Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	94030
Gene name	Leucine rich repeat containing 4B
Gene symbol	LRRC4B
Synonyms (NCBI Gene)	HSMLRIG4NGL-3
Chromosome	19
Chromosome location	19q13.33

Show/Hide all (71)

miRTarBase ID	miRNA	Experiments	Reference
MIRT485888	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT485886	hsa-miR-6850-3p	PAR-CLIP	23592263
MIRT485887	hsa-miR-4468	PAR-CLIP	23592263
MIRT485885	hsa-miR-6081	PAR-CLIP	23592263
MIRT485888	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT485886	hsa-miR-6850-3p	PAR-CLIP	23592263
MIRT485887	hsa-miR-4468	PAR-CLIP	23592263
MIRT485885	hsa-miR-6081	PAR-CLIP	23592263
MIRT1119761	hsa-miR-1538	CLIP-seq
MIRT1119762	hsa-miR-2278	CLIP-seq
MIRT1119763	hsa-miR-3202	CLIP-seq
MIRT1119764	hsa-miR-3960	CLIP-seq
MIRT740008	hsa-miR-4287	CLIP-seq
MIRT1119765	hsa-miR-4308	CLIP-seq
MIRT1119766	hsa-miR-4467	CLIP-seq
MIRT1119767	hsa-miR-4533	CLIP-seq
MIRT740007	hsa-miR-4685-3p	CLIP-seq
MIRT1119768	hsa-miR-4745-3p	CLIP-seq
MIRT1119769	hsa-miR-4797-5p	CLIP-seq
MIRT1119770	hsa-miR-548a-5p	CLIP-seq
MIRT1119771	hsa-miR-548ab	CLIP-seq
MIRT1119772	hsa-miR-548ak	CLIP-seq
MIRT1119773	hsa-miR-548b-5p	CLIP-seq
MIRT1119774	hsa-miR-548c-5p	CLIP-seq
MIRT1119775	hsa-miR-548d-5p	CLIP-seq
MIRT1119776	hsa-miR-548h	CLIP-seq
MIRT1119777	hsa-miR-548i	CLIP-seq
MIRT1119778	hsa-miR-548j	CLIP-seq
MIRT1119779	hsa-miR-548k	CLIP-seq
MIRT1119780	hsa-miR-548l	CLIP-seq
MIRT1119781	hsa-miR-548w	CLIP-seq
MIRT1119782	hsa-miR-548y	CLIP-seq
MIRT1119783	hsa-miR-559	CLIP-seq
MIRT2390341	hsa-miR-1321	CLIP-seq
MIRT2390342	hsa-miR-1587	CLIP-seq
MIRT2390343	hsa-miR-3689a-3p	CLIP-seq
MIRT2390344	hsa-miR-3689c	CLIP-seq
MIRT2390345	hsa-miR-378g	CLIP-seq
MIRT2390346	hsa-miR-4417	CLIP-seq
MIRT2390347	hsa-miR-4419a	CLIP-seq
MIRT2390348	hsa-miR-4492	CLIP-seq
MIRT2390349	hsa-miR-4498	CLIP-seq
MIRT2390350	hsa-miR-4505	CLIP-seq
MIRT2390351	hsa-miR-4510	CLIP-seq
MIRT2390352	hsa-miR-4648	CLIP-seq
MIRT2390353	hsa-miR-4654	CLIP-seq
MIRT2390354	hsa-miR-4656	CLIP-seq
MIRT2390355	hsa-miR-4675	CLIP-seq
MIRT2390356	hsa-miR-4728-5p	CLIP-seq
MIRT2390357	hsa-miR-4739	CLIP-seq
MIRT2390358	hsa-miR-4741	CLIP-seq
MIRT2390359	hsa-miR-4756-5p	CLIP-seq
MIRT2390360	hsa-miR-4769-5p	CLIP-seq
MIRT2390361	hsa-miR-541	CLIP-seq
MIRT2390362	hsa-miR-654-5p	CLIP-seq
MIRT2390363	hsa-miR-762	CLIP-seq
MIRT2390341	hsa-miR-1321	CLIP-seq
MIRT2453362	hsa-miR-3141	CLIP-seq
MIRT2453363	hsa-miR-3616-3p	CLIP-seq
MIRT2390343	hsa-miR-3689a-3p	CLIP-seq
MIRT2390344	hsa-miR-3689c	CLIP-seq
MIRT2390347	hsa-miR-4419a	CLIP-seq
MIRT2453364	hsa-miR-4481	CLIP-seq
MIRT2390351	hsa-miR-4510	CLIP-seq
MIRT2453365	hsa-miR-4721	CLIP-seq
MIRT2390356	hsa-miR-4728-5p	CLIP-seq
MIRT2390357	hsa-miR-4739	CLIP-seq
MIRT2453366	hsa-miR-4745-5p	CLIP-seq
MIRT2390359	hsa-miR-4756-5p	CLIP-seq
MIRT2453367	hsa-miR-658	CLIP-seq
MIRT2453368	hsa-miR-765	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0044300	Component	Cerebellar mossy fiber	IEA
GO:0045202	Component	Synapse	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IBA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0051965	Process	Positive regulation of synapse assembly	ISS
GO:0098632	Function	Cell-cell adhesion mediator activity	IBA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099151	Process	Regulation of postsynaptic density assembly	IBA
GO:0099151	Process	Regulation of postsynaptic density assembly	IEA
GO:0099560	Process	Synaptic membrane adhesion	IBA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1905606	Process	Regulation of presynapse assembly	IBA
GO:1905606	Process	Regulation of presynapse assembly	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9NT99

Protein name

Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)

Protein function

Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	86 → 146	Leucine rich repeat	Repeat
PF13855	LRR_8	114 → 170	Leucine rich repeat	Repeat
PF13855	LRR_8	137 → 190	Leucine rich repeat	Repeat
PF13855	LRR_8	224 → 265	Leucine rich repeat	Repeat
PF13855	LRR_8	260 → 312	Leucine rich repeat	Repeat
PF07679	I-set	364 → 453	Immunoglobulin I-set domain	Domain

Sequence

MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVA
CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN
LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR
VPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNR
LDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPL
HRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFT
CYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGT
LNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGG
SGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTA
PAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLR
KQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHL
NHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI

Sequence length

713

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules		Receptor-type tyrosine-protein phosphatases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	34313788	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LRRC4B (leucine rich repeat containing 4B)