23824327
MIRT483452	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT483451	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT539123	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT483450	hsa-miR-1253	HITS-CLIP	23824327
MIRT483449	hsa-miR-4419a	HITS-CLIP	23824327
MIRT483448	hsa-miR-4510	HITS-CLIP	23824327
MIRT483447	hsa-miR-6127	HITS-CLIP	23824327
MIRT483446	hsa-miR-6129	HITS-CLIP	23824327
MIRT483445	hsa-miR-6130	HITS-CLIP	23824327
MIRT483444	hsa-miR-6133	HITS-CLIP	23824327
MIRT483443	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT483441	hsa-miR-4306	HITS-CLIP	23824327
MIRT483442	hsa-miR-4644	HITS-CLIP	23824327
MIRT483440	hsa-miR-6731-5p	HITS-CLIP	23824327
MIRT483439	hsa-miR-8085	HITS-CLIP	23824327
MIRT483456	hsa-miR-888-5p	PAR-CLIP	22012620
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	22012620
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	22012620
MIRT539123	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT483449	hsa-miR-4419a	PAR-CLIP	22012620
MIRT483448	hsa-miR-4510	PAR-CLIP	22012620
MIRT483447	hsa-miR-6127	PAR-CLIP	22012620
MIRT483446	hsa-miR-6129	PAR-CLIP	22012620
MIRT483445	hsa-miR-6130	PAR-CLIP	22012620
MIRT483444	hsa-miR-6133	PAR-CLIP	22012620
MIRT483443	hsa-miR-185-5p	PAR-CLIP	22012620
MIRT483441	hsa-miR-4306	PAR-CLIP	22012620
MIRT483442	hsa-miR-4644	PAR-CLIP	22012620
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT483439	hsa-miR-8085	PAR-CLIP	22012620
MIRT483456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT483455	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT483450	hsa-miR-1253	PAR-CLIP	23592263
MIRT483449	hsa-miR-4419a	PAR-CLIP	23592263
MIRT483448	hsa-miR-4510	PAR-CLIP	23592263
MIRT483447	hsa-miR-6127	PAR-CLIP	23592263
MIRT483446	hsa-miR-6129	PAR-CLIP	23592263
MIRT483445	hsa-miR-6130	PAR-CLIP	23592263
MIRT483444	hsa-miR-6133	PAR-CLIP	23592263
MIRT483443	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT483441	hsa-miR-4306	PAR-CLIP	23592263
MIRT483442	hsa-miR-4644	PAR-CLIP	23592263
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483439	hsa-miR-8085	PAR-CLIP	23592263
MIRT483450	hsa-miR-1253	PAR-CLIP	27292025
MIRT483443	hsa-miR-185-5p	PAR-CLIP	27292025
MIRT539123	hsa-miR-371a-5p	PAR-CLIP	27292025
MIRT483441	hsa-miR-4306	PAR-CLIP	27292025
MIRT483449	hsa-miR-4419a	PAR-CLIP	27292025
MIRT483448	hsa-miR-4510	PAR-CLIP	27292025
MIRT483442	hsa-miR-4644	PAR-CLIP	27292025
MIRT483455	hsa-miR-5197-3p	PAR-CLIP	27292025
MIRT483447	hsa-miR-6127	PAR-CLIP	27292025
MIRT483446	hsa-miR-6129	PAR-CLIP	27292025
MIRT483445	hsa-miR-6130	PAR-CLIP	27292025
MIRT483444	hsa-miR-6133	PAR-CLIP	27292025
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	27292025
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	27292025
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	27292025
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	27292025
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	27292025
MIRT483439	hsa-miR-8085	PAR-CLIP	27292025
