UBE4A (ubiquitination factor E4A)

Gene

• Entrez ID: 9354
• Gene name: Ubiquitination factor E4A
• Gene symbol: UBE4A
• Synonyms (NCBI Gene): E4, NEDHMS, UBOX2, UFD2
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1565532385	CA>-	Likely-pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001399	hsa-miR-16-5p	pSILAC	18668040
MIRT001399	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT050796	hsa-miR-17-5p	CLASH	23622248
MIRT464637	hsa-miR-514a-5p	PAR-CLIP	23592263
MIRT464636	hsa-miR-326	PAR-CLIP	23592263
MIRT464635	hsa-miR-330-5p	PAR-CLIP	23592263
MIRT464634	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT464633	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT464632	hsa-miR-8089	PAR-CLIP	23592263
MIRT464631	hsa-miR-637	PAR-CLIP	23592263
MIRT464630	hsa-miR-7155-5p	PAR-CLIP	23592263
MIRT464629	hsa-miR-193b-5p	PAR-CLIP	23592263
MIRT464628	hsa-miR-5087	PAR-CLIP	23592263
MIRT464627	hsa-miR-7703	PAR-CLIP	23592263
MIRT464626	hsa-miR-3170	PAR-CLIP	23592263
MIRT464624	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT464625	hsa-miR-29b-2-5p	PAR-CLIP	23592263
MIRT464622	hsa-miR-659-3p	PAR-CLIP	23592263
MIRT128766	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT128798	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT128804	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT001399	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT128805	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT128766	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT464629	hsa-miR-193b-5p	PAR-CLIP	26701625
MIRT464629	hsa-miR-193b-5p	PAR-CLIP	26701625
MIRT464625	hsa-miR-29b-2-5p	PAR-CLIP	26701625
MIRT464625	hsa-miR-29b-2-5p	PAR-CLIP	26701625
MIRT464626	hsa-miR-3170	PAR-CLIP	26701625
MIRT464626	hsa-miR-3170	PAR-CLIP	26701625
MIRT464636	hsa-miR-326	PAR-CLIP	26701625
MIRT464636	hsa-miR-326	PAR-CLIP	26701625
MIRT464635	hsa-miR-330-5p	PAR-CLIP	26701625
MIRT464635	hsa-miR-330-5p	PAR-CLIP	26701625
MIRT464634	hsa-miR-4667-5p	PAR-CLIP	26701625
MIRT464634	hsa-miR-4667-5p	PAR-CLIP	26701625
MIRT464633	hsa-miR-4700-5p	PAR-CLIP	26701625
MIRT464633	hsa-miR-4700-5p	PAR-CLIP	26701625
MIRT464628	hsa-miR-5087	PAR-CLIP	26701625
MIRT464628	hsa-miR-5087	PAR-CLIP	26701625
MIRT464637	hsa-miR-514a-5p	PAR-CLIP	26701625
MIRT464637	hsa-miR-514a-5p	PAR-CLIP	26701625
MIRT464631	hsa-miR-637	PAR-CLIP	26701625
MIRT464631	hsa-miR-637	PAR-CLIP	26701625
MIRT464622	hsa-miR-659-3p	PAR-CLIP	26701625
MIRT464622	hsa-miR-659-3p	PAR-CLIP	26701625
MIRT464624	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT464624	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT464630	hsa-miR-7155-5p	PAR-CLIP	26701625
MIRT464630	hsa-miR-7155-5p	PAR-CLIP	26701625
MIRT464627	hsa-miR-7703	PAR-CLIP	26701625
