TMEM203 (transmembrane protein 203)

Gene

• Entrez ID: 94107
• Gene name: Transmembrane protein 203
• Gene symbol: TMEM203
• Synonyms (NCBI Gene): HBEBP1
• Chromosome: 9
• Chromosome location: 9q34.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040845	hsa-miR-18a-3p	CLASH	23622248
MIRT1435076	hsa-miR-101	CLIP-seq
MIRT1435077	hsa-miR-1200	CLIP-seq
MIRT1435078	hsa-miR-1301	CLIP-seq
MIRT1435079	hsa-miR-1324	CLIP-seq
MIRT1435080	hsa-miR-138	CLIP-seq
MIRT1435081	hsa-miR-19a	CLIP-seq
MIRT1435082	hsa-miR-19b	CLIP-seq
MIRT1435083	hsa-miR-2113	CLIP-seq
MIRT1435084	hsa-miR-4267	CLIP-seq
MIRT1435085	hsa-miR-4324	CLIP-seq
MIRT1435086	hsa-miR-4443	CLIP-seq
MIRT1435087	hsa-miR-4700-3p	CLIP-seq
MIRT1435088	hsa-miR-4709-5p	CLIP-seq
MIRT1435089	hsa-miR-5047	CLIP-seq
MIRT1435090	hsa-miR-544b	CLIP-seq
MIRT1435091	hsa-miR-578	CLIP-seq
MIRT1435092	hsa-miR-635	CLIP-seq
MIRT1435093	hsa-miR-765	CLIP-seq
MIRT1435077	hsa-miR-1200	CLIP-seq
MIRT2130357	hsa-miR-1231	CLIP-seq
MIRT2130358	hsa-miR-1236	CLIP-seq
MIRT2130359	hsa-miR-1254	CLIP-seq
MIRT1435078	hsa-miR-1301	CLIP-seq
MIRT2130360	hsa-miR-1321	CLIP-seq
MIRT1435080	hsa-miR-138	CLIP-seq
MIRT1435083	hsa-miR-2113	CLIP-seq
MIRT2130361	hsa-miR-3116	CLIP-seq
MIRT2130362	hsa-miR-3120-5p	CLIP-seq
MIRT2130363	hsa-miR-3162-5p	CLIP-seq
MIRT2130364	hsa-miR-3169	CLIP-seq
MIRT2130365	hsa-miR-3176	CLIP-seq
MIRT2130366	hsa-miR-3183	CLIP-seq
MIRT2130367	hsa-miR-3188	CLIP-seq
MIRT2130368	hsa-miR-3607-5p	CLIP-seq
MIRT2130369	hsa-miR-3690	CLIP-seq
MIRT2130370	hsa-miR-3922-3p	CLIP-seq
MIRT2130371	hsa-miR-4257	CLIP-seq
MIRT1435084	hsa-miR-4267	CLIP-seq
MIRT2130372	hsa-miR-4300	CLIP-seq
MIRT1435085	hsa-miR-4324	CLIP-seq
MIRT2130373	hsa-miR-4326	CLIP-seq
MIRT2130374	hsa-miR-4436a	CLIP-seq
MIRT1435086	hsa-miR-4443	CLIP-seq
MIRT2130375	hsa-miR-4503	CLIP-seq
MIRT2130376	hsa-miR-4519	CLIP-seq
MIRT2130377	hsa-miR-4520a-3p	CLIP-seq
MIRT2130378	hsa-miR-4638-3p	CLIP-seq
MIRT2130379	hsa-miR-4723-3p	CLIP-seq
MIRT2130380	hsa-miR-4739	CLIP-seq
MIRT2130381	hsa-miR-4756-5p	CLIP-seq
MIRT1435089	hsa-miR-5047	CLIP-seq
MIRT2130382	hsa-miR-510	CLIP-seq
MIRT2130383	hsa-miR-512-5p	CLIP-seq
MIRT2130384	hsa-miR-515-3p	CLIP-seq
MIRT2130385	hsa-miR-519e	CLIP-seq
MIRT1435090	hsa-miR-544b	CLIP-seq
MIRT2130386	hsa-miR-550a	CLIP-seq
MIRT2130387	hsa-miR-622	CLIP-seq
MIRT2130388	hsa-miR-637	CLIP-seq
MIRT2130389	hsa-miR-661	CLIP-seq
MIRT1435093	hsa-miR-765	CLIP-seq
MIRT2130390	hsa-miR-920	CLIP-seq
MIRT2130391	hsa-miR-922	CLIP-seq
MIRT1435076	hsa-miR-101	CLIP-seq
MIRT1435077	hsa-miR-1200	CLIP-seq
MIRT2130357	hsa-miR-1231	CLIP-seq
