Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	94120
Gene name	Synaptotagmin like 3
Gene symbol	SYTL3
Synonyms (NCBI Gene)	SLP3
Chromosome	6
Chromosome location	6q25.3
Summary	The protein encoded by this gene belongs to a family of peripheral membrane proteins that play a role in vesicular trafficking. This protein binds phospholipids in the presence of calcium ions. Alternatively spliced transcript variants encoding different

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miRTarBase ID	miRNA	Experiments	Reference
MIRT516511	hsa-miR-302f	HITS-CLIP	23313552
MIRT693307	hsa-miR-890	HITS-CLIP	23313552
MIRT693306	hsa-miR-5690	HITS-CLIP	23313552
MIRT516510	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT516509	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT516508	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT516507	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT516506	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT516505	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT516504	hsa-miR-4505	HITS-CLIP	23313552
MIRT516503	hsa-miR-5787	HITS-CLIP	23313552
MIRT693305	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT693304	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT693303	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT693302	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT693301	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT693300	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT516502	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT516501	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT516500	hsa-miR-449c-3p	HITS-CLIP	23313552
MIRT693299	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT693298	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT693297	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT693296	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT693295	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT693294	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT693293	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT693292	hsa-miR-3689c	HITS-CLIP	23313552
MIRT693291	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT693290	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT693289	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT516511	hsa-miR-302f	PAR-CLIP	23446348
MIRT516510	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT516509	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT516508	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT516507	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT516506	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT516505	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT516504	hsa-miR-4505	PAR-CLIP	23446348
MIRT516503	hsa-miR-5787	PAR-CLIP	23446348
MIRT516502	hsa-miR-6721-5p	PAR-CLIP	23446348
MIRT516501	hsa-miR-486-3p	PAR-CLIP	23446348
MIRT516500	hsa-miR-449c-3p	PAR-CLIP	23446348
MIRT516511	hsa-miR-302f	HITS-CLIP	23313552
MIRT693307	hsa-miR-890	HITS-CLIP	23313552
MIRT693306	hsa-miR-5690	HITS-CLIP	23313552
MIRT516510	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT516509	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT516508	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT516507	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT516506	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT516505	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT516504	hsa-miR-4505	HITS-CLIP	23313552
MIRT516503	hsa-miR-5787	HITS-CLIP	23313552
MIRT693305	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT693304	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT693303	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT693302	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT693301	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT693300	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT516502	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT516501	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT516500	hsa-miR-449c-3p	HITS-CLIP	23313552
MIRT693299	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT693298	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT693297	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT693296	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT693295	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT693294	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT693293	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT693292	hsa-miR-3689c	HITS-CLIP	23313552
MIRT693291	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT693290	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT693289	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT516511	hsa-miR-302f	PAR-CLIP	23446348
MIRT516510	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT516509	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT516508	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT516507	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT516506	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT516505	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT516504	hsa-miR-4505	PAR-CLIP	23446348
MIRT516503	hsa-miR-5787	PAR-CLIP	23446348
MIRT516502	hsa-miR-6721-5p	PAR-CLIP	23446348
MIRT516501	hsa-miR-486-3p	PAR-CLIP	23446348
MIRT516500	hsa-miR-449c-3p	PAR-CLIP	23446348

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005543	Function	Phospholipid binding	IEA
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006887	Process	Exocytosis	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0042043	Function	Neurexin family protein binding	IBA
GO:0042043	Function	Neurexin family protein binding	IEA
GO:0070382	Component	Exocytic vesicle	IBA

MIM	HGNC	e!Ensembl
620973	15587	ENSG00000164674

Q4VX76

Protein name

Synaptotagmin-like protein 3 (Exophilin-6)

Protein function

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02318	FYVE_2	8 → 124	FYVE-type zinc finger	Family
PF00168	C2	321 → 433	C2 domain	Domain
PF00168	C2	480 → 585	C2 domain	Domain

Sequence

MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEHKE
KCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWF
YEERAKKFPTGGKHETVGGQLLQSYQKLSKISVVPPTPPPVSESQCSRSPGRLQEFGQFR
GFNKSVENLFLSLATHVKKLSKSQNDMTSEKHLLATGPRQCVGQTERRSQSDTAVNVTTR
KVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGN
FDNANVTGEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQGK
RKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDF
EDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHG
QLCLVVLGAKNLPVRPDGTLNSFVKGCLTLPDQQKLRLKSPVLRKQACPQWKHSFVFSGV
TPAQLRQSSLELTVWDQALFGMNDRLLGGTRLGSKGDTAVGGDACSLSKLQWQKVLSSPN
LWTDMTLVLH

Sequence length

610

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PERIPHERAL ARTERIAL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	33797837	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	32108034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chediak-Higashi Syndrome	Chediak-Higashi Syndrome	BEFREE	25425525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	29195083		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Arterial Diseases	Vascular Diseases	GWASCAT_DG	31388106		★★★★★ ★☆☆☆☆ Found in Text Mining only

SYTL3 (synaptotagmin like 3)