MIRT483456	hsa-miR-888-5p	PAR-CLIP	27292025
MIRT483456	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT483455	hsa-miR-5197-3p	HITS-CLIP	23824327
MIRT483454	hsa-miR-6758-5p	HITS-CLIP	23824327
MIRT483453	hsa-miR-6856-5p	HITS-CLIP	23824327
MIRT483452	hsa-miR-6873-5p	HITS-CLIP	23824327
MIRT483451	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT539123	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT483450	hsa-miR-1253	HITS-CLIP	23824327
MIRT483449	hsa-miR-4419a	HITS-CLIP	23824327
MIRT483448	hsa-miR-4510	HITS-CLIP	23824327
MIRT483447	hsa-miR-6127	HITS-CLIP	23824327
MIRT483446	hsa-miR-6129	HITS-CLIP	23824327
MIRT483445	hsa-miR-6130	HITS-CLIP	23824327
MIRT483444	hsa-miR-6133	HITS-CLIP	23824327
MIRT483443	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT483441	hsa-miR-4306	HITS-CLIP	23824327
MIRT483442	hsa-miR-4644	HITS-CLIP	23824327
MIRT483440	hsa-miR-6731-5p	HITS-CLIP	23824327
MIRT483439	hsa-miR-8085	HITS-CLIP	23824327
MIRT483456	hsa-miR-888-5p	PAR-CLIP	22012620
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	22012620
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	22012620
MIRT539123	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT483449	hsa-miR-4419a	PAR-CLIP	22012620
MIRT483448	hsa-miR-4510	PAR-CLIP	22012620
MIRT483447	hsa-miR-6127	PAR-CLIP	22012620
MIRT483446	hsa-miR-6129	PAR-CLIP	22012620
MIRT483445	hsa-miR-6130	PAR-CLIP	22012620
MIRT483444	hsa-miR-6133	PAR-CLIP	22012620
MIRT483443	hsa-miR-185-5p	PAR-CLIP	22012620
MIRT483441	hsa-miR-4306	PAR-CLIP	22012620
MIRT483442	hsa-miR-4644	PAR-CLIP	22012620
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT483439	hsa-miR-8085	PAR-CLIP	22012620
MIRT483456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT483455	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT483454	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT483453	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT483452	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT483451	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT483450	hsa-miR-1253	PAR-CLIP	23592263
MIRT483449	hsa-miR-4419a	PAR-CLIP	23592263
MIRT483448	hsa-miR-4510	PAR-CLIP	23592263
MIRT483447	hsa-miR-6127	PAR-CLIP	23592263
MIRT483446	hsa-miR-6129	PAR-CLIP	23592263
MIRT483445	hsa-miR-6130	PAR-CLIP	23592263
MIRT483444	hsa-miR-6133	PAR-CLIP	23592263
MIRT483443	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT483441	hsa-miR-4306	PAR-CLIP	23592263
MIRT483442	hsa-miR-4644	PAR-CLIP	23592263
MIRT483440	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT483439	hsa-miR-8085	PAR-CLIP	23592263
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT795986	hsa-miR-1252	CLIP-seq
MIRT795987	hsa-miR-125a-5p	CLIP-seq
MIRT795988	hsa-miR-125b	CLIP-seq
MIRT795989	hsa-miR-1295	CLIP-seq
MIRT795990	hsa-miR-134	CLIP-seq
MIRT795991	hsa-miR-1343	CLIP-seq
MIRT795992	hsa-miR-185	CLIP-seq
MIRT795993	hsa-miR-186	CLIP-seq
MIRT795994	hsa-miR-1910	CLIP-seq
