TGFBRAP1 (transforming growth factor beta receptor associated protein 1)

Gene

• Entrez ID: 9392
• Gene name: Transforming growth factor beta receptor associated protein 1
• Gene symbol: TGFBRAP1
• Synonyms (NCBI Gene): TRAP-1, TRAP1, VPS3
• Chromosome: 2
• Chromosome location: 2q12.1-q12.2
• Summary: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent associati

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023387	hsa-miR-122-5p	Microarray	17612493
MIRT049371	hsa-miR-92a-3p	CLASH	23622248
MIRT039586	hsa-miR-628-3p	CLASH	23622248
MIRT053662	hsa-miR-181a-5p	Microarray	22942087
MIRT053662	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	22714950
MIRT053662	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	22714950
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT652722	hsa-miR-4428	HITS-CLIP	23824327
MIRT652721	hsa-miR-4729	HITS-CLIP	23824327
MIRT652720	hsa-miR-5696	HITS-CLIP	23824327
MIRT652719	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652718	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652717	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT439464	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439464	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT652722	hsa-miR-4428	HITS-CLIP	23824327
MIRT652721	hsa-miR-4729	HITS-CLIP	23824327
MIRT652720	hsa-miR-5696	HITS-CLIP	23824327
MIRT652719	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652718	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652717	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT2126436	hsa-miR-125a-3p	CLIP-seq
MIRT2126437	hsa-miR-1289	CLIP-seq
MIRT2126438	hsa-miR-1290	CLIP-seq
MIRT2126439	hsa-miR-151-5p	CLIP-seq
MIRT2126440	hsa-miR-151b	CLIP-seq
MIRT2126441	hsa-miR-181a	CLIP-seq
MIRT2126442	hsa-miR-181b	CLIP-seq
MIRT2126443	hsa-miR-181c	CLIP-seq
MIRT2126444	hsa-miR-181d	CLIP-seq
MIRT2126445	hsa-miR-184	CLIP-seq
MIRT2126446	hsa-miR-2052	CLIP-seq
MIRT2126447	hsa-miR-2110	CLIP-seq
MIRT2126448	hsa-miR-214	CLIP-seq
MIRT2126449	hsa-miR-2909	CLIP-seq
MIRT2126450	hsa-miR-297	CLIP-seq
MIRT2126451	hsa-miR-3149	CLIP-seq
MIRT2126452	hsa-miR-3150a-3p	CLIP-seq
MIRT2126453	hsa-miR-3619-5p	CLIP-seq
MIRT2126454	hsa-miR-3690	CLIP-seq
MIRT2126455	hsa-miR-376a	CLIP-seq
MIRT2126456	hsa-miR-376b	CLIP-seq
MIRT2126457	hsa-miR-4260	CLIP-seq
MIRT2126458	hsa-miR-4262	CLIP-seq
MIRT2126459	hsa-miR-4278	CLIP-seq
MIRT2126460	hsa-miR-4291	CLIP-seq
MIRT2126461	hsa-miR-4307	CLIP-seq
MIRT2126462	hsa-miR-4450	CLIP-seq
MIRT2126463	hsa-miR-4520a-3p	CLIP-seq
MIRT2126464	hsa-miR-4638-3p	CLIP-seq
MIRT2126465	hsa-miR-4652-3p	CLIP-seq
MIRT2126466	hsa-miR-4680-5p	CLIP-seq
MIRT2126467	hsa-miR-4716-5p	CLIP-seq
MIRT2126468	hsa-miR-4804-5p	CLIP-seq
MIRT2126469	hsa-miR-503	CLIP-seq
MIRT2126470	hsa-miR-552	CLIP-seq
MIRT2126471	hsa-miR-567	CLIP-seq
MIRT2126472	hsa-miR-587	CLIP-seq
MIRT2126473	hsa-miR-619	CLIP-seq
MIRT2126474	hsa-miR-642b	CLIP-seq
MIRT2126475	hsa-miR-643	CLIP-seq
MIRT2126476	hsa-miR-761	CLIP-seq
MIRT2126477	hsa-miR-922	CLIP-seq
MIRT2641325	hsa-miR-198	CLIP-seq
MIRT2126448	hsa-miR-214	CLIP-seq
MIRT2641326	hsa-miR-24	CLIP-seq
MIRT2641327	hsa-miR-3133	CLIP-seq
MIRT2641328	hsa-miR-3155	CLIP-seq
MIRT2641329	hsa-miR-3155b	CLIP-seq
MIRT2641330	hsa-miR-323-5p	CLIP-seq
MIRT2641331	hsa-miR-338-3p	CLIP-seq
MIRT2126453	hsa-miR-3619-5p	CLIP-seq
MIRT2641332	hsa-miR-4511	CLIP-seq
MIRT2641333	hsa-miR-4530	CLIP-seq
MIRT2641334	hsa-miR-4686	CLIP-seq
MIRT2641335	hsa-miR-4690-5p	CLIP-seq
MIRT2641336	hsa-miR-484	CLIP-seq
MIRT2126474	hsa-miR-642b	CLIP-seq
MIRT2126476	hsa-miR-761	CLIP-seq
MIRT2641337	hsa-miR-767-3p	CLIP-seq
MIRT2641338	hsa-miR-876-3p	CLIP-seq
MIRT2641325	hsa-miR-198	CLIP-seq
MIRT2126448	hsa-miR-214	CLIP-seq
MIRT2641326	hsa-miR-24	CLIP-seq
MIRT2641327	hsa-miR-3133	CLIP-seq
MIRT2641328	hsa-miR-3155	CLIP-seq
MIRT2641329	hsa-miR-3155b	CLIP-seq
MIRT2641330	hsa-miR-323-5p	CLIP-seq
MIRT2641331	hsa-miR-338-3p	CLIP-seq
MIRT2126453	hsa-miR-3619-5p	CLIP-seq
MIRT2641332	hsa-miR-4511	CLIP-seq
MIRT2641333	hsa-miR-4530	CLIP-seq
MIRT2641334	hsa-miR-4686	CLIP-seq
MIRT2641335	hsa-miR-4690-5p	CLIP-seq
MIRT2641336	hsa-miR-484	CLIP-seq
MIRT2126474	hsa-miR-642b	CLIP-seq
MIRT2126476	hsa-miR-761	CLIP-seq
MIRT2641337	hsa-miR-767-3p	CLIP-seq
MIRT2641338	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005160	Function	Transforming growth factor beta receptor binding	IDA	11278302
GO:0005515	Function	Protein binding	IPI	11278302, 25266290, 26496610, 28514442, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	25266290
GO:0005769	Component	Early endosome	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	11278302
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006914	Process	Autophagy	IBA
GO:0007165	Process	Signal transduction	IDA	11278302
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	TAS	9545258
GO:0008333	Process	Endosome to lysosome transport	IMP	25266290
GO:0012505	Component	Endomembrane system	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	11278302
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0033263	Component	CORVET complex	IEA
GO:0033263	Component	CORVET complex	NAS	31092635
GO:0034058	Process	Endosomal vesicle fusion	IBA
GO:0034058	Process	Endosomal vesicle fusion	IMP	25266290
GO:0034058	Process	Endosomal vesicle fusion	NAS	31092635
GO:0035542	Process	Regulation of SNARE complex assembly	NAS	31092635
GO:0046332	Function	SMAD binding	IDA	11278302

