Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9358
Gene name	Integrin subunit beta like 1
Gene symbol	ITGBL1
Synonyms (NCBI Gene)	OSCPTIED
Chromosome	13
Chromosome location	13q33.1
Summary	This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 201

156

Show/Hide all (156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021246	hsa-miR-146a-5p	Microarray	18057241
MIRT702628	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT702627	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT702626	hsa-miR-382-3p	HITS-CLIP	23313552
MIRT702625	hsa-miR-20a-3p	HITS-CLIP	23313552
MIRT702624	hsa-miR-889-3p	HITS-CLIP	23313552
MIRT702623	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT702622	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT702621	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT607368	hsa-miR-8485	HITS-CLIP	23313552
MIRT608226	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT608225	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT608224	hsa-miR-603	HITS-CLIP	23313552
MIRT687825	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23313552
MIRT608222	hsa-miR-3941	HITS-CLIP	23313552
MIRT608221	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT657136	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT657136	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	24906430
MIRT608226	hsa-miR-329-3p	HITS-CLIP	24906430
MIRT608225	hsa-miR-362-3p	HITS-CLIP	24906430
MIRT608224	hsa-miR-603	HITS-CLIP	24906430
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	24906430
MIRT608222	hsa-miR-3941	HITS-CLIP	24906430
MIRT608221	hsa-miR-4789-5p	HITS-CLIP	24906430
MIRT607368	hsa-miR-8485	HITS-CLIP	24906430
MIRT608226	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT608226	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT608226	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT608226	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT608226	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT608225	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT608225	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT608225	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT608225	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT608225	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT608222	hsa-miR-3941	HITS-CLIP	27418678
MIRT608222	hsa-miR-3941	HITS-CLIP	27418678
MIRT608222	hsa-miR-3941	HITS-CLIP	27418678
MIRT608222	hsa-miR-3941	HITS-CLIP	27418678
MIRT608222	hsa-miR-3941	HITS-CLIP	27418678
MIRT687825	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT687825	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT687825	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT687825	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT608221	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT608221	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT608221	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT608221	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT608224	hsa-miR-603	HITS-CLIP	27418678
MIRT608224	hsa-miR-603	HITS-CLIP	27418678
MIRT608224	hsa-miR-603	HITS-CLIP	27418678
MIRT608224	hsa-miR-603	HITS-CLIP	27418678
MIRT608224	hsa-miR-603	HITS-CLIP	27418678
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	27418678
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	27418678
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	27418678
MIRT607368	hsa-miR-8485	HITS-CLIP	27418678
MIRT607368	hsa-miR-8485	HITS-CLIP	27418678
MIRT607368	hsa-miR-8485	HITS-CLIP	27418678
MIRT607368	hsa-miR-8485	HITS-CLIP	27418678
MIRT607368	hsa-miR-8485	HITS-CLIP	27418678
MIRT607368	hsa-miR-8485	HITS-CLIP	27418678
MIRT702628	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT702627	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT702626	hsa-miR-382-3p	HITS-CLIP	23313552
MIRT702625	hsa-miR-20a-3p	HITS-CLIP	23313552
MIRT702624	hsa-miR-889-3p	HITS-CLIP	23313552
MIRT702623	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT702622	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT702621	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT607368	hsa-miR-8485	HITS-CLIP	23313552
MIRT608226	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT608225	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT608224	hsa-miR-603	HITS-CLIP	23313552
MIRT687825	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23313552
MIRT608222	hsa-miR-3941	HITS-CLIP	23313552
MIRT608221	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT657136	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT657136	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607368	hsa-miR-8485	HITS-CLIP	23824327
MIRT608223	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT1074342	hsa-miR-1257	CLIP-seq
MIRT1074343	hsa-miR-153	CLIP-seq
MIRT1074344	hsa-miR-3123	CLIP-seq
MIRT1074345	hsa-miR-4263	CLIP-seq
MIRT1074346	hsa-miR-4307	CLIP-seq
MIRT1074347	hsa-miR-448	CLIP-seq
MIRT1074348	hsa-miR-4710	CLIP-seq
MIRT1074349	hsa-miR-4778-3p	CLIP-seq
MIRT1074350	hsa-miR-4792	CLIP-seq
MIRT1074351	hsa-miR-4799-5p	CLIP-seq
MIRT1074352	hsa-miR-513a-3p	CLIP-seq
MIRT1074353	hsa-miR-576-5p	CLIP-seq
MIRT1074354	hsa-miR-586	CLIP-seq
MIRT1074355	hsa-miR-9	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005178	Function	Integrin binding	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	10051402
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IBA
GO:0008305	Component	Integrin complex	IBA
GO:0009986	Component	Cell surface	IBA
GO:0016477	Process	Cell migration	IBA
GO:0033627	Process	Cell adhesion mediated by integrin	IBA
GO:0098609	Process	Cell-cell adhesion	IBA

MIM	HGNC	e!Ensembl
604234	6164	ENSG00000198542

O95965

Protein name

Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07974	EGF_2	96 → 126	EGF-like domain	Domain
PF07974	EGF_2	185 → 216	EGF-like domain	Domain
PF07974	EGF_2	276 → 310	EGF-like domain	Domain
PF07974	EGF_2	368 → 398	EGF-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in many tissues, but readily detectable only in aorta. {ECO:0000269|PubMed:10051402}.

Sequence

MRPPGFRNFLLLASSLLFAGLSAVPQSFSPSLRSWPGAACRLSRAESERRCRAPGQPPGA
ALCHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGSTCAGHGKCDCGKCKCDQG
WYGDACQYPTNCDLTKKKSNQMCKNSQDIICSNAGTCHCGRCKCDNSDGSGLVYGKFCEC
DDRECIDDETEEICGGHGKCYCGNCYCKAGWHGDKCEFQCDITPWESKRRCTSPDGKICS
NRGTCVCGECTCHDVDPTGDWGDIHGDTCECDERDCRAVYDRYSDDFCSGHGQCNCGRCD
CKAGWYGKKCEHPQSCTLSAEESIRKCQGSSDLPCSGRGKCECGKCTCYPPGDRRVYGKT
CECDDRRCEDLDGVVCGGHGTCSCGRCVCERGWFGKLCQHPRKCNMTEEQSKNLCESADG
ILCSGKGSCHCGKCICSAEEWYISGEFCDCDDRDCDKHDGLICTGNGICSCGNCECWDGW
NGNACEIWLGSEYP

Sequence length

494

Interactions

View interactions

	Reactome
			RUNX2 regulates genes involved in cell migration

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (27)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis	Arthritis	BEFREE	30305454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	29285211		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26060017		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36046013	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31683459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cartilage Diseases	Cartilage Diseases	BEFREE	30305454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29772438, 30717807		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30717807	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	34409913	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	28262670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis B Chronic	Hepatitis b	Pubtator	26709788	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	30317626		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	28262670	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26060017		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	31683459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31190876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29151964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26307393, 31683459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26307393		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	26307393		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	39849508	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	31683459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	35584452	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31190876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	29285211		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29151964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	33049688, 35596183	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ITGBL1 (integrin subunit beta like 1)