MIRT795995	hsa-miR-1911	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795997	hsa-miR-2052	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT795999	hsa-miR-2467-3p	CLIP-seq
MIRT796000	hsa-miR-3118	CLIP-seq
MIRT796001	hsa-miR-3140-5p	CLIP-seq
MIRT796002	hsa-miR-3164	CLIP-seq
MIRT796003	hsa-miR-338-3p	CLIP-seq
MIRT796004	hsa-miR-3545-3p	CLIP-seq
MIRT796005	hsa-miR-3616-3p	CLIP-seq
MIRT796006	hsa-miR-3661	CLIP-seq
MIRT796007	hsa-miR-3678-3p	CLIP-seq
MIRT796008	hsa-miR-378g	CLIP-seq
MIRT796009	hsa-miR-425	CLIP-seq
MIRT796010	hsa-miR-4264	CLIP-seq
MIRT796011	hsa-miR-4291	CLIP-seq
MIRT796012	hsa-miR-4319	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT796014	hsa-miR-4424	CLIP-seq
MIRT796015	hsa-miR-4427	CLIP-seq
MIRT796016	hsa-miR-4437	CLIP-seq
MIRT796017	hsa-miR-4445	CLIP-seq
MIRT796018	hsa-miR-4481	CLIP-seq
MIRT796019	hsa-miR-4501	CLIP-seq
MIRT796020	hsa-miR-4523	CLIP-seq
MIRT796021	hsa-miR-4530	CLIP-seq
MIRT796022	hsa-miR-455-3p	CLIP-seq
MIRT796023	hsa-miR-4666-5p	CLIP-seq
MIRT796024	hsa-miR-4674	CLIP-seq
MIRT796025	hsa-miR-4677-3p	CLIP-seq
MIRT796026	hsa-miR-4679	CLIP-seq
MIRT796027	hsa-miR-4682	CLIP-seq
MIRT796028	hsa-miR-4684-3p	CLIP-seq
MIRT796029	hsa-miR-4717-5p	CLIP-seq
MIRT796030	hsa-miR-4721	CLIP-seq
MIRT796031	hsa-miR-4745-5p	CLIP-seq
MIRT796032	hsa-miR-4758-5p	CLIP-seq
MIRT796033	hsa-miR-4764-5p	CLIP-seq
MIRT796034	hsa-miR-4797-3p	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT796037	hsa-miR-520a-5p	CLIP-seq
MIRT796038	hsa-miR-525-5p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT796041	hsa-miR-631	CLIP-seq
MIRT1545513	hsa-miR-1246	CLIP-seq
MIRT1545514	hsa-miR-198	CLIP-seq
MIRT1545515	hsa-miR-3134	CLIP-seq
MIRT1545516	hsa-miR-4534	CLIP-seq
MIRT1545517	hsa-miR-4712-5p	CLIP-seq
MIRT1545518	hsa-miR-628-5p	CLIP-seq
MIRT1545519	hsa-miR-770-5p	CLIP-seq
MIRT1545520	hsa-miR-936	CLIP-seq
MIRT1935103	hsa-miR-1200	CLIP-seq
MIRT1935104	hsa-miR-1224-3p	CLIP-seq
MIRT1935105	hsa-miR-140-3p	CLIP-seq
MIRT1935106	hsa-miR-146b-3p	CLIP-seq
MIRT795999	hsa-miR-2467-3p	CLIP-seq
MIRT1935107	hsa-miR-3187-3p	CLIP-seq
MIRT796004	hsa-miR-3545-3p	CLIP-seq
MIRT1935108	hsa-miR-3649	CLIP-seq
MIRT796007	hsa-miR-3678-3p	CLIP-seq
MIRT1935109	hsa-miR-4324	CLIP-seq
MIRT1935110	hsa-miR-4435	CLIP-seq
MIRT1935111	hsa-miR-4436b-3p	CLIP-seq
MIRT796028	hsa-miR-4684-3p	CLIP-seq
MIRT1935112	hsa-miR-4701-5p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT1935113	hsa-miR-548s	CLIP-seq
MIRT1935114	hsa-miR-552	CLIP-seq
MIRT1935115	hsa-miR-588	CLIP-seq
MIRT2175048	hsa-miR-103a	CLIP-seq
MIRT2175049	hsa-miR-105	CLIP-seq
MIRT2175050	hsa-miR-107	CLIP-seq
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT1935103	hsa-miR-1200	CLIP-seq
MIRT1935104	hsa-miR-1224-3p	CLIP-seq
MIRT795987	hsa-miR-125a-5p	CLIP-seq
MIRT795988	hsa-miR-125b	CLIP-seq
MIRT2175051	hsa-miR-1260	CLIP-seq
MIRT2175052	hsa-miR-1260b	CLIP-seq
MIRT2175053	hsa-miR-1280	CLIP-seq
MIRT795991	hsa-miR-1343	CLIP-seq
MIRT1935105	hsa-miR-140-3p	CLIP-seq