MIRT464627	hsa-miR-7703	PAR-CLIP	26701625
MIRT464632	hsa-miR-8089	PAR-CLIP	26701625
MIRT464632	hsa-miR-8089	PAR-CLIP	26701625
MIRT464637	hsa-miR-514a-5p	PAR-CLIP	23592263
MIRT464636	hsa-miR-326	PAR-CLIP	23592263
MIRT464635	hsa-miR-330-5p	PAR-CLIP	23592263
MIRT464634	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT464633	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT464632	hsa-miR-8089	PAR-CLIP	23592263
MIRT464631	hsa-miR-637	PAR-CLIP	23592263
MIRT464630	hsa-miR-7155-5p	PAR-CLIP	23592263
MIRT464629	hsa-miR-193b-5p	PAR-CLIP	23592263
MIRT464628	hsa-miR-5087	PAR-CLIP	23592263
MIRT464627	hsa-miR-7703	PAR-CLIP	23592263
MIRT464626	hsa-miR-3170	PAR-CLIP	23592263
MIRT464624	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT464625	hsa-miR-29b-2-5p	PAR-CLIP	23592263
MIRT464622	hsa-miR-659-3p	PAR-CLIP	23592263
MIRT1469491	hsa-miR-2276	CLIP-seq
MIRT1469492	hsa-miR-3074-5p	CLIP-seq
MIRT1469493	hsa-miR-3157-3p	CLIP-seq
MIRT1469494	hsa-miR-3159	CLIP-seq
MIRT1469495	hsa-miR-4311	CLIP-seq
MIRT1469496	hsa-miR-874	CLIP-seq
MIRT1469497	hsa-miR-939	CLIP-seq
MIRT1469498	hsa-miR-103a	CLIP-seq
MIRT1469499	hsa-miR-103b	CLIP-seq
MIRT1469500	hsa-miR-107	CLIP-seq
MIRT1469501	hsa-miR-1224-5p	CLIP-seq
MIRT1469502	hsa-miR-1264	CLIP-seq
MIRT1469503	hsa-miR-1273d	CLIP-seq
MIRT1469504	hsa-miR-1273e	CLIP-seq
MIRT1469505	hsa-miR-1288	CLIP-seq
MIRT1469506	hsa-miR-1290	CLIP-seq
MIRT1469507	hsa-miR-1304	CLIP-seq
MIRT1469508	hsa-miR-141	CLIP-seq
MIRT1469509	hsa-miR-148a	CLIP-seq
MIRT1469510	hsa-miR-148b	CLIP-seq
MIRT1469511	hsa-miR-152	CLIP-seq
MIRT1469512	hsa-miR-15a	CLIP-seq
MIRT1469513	hsa-miR-15b	CLIP-seq
MIRT1469514	hsa-miR-16	CLIP-seq
MIRT1469515	hsa-miR-181a	CLIP-seq
MIRT1469516	hsa-miR-181b	CLIP-seq
MIRT1469517	hsa-miR-181c	CLIP-seq
MIRT1469518	hsa-miR-181d	CLIP-seq
MIRT1469519	hsa-miR-1908	CLIP-seq
MIRT1469520	hsa-miR-194	CLIP-seq
MIRT1469521	hsa-miR-195	CLIP-seq
MIRT1469522	hsa-miR-200a	CLIP-seq
MIRT1469523	hsa-miR-2052	CLIP-seq
MIRT1469524	hsa-miR-2053	CLIP-seq
MIRT1469525	hsa-miR-21	CLIP-seq
MIRT1469526	hsa-miR-2115	CLIP-seq
MIRT1469527	hsa-miR-214	CLIP-seq
MIRT1469528	hsa-miR-218	CLIP-seq
MIRT1469491	hsa-miR-2276	CLIP-seq
MIRT1469529	hsa-miR-2467-3p	CLIP-seq
MIRT1469530	hsa-miR-2467-5p	CLIP-seq
MIRT1469531	hsa-miR-2682	CLIP-seq
MIRT1469532	hsa-miR-298	CLIP-seq
MIRT1469533	hsa-miR-300	CLIP-seq
MIRT1469492	hsa-miR-3074-5p	CLIP-seq
MIRT1469534	hsa-miR-3130-3p	CLIP-seq
MIRT1469535	hsa-miR-3169	CLIP-seq
MIRT1469536	hsa-miR-3180-5p	CLIP-seq
MIRT1469537	hsa-miR-3188	CLIP-seq
MIRT1469538	hsa-miR-329	CLIP-seq
MIRT1469539	hsa-miR-3607-3p	CLIP-seq
MIRT1469540	hsa-miR-3613-3p	CLIP-seq
MIRT1469541	hsa-miR-3619-5p	CLIP-seq
MIRT1469542	hsa-miR-362-3p	CLIP-seq
MIRT1469543	hsa-miR-3678-3p	CLIP-seq
MIRT1469544	hsa-miR-3685	CLIP-seq
