KCNK6 (potassium two pore domain channel subfamily K member 6)

Gene

• Entrez ID: 9424
• Gene name: Potassium two pore domain channel subfamily K member 6
• Gene symbol: KCNK6
• Synonyms (NCBI Gene): K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2
• Chromosome: 19
• Chromosome location: 19q13.2
• Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by in

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT696051	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT696050	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT696049	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT696048	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT696047	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT696046	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT696045	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT696044	hsa-miR-8073	HITS-CLIP	23313552
MIRT696043	hsa-miR-2116-3p	HITS-CLIP	23313552
MIRT696042	hsa-miR-3176	HITS-CLIP	23313552
MIRT696041	hsa-miR-3922-3p	HITS-CLIP	23313552
MIRT696040	hsa-miR-7152-3p	HITS-CLIP	23313552
MIRT696039	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696038	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT696037	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT696036	hsa-miR-601	HITS-CLIP	23313552
MIRT696035	hsa-miR-6749-3p	HITS-CLIP	23313552
MIRT696034	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT519073	hsa-miR-2114-3p	HITS-CLIP	23313552
MIRT685597	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT685596	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT685595	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT685594	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT685593	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT685592	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT685591	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT685590	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT685589	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT685588	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT685587	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT685586	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT685585	hsa-miR-302e	HITS-CLIP	23313552
MIRT685584	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT685583	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT685582	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT685581	hsa-miR-520b	HITS-CLIP	23313552
MIRT685580	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT685579	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT685578	hsa-miR-520e	HITS-CLIP	23313552
MIRT685577	hsa-miR-5683	HITS-CLIP	23313552
MIRT685576	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT685575	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT685574	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT685573	hsa-miR-520h	HITS-CLIP	23313552
MIRT685572	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT685571	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT685570	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT685569	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT685568	hsa-miR-636	HITS-CLIP	23313552
MIRT685567	hsa-miR-3157-5p	HITS-CLIP	23313552
MIRT685566	hsa-miR-3977	HITS-CLIP	23313552
MIRT440405	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT649604	hsa-miR-567	HITS-CLIP	23824327