MIRT2175054	hsa-miR-1913	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT795999	hsa-miR-2467-3p	CLIP-seq
MIRT2175055	hsa-miR-3166	CLIP-seq
MIRT2175056	hsa-miR-324-3p	CLIP-seq
MIRT796004	hsa-miR-3545-3p	CLIP-seq
MIRT1935108	hsa-miR-3649	CLIP-seq
MIRT796007	hsa-miR-3678-3p	CLIP-seq
MIRT796008	hsa-miR-378g	CLIP-seq
MIRT2175057	hsa-miR-3934	CLIP-seq
MIRT2175058	hsa-miR-3944-5p	CLIP-seq
MIRT796009	hsa-miR-425	CLIP-seq
MIRT2175059	hsa-miR-4265	CLIP-seq
MIRT2175060	hsa-miR-4271	CLIP-seq
MIRT2175061	hsa-miR-4296	CLIP-seq
MIRT2175062	hsa-miR-4313	CLIP-seq
MIRT796012	hsa-miR-4319	CLIP-seq
MIRT2175063	hsa-miR-4322	CLIP-seq
MIRT1935109	hsa-miR-4324	CLIP-seq
MIRT2175064	hsa-miR-4417	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT796014	hsa-miR-4424	CLIP-seq
MIRT796016	hsa-miR-4437	CLIP-seq
MIRT2175065	hsa-miR-4533	CLIP-seq
MIRT2175066	hsa-miR-4640-5p	CLIP-seq
MIRT796023	hsa-miR-4666-5p	CLIP-seq
MIRT796024	hsa-miR-4674	CLIP-seq
MIRT796027	hsa-miR-4682	CLIP-seq
MIRT796028	hsa-miR-4684-3p	CLIP-seq
MIRT2175067	hsa-miR-4725-3p	CLIP-seq
MIRT2175068	hsa-miR-4726-5p	CLIP-seq
MIRT2175069	hsa-miR-4727-5p	CLIP-seq
MIRT2175070	hsa-miR-4747-5p	CLIP-seq
MIRT2175071	hsa-miR-4789-3p	CLIP-seq
MIRT2175072	hsa-miR-501-3p	CLIP-seq
MIRT2175073	hsa-miR-502-3p	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT2175074	hsa-miR-532-3p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT2175075	hsa-miR-548a-5p	CLIP-seq
MIRT2175076	hsa-miR-548ab	CLIP-seq
MIRT2175077	hsa-miR-548ak	CLIP-seq
MIRT2175078	hsa-miR-548b-5p	CLIP-seq
MIRT2175079	hsa-miR-548c-5p	CLIP-seq
MIRT2175080	hsa-miR-548d-5p	CLIP-seq
MIRT2175081	hsa-miR-548h	CLIP-seq
MIRT2175082	hsa-miR-548i	CLIP-seq
MIRT2175083	hsa-miR-548j	CLIP-seq
MIRT2175084	hsa-miR-548w	CLIP-seq
MIRT2175085	hsa-miR-548y	CLIP-seq
MIRT1935114	hsa-miR-552	CLIP-seq
MIRT2175086	hsa-miR-559	CLIP-seq
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT1935103	hsa-miR-1200	CLIP-seq
MIRT1935104	hsa-miR-1224-3p	CLIP-seq
MIRT2175051	hsa-miR-1260	CLIP-seq
MIRT2175052	hsa-miR-1260b	CLIP-seq
MIRT2175053	hsa-miR-1280	CLIP-seq
MIRT795991	hsa-miR-1343	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT2384442	hsa-miR-330-3p	CLIP-seq
MIRT1935109	hsa-miR-4324	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT2175074	hsa-miR-532-3p	CLIP-seq
MIRT796039	hsa-miR-544b	CLIP-seq
MIRT2175075	hsa-miR-548a-5p	CLIP-seq
MIRT2175076	hsa-miR-548ab	CLIP-seq
MIRT2175077	hsa-miR-548ak	CLIP-seq
MIRT2175078	hsa-miR-548b-5p	CLIP-seq
MIRT2175079	hsa-miR-548c-5p	CLIP-seq
MIRT2175080	hsa-miR-548d-5p	CLIP-seq
MIRT2175081	hsa-miR-548h	CLIP-seq
MIRT2175082	hsa-miR-548i	CLIP-seq
MIRT2175083	hsa-miR-548j	CLIP-seq
MIRT2175084	hsa-miR-548w	CLIP-seq
MIRT2175085	hsa-miR-548y	CLIP-seq
MIRT2175086	hsa-miR-559	CLIP-seq
MIRT2443960	hsa-miR-338-5p	CLIP-seq
MIRT2443961	hsa-miR-450b-5p	CLIP-seq
MIRT2443962	hsa-miR-4729	CLIP-seq
MIRT2443963	hsa-miR-4762-5p	CLIP-seq
MIRT2443964	hsa-miR-518a-5p	CLIP-seq
MIRT2443965	hsa-miR-527	CLIP-seq