MIRT1469545	hsa-miR-3686	CLIP-seq
MIRT1469546	hsa-miR-3688-3p	CLIP-seq
MIRT1469547	hsa-miR-3691-3p	CLIP-seq
MIRT1469548	hsa-miR-369-3p	CLIP-seq
MIRT1469549	hsa-miR-374a	CLIP-seq
MIRT1469550	hsa-miR-374b	CLIP-seq
MIRT1469551	hsa-miR-376c	CLIP-seq
MIRT1469552	hsa-miR-381	CLIP-seq
MIRT1469553	hsa-miR-3913-3p	CLIP-seq
MIRT1469554	hsa-miR-3923	CLIP-seq
MIRT1469555	hsa-miR-3936	CLIP-seq
MIRT1469556	hsa-miR-3941	CLIP-seq
MIRT1469557	hsa-miR-3944-5p	CLIP-seq
MIRT1469558	hsa-miR-3975	CLIP-seq
MIRT1469559	hsa-miR-421	CLIP-seq
MIRT1469560	hsa-miR-424	CLIP-seq
MIRT1469561	hsa-miR-4262	CLIP-seq
MIRT1469562	hsa-miR-4267	CLIP-seq
MIRT1469563	hsa-miR-4291	CLIP-seq
MIRT1469564	hsa-miR-4310	CLIP-seq
MIRT1469495	hsa-miR-4311	CLIP-seq
MIRT1469565	hsa-miR-449c	CLIP-seq
MIRT1469566	hsa-miR-4503	CLIP-seq
MIRT1469567	hsa-miR-4645-5p	CLIP-seq
MIRT1469568	hsa-miR-4672	CLIP-seq
MIRT1469569	hsa-miR-4673	CLIP-seq
MIRT1469570	hsa-miR-4686	CLIP-seq
MIRT1469571	hsa-miR-4690-5p	CLIP-seq
MIRT1469572	hsa-miR-4709-3p	CLIP-seq
MIRT1469573	hsa-miR-4709-5p	CLIP-seq
MIRT1469574	hsa-miR-4711-5p	CLIP-seq
MIRT1469575	hsa-miR-4742-5p	CLIP-seq
MIRT1469576	hsa-miR-4751	CLIP-seq
MIRT1469577	hsa-miR-4755-3p	CLIP-seq
MIRT1469578	hsa-miR-4759	CLIP-seq
MIRT1469579	hsa-miR-4789-5p	CLIP-seq
MIRT1469580	hsa-miR-4793-3p	CLIP-seq
MIRT1469581	hsa-miR-485-5p	CLIP-seq
MIRT1469582	hsa-miR-489	CLIP-seq
MIRT1469583	hsa-miR-495	CLIP-seq
MIRT1469584	hsa-miR-497	CLIP-seq
MIRT1469585	hsa-miR-514	CLIP-seq
MIRT1469586	hsa-miR-514b-3p	CLIP-seq
MIRT1469587	hsa-miR-520a-5p	CLIP-seq
MIRT1469588	hsa-miR-525-5p	CLIP-seq
MIRT1469589	hsa-miR-539	CLIP-seq
MIRT1469590	hsa-miR-548ac	CLIP-seq
MIRT1469591	hsa-miR-548d-3p	CLIP-seq
MIRT1469592	hsa-miR-548z	CLIP-seq
MIRT1469593	hsa-miR-569	CLIP-seq
MIRT1469594	hsa-miR-577	CLIP-seq
MIRT1469595	hsa-miR-581	CLIP-seq
MIRT1469596	hsa-miR-590-5p	CLIP-seq
MIRT1469597	hsa-miR-600	CLIP-seq
MIRT1469598	hsa-miR-603	CLIP-seq
MIRT1469599	hsa-miR-624	CLIP-seq
MIRT1469600	hsa-miR-628-3p	CLIP-seq
MIRT1469601	hsa-miR-663	CLIP-seq
MIRT1469602	hsa-miR-7	CLIP-seq
MIRT1469603	hsa-miR-761	CLIP-seq
MIRT1469604	hsa-miR-891b	CLIP-seq
MIRT1469605	hsa-miR-922	CLIP-seq
MIRT1469497	hsa-miR-939	CLIP-seq
MIRT1469606	hsa-miR-940	CLIP-seq
MIRT2141146	hsa-miR-548an	CLIP-seq
MIRT2141147	hsa-miR-1	CLIP-seq
MIRT2141148	hsa-miR-124	CLIP-seq
MIRT1469503	hsa-miR-1273d	CLIP-seq
MIRT2141149	hsa-miR-127-5p	CLIP-seq
MIRT2141150	hsa-miR-1285	CLIP-seq
MIRT2141151	hsa-miR-142-5p	CLIP-seq
MIRT1469512	hsa-miR-15a	CLIP-seq
MIRT1469513	hsa-miR-15b	CLIP-seq
MIRT1469514	hsa-miR-16	CLIP-seq
MIRT1469519	hsa-miR-1908	CLIP-seq
MIRT2141152	hsa-miR-1915	CLIP-seq
MIRT1469521	hsa-miR-195	CLIP-seq
MIRT2141153	hsa-miR-205	CLIP-seq
MIRT1469524	hsa-miR-2053	CLIP-seq
MIRT2141154	hsa-miR-206	CLIP-seq
