Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9425
Gene name	Chromodomain Y like
Gene symbol	CDYL
Synonyms (NCBI Gene)	CDYL1
Chromosome	6
Chromosome location	6p25.1
Summary	Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by r

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006174	hsa-miR-141-3p	Luciferase reporter assayWestern blot	21867514
MIRT006174	hsa-miR-141-3p	Luciferase reporter assayWestern blot	21867514
MIRT006174	hsa-miR-141-3p	Luciferase reporter assayWestern blot	21867514
MIRT735364	hsa-miR-1180-3p	Luciferase reporter assayWestern blottingqRT-PCR	32321304
MIRT882877	hsa-miR-3154	CLIP-seq
MIRT882878	hsa-miR-3179	CLIP-seq
MIRT882879	hsa-miR-4310	CLIP-seq
MIRT882877	hsa-miR-3154	CLIP-seq
MIRT882880	hsa-miR-3942-3p	CLIP-seq
MIRT882881	hsa-miR-548ae	CLIP-seq
MIRT882882	hsa-miR-548aj	CLIP-seq
MIRT882883	hsa-miR-548am	CLIP-seq
MIRT882884	hsa-miR-548x	CLIP-seq
MIRT882885	hsa-miR-1227	CLIP-seq
MIRT882886	hsa-miR-129-5p	CLIP-seq
MIRT882887	hsa-miR-186	CLIP-seq
MIRT882888	hsa-miR-196a	CLIP-seq
MIRT882889	hsa-miR-196b	CLIP-seq
MIRT882890	hsa-miR-2052	CLIP-seq
MIRT882891	hsa-miR-2467-3p	CLIP-seq
MIRT882892	hsa-miR-3168	CLIP-seq
MIRT882893	hsa-miR-329	CLIP-seq
MIRT882894	hsa-miR-33a	CLIP-seq
MIRT882895	hsa-miR-33b	CLIP-seq
MIRT882896	hsa-miR-340	CLIP-seq
MIRT882897	hsa-miR-362-3p	CLIP-seq
MIRT882898	hsa-miR-3941	CLIP-seq
MIRT882899	hsa-miR-409-3p	CLIP-seq
MIRT882900	hsa-miR-450b-5p	CLIP-seq
MIRT882901	hsa-miR-466	CLIP-seq
MIRT882902	hsa-miR-4672	CLIP-seq
MIRT882903	hsa-miR-4803	CLIP-seq
MIRT882904	hsa-miR-488	CLIP-seq
MIRT882905	hsa-miR-507	CLIP-seq
MIRT882906	hsa-miR-548ag	CLIP-seq
MIRT882907	hsa-miR-548ai	CLIP-seq
MIRT882908	hsa-miR-548c-3p	CLIP-seq
MIRT882909	hsa-miR-557	CLIP-seq
MIRT882910	hsa-miR-568	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq
MIRT882912	hsa-miR-633	CLIP-seq
MIRT882913	hsa-miR-648	CLIP-seq
MIRT882914	hsa-miR-653	CLIP-seq
MIRT1961777	hsa-miR-101	CLIP-seq
MIRT1961778	hsa-miR-1290	CLIP-seq
MIRT1961779	hsa-miR-144	CLIP-seq
MIRT1961780	hsa-miR-200b	CLIP-seq
MIRT1961781	hsa-miR-200c	CLIP-seq
MIRT1961782	hsa-miR-429	CLIP-seq
MIRT1961783	hsa-miR-561	CLIP-seq
MIRT1961784	hsa-miR-582-5p	CLIP-seq
MIRT2198331	hsa-miR-4724-5p	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq
MIRT2198332	hsa-miR-1231	CLIP-seq
MIRT1961778	hsa-miR-1290	CLIP-seq
MIRT2198333	hsa-miR-3170	CLIP-seq
MIRT2198334	hsa-miR-4260	CLIP-seq
MIRT2198335	hsa-miR-4268	CLIP-seq
MIRT2198336	hsa-miR-4448	CLIP-seq
MIRT2198337	hsa-miR-654-3p	CLIP-seq
MIRT2385899	hsa-miR-3654	CLIP-seq
MIRT2385900	hsa-miR-4511	CLIP-seq
MIRT2385901	hsa-miR-548b-3p	CLIP-seq
MIRT2385902	hsa-miR-555	CLIP-seq
MIRT2385903	hsa-miR-582-3p	CLIP-seq
MIRT2501432	hsa-miR-1204	CLIP-seq
MIRT2501433	hsa-miR-1252	CLIP-seq
MIRT2501434	hsa-miR-1323	CLIP-seq
MIRT2501435	hsa-miR-223	CLIP-seq
MIRT882877	hsa-miR-3154	CLIP-seq
MIRT882892	hsa-miR-3168	CLIP-seq
MIRT2501436	hsa-miR-3180-5p	CLIP-seq
MIRT2501437	hsa-miR-323-5p	CLIP-seq
MIRT882893	hsa-miR-329	CLIP-seq
MIRT882897	hsa-miR-362-3p	CLIP-seq
MIRT2501438	hsa-miR-3689d	CLIP-seq
MIRT2501439	hsa-miR-3915	CLIP-seq
MIRT2501440	hsa-miR-3928	CLIP-seq
MIRT882898	hsa-miR-3941	CLIP-seq
MIRT2501441	hsa-miR-4263	CLIP-seq
MIRT2501442	hsa-miR-4277	CLIP-seq
MIRT2501443	hsa-miR-4652-3p	CLIP-seq
MIRT882901	hsa-miR-466	CLIP-seq
MIRT882902	hsa-miR-4672	CLIP-seq
MIRT2501444	hsa-miR-4743	CLIP-seq
MIRT2501445	hsa-miR-4760-5p	CLIP-seq
MIRT2501446	hsa-miR-4777-5p	CLIP-seq
MIRT2501447	hsa-miR-4778-5p	CLIP-seq
MIRT2501448	hsa-miR-495	CLIP-seq
MIRT2501449	hsa-miR-499a-5p	CLIP-seq
MIRT2501450	hsa-miR-518d-5p	CLIP-seq
MIRT2501451	hsa-miR-519b-5p	CLIP-seq
MIRT2501452	hsa-miR-519c-5p	CLIP-seq
MIRT2501453	hsa-miR-520a-5p	CLIP-seq
MIRT2501454	hsa-miR-520c-5p	CLIP-seq
MIRT2501455	hsa-miR-525-5p	CLIP-seq
MIRT2501456	hsa-miR-526a	CLIP-seq
MIRT2501457	hsa-miR-548a-3p	CLIP-seq
MIRT2501458	hsa-miR-548e	CLIP-seq
MIRT2501459	hsa-miR-548f	CLIP-seq
MIRT2501460	hsa-miR-548g	CLIP-seq
MIRT2501461	hsa-miR-548o	CLIP-seq
MIRT2501462	hsa-miR-570	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq
MIRT2501432	hsa-miR-1204	CLIP-seq
MIRT2501434	hsa-miR-1323	CLIP-seq
MIRT2501435	hsa-miR-223	CLIP-seq
MIRT882892	hsa-miR-3168	CLIP-seq
MIRT2501437	hsa-miR-323-5p	CLIP-seq
MIRT882893	hsa-miR-329	CLIP-seq
MIRT882897	hsa-miR-362-3p	CLIP-seq
MIRT2501438	hsa-miR-3689d	CLIP-seq
MIRT882898	hsa-miR-3941	CLIP-seq
MIRT2501441	hsa-miR-4263	CLIP-seq
MIRT2501442	hsa-miR-4277	CLIP-seq
MIRT882901	hsa-miR-466	CLIP-seq
MIRT882902	hsa-miR-4672	CLIP-seq
MIRT2501444	hsa-miR-4743	CLIP-seq
MIRT2501457	hsa-miR-548a-3p	CLIP-seq
MIRT2501458	hsa-miR-548e	CLIP-seq
MIRT2501459	hsa-miR-548f	CLIP-seq
MIRT2501460	hsa-miR-548g	CLIP-seq
MIRT2501461	hsa-miR-548o	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IEA
GO:0003682	Function	Chromatin binding	ISS
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IMP	19061646
GO:0005515	Function	Protein binding	IPI	16415788, 19061646, 21653829, 22009739, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	18450745
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005694	Component	Chromosome	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	TAS	10192397
GO:0007286	Process	Spermatid development	IEA
GO:0007286	Process	Spermatid development	ISS
GO:0016607	Component	Nuclear speck	IDA
GO:0016829	Function	Lyase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IPI	19061646
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0060816	Process	Random inactivation of X chromosome	IEA
GO:0060816	Process	Random inactivation of X chromosome	ISS
GO:0120092	Function	Crotonyl-CoA hydratase activity	IDA	28803779
GO:0120092	Function	Crotonyl-CoA hydratase activity	IEA
GO:0120094	Process	Negative regulation of peptidyl-lysine crotonylation	IDA	28803779