MIRT2443963	hsa-miR-4762-5p	CLIP-seq
MIRT795985	hsa-miR-1184	CLIP-seq
MIRT795989	hsa-miR-1295	CLIP-seq
MIRT2478258	hsa-miR-1297	CLIP-seq
MIRT795990	hsa-miR-134	CLIP-seq
MIRT2478259	hsa-miR-139-5p	CLIP-seq
MIRT1935105	hsa-miR-140-3p	CLIP-seq
MIRT795996	hsa-miR-192	CLIP-seq
MIRT795998	hsa-miR-215	CLIP-seq
MIRT2478260	hsa-miR-2681	CLIP-seq
MIRT2478261	hsa-miR-2682	CLIP-seq
MIRT2478262	hsa-miR-26a	CLIP-seq
MIRT2478263	hsa-miR-26b	CLIP-seq
MIRT796000	hsa-miR-3118	CLIP-seq
MIRT2478264	hsa-miR-3126-5p	CLIP-seq
MIRT2478265	hsa-miR-3153	CLIP-seq
MIRT796002	hsa-miR-3164	CLIP-seq
MIRT2478266	hsa-miR-320a	CLIP-seq
MIRT2478267	hsa-miR-320b	CLIP-seq
MIRT2478268	hsa-miR-320c	CLIP-seq
MIRT2478269	hsa-miR-320d	CLIP-seq
MIRT2478270	hsa-miR-320e	CLIP-seq
MIRT2478271	hsa-miR-325	CLIP-seq
MIRT2478272	hsa-miR-329	CLIP-seq
MIRT2443960	hsa-miR-338-5p	CLIP-seq
MIRT2478273	hsa-miR-362-3p	CLIP-seq
MIRT1935108	hsa-miR-3649	CLIP-seq
MIRT2478274	hsa-miR-3672	CLIP-seq
MIRT2175057	hsa-miR-3934	CLIP-seq
MIRT2478275	hsa-miR-3941	CLIP-seq
MIRT796010	hsa-miR-4264	CLIP-seq
MIRT2478276	hsa-miR-4268	CLIP-seq
MIRT2478277	hsa-miR-4328	CLIP-seq
MIRT796013	hsa-miR-4418	CLIP-seq
MIRT2478278	hsa-miR-4429	CLIP-seq
MIRT1935111	hsa-miR-4436b-3p	CLIP-seq
MIRT2478279	hsa-miR-4465	CLIP-seq
MIRT2478280	hsa-miR-4484	CLIP-seq
MIRT2478281	hsa-miR-449c	CLIP-seq
MIRT2478282	hsa-miR-466	CLIP-seq
MIRT2478283	hsa-miR-4668-5p	CLIP-seq
MIRT2478284	hsa-miR-4672	CLIP-seq
MIRT796025	hsa-miR-4677-3p	CLIP-seq
MIRT796026	hsa-miR-4679	CLIP-seq
MIRT2478285	hsa-miR-4680-3p	CLIP-seq
MIRT2478286	hsa-miR-4704-5p	CLIP-seq
MIRT796029	hsa-miR-4717-5p	CLIP-seq
MIRT2478287	hsa-miR-4731-5p	CLIP-seq
MIRT2478288	hsa-miR-4761-3p	CLIP-seq
MIRT796033	hsa-miR-4764-5p	CLIP-seq
MIRT2478289	hsa-miR-4775	CLIP-seq
MIRT796034	hsa-miR-4797-3p	CLIP-seq
MIRT2478290	hsa-miR-4799-5p	CLIP-seq
MIRT2478291	hsa-miR-490-3p	CLIP-seq
MIRT796035	hsa-miR-509-3-5p	CLIP-seq
MIRT796036	hsa-miR-509-5p	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT1935114	hsa-miR-552	CLIP-seq
MIRT2478292	hsa-miR-578	CLIP-seq
MIRT2478293	hsa-miR-582-5p	CLIP-seq
MIRT2478294	hsa-miR-590-3p	CLIP-seq
MIRT2478295	hsa-miR-603	CLIP-seq
MIRT2478296	hsa-miR-607	CLIP-seq
MIRT2478297	hsa-miR-626	CLIP-seq
MIRT2478298	hsa-miR-628-3p	CLIP-seq
MIRT2478299	hsa-miR-637	CLIP-seq
MIRT2478300	hsa-miR-642b	CLIP-seq
MIRT2478301	hsa-miR-652	CLIP-seq
MIRT2478302	hsa-miR-940	CLIP-seq
MIRT2478303	hsa-miR-943	CLIP-seq
MIRT795986	hsa-miR-1252	CLIP-seq
MIRT795989	hsa-miR-1295	CLIP-seq
MIRT2675337	hsa-miR-1321	CLIP-seq
MIRT795990	hsa-miR-134	CLIP-seq
MIRT2478259	hsa-miR-139-5p	CLIP-seq
MIRT2675338	hsa-miR-155	CLIP-seq
MIRT1545514	hsa-miR-198	CLIP-seq
MIRT795997	hsa-miR-2052	CLIP-seq
MIRT2675339	hsa-miR-219-5p	CLIP-seq
MIRT2478260	hsa-miR-2681	CLIP-seq
MIRT2478261	hsa-miR-2682	CLIP-seq
MIRT796000	hsa-miR-3118	CLIP-seq
MIRT2478264	hsa-miR-3126-5p	CLIP-seq
MIRT2478265	hsa-miR-3153	CLIP-seq
MIRT796002	hsa-miR-3164	CLIP-seq
MIRT2675340	hsa-miR-3184	CLIP-seq