MIRT649603	hsa-miR-675-3p	HITS-CLIP	23824327
MIRT649602	hsa-miR-297	HITS-CLIP	23824327
MIRT649601	hsa-miR-3149	HITS-CLIP	23824327
MIRT649600	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT626790	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT626789	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626788	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626787	hsa-miR-498	HITS-CLIP	23824327
MIRT635815	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT635816	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT635814	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT635813	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT635812	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT635811	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT635810	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT635809	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT626790	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT626788	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626787	hsa-miR-498	HITS-CLIP	23824327
MIRT626790	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT626789	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626788	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626787	hsa-miR-498	HITS-CLIP	23824327
MIRT519077	hsa-miR-4438	PAR-CLIP	23446348
MIRT519078	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT519076	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT519075	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT519074	hsa-miR-4537	PAR-CLIP	23446348
MIRT519073	hsa-miR-2114-3p	PAR-CLIP	23446348
MIRT519072	hsa-miR-6823-3p	PAR-CLIP	23446348
MIRT519071	hsa-miR-4663	PAR-CLIP	23446348
MIRT519070	hsa-miR-3119	PAR-CLIP	23446348
MIRT519069	hsa-miR-5095	PAR-CLIP	23446348
MIRT519068	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT519067	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT519066	hsa-miR-6832-3p	PAR-CLIP	23446348
MIRT519064	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT519065	hsa-miR-4252	PAR-CLIP	23446348
MIRT519063	hsa-miR-1254	PAR-CLIP	23446348
MIRT519062	hsa-miR-3116	PAR-CLIP	23446348
MIRT519061	hsa-miR-661	PAR-CLIP	23446348
MIRT519060	hsa-miR-1291	PAR-CLIP	23446348
MIRT519059	hsa-miR-6775-3p	PAR-CLIP	23446348
MIRT519058	hsa-miR-6851-3p	PAR-CLIP	23446348
MIRT519057	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT519056	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT519055	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT519054	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT519053	hsa-miR-328-3p	PAR-CLIP	23446348
MIRT519052	hsa-miR-550b-2-5p	PAR-CLIP	23446348
MIRT461064	hsa-miR-495-5p	PAR-CLIP	23446348
MIRT461063	hsa-miR-4459	PAR-CLIP	23446348
MIRT461062	hsa-miR-665	PAR-CLIP	23446348
MIRT461061	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT461060	hsa-miR-6134	PAR-CLIP	23446348
MIRT461059	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT461058	hsa-miR-3689d	PAR-CLIP	23446348
MIRT461057	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT461056	hsa-miR-3190-3p	PAR-CLIP	23446348
MIRT461055	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT461054	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT461064	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT461063	hsa-miR-4459	PAR-CLIP	23592263