MIRT2141155	hsa-miR-2113	CLIP-seq
MIRT2141156	hsa-miR-2116	CLIP-seq
MIRT2141157	hsa-miR-2117	CLIP-seq
MIRT1469491	hsa-miR-2276	CLIP-seq
MIRT2141158	hsa-miR-2278	CLIP-seq
MIRT2141159	hsa-miR-23a	CLIP-seq
MIRT2141160	hsa-miR-23b	CLIP-seq
MIRT2141161	hsa-miR-23c	CLIP-seq
MIRT1469529	hsa-miR-2467-3p	CLIP-seq
MIRT2141162	hsa-miR-27a	CLIP-seq
MIRT2141163	hsa-miR-27b	CLIP-seq
MIRT2141164	hsa-miR-28-3p	CLIP-seq
MIRT1469492	hsa-miR-3074-5p	CLIP-seq
MIRT2141165	hsa-miR-3130-5p	CLIP-seq
MIRT2141166	hsa-miR-3140-3p	CLIP-seq
MIRT2141167	hsa-miR-3143	CLIP-seq
MIRT2141168	hsa-miR-3145-5p	CLIP-seq
MIRT2141169	hsa-miR-3163	CLIP-seq
MIRT1469536	hsa-miR-3180-5p	CLIP-seq
MIRT2141170	hsa-miR-3187-5p	CLIP-seq
MIRT2141171	hsa-miR-335	CLIP-seq
MIRT2141172	hsa-miR-338-3p	CLIP-seq
MIRT2141173	hsa-miR-340	CLIP-seq
MIRT2141174	hsa-miR-34c-3p	CLIP-seq
MIRT2141175	hsa-miR-3655	CLIP-seq
MIRT2141176	hsa-miR-3671	CLIP-seq
MIRT2141177	hsa-miR-3674	CLIP-seq
MIRT1469543	hsa-miR-3678-3p	CLIP-seq
MIRT2141178	hsa-miR-3689a-5p	CLIP-seq
MIRT2141179	hsa-miR-3689b	CLIP-seq
MIRT2141180	hsa-miR-3689e	CLIP-seq
MIRT2141181	hsa-miR-3689f	CLIP-seq
MIRT1469548	hsa-miR-369-3p	CLIP-seq
MIRT1469549	hsa-miR-374a	CLIP-seq
MIRT1469550	hsa-miR-374b	CLIP-seq
MIRT2141182	hsa-miR-378g	CLIP-seq
MIRT1469553	hsa-miR-3913-3p	CLIP-seq
MIRT2141183	hsa-miR-411	CLIP-seq
MIRT1469559	hsa-miR-421	CLIP-seq
MIRT1469560	hsa-miR-424	CLIP-seq
MIRT2141184	hsa-miR-425	CLIP-seq
MIRT2141185	hsa-miR-4270	CLIP-seq
MIRT2141186	hsa-miR-4277	CLIP-seq
MIRT1469563	hsa-miR-4291	CLIP-seq
MIRT1469564	hsa-miR-4310	CLIP-seq
MIRT2141187	hsa-miR-4328	CLIP-seq
MIRT2141188	hsa-miR-4420	CLIP-seq
MIRT2141189	hsa-miR-4441	CLIP-seq
MIRT2141190	hsa-miR-4482	CLIP-seq
MIRT2141191	hsa-miR-4484	CLIP-seq
MIRT2141192	hsa-miR-4486	CLIP-seq
MIRT2141193	hsa-miR-4501	CLIP-seq
MIRT1469566	hsa-miR-4503	CLIP-seq
MIRT2141194	hsa-miR-4504	CLIP-seq
MIRT2141195	hsa-miR-451b	CLIP-seq
MIRT2141196	hsa-miR-4530	CLIP-seq
MIRT2141197	hsa-miR-4684-5p	CLIP-seq
MIRT1469571	hsa-miR-4690-5p	CLIP-seq
MIRT1469573	hsa-miR-4709-5p	CLIP-seq
MIRT2141198	hsa-miR-4732-5p	CLIP-seq
MIRT2141199	hsa-miR-4735-5p	CLIP-seq
MIRT2141200	hsa-miR-4766-3p	CLIP-seq
MIRT2141201	hsa-miR-487a	CLIP-seq
MIRT1469582	hsa-miR-489	CLIP-seq
MIRT1469584	hsa-miR-497	CLIP-seq
MIRT2141202	hsa-miR-499-3p	CLIP-seq
MIRT2141203	hsa-miR-499a-3p	CLIP-seq
MIRT2141204	hsa-miR-506	CLIP-seq
MIRT2141205	hsa-miR-508-5p	CLIP-seq
MIRT2141206	hsa-miR-5096	CLIP-seq
MIRT2141207	hsa-miR-513a-5p	CLIP-seq
MIRT2141208	hsa-miR-526b	CLIP-seq
MIRT1469589	hsa-miR-539	CLIP-seq
MIRT2141209	hsa-miR-542-3p	CLIP-seq
MIRT2141210	hsa-miR-543	CLIP-seq
MIRT2141211	hsa-miR-545	CLIP-seq
MIRT2141212	hsa-miR-548a-5p	CLIP-seq
MIRT2141213	hsa-miR-548ab	CLIP-seq