MIRT2130358	hsa-miR-1236	CLIP-seq
MIRT2130359	hsa-miR-1254	CLIP-seq
MIRT1435078	hsa-miR-1301	CLIP-seq
MIRT2351732	hsa-miR-1307	CLIP-seq
MIRT1435080	hsa-miR-138	CLIP-seq
MIRT2351733	hsa-miR-1469	CLIP-seq
MIRT2351734	hsa-miR-151-3p	CLIP-seq
MIRT2351735	hsa-miR-1915	CLIP-seq
MIRT1435081	hsa-miR-19a	CLIP-seq
MIRT1435082	hsa-miR-19b	CLIP-seq
MIRT1435083	hsa-miR-2113	CLIP-seq
MIRT2351736	hsa-miR-2276	CLIP-seq
MIRT2130361	hsa-miR-3116	CLIP-seq
MIRT2130362	hsa-miR-3120-5p	CLIP-seq
MIRT2351737	hsa-miR-3135	CLIP-seq
MIRT2130364	hsa-miR-3169	CLIP-seq
MIRT2130365	hsa-miR-3176	CLIP-seq
MIRT2351738	hsa-miR-3182	CLIP-seq
MIRT2130366	hsa-miR-3183	CLIP-seq
MIRT2351739	hsa-miR-3663-5p	CLIP-seq
MIRT2130369	hsa-miR-3690	CLIP-seq
MIRT2351740	hsa-miR-3691-3p	CLIP-seq
MIRT2130370	hsa-miR-3922-3p	CLIP-seq
MIRT2130371	hsa-miR-4257	CLIP-seq
MIRT1435084	hsa-miR-4267	CLIP-seq
MIRT2351741	hsa-miR-4270	CLIP-seq
MIRT2351742	hsa-miR-4279	CLIP-seq
MIRT2351743	hsa-miR-4297	CLIP-seq
MIRT2130372	hsa-miR-4300	CLIP-seq
MIRT1435085	hsa-miR-4324	CLIP-seq
MIRT2130373	hsa-miR-4326	CLIP-seq
MIRT2351744	hsa-miR-4328	CLIP-seq
MIRT2351745	hsa-miR-4426	CLIP-seq
MIRT2130374	hsa-miR-4436a	CLIP-seq
MIRT2351746	hsa-miR-4441	CLIP-seq
MIRT1435086	hsa-miR-4443	CLIP-seq
MIRT2351747	hsa-miR-4463	CLIP-seq
MIRT2351748	hsa-miR-4494	CLIP-seq
MIRT2351749	hsa-miR-4499	CLIP-seq
MIRT2130376	hsa-miR-4519	CLIP-seq
MIRT2130377	hsa-miR-4520a-3p	CLIP-seq
MIRT2351750	hsa-miR-4527	CLIP-seq
MIRT2130378	hsa-miR-4638-3p	CLIP-seq
MIRT2351751	hsa-miR-4642	CLIP-seq
MIRT2351752	hsa-miR-4647	CLIP-seq
MIRT2351753	hsa-miR-4659a-3p	CLIP-seq
MIRT2351754	hsa-miR-4659b-3p	CLIP-seq
MIRT2351755	hsa-miR-4661-3p	CLIP-seq
MIRT2351756	hsa-miR-4662b	CLIP-seq
MIRT1435088	hsa-miR-4709-5p	CLIP-seq
MIRT2351757	hsa-miR-4720-5p	CLIP-seq
MIRT2130379	hsa-miR-4723-3p	CLIP-seq
MIRT2351758	hsa-miR-4726-3p	CLIP-seq
MIRT2351759	hsa-miR-4746-3p	CLIP-seq
MIRT2351760	hsa-miR-4782-5p	CLIP-seq
MIRT2351761	hsa-miR-4799-3p	CLIP-seq
MIRT2351762	hsa-miR-483-5p	CLIP-seq
MIRT2351763	hsa-miR-499a-5p	CLIP-seq
MIRT1435089	hsa-miR-5047	CLIP-seq
MIRT2130382	hsa-miR-510	CLIP-seq
MIRT2130383	hsa-miR-512-5p	CLIP-seq
MIRT2130384	hsa-miR-515-3p	CLIP-seq
MIRT2130385	hsa-miR-519e	CLIP-seq
MIRT2351764	hsa-miR-543	CLIP-seq
MIRT1435090	hsa-miR-544b	CLIP-seq
MIRT2130386	hsa-miR-550a	CLIP-seq
MIRT2351765	hsa-miR-593	CLIP-seq
MIRT2351766	hsa-miR-619	CLIP-seq
MIRT2130387	hsa-miR-622	CLIP-seq
MIRT2130389	hsa-miR-661	CLIP-seq
MIRT2351767	hsa-miR-759	CLIP-seq
MIRT1435093	hsa-miR-765	CLIP-seq
MIRT2130390	hsa-miR-920	CLIP-seq
MIRT2130391	hsa-miR-922	CLIP-seq
