CD101 (CD101 molecule)

Gene

• Entrez ID: 9398
• Gene name: CD101 molecule
• Gene symbol: CD101
• Synonyms (NCBI Gene): EWI-101, IGSF2, V7
• Chromosome: 1
• Chromosome location: 1p13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019170	hsa-miR-335-5p	Microarray	18185580
MIRT719712	hsa-miR-4457	HITS-CLIP	19536157
MIRT719711	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT719710	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT719709	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT719712	hsa-miR-4457	HITS-CLIP	19536157
MIRT719711	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT719710	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT719709	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT873622	hsa-miR-185	CLIP-seq
MIRT873623	hsa-miR-3115	CLIP-seq
MIRT873624	hsa-miR-3134	CLIP-seq
MIRT873625	hsa-miR-342-5p	CLIP-seq
MIRT873626	hsa-miR-3675-5p	CLIP-seq
MIRT873627	hsa-miR-4306	CLIP-seq
MIRT873628	hsa-miR-4459	CLIP-seq
MIRT873629	hsa-miR-4534	CLIP-seq
MIRT873630	hsa-miR-4644	CLIP-seq
MIRT873631	hsa-miR-4646-5p	CLIP-seq
MIRT873632	hsa-miR-4651	CLIP-seq
MIRT873633	hsa-miR-4664-5p	CLIP-seq
MIRT873634	hsa-miR-4779	CLIP-seq
MIRT873635	hsa-miR-515-5p	CLIP-seq
MIRT873636	hsa-miR-608	CLIP-seq
MIRT873622	hsa-miR-185	CLIP-seq
MIRT873623	hsa-miR-3115	CLIP-seq
MIRT873624	hsa-miR-3134	CLIP-seq
MIRT873625	hsa-miR-342-5p	CLIP-seq
MIRT873626	hsa-miR-3675-5p	CLIP-seq
MIRT873627	hsa-miR-4306	CLIP-seq
MIRT873628	hsa-miR-4459	CLIP-seq
MIRT873629	hsa-miR-4534	CLIP-seq
MIRT873630	hsa-miR-4644	CLIP-seq
MIRT873632	hsa-miR-4651	CLIP-seq
MIRT873633	hsa-miR-4664-5p	CLIP-seq
MIRT873636	hsa-miR-608	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002763	Process	Positive regulation of myeloid leukocyte differentiation	IEA
GO:0005886	Component	Plasma membrane	TAS	7722300
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	7722300
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7722300
GO:0016812	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 604516
• HGNC: 5949
• e!Ensembl: ENSG00000134256

Protein

• UniProt ID: Q93033
• Protein name: Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101)
• Protein function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phosph
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	27 → 143	Immunoglobulin V-set domain	Domain
  PF07686	V-set	151 → 273	Immunoglobulin V-set domain	Domain
  PF07679	I-set	413 → 532	Immunoglobulin I-set domain	Domain
  PF07686	V-set	821 → 938	Immunoglobulin V-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+
• Sequence:

  MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSV
  YLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYE
  CHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHL
  SVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQ
  SSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPL
  ELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAF
  SLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNK
  QQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSY
  HGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESS
  LQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGT
  IEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASA
  ISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVST
  NASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAV
  EEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVG
  SSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVE
  MEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLF
  ICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEG
  N

• Sequence length: 1021

Pathways

Reactome:

Generation of second messenger molecules

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CD101-related disorder	Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	30689488		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	30087444	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	35350788	Associate	★☆☆☆☆ Found in Text Mining only
Blast Crisis	Blast crisis	Pubtator	19654405	Associate	★☆☆☆☆ Found in Text Mining only
Chronic colitis	Colitis	BEFREE	26813346		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	26813346		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	27888582		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	27888582		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	33773220	Inhibit	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	27888582, 31199784		★☆☆☆☆ Found in Text Mining only
Enterocolitis	Enterocolitis	Pubtator	33773220	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35350788	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	26813346		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	33773220	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	21467233		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30689488		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	21467233		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	21467233	Associate	★☆☆☆☆ Found in Text Mining only