MIRT1469590	hsa-miR-548ac	CLIP-seq
MIRT2141214	hsa-miR-548ak	CLIP-seq
MIRT2141146	hsa-miR-548an	CLIP-seq
MIRT2141215	hsa-miR-548b-5p	CLIP-seq
MIRT2141216	hsa-miR-548c-5p	CLIP-seq
MIRT1469591	hsa-miR-548d-3p	CLIP-seq
MIRT2141217	hsa-miR-548d-5p	CLIP-seq
MIRT2141218	hsa-miR-548h	CLIP-seq
MIRT2141219	hsa-miR-548i	CLIP-seq
MIRT2141220	hsa-miR-548j	CLIP-seq
MIRT2141221	hsa-miR-548k	CLIP-seq
MIRT2141222	hsa-miR-548l	CLIP-seq
MIRT2141223	hsa-miR-548w	CLIP-seq
MIRT2141224	hsa-miR-548y	CLIP-seq
MIRT1469592	hsa-miR-548z	CLIP-seq
MIRT2141225	hsa-miR-559	CLIP-seq
MIRT2141226	hsa-miR-562	CLIP-seq
MIRT2141227	hsa-miR-574-5p	CLIP-seq
MIRT2141228	hsa-miR-578	CLIP-seq
MIRT2141229	hsa-miR-579	CLIP-seq
MIRT2141230	hsa-miR-612	CLIP-seq
MIRT2141231	hsa-miR-613	CLIP-seq
MIRT2141232	hsa-miR-640	CLIP-seq
MIRT2141233	hsa-miR-660	CLIP-seq
MIRT1469601	hsa-miR-663	CLIP-seq
MIRT2141234	hsa-miR-668	CLIP-seq
MIRT1469602	hsa-miR-7	CLIP-seq
MIRT2141235	hsa-miR-766	CLIP-seq
MIRT2141236	hsa-miR-936	CLIP-seq
MIRT1469497	hsa-miR-939	CLIP-seq
MIRT1469498	hsa-miR-103a	CLIP-seq
MIRT1469500	hsa-miR-107	CLIP-seq
MIRT2362163	hsa-miR-1265	CLIP-seq
MIRT1469507	hsa-miR-1304	CLIP-seq
MIRT1469509	hsa-miR-148a	CLIP-seq
MIRT1469510	hsa-miR-148b	CLIP-seq
MIRT1469511	hsa-miR-152	CLIP-seq
MIRT1469512	hsa-miR-15a	CLIP-seq
MIRT1469513	hsa-miR-15b	CLIP-seq
MIRT1469514	hsa-miR-16	CLIP-seq
MIRT1469521	hsa-miR-195	CLIP-seq
MIRT2141156	hsa-miR-2116	CLIP-seq
MIRT2141158	hsa-miR-2278	CLIP-seq
MIRT2362164	hsa-miR-2392	CLIP-seq
MIRT1469530	hsa-miR-2467-5p	CLIP-seq
MIRT2141168	hsa-miR-3145-5p	CLIP-seq
MIRT1469537	hsa-miR-3188	CLIP-seq
MIRT2141171	hsa-miR-335	CLIP-seq
MIRT2141172	hsa-miR-338-3p	CLIP-seq
MIRT1469540	hsa-miR-3613-3p	CLIP-seq
MIRT2362165	hsa-miR-3682-3p	CLIP-seq
MIRT1469557	hsa-miR-3944-5p	CLIP-seq
MIRT1469558	hsa-miR-3975	CLIP-seq
MIRT1469559	hsa-miR-421	CLIP-seq
MIRT1469560	hsa-miR-424	CLIP-seq
MIRT2141186	hsa-miR-4277	CLIP-seq
MIRT1469563	hsa-miR-4291	CLIP-seq
MIRT2141195	hsa-miR-451b	CLIP-seq
MIRT2141196	hsa-miR-4530	CLIP-seq
MIRT2362166	hsa-miR-4687-5p	CLIP-seq
MIRT1469573	hsa-miR-4709-5p	CLIP-seq
MIRT1469574	hsa-miR-4711-5p	CLIP-seq
MIRT2362167	hsa-miR-4747-5p	CLIP-seq
MIRT2362168	hsa-miR-4760-5p	CLIP-seq
MIRT1469581	hsa-miR-485-5p	CLIP-seq
MIRT2141201	hsa-miR-487a	CLIP-seq
MIRT1469584	hsa-miR-497	CLIP-seq
MIRT2141205	hsa-miR-508-5p	CLIP-seq
MIRT2141211	hsa-miR-545	CLIP-seq
MIRT1469590	hsa-miR-548ac	CLIP-seq
MIRT1469591	hsa-miR-548d-3p	CLIP-seq
MIRT1469592	hsa-miR-548z	CLIP-seq
MIRT2141229	hsa-miR-579	CLIP-seq
MIRT2362169	hsa-miR-671-5p	CLIP-seq
MIRT2141235	hsa-miR-766	CLIP-seq
MIRT2141148	hsa-miR-124	CLIP-seq
MIRT2362170	hsa-miR-3614-5p	CLIP-seq
MIRT1469564	hsa-miR-4310	CLIP-seq
MIRT2141191	hsa-miR-4484	CLIP-seq
MIRT2362171	hsa-miR-4495	CLIP-seq