MIRT2130358	hsa-miR-1236	CLIP-seq
MIRT2130366	hsa-miR-3183	CLIP-seq
MIRT2130373	hsa-miR-4326	CLIP-seq
MIRT2130379	hsa-miR-4723-3p	CLIP-seq
MIRT2130387	hsa-miR-622	CLIP-seq
MIRT2645437	hsa-miR-1202	CLIP-seq
MIRT2130358	hsa-miR-1236	CLIP-seq
MIRT2645438	hsa-miR-125a-3p	CLIP-seq
MIRT2645439	hsa-miR-1266	CLIP-seq
MIRT2130360	hsa-miR-1321	CLIP-seq
MIRT2645440	hsa-miR-300	CLIP-seq
MIRT2130362	hsa-miR-3120-5p	CLIP-seq
MIRT2130363	hsa-miR-3162-5p	CLIP-seq
MIRT2130366	hsa-miR-3183	CLIP-seq
MIRT2130367	hsa-miR-3188	CLIP-seq
MIRT2645441	hsa-miR-3194-5p	CLIP-seq
MIRT2645442	hsa-miR-323-5p	CLIP-seq
MIRT2130368	hsa-miR-3607-5p	CLIP-seq
MIRT2351739	hsa-miR-3663-5p	CLIP-seq
MIRT2645443	hsa-miR-3664-3p	CLIP-seq
MIRT2645444	hsa-miR-3689a-5p	CLIP-seq
MIRT2645445	hsa-miR-3689b	CLIP-seq
MIRT2645446	hsa-miR-3689e	CLIP-seq
MIRT2645447	hsa-miR-3689f	CLIP-seq
MIRT2645448	hsa-miR-381	CLIP-seq
MIRT2645449	hsa-miR-3910	CLIP-seq
MIRT2645450	hsa-miR-3934	CLIP-seq
MIRT2645451	hsa-miR-3972	CLIP-seq
MIRT2130373	hsa-miR-4326	CLIP-seq
MIRT2645452	hsa-miR-4428	CLIP-seq
MIRT2645453	hsa-miR-4518	CLIP-seq
MIRT2351750	hsa-miR-4527	CLIP-seq
MIRT2645454	hsa-miR-4533	CLIP-seq
MIRT2645455	hsa-miR-4639-5p	CLIP-seq
MIRT2645456	hsa-miR-4666-5p	CLIP-seq
MIRT2645457	hsa-miR-4690-3p	CLIP-seq
MIRT2130379	hsa-miR-4723-3p	CLIP-seq
MIRT2130380	hsa-miR-4739	CLIP-seq
MIRT2645458	hsa-miR-4747-5p	CLIP-seq
MIRT2130381	hsa-miR-4756-5p	CLIP-seq
MIRT2645459	hsa-miR-4761-5p	CLIP-seq
MIRT2351760	hsa-miR-4782-5p	CLIP-seq
MIRT2645460	hsa-miR-495	CLIP-seq
MIRT2645461	hsa-miR-548an	CLIP-seq
MIRT2130387	hsa-miR-622	CLIP-seq
MIRT2645462	hsa-miR-764	CLIP-seq
MIRT2645437	hsa-miR-1202	CLIP-seq
MIRT2130358	hsa-miR-1236	CLIP-seq
MIRT2645438	hsa-miR-125a-3p	CLIP-seq
MIRT2645439	hsa-miR-1266	CLIP-seq
MIRT2130360	hsa-miR-1321	CLIP-seq
MIRT2693481	hsa-miR-148a	CLIP-seq
MIRT2693482	hsa-miR-148b	CLIP-seq
MIRT2693483	hsa-miR-152	CLIP-seq
MIRT2645440	hsa-miR-300	CLIP-seq
MIRT2693484	hsa-miR-3065-5p	CLIP-seq
MIRT2130362	hsa-miR-3120-5p	CLIP-seq
MIRT2130363	hsa-miR-3162-5p	CLIP-seq
MIRT2130366	hsa-miR-3183	CLIP-seq
MIRT2130367	hsa-miR-3188	CLIP-seq
MIRT2645441	hsa-miR-3194-5p	CLIP-seq
MIRT2645442	hsa-miR-323-5p	CLIP-seq
MIRT2130368	hsa-miR-3607-5p	CLIP-seq
MIRT2351739	hsa-miR-3663-5p	CLIP-seq
MIRT2645443	hsa-miR-3664-3p	CLIP-seq
MIRT2693485	hsa-miR-3674	CLIP-seq
MIRT2645444	hsa-miR-3689a-5p	CLIP-seq
MIRT2645445	hsa-miR-3689b	CLIP-seq
MIRT2645446	hsa-miR-3689e	CLIP-seq
MIRT2645447	hsa-miR-3689f	CLIP-seq
MIRT2645448	hsa-miR-381	CLIP-seq
MIRT2645449	hsa-miR-3910	CLIP-seq
MIRT2645450	hsa-miR-3934	CLIP-seq