MIRT461062	hsa-miR-665	PAR-CLIP	23592263
MIRT461061	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461060	hsa-miR-6134	PAR-CLIP	23592263
MIRT461059	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461058	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461057	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT461056	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT461055	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461054	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT440405	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440405	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT519066	hsa-miR-6832-3p	HITS-CLIP	27418678
MIRT519066	hsa-miR-6832-3p	HITS-CLIP	27418678
MIRT519066	hsa-miR-6832-3p	HITS-CLIP	27418678
MIRT519066	hsa-miR-6832-3p	HITS-CLIP	27418678
MIRT696051	hsa-miR-548a-3p	HITS-CLIP	23313552
MIRT696050	hsa-miR-548ar-3p	HITS-CLIP	23313552
MIRT696049	hsa-miR-548az-3p	HITS-CLIP	23313552
MIRT696048	hsa-miR-548e-3p	HITS-CLIP	23313552
MIRT696047	hsa-miR-548f-3p	HITS-CLIP	23313552
MIRT696046	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT696045	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT696044	hsa-miR-8073	HITS-CLIP	23313552
MIRT696043	hsa-miR-2116-3p	HITS-CLIP	23313552
MIRT696042	hsa-miR-3176	HITS-CLIP	23313552
MIRT696041	hsa-miR-3922-3p	HITS-CLIP	23313552
MIRT696040	hsa-miR-7152-3p	HITS-CLIP	23313552
MIRT696039	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696038	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT696037	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT696036	hsa-miR-601	HITS-CLIP	23313552
MIRT696035	hsa-miR-6749-3p	HITS-CLIP	23313552
MIRT696034	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT519073	hsa-miR-2114-3p	HITS-CLIP	23313552
MIRT685597	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT685596	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT685595	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT685594	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT685593	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT685592	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT685591	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT685590	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT685589	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT685588	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT685587	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT685586	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT685585	hsa-miR-302e	HITS-CLIP	23313552
MIRT685584	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT685583	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT685582	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT685581	hsa-miR-520b	HITS-CLIP	23313552
MIRT685580	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT685579	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT685578	hsa-miR-520e	HITS-CLIP	23313552
MIRT685577	hsa-miR-5683	HITS-CLIP	23313552
MIRT685576	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT685575	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT685574	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT685573	hsa-miR-520h	HITS-CLIP	23313552