MIRT2478266	hsa-miR-320a	CLIP-seq
MIRT2478267	hsa-miR-320b	CLIP-seq
MIRT2478268	hsa-miR-320c	CLIP-seq
MIRT2478269	hsa-miR-320d	CLIP-seq
MIRT2478271	hsa-miR-325	CLIP-seq
MIRT2478272	hsa-miR-329	CLIP-seq
MIRT2443960	hsa-miR-338-5p	CLIP-seq
MIRT2675341	hsa-miR-3607-5p	CLIP-seq
MIRT2675342	hsa-miR-3612	CLIP-seq
MIRT2478273	hsa-miR-362-3p	CLIP-seq
MIRT2478274	hsa-miR-3672	CLIP-seq
MIRT2478275	hsa-miR-3941	CLIP-seq
MIRT2675343	hsa-miR-423-5p	CLIP-seq
MIRT796010	hsa-miR-4264	CLIP-seq
MIRT2478276	hsa-miR-4268	CLIP-seq
MIRT2478277	hsa-miR-4328	CLIP-seq
MIRT2478278	hsa-miR-4429	CLIP-seq
MIRT1935111	hsa-miR-4436b-3p	CLIP-seq
MIRT796017	hsa-miR-4445	CLIP-seq
MIRT2478280	hsa-miR-4484	CLIP-seq
MIRT2478281	hsa-miR-449c	CLIP-seq
MIRT2478282	hsa-miR-466	CLIP-seq
MIRT2478283	hsa-miR-4668-5p	CLIP-seq
MIRT2478284	hsa-miR-4672	CLIP-seq
MIRT796025	hsa-miR-4677-3p	CLIP-seq
MIRT796026	hsa-miR-4679	CLIP-seq
MIRT2478285	hsa-miR-4680-3p	CLIP-seq
MIRT2478286	hsa-miR-4704-5p	CLIP-seq
MIRT1545517	hsa-miR-4712-5p	CLIP-seq
MIRT796029	hsa-miR-4717-5p	CLIP-seq
MIRT2675344	hsa-miR-4739	CLIP-seq
MIRT2675345	hsa-miR-4756-5p	CLIP-seq
MIRT2478288	hsa-miR-4761-3p	CLIP-seq
MIRT2443963	hsa-miR-4762-5p	CLIP-seq
MIRT796033	hsa-miR-4764-5p	CLIP-seq
MIRT2478289	hsa-miR-4775	CLIP-seq
MIRT2675346	hsa-miR-4778-3p	CLIP-seq
MIRT2675347	hsa-miR-4782-3p	CLIP-seq
MIRT796034	hsa-miR-4797-3p	CLIP-seq
MIRT2478290	hsa-miR-4799-5p	CLIP-seq
MIRT796040	hsa-miR-545	CLIP-seq
MIRT2675348	hsa-miR-548aa	CLIP-seq
MIRT2478292	hsa-miR-578	CLIP-seq
MIRT2478293	hsa-miR-582-5p	CLIP-seq
MIRT2478294	hsa-miR-590-3p	CLIP-seq
MIRT2675349	hsa-miR-601	CLIP-seq
MIRT2478295	hsa-miR-603	CLIP-seq
MIRT2478297	hsa-miR-626	CLIP-seq
MIRT2478298	hsa-miR-628-3p	CLIP-seq
MIRT2478300	hsa-miR-642b	CLIP-seq
MIRT2675350	hsa-miR-649	CLIP-seq
MIRT2675351	hsa-miR-650	CLIP-seq
MIRT2478301	hsa-miR-652	CLIP-seq
MIRT1545519	hsa-miR-770-5p	CLIP-seq
MIRT1545520	hsa-miR-936	CLIP-seq
MIRT2478302	hsa-miR-940	CLIP-seq
MIRT2478303	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	NAS	11017088
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005096	Function	GTPase activator activity	NAS	9582122
GO:0005515	Function	Protein binding	IPI	11864573, 16374509, 16983070, 21295525, 21900206, 23455922, 31980649, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005911	Component	Cell-cell junction	IEA
GO:0006915	Process	Apoptotic process	NAS	11564864
GO:0007254	Process	JNK cascade	NAS	11564864
GO:0030027	Component	Lamellipodium	IBA
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030032	Process	Lamellipodium assembly	IBA
GO:0030032	Process	Lamellipodium assembly	IEA
GO:0030032	Process	Lamellipodium assembly	ISS
GO:0042995	Component	Cell projection	IEA

Other IDs

• MIM: 300267
• HGNC: 685
• e!Ensembl: ENSG00000129675

Protein

• UniProt ID: Q15052
• Protein name: Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
• Protein function: Acts as a RAC1 guanine nucleotide exchange factor (GEF).