MIRT2141204	hsa-miR-506	CLIP-seq
MIRT2141146	hsa-miR-548an	CLIP-seq
MIRT2141232	hsa-miR-640	CLIP-seq
MIRT1469568	hsa-miR-4672	CLIP-seq
MIRT2362170	hsa-miR-3614-5p	CLIP-seq
MIRT1469590	hsa-miR-548ac	CLIP-seq
MIRT1469591	hsa-miR-548d-3p	CLIP-seq
MIRT1469592	hsa-miR-548z	CLIP-seq
MIRT2441591	hsa-miR-767-5p	CLIP-seq
MIRT1469559	hsa-miR-421	CLIP-seq
MIRT1469573	hsa-miR-4709-5p	CLIP-seq
MIRT2141147	hsa-miR-1	CLIP-seq
MIRT2655907	hsa-miR-100	CLIP-seq
MIRT1469498	hsa-miR-103a	CLIP-seq
MIRT1469500	hsa-miR-107	CLIP-seq
MIRT2655908	hsa-miR-1238	CLIP-seq
MIRT2141148	hsa-miR-124	CLIP-seq
MIRT2655909	hsa-miR-1244	CLIP-seq
MIRT2655910	hsa-miR-1245b-5p	CLIP-seq
MIRT2655911	hsa-miR-1267	CLIP-seq
MIRT1469504	hsa-miR-1273e	CLIP-seq
MIRT2141150	hsa-miR-1285	CLIP-seq
MIRT2655912	hsa-miR-1295	CLIP-seq
MIRT2655913	hsa-miR-132	CLIP-seq
MIRT2655914	hsa-miR-1343	CLIP-seq
MIRT2141151	hsa-miR-142-5p	CLIP-seq
MIRT1469509	hsa-miR-148a	CLIP-seq
MIRT1469510	hsa-miR-148b	CLIP-seq
MIRT1469511	hsa-miR-152	CLIP-seq
MIRT1469512	hsa-miR-15a	CLIP-seq
MIRT1469513	hsa-miR-15b	CLIP-seq
MIRT1469514	hsa-miR-16	CLIP-seq
MIRT2655915	hsa-miR-1827	CLIP-seq
MIRT1469519	hsa-miR-1908	CLIP-seq
MIRT2655916	hsa-miR-1912	CLIP-seq
MIRT1469521	hsa-miR-195	CLIP-seq
MIRT2655917	hsa-miR-203	CLIP-seq
MIRT2141153	hsa-miR-205	CLIP-seq
MIRT1469524	hsa-miR-2053	CLIP-seq
MIRT2141154	hsa-miR-206	CLIP-seq
MIRT2655918	hsa-miR-212	CLIP-seq
MIRT2141158	hsa-miR-2278	CLIP-seq
MIRT2141159	hsa-miR-23a	CLIP-seq
MIRT2141160	hsa-miR-23b	CLIP-seq
MIRT2141161	hsa-miR-23c	CLIP-seq
MIRT1469492	hsa-miR-3074-5p	CLIP-seq
MIRT2655919	hsa-miR-3123	CLIP-seq
MIRT2655920	hsa-miR-3128	CLIP-seq
MIRT2655921	hsa-miR-3136-3p	CLIP-seq
MIRT2655922	hsa-miR-3138	CLIP-seq
MIRT2655923	hsa-miR-3142	CLIP-seq
MIRT2141167	hsa-miR-3143	CLIP-seq
MIRT2655924	hsa-miR-3145-3p	CLIP-seq
MIRT1469493	hsa-miR-3157-3p	CLIP-seq
MIRT1469494	hsa-miR-3159	CLIP-seq
MIRT2655925	hsa-miR-3160-3p	CLIP-seq
MIRT2655926	hsa-miR-3161	CLIP-seq
MIRT2655927	hsa-miR-3162-3p	CLIP-seq
MIRT2141169	hsa-miR-3163	CLIP-seq
MIRT2655928	hsa-miR-3174	CLIP-seq
MIRT2655929	hsa-miR-3185	CLIP-seq
MIRT2141170	hsa-miR-3187-5p	CLIP-seq
MIRT2655930	hsa-miR-3201	CLIP-seq
MIRT2655931	hsa-miR-320e	CLIP-seq
MIRT2141173	hsa-miR-340	CLIP-seq
MIRT2141174	hsa-miR-34c-3p	CLIP-seq
MIRT2655932	hsa-miR-3591-5p	CLIP-seq
MIRT2655933	hsa-miR-3612	CLIP-seq
MIRT2362170	hsa-miR-3614-5p	CLIP-seq
MIRT2655934	hsa-miR-3622b-5p	CLIP-seq
MIRT2141175	hsa-miR-3655	CLIP-seq
MIRT2655935	hsa-miR-3662	CLIP-seq
MIRT2655936	hsa-miR-3667-3p	CLIP-seq
MIRT2655937	hsa-miR-3670	CLIP-seq
MIRT2655938	hsa-miR-3673	CLIP-seq
MIRT2141177	hsa-miR-3674	CLIP-seq
MIRT2655939	hsa-miR-3681	CLIP-seq
MIRT2141178	hsa-miR-3689a-5p	CLIP-seq
MIRT2141179	hsa-miR-3689b	CLIP-seq