MIRT685572	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT685571	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT685570	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT685569	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT685568	hsa-miR-636	HITS-CLIP	23313552
MIRT685567	hsa-miR-3157-5p	HITS-CLIP	23313552
MIRT685566	hsa-miR-3977	HITS-CLIP	23313552
MIRT440405	hsa-miR-218-5p	HITS-CLIP	23313552
MIRT649604	hsa-miR-567	HITS-CLIP	23824327
MIRT649603	hsa-miR-675-3p	HITS-CLIP	23824327
MIRT649602	hsa-miR-297	HITS-CLIP	23824327
MIRT649601	hsa-miR-3149	HITS-CLIP	23824327
MIRT649600	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT626790	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT626789	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626788	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626787	hsa-miR-498	HITS-CLIP	23824327
MIRT635815	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT635816	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT635814	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT635813	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT635812	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT635811	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT635810	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT635809	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT626790	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT626788	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626787	hsa-miR-498	HITS-CLIP	23824327
MIRT626790	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT626789	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626788	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626787	hsa-miR-498	HITS-CLIP	23824327
MIRT519077	hsa-miR-4438	PAR-CLIP	23446348
MIRT519078	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT519076	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT519075	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT519074	hsa-miR-4537	PAR-CLIP	23446348
MIRT519073	hsa-miR-2114-3p	PAR-CLIP	23446348
MIRT519072	hsa-miR-6823-3p	PAR-CLIP	23446348
MIRT519071	hsa-miR-4663	PAR-CLIP	23446348
MIRT519070	hsa-miR-3119	PAR-CLIP	23446348
MIRT519069	hsa-miR-5095	PAR-CLIP	23446348
MIRT519068	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT519067	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT519066	hsa-miR-6832-3p	PAR-CLIP	23446348
MIRT519064	hsa-miR-6889-3p	PAR-CLIP	23446348
MIRT519065	hsa-miR-4252	PAR-CLIP	23446348
MIRT519063	hsa-miR-1254	PAR-CLIP	23446348
MIRT519062	hsa-miR-3116	PAR-CLIP	23446348
MIRT519061	hsa-miR-661	PAR-CLIP	23446348
MIRT519060	hsa-miR-1291	PAR-CLIP	23446348
MIRT519059	hsa-miR-6775-3p	PAR-CLIP	23446348
MIRT519058	hsa-miR-6851-3p	PAR-CLIP	23446348
MIRT519057	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT519056	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT519055	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT519054	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT519053	hsa-miR-328-3p	PAR-CLIP	23446348
MIRT519052	hsa-miR-550b-2-5p	PAR-CLIP	23446348
MIRT461064	hsa-miR-495-5p	PAR-CLIP	23446348
MIRT461063	hsa-miR-4459	PAR-CLIP	23446348
MIRT461062	hsa-miR-665	PAR-CLIP	23446348
MIRT461061	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT461060	hsa-miR-6134	PAR-CLIP	23446348
MIRT461059	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT461058	hsa-miR-3689d	PAR-CLIP	23446348