Other IDs

• MIM: 606237
• HGNC: 16836
• e!Ensembl: ENSG00000135966

Protein

• UniProt ID: Q8WUH2
• Protein name: Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)
• Protein function: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00780	CNH	34 → 292	CNH domain	Family
  PF10366	Vps39_1	448 → 550	Vacuolar sorting protein 39 domain 1	Family
  PF00637	Clathrin	569 → 729	Region in Clathrin and VPS	Family
  PF10367	Vps39_2	738 → 846	Vacuolar sorting protein 39 domain 2	Domain

• Sequence:

  MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGP
  ATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAA
  TFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFL
  CLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQ
  RAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVA
  TSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQ
  FAQLQFLEAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEK
  MAKCKRFLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSA
  AWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDLYEYIVDFLTYCLDEE
  LVWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKALVKYLEHLVID
  KRLQKEEYHTHLAVLYLEEVLLQRASASGKGAEATETQAKLRRLLQKSDLYRVHFLLERL
  QGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLL
  AIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHA
  RRTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVH
  THCAASRHTNPSSSSPGTRT

• Sequence length: 860

Pathways

KEGG:

Efferocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREECLAMPSIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aggressive Periodontitis	Aggressive Periodontitis	BEFREE	25466412		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23139614, 29552185		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	25466412		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	30461200	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	30461200	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	30461200		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	34725559	Inhibit	★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	BEFREE	25856002		★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	Pubtator	25856002	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	25856002	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	25856002		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29535540		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29552185		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23139614		★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary fibrosis	Pubtator	31085559	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma	Carcinoma	BEFREE	27301951		★☆☆☆☆ Found in Text Mining only