MIRT2693486	hsa-miR-3935	CLIP-seq
MIRT2645451	hsa-miR-3972	CLIP-seq
MIRT2693487	hsa-miR-4264	CLIP-seq
MIRT2351741	hsa-miR-4270	CLIP-seq
MIRT2130372	hsa-miR-4300	CLIP-seq
MIRT2130373	hsa-miR-4326	CLIP-seq
MIRT2351745	hsa-miR-4426	CLIP-seq
MIRT2645452	hsa-miR-4428	CLIP-seq
MIRT2351746	hsa-miR-4441	CLIP-seq
MIRT2693488	hsa-miR-4457	CLIP-seq
MIRT2645453	hsa-miR-4518	CLIP-seq
MIRT2351750	hsa-miR-4527	CLIP-seq
MIRT2645454	hsa-miR-4533	CLIP-seq
MIRT2645455	hsa-miR-4639-5p	CLIP-seq
MIRT2693489	hsa-miR-4640-5p	CLIP-seq
MIRT2351751	hsa-miR-4642	CLIP-seq
MIRT2351752	hsa-miR-4647	CLIP-seq
MIRT2351756	hsa-miR-4662b	CLIP-seq
MIRT2645456	hsa-miR-4666-5p	CLIP-seq
MIRT2645457	hsa-miR-4690-3p	CLIP-seq
MIRT2693490	hsa-miR-4695-3p	CLIP-seq
MIRT2693491	hsa-miR-4717-5p	CLIP-seq
MIRT2130379	hsa-miR-4723-3p	CLIP-seq
MIRT2693492	hsa-miR-4726-5p	CLIP-seq
MIRT2130380	hsa-miR-4739	CLIP-seq
MIRT2645458	hsa-miR-4747-5p	CLIP-seq
MIRT2130381	hsa-miR-4756-5p	CLIP-seq
MIRT2645459	hsa-miR-4761-5p	CLIP-seq
MIRT2351760	hsa-miR-4782-5p	CLIP-seq
MIRT2693493	hsa-miR-4797-3p	CLIP-seq
MIRT2351762	hsa-miR-483-5p	CLIP-seq
MIRT2645460	hsa-miR-495	CLIP-seq
MIRT2693494	hsa-miR-496	CLIP-seq
MIRT2693495	hsa-miR-513b	CLIP-seq
MIRT2130384	hsa-miR-515-3p	CLIP-seq
MIRT2130385	hsa-miR-519e	CLIP-seq
MIRT2645461	hsa-miR-548an	CLIP-seq
MIRT2130387	hsa-miR-622	CLIP-seq
MIRT2645462	hsa-miR-764	CLIP-seq
MIRT2130390	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25996873, 32296183
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	25996873
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IBA
GO:0006874	Process	Intracellular calcium ion homeostasis	IDA	25996873
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 616499
• HGNC: 28217
• e!Ensembl: ENSG00000187713

Protein

• UniProt ID: Q969S6
• Protein name: Transmembrane protein 203
• Protein function: Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). Acts as a regulator of STING-mediated inflammatory signaling in macrophages (PubMed:31346090). Forms a complex with STIN
• Tissue specificity: TISSUE SPECIFICITY: Increased expression seen in T-lymphocytes from patients with systemic lupus erythematosus (SLE). {ECO:0000269|PubMed:25996873}.
• Sequence:

  MLFSLRELVQWLGFATFEIFVHLLALLVFSVLLALRVDGLVPGLSWWNVFVPFFAADGLS
  TYFTTIVSVRLFQDGEKRLAVLRLFWVLTVLSLKFVFEMLLCQKLAEQTRELWFGLITSP
  LFILLQLLMIRACRVN

• Sequence length: 136

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DEAFNESS, AUTOSOMAL RECESSIVE 79	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	31346090	Associate	★☆☆☆☆ Found in Text Mining only