MIRT461057	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT461056	hsa-miR-3190-3p	PAR-CLIP	23446348
MIRT461055	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT461054	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT461064	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT461063	hsa-miR-4459	PAR-CLIP	23592263
MIRT461062	hsa-miR-665	PAR-CLIP	23592263
MIRT461061	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461060	hsa-miR-6134	PAR-CLIP	23592263
MIRT461059	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461058	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461057	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT461056	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT461055	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT461054	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1081919	hsa-miR-103a	CLIP-seq
MIRT1081920	hsa-miR-107	CLIP-seq
MIRT1081921	hsa-miR-122	CLIP-seq
MIRT1081922	hsa-miR-1255a	CLIP-seq
MIRT1081923	hsa-miR-1255b	CLIP-seq
MIRT1081924	hsa-miR-1271	CLIP-seq
MIRT1081925	hsa-miR-1272	CLIP-seq
MIRT1081926	hsa-miR-1273g	CLIP-seq
MIRT1081927	hsa-miR-1276	CLIP-seq
MIRT1081928	hsa-miR-128	CLIP-seq
MIRT1081929	hsa-miR-1322	CLIP-seq
MIRT1081930	hsa-miR-154	CLIP-seq
MIRT1081931	hsa-miR-182	CLIP-seq
MIRT1081932	hsa-miR-1827	CLIP-seq
MIRT1081933	hsa-miR-2113	CLIP-seq
MIRT1081934	hsa-miR-24	CLIP-seq
MIRT1081935	hsa-miR-3124-3p	CLIP-seq
MIRT1081936	hsa-miR-3135b	CLIP-seq
MIRT1081937	hsa-miR-3138	CLIP-seq
MIRT1081938	hsa-miR-3153	CLIP-seq
MIRT1081939	hsa-miR-323b-5p	CLIP-seq
MIRT1081940	hsa-miR-3605-5p	CLIP-seq
MIRT1081941	hsa-miR-3614-5p	CLIP-seq
MIRT1081942	hsa-miR-3652	CLIP-seq
MIRT1081943	hsa-miR-3667-3p	CLIP-seq
MIRT1081944	hsa-miR-3670	CLIP-seq
MIRT1081945	hsa-miR-3682-3p	CLIP-seq
MIRT1081946	hsa-miR-371-5p	CLIP-seq
MIRT1081947	hsa-miR-371b-5p	CLIP-seq
MIRT1081948	hsa-miR-382	CLIP-seq
MIRT1081949	hsa-miR-3915	CLIP-seq
MIRT1081950	hsa-miR-3919	CLIP-seq
MIRT1081951	hsa-miR-3922-5p	CLIP-seq
MIRT1081952	hsa-miR-3925-5p	CLIP-seq
MIRT1081953	hsa-miR-3928	CLIP-seq
MIRT1081954	hsa-miR-3929	CLIP-seq
MIRT1081955	hsa-miR-3944-5p	CLIP-seq
MIRT1081956	hsa-miR-4259	CLIP-seq
MIRT1081957	hsa-miR-4261	CLIP-seq
MIRT1081958	hsa-miR-4311	CLIP-seq
MIRT1081959	hsa-miR-4419b	CLIP-seq
MIRT1081960	hsa-miR-4425	CLIP-seq
MIRT1081961	hsa-miR-4430	CLIP-seq
MIRT1081962	hsa-miR-4449	CLIP-seq
MIRT1081963	hsa-miR-4461	CLIP-seq
MIRT1081964	hsa-miR-4474-5p	CLIP-seq
MIRT1081965	hsa-miR-4478	CLIP-seq
MIRT1081966	hsa-miR-4491	CLIP-seq
MIRT1081967	hsa-miR-4496	CLIP-seq
MIRT1081968	hsa-miR-450b-3p	CLIP-seq
MIRT1081969	hsa-miR-4519	CLIP-seq
MIRT1081970	hsa-miR-4520a-3p	CLIP-seq
MIRT1081971	hsa-miR-4657	CLIP-seq
MIRT1081972	hsa-miR-4676-5p	CLIP-seq
MIRT1081973	hsa-miR-4685-5p	CLIP-seq
MIRT1081974	hsa-miR-4704-3p	CLIP-seq
MIRT1081975	hsa-miR-4712-3p	CLIP-seq
MIRT1081976	hsa-miR-4735-5p	CLIP-seq
MIRT1081977	hsa-miR-4756-3p	CLIP-seq
MIRT1081978	hsa-miR-4760-5p	CLIP-seq
MIRT1081979	hsa-miR-4775	CLIP-seq
MIRT1081980	hsa-miR-4781-3p	CLIP-seq
MIRT1081981	hsa-miR-4800-5p	CLIP-seq
MIRT1081982	hsa-miR-483-5p	CLIP-seq
MIRT1081983	hsa-miR-501-3p	CLIP-seq
MIRT1081984	hsa-miR-502-3p	CLIP-seq
MIRT1081985	hsa-miR-513a-5p	CLIP-seq
MIRT1081986	hsa-miR-575	CLIP-seq
MIRT1081987	hsa-miR-583	CLIP-seq
MIRT1081988	hsa-miR-590-3p	CLIP-seq
MIRT1081989	hsa-miR-600	CLIP-seq
MIRT1081990	hsa-miR-624	CLIP-seq