MIRT2141180	hsa-miR-3689e	CLIP-seq
MIRT2141181	hsa-miR-3689f	CLIP-seq
MIRT2655940	hsa-miR-3690	CLIP-seq
MIRT1469547	hsa-miR-3691-3p	CLIP-seq
MIRT2655941	hsa-miR-377	CLIP-seq
MIRT2141182	hsa-miR-378g	CLIP-seq
MIRT1469553	hsa-miR-3913-3p	CLIP-seq
MIRT2655942	hsa-miR-3942-5p	CLIP-seq
MIRT1469557	hsa-miR-3944-5p	CLIP-seq
MIRT1469559	hsa-miR-421	CLIP-seq
MIRT1469560	hsa-miR-424	CLIP-seq
MIRT2141184	hsa-miR-425	CLIP-seq
MIRT2655943	hsa-miR-4254	CLIP-seq
MIRT2655944	hsa-miR-4279	CLIP-seq
MIRT1469564	hsa-miR-4310	CLIP-seq
MIRT2141187	hsa-miR-4328	CLIP-seq
MIRT2655945	hsa-miR-4423-5p	CLIP-seq
MIRT2655946	hsa-miR-4443	CLIP-seq
MIRT2655947	hsa-miR-4463	CLIP-seq
MIRT2655948	hsa-miR-4468	CLIP-seq
MIRT2655949	hsa-miR-4476	CLIP-seq
MIRT2655950	hsa-miR-4477a	CLIP-seq
MIRT2141191	hsa-miR-4484	CLIP-seq
MIRT2141192	hsa-miR-4486	CLIP-seq
MIRT2655951	hsa-miR-4494	CLIP-seq
MIRT2362171	hsa-miR-4495	CLIP-seq
MIRT2655952	hsa-miR-4496	CLIP-seq
MIRT2655953	hsa-miR-4517	CLIP-seq
MIRT2655954	hsa-miR-452	CLIP-seq
MIRT2655955	hsa-miR-4540	CLIP-seq
MIRT2655956	hsa-miR-4652-3p	CLIP-seq
MIRT1469568	hsa-miR-4672	CLIP-seq
MIRT2655957	hsa-miR-4676-3p	CLIP-seq
MIRT2655958	hsa-miR-4687-3p	CLIP-seq
MIRT1469571	hsa-miR-4690-5p	CLIP-seq
MIRT2655959	hsa-miR-4698	CLIP-seq
MIRT2655960	hsa-miR-4703-3p	CLIP-seq
MIRT2655961	hsa-miR-4703-5p	CLIP-seq
MIRT2655962	hsa-miR-4705	CLIP-seq
MIRT1469572	hsa-miR-4709-3p	CLIP-seq
MIRT1469573	hsa-miR-4709-5p	CLIP-seq
MIRT2655963	hsa-miR-4711-3p	CLIP-seq
MIRT1469574	hsa-miR-4711-5p	CLIP-seq
MIRT2655964	hsa-miR-4714-3p	CLIP-seq
MIRT2655965	hsa-miR-4720-5p	CLIP-seq
MIRT2655966	hsa-miR-4729	CLIP-seq
MIRT2655967	hsa-miR-4731-5p	CLIP-seq
MIRT2655968	hsa-miR-4774-3p	CLIP-seq
MIRT2655969	hsa-miR-4791	CLIP-seq
MIRT2655970	hsa-miR-4796-3p	CLIP-seq
MIRT2655971	hsa-miR-4799-3p	CLIP-seq
MIRT2655972	hsa-miR-4800-5p	CLIP-seq
MIRT1469582	hsa-miR-489	CLIP-seq
MIRT2655973	hsa-miR-490-5p	CLIP-seq
MIRT1469584	hsa-miR-497	CLIP-seq
MIRT2141202	hsa-miR-499-3p	CLIP-seq
MIRT2141203	hsa-miR-499a-3p	CLIP-seq
MIRT2141204	hsa-miR-506	CLIP-seq
MIRT2141206	hsa-miR-5096	CLIP-seq
MIRT2141208	hsa-miR-526b	CLIP-seq
MIRT1469589	hsa-miR-539	CLIP-seq
MIRT2141210	hsa-miR-543	CLIP-seq
MIRT1469590	hsa-miR-548ac	CLIP-seq
MIRT2141146	hsa-miR-548an	CLIP-seq
MIRT1469591	hsa-miR-548d-3p	CLIP-seq
MIRT2141222	hsa-miR-548l	CLIP-seq
MIRT2655974	hsa-miR-548n	CLIP-seq
MIRT2655975	hsa-miR-548u	CLIP-seq
MIRT1469592	hsa-miR-548z	CLIP-seq
MIRT2655976	hsa-miR-554	CLIP-seq
MIRT2655977	hsa-miR-556-5p	CLIP-seq
MIRT2141228	hsa-miR-578	CLIP-seq
MIRT2141229	hsa-miR-579	CLIP-seq
MIRT1469598	hsa-miR-603	CLIP-seq
MIRT2655978	hsa-miR-607	CLIP-seq
MIRT2141230	hsa-miR-612	CLIP-seq
MIRT2141231	hsa-miR-613	CLIP-seq
MIRT2141232	hsa-miR-640	CLIP-seq
MIRT2655979	hsa-miR-650	CLIP-seq