MIM	HGNC	e!Ensembl
603778	1811	ENSG00000153046

Q9Y232

Protein name

Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-)

Protein function

[Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part o

PDB

2DNT , 2GTR , 7N27

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00385	Chromo	61 → 112	Chromo (CHRromatin Organisation MOdifier) domain	Domain
PF00378	ECH_1	347 → 598	Enoyl-CoA hydratase/isomerase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level) (PubMed:28842554). Ubiquitous (PubMed:19808672). Expressed at moderate levels in all tissues examined (PubMe

Sequence

MTFQASHRSAWGKSRKKNWQYEGPTQKLFLKRNNVSAPDGPSDPSISVSSEQSGAQQPPA
LQVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKES
TLTRTNRTSPNNARKQISRSTNSNFSKTSPKALVIGKDHESKNSQLFAASQKFRKNTAPS
LSSRKNMDLAKSGIKILVPKSPVKSRTAVDGFQSESPEKLDPVEQGQEDTVAPEVAAEKP
VGALLGPGAERARMGSRPRIHPLVPQVPGPVTAAMATGLAVNGKGTSPFMDALTANGTTN
IQTSVTGVTASKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTK
SSENNSLNPEVMREVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRES
TKMAEAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQ
SPDGCSTVMFPKIMGGASANEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKEL
ASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF

Sequence length

598

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CONNECTIVE TISSUE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIXED CONNECTIVE TISSUE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL CELL LUNG CARCINOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anhedonia	Anhedonia	BEFREE	30665597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	30961553	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	21685187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASDB_DG	21685187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	30665597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	28076783, 28842554, 30009487		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	28842554		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroschisis	Gastroschisis	Pubtator	31075877	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	23629948, 31148183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	30665597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malformations of Cortical Development, Group II	Malformation of cortical development	BEFREE	28076783		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	30665597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	28076783		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	CTD_human_DG	22941189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	31367252		★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	30665597		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	30968727	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	19061646	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CDYL (chromodomain Y like)