MIRT1081991	hsa-miR-767-5p	CLIP-seq
MIRT1081992	hsa-miR-769-3p	CLIP-seq
MIRT1081993	hsa-miR-885-3p	CLIP-seq
MIRT1081994	hsa-miR-96	CLIP-seq
MIRT2020333	hsa-let-7a	CLIP-seq
MIRT2020334	hsa-let-7b	CLIP-seq
MIRT2020335	hsa-let-7c	CLIP-seq
MIRT2020336	hsa-let-7d	CLIP-seq
MIRT2020337	hsa-let-7e	CLIP-seq
MIRT2020338	hsa-let-7f	CLIP-seq
MIRT2020339	hsa-let-7g	CLIP-seq
MIRT2020340	hsa-let-7i	CLIP-seq
MIRT1081919	hsa-miR-103a	CLIP-seq
MIRT1081920	hsa-miR-107	CLIP-seq
MIRT2020341	hsa-miR-1197	CLIP-seq
MIRT2020342	hsa-miR-1208	CLIP-seq
MIRT1081921	hsa-miR-122	CLIP-seq
MIRT2020343	hsa-miR-125a-5p	CLIP-seq
MIRT2020344	hsa-miR-125b	CLIP-seq
MIRT1081927	hsa-miR-1276	CLIP-seq
MIRT1081928	hsa-miR-128	CLIP-seq
MIRT2020345	hsa-miR-134	CLIP-seq
MIRT2020346	hsa-miR-140-5p	CLIP-seq
MIRT2020347	hsa-miR-142-3p	CLIP-seq
MIRT2020348	hsa-miR-196a	CLIP-seq
MIRT2020349	hsa-miR-196b	CLIP-seq
MIRT2020350	hsa-miR-1972	CLIP-seq
MIRT2020351	hsa-miR-2467-3p	CLIP-seq
MIRT2020352	hsa-miR-2909	CLIP-seq
MIRT2020353	hsa-miR-2964a-5p	CLIP-seq
MIRT2020354	hsa-miR-3065-3p	CLIP-seq
MIRT2020355	hsa-miR-3118	CLIP-seq
MIRT2020356	hsa-miR-3123	CLIP-seq
MIRT1081936	hsa-miR-3135b	CLIP-seq
MIRT1081937	hsa-miR-3138	CLIP-seq
MIRT2020357	hsa-miR-3144-5p	CLIP-seq
MIRT2020358	hsa-miR-3164	CLIP-seq
MIRT2020359	hsa-miR-3191	CLIP-seq
MIRT2020360	hsa-miR-3616-5p	CLIP-seq
MIRT2020361	hsa-miR-3647-5p	CLIP-seq
MIRT1081942	hsa-miR-3652	CLIP-seq
MIRT1081943	hsa-miR-3667-3p	CLIP-seq
MIRT1081944	hsa-miR-3670	CLIP-seq
MIRT1081948	hsa-miR-382	CLIP-seq
MIRT1081950	hsa-miR-3919	CLIP-seq
MIRT1081954	hsa-miR-3929	CLIP-seq
MIRT1081955	hsa-miR-3944-5p	CLIP-seq
MIRT1081956	hsa-miR-4259	CLIP-seq
MIRT2020362	hsa-miR-4278	CLIP-seq
MIRT2020363	hsa-miR-4293	CLIP-seq
MIRT1081958	hsa-miR-4311	CLIP-seq
MIRT2020364	hsa-miR-4319	CLIP-seq
MIRT1081959	hsa-miR-4419b	CLIP-seq
MIRT1081960	hsa-miR-4425	CLIP-seq
MIRT1081961	hsa-miR-4430	CLIP-seq
MIRT2020365	hsa-miR-4436b-3p	CLIP-seq
MIRT1081962	hsa-miR-4449	CLIP-seq
MIRT2020366	hsa-miR-4458	CLIP-seq
MIRT2020367	hsa-miR-4476	CLIP-seq
MIRT1081965	hsa-miR-4478	CLIP-seq
MIRT1081966	hsa-miR-4491	CLIP-seq
MIRT2020368	hsa-miR-4500	CLIP-seq
MIRT1081968	hsa-miR-450b-3p	CLIP-seq
MIRT1081969	hsa-miR-4519	CLIP-seq
MIRT1081970	hsa-miR-4520a-3p	CLIP-seq
MIRT2020369	hsa-miR-4640-5p	CLIP-seq
MIRT2020370	hsa-miR-4652-5p	CLIP-seq
MIRT1081971	hsa-miR-4657	CLIP-seq
MIRT2020371	hsa-miR-4670-3p	CLIP-seq
MIRT1081973	hsa-miR-4685-5p	CLIP-seq
MIRT2020372	hsa-miR-4688	CLIP-seq
MIRT2020373	hsa-miR-4690-3p	CLIP-seq
MIRT2020374	hsa-miR-4726-5p	CLIP-seq
MIRT2020375	hsa-miR-4732-3p	CLIP-seq
MIRT1081976	hsa-miR-4735-5p	CLIP-seq
MIRT1081977	hsa-miR-4756-3p	CLIP-seq
MIRT1081979	hsa-miR-4775	CLIP-seq
MIRT2020376	hsa-miR-4779	CLIP-seq
MIRT1081981	hsa-miR-4800-5p	CLIP-seq
MIRT2020377	hsa-miR-485-5p	CLIP-seq
MIRT2020378	hsa-miR-500a	CLIP-seq
MIRT1081983	hsa-miR-501-3p	CLIP-seq
MIRT2020379	hsa-miR-501-5p	CLIP-seq
MIRT1081984	hsa-miR-502-3p	CLIP-seq
MIRT1081985	hsa-miR-513a-5p	CLIP-seq
MIRT2020380	hsa-miR-573	CLIP-seq
MIRT1081987	hsa-miR-583	CLIP-seq
MIRT1081988	hsa-miR-590-3p	CLIP-seq
MIRT1081989	hsa-miR-600	CLIP-seq
MIRT2020381	hsa-miR-629	CLIP-seq
MIRT2020382	hsa-miR-648	CLIP-seq
MIRT2020383	hsa-miR-670	CLIP-seq
MIRT1081991	hsa-miR-767-5p	CLIP-seq
MIRT1081992	hsa-miR-769-3p	CLIP-seq
MIRT2020384	hsa-miR-98	CLIP-seq