• PDB: 1UJY, 1WYR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	1 → 112	Calponin homology (CH) domain	Domain
  PF16615	RhoGEF67_u1	114 → 160		Disordered
  PF07653	SH3_2	164 → 217	Variant SH3 domain	Domain
  PF00621	RhoGEF	245 → 419	RhoGEF domain	Domain
  PF00169	PH	443 → 548	PH domain	Domain
  PF16614	RhoGEF67_u2	570 → 678		Disordered
  PF16523	betaPIX_CC	681 → 769	betaPIX coiled coil	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP
  QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG
  RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS
  VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN
  YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC
  QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG
  ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD
  LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM
  LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL
  EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL
  RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL
  KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA
  LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP

• Sequence length: 776

Pathways

KEGG:

Regulation of actin cytoskeleton
Pancreatic cancer

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G beta:gamma signalling through CDC42

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARHGEF6-associated Neurodevelopmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARHGEF6-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CAKUT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ATAXIA WITH CENTRAL NERVOUS SYSTEM HYPOMYELINIZATION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL ANOMALY OF KIDNEY AND URINARY TRACT	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Genetic developmental and epileptic encephalopathy	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
History of neurodevelopmental disorder	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED 46	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability, X-linked 46	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar GenCC	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MENTAL RETARDATION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION, X-LINKED NONSYNDROMIC	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Non-syndromic X-linked intellectual disability	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign	ClinVar ClinGen, GWAS catalog	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vanishing white matter disease	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
X-LINKED INTELLECTUAL DISABILITY	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
X-LINKED NON-SYNDROMIC INTELLECTUAL DISABILITY	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
2-3 toe syndactyly	Syndactyly Of The Toes	HPO_DG			★☆☆☆☆ Found in Text Mining only
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	34069769	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic behavior	Autism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Borjeson-Forssman-Lehmann syndrome	Borjeson-Forssman-Lehmann Syndrome	BEFREE	11337747		★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	25479423	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24504536	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	25479423		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	25479423	Associate	★☆☆☆☆ Found in Text Mining only
Facial paralysis	Facial paralysis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	16320026		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	16320026		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	25479423, 28333213		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	25479423	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	11017088, 11337747		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual Disability	Intellectual developmental disorder	Pubtator	23871722	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	37027440	Associate	★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Meckel Diverticulum	Meckel Diverticulum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	11337747		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mental Retardation, X-Linked	Mental retardation	GENOMICS_ENGLAND_DG	11017088		★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked	Mental retardation	BEFREE	11337747		★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked 1	Mental Retardation, X-Linked	ORPHANET_DG	11017088		★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked 46	Mental retardation	GENOMICS_ENGLAND_DG	11017088		★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked Nonsyndromic	Mental retardation	CLINGEN_DG	11017088, 17304053, 19377476, 21989057		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mild neurosensory hearing impairment	Neurosensory Hearing impairment	HPO_DG			★☆☆☆☆ Found in Text Mining only
Moderate intellectual disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	HPO_DG			★☆☆☆☆ Found in Text Mining only
Progressive hearing loss stapes fixation	Hearing loss with stapes fixation	Pubtator	35202564	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	29759351		★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	25479423		★☆☆☆☆ Found in Text Mining only
X-linked non-syndromic intellectual disability	Non-Syndromic Intellectual Disability, X-Linked	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations