Gene Gene information from NCBI Gene database.
Entrez ID 94241
Gene name Tumor protein p53 inducible nuclear protein 1
Gene symbol TP53INP1
Synonyms (NCBI Gene)
SIPTP53DINP1TP53INP1ATP53INP1BTeapp53DINP1
Chromosome 8
Chromosome location 8q22.1
miRNA miRNA information provided by mirtarbase database.
1674
miRTarBase ID miRNA Experiments Reference
MIRT003007 hsa-miR-155-5p Western blotLuciferase reporter assay 17911264
MIRT003007 hsa-miR-155-5p Luciferase reporter assay 17911264
MIRT000021 hsa-miR-93-5p Luciferase reporter assayWestern blot 18974142
MIRT000021 hsa-miR-93-5p Luciferase reporter assayWestern blot 18974142
MIRT000335 hsa-miR-130b-3p Luciferase reporter assayWestern blot 18974142
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
E2F1 Activation 15706352
MYCN Repression 17495526
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA
GO:0005515 Function Protein binding IPI 22421968, 22470510, 32296183
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 22470510
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606185 18022 ENSG00000164938
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96A56
Protein name Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)
Protein function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relo
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14839 DOR 24 236 DOR family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:12067065}.
Sequence
Sequence length 240
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Regulation of TP53 Activity through Phosphorylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute pancreatitis Pancreatitis BEFREE 12067065, 16044147
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 21052763, 30398034
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 24922517, 33712570 Associate
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety Disorder BEFREE 28749453, 28984682
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety Disorder BEFREE 28749453, 28984682
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 31410122
★☆☆☆☆
Found in Text Mining only
Bone Neoplasms Bone neoplasm Pubtator 30592172 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 20585948, 22037216, 29146309, 29329575, 29655255, 30015868
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 17201159, 24152184, 28791367, 29329575, 30015868, 35617355, 36755123 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 22051041 Inhibit
★☆☆☆☆
Found in Text Mining only