MIRT2020333	hsa-let-7a	CLIP-seq
MIRT2020334	hsa-let-7b	CLIP-seq
MIRT2020335	hsa-let-7c	CLIP-seq
MIRT2020336	hsa-let-7d	CLIP-seq
MIRT2020337	hsa-let-7e	CLIP-seq
MIRT2020338	hsa-let-7f	CLIP-seq
MIRT2020339	hsa-let-7g	CLIP-seq
MIRT2020340	hsa-let-7i	CLIP-seq
MIRT1081919	hsa-miR-103a	CLIP-seq
MIRT1081920	hsa-miR-107	CLIP-seq
MIRT2252129	hsa-miR-1184	CLIP-seq
MIRT2020341	hsa-miR-1197	CLIP-seq
MIRT1081921	hsa-miR-122	CLIP-seq
MIRT2252130	hsa-miR-1269	CLIP-seq
MIRT2252131	hsa-miR-1269b	CLIP-seq
MIRT2252132	hsa-miR-1288	CLIP-seq
MIRT2020345	hsa-miR-134	CLIP-seq
MIRT2020347	hsa-miR-142-3p	CLIP-seq
MIRT2020348	hsa-miR-196a	CLIP-seq
MIRT2020349	hsa-miR-196b	CLIP-seq
MIRT2252133	hsa-miR-198	CLIP-seq
MIRT2252134	hsa-miR-2276	CLIP-seq
MIRT2252135	hsa-miR-3074-5p	CLIP-seq
MIRT2020355	hsa-miR-3118	CLIP-seq
MIRT1081936	hsa-miR-3135b	CLIP-seq
MIRT1081937	hsa-miR-3138	CLIP-seq
MIRT2020358	hsa-miR-3164	CLIP-seq
MIRT1081941	hsa-miR-3614-5p	CLIP-seq
MIRT1081942	hsa-miR-3652	CLIP-seq
MIRT2252136	hsa-miR-3654	CLIP-seq
MIRT1081944	hsa-miR-3670	CLIP-seq
MIRT2252137	hsa-miR-3680	CLIP-seq
MIRT2252138	hsa-miR-378	CLIP-seq
MIRT2252139	hsa-miR-378b	CLIP-seq
MIRT2252140	hsa-miR-378c	CLIP-seq
MIRT2252141	hsa-miR-378d	CLIP-seq
MIRT2252142	hsa-miR-378e	CLIP-seq
MIRT2252143	hsa-miR-378f	CLIP-seq
MIRT2252144	hsa-miR-378h	CLIP-seq
MIRT2252145	hsa-miR-378i	CLIP-seq
MIRT1081949	hsa-miR-3915	CLIP-seq
MIRT1081950	hsa-miR-3919	CLIP-seq
MIRT1081951	hsa-miR-3922-5p	CLIP-seq
MIRT1081953	hsa-miR-3928	CLIP-seq
MIRT1081954	hsa-miR-3929	CLIP-seq
MIRT1081955	hsa-miR-3944-5p	CLIP-seq
MIRT2252146	hsa-miR-422a	CLIP-seq
MIRT2252147	hsa-miR-4418	CLIP-seq
MIRT1081959	hsa-miR-4419b	CLIP-seq
MIRT1081960	hsa-miR-4425	CLIP-seq
MIRT1081961	hsa-miR-4430	CLIP-seq
MIRT2020365	hsa-miR-4436b-3p	CLIP-seq
MIRT1081962	hsa-miR-4449	CLIP-seq
MIRT2020366	hsa-miR-4458	CLIP-seq
MIRT1081965	hsa-miR-4478	CLIP-seq
MIRT1081966	hsa-miR-4491	CLIP-seq
MIRT2020368	hsa-miR-4500	CLIP-seq
MIRT1081968	hsa-miR-450b-3p	CLIP-seq
MIRT2252148	hsa-miR-4515	CLIP-seq
MIRT1081969	hsa-miR-4519	CLIP-seq
MIRT1081970	hsa-miR-4520a-3p	CLIP-seq
MIRT1081971	hsa-miR-4657	CLIP-seq
MIRT2252149	hsa-miR-4670-5p	CLIP-seq
MIRT1081973	hsa-miR-4685-5p	CLIP-seq
MIRT1081974	hsa-miR-4704-3p	CLIP-seq
MIRT2252150	hsa-miR-4722-3p	CLIP-seq
MIRT2252151	hsa-miR-4740-5p	CLIP-seq
MIRT2252152	hsa-miR-4755-3p	CLIP-seq
MIRT1081977	hsa-miR-4756-3p	CLIP-seq
MIRT2252153	hsa-miR-4763-5p	CLIP-seq
MIRT1081981	hsa-miR-4800-5p	CLIP-seq
MIRT2252154	hsa-miR-509-3-5p	CLIP-seq
MIRT2252155	hsa-miR-509-5p	CLIP-seq
MIRT1081989	hsa-miR-600	CLIP-seq
MIRT2020382	hsa-miR-648	CLIP-seq
MIRT1081992	hsa-miR-769-3p	CLIP-seq
MIRT2020384	hsa-miR-98	CLIP-seq
MIRT1081919	hsa-miR-103a	CLIP-seq
MIRT1081920	hsa-miR-107	CLIP-seq
MIRT2252129	hsa-miR-1184	CLIP-seq
MIRT1081921	hsa-miR-122	CLIP-seq
MIRT1081936	hsa-miR-3135b	CLIP-seq
MIRT1081942	hsa-miR-3652	CLIP-seq
MIRT2252137	hsa-miR-3680	CLIP-seq
MIRT1081946	hsa-miR-371-5p	CLIP-seq
MIRT2389666	hsa-miR-3940-3p	CLIP-seq
MIRT1081955	hsa-miR-3944-5p	CLIP-seq
MIRT2252147	hsa-miR-4418	CLIP-seq
MIRT1081961	hsa-miR-4430	CLIP-seq
MIRT1081962	hsa-miR-4449	CLIP-seq
MIRT1081969	hsa-miR-4519	CLIP-seq
MIRT2252154	hsa-miR-509-3-5p	CLIP-seq
MIRT2252155	hsa-miR-509-5p	CLIP-seq
MIRT2020351	hsa-miR-2467-3p	CLIP-seq
MIRT1081949	hsa-miR-3915	CLIP-seq
MIRT1081953	hsa-miR-3928	CLIP-seq
MIRT2252152	hsa-miR-4755-3p	CLIP-seq
MIRT2020377	hsa-miR-485-5p	CLIP-seq
MIRT2020351	hsa-miR-2467-3p	CLIP-seq
MIRT2020377	hsa-miR-485-5p	CLIP-seq
MIRT1081983	hsa-miR-501-3p	CLIP-seq
MIRT1081984	hsa-miR-502-3p	CLIP-seq
MIRT1081985	hsa-miR-513a-5p	CLIP-seq
MIRT1081991	hsa-miR-767-5p	CLIP-seq
MIRT1081983	hsa-miR-501-3p	CLIP-seq
MIRT1081984	hsa-miR-502-3p	CLIP-seq
MIRT1081985	hsa-miR-513a-5p	CLIP-seq
MIRT1081991	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003073	Process	Regulation of systemic arterial blood pressure	IEA
GO:0003085	Process	Negative regulation of systemic arterial blood pressure	IEA
GO:0005242	Function	Inward rectifier potassium channel activity	TAS	10075682
GO:0005267	Function	Potassium channel activity	IDA	28381826
GO:0005267	Function	Potassium channel activity	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	28381826
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006813	Process	Potassium ion transport	TAS	10075682
GO:0008076	Component	Voltage-gated potassium channel complex	TAS	10075682
GO:0015271	Function	Outward rectifier potassium channel activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0022841	Function	Potassium ion leak channel activity	IBA
GO:0031902	Component	Late endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	ISS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060075	Process	Regulation of resting membrane potential	IEA
GO:0062196	Process	Regulation of lysosome size	ISS
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IEA
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IEA
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	ISS

Other IDs

• MIM: 603939
• HGNC: 6281
• e!Ensembl: ENSG00000099337

Protein

• UniProt ID: Q9Y257
• Protein name: Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)
• Protein function: K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:10887187, PubMed:28381826). Active in lysosomes where it regulates lysosome numbers and size (PubMed:28381826). In macrophages, enables K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07885	Ion_trans_2	72 → 146	Ion channel	Family
  PF07885	Ion_trans_2	168 → 260	Ion channel	Family

• Tissue specificity: TISSUE SPECIFICITY: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus
• Sequence:

  MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALD
  AFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGK
  AFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVV
  VTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTV
  YLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQL
  SASSHTDYASIPR

• Sequence length: 313

Pathways

Reactome:

Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Phase 4 - resting membrane potential

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
FOCAL SEGMENTAL GLOMERULOSCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anemia Sickle Cell	Sickle cell anemia	Pubtator	20029952	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	32512817	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	34337010	Associate	★☆☆☆☆ Found in Text Mining only
Linear atrophy	Atrophy	BEFREE	14689445		★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	36255321	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	34349187	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	29437071		★☆☆☆☆ Found in Text Mining only