MIRT2655980	hsa-miR-651	CLIP-seq
MIRT2655981	hsa-miR-656	CLIP-seq
MIRT2141233	hsa-miR-660	CLIP-seq
MIRT1469601	hsa-miR-663	CLIP-seq
MIRT2141234	hsa-miR-668	CLIP-seq
MIRT1469602	hsa-miR-7	CLIP-seq
MIRT2441591	hsa-miR-767-5p	CLIP-seq
MIRT1469496	hsa-miR-874	CLIP-seq
MIRT2655982	hsa-miR-885-5p	CLIP-seq
MIRT2655983	hsa-miR-921	CLIP-seq
MIRT2655984	hsa-miR-924	CLIP-seq
MIRT2655985	hsa-miR-99a	CLIP-seq
MIRT2655986	hsa-miR-99b	CLIP-seq
MIRT2141147	hsa-miR-1	CLIP-seq
MIRT2655907	hsa-miR-100	CLIP-seq
MIRT1469498	hsa-miR-103a	CLIP-seq
MIRT1469500	hsa-miR-107	CLIP-seq
MIRT2141148	hsa-miR-124	CLIP-seq
MIRT2655909	hsa-miR-1244	CLIP-seq
MIRT2655910	hsa-miR-1245b-5p	CLIP-seq
MIRT2655911	hsa-miR-1267	CLIP-seq
MIRT1469504	hsa-miR-1273e	CLIP-seq
MIRT2141150	hsa-miR-1285	CLIP-seq
MIRT2655912	hsa-miR-1295	CLIP-seq
MIRT2655913	hsa-miR-132	CLIP-seq
MIRT2655914	hsa-miR-1343	CLIP-seq
MIRT2141151	hsa-miR-142-5p	CLIP-seq
MIRT1469509	hsa-miR-148a	CLIP-seq
MIRT1469510	hsa-miR-148b	CLIP-seq
MIRT1469511	hsa-miR-152	CLIP-seq
MIRT1469512	hsa-miR-15a	CLIP-seq
MIRT1469513	hsa-miR-15b	CLIP-seq
MIRT1469514	hsa-miR-16	CLIP-seq
MIRT2655915	hsa-miR-1827	CLIP-seq
MIRT1469519	hsa-miR-1908	CLIP-seq
MIRT2655916	hsa-miR-1912	CLIP-seq
MIRT1469521	hsa-miR-195	CLIP-seq
MIRT2655917	hsa-miR-203	CLIP-seq
MIRT2141153	hsa-miR-205	CLIP-seq
MIRT1469524	hsa-miR-2053	CLIP-seq
MIRT2141154	hsa-miR-206	CLIP-seq
MIRT2655918	hsa-miR-212	CLIP-seq
MIRT2141159	hsa-miR-23a	CLIP-seq
MIRT2141160	hsa-miR-23b	CLIP-seq
MIRT2141161	hsa-miR-23c	CLIP-seq
MIRT1469492	hsa-miR-3074-5p	CLIP-seq
MIRT2655919	hsa-miR-3123	CLIP-seq
MIRT2655920	hsa-miR-3128	CLIP-seq
MIRT2655921	hsa-miR-3136-3p	CLIP-seq
MIRT2655923	hsa-miR-3142	CLIP-seq
MIRT2141167	hsa-miR-3143	CLIP-seq
MIRT2655924	hsa-miR-3145-3p	CLIP-seq
MIRT1469493	hsa-miR-3157-3p	CLIP-seq
MIRT1469494	hsa-miR-3159	CLIP-seq
MIRT2655926	hsa-miR-3161	CLIP-seq
MIRT2655927	hsa-miR-3162-3p	CLIP-seq
MIRT2141169	hsa-miR-3163	CLIP-seq
MIRT2655928	hsa-miR-3174	CLIP-seq
MIRT2655929	hsa-miR-3185	CLIP-seq
MIRT2141170	hsa-miR-3187-5p	CLIP-seq
MIRT2655930	hsa-miR-3201	CLIP-seq
MIRT2655931	hsa-miR-320e	CLIP-seq
MIRT2141173	hsa-miR-340	CLIP-seq
MIRT2141174	hsa-miR-34c-3p	CLIP-seq
MIRT2655932	hsa-miR-3591-5p	CLIP-seq
MIRT2655933	hsa-miR-3612	CLIP-seq
MIRT2362170	hsa-miR-3614-5p	CLIP-seq
MIRT2655934	hsa-miR-3622b-5p	CLIP-seq
MIRT2141175	hsa-miR-3655	CLIP-seq
MIRT2655935	hsa-miR-3662	CLIP-seq
MIRT2655936	hsa-miR-3667-3p	CLIP-seq
MIRT2655937	hsa-miR-3670	CLIP-seq
MIRT2655938	hsa-miR-3673	CLIP-seq
MIRT2141177	hsa-miR-3674	CLIP-seq
MIRT2141178	hsa-miR-3689a-5p	CLIP-seq
MIRT2141179	hsa-miR-3689b	CLIP-seq
MIRT2141180	hsa-miR-3689e	CLIP-seq
MIRT2141181	hsa-miR-3689f	CLIP-seq
MIRT2655940	hsa-miR-3690	CLIP-seq
MIRT1469547	hsa-miR-3691-3p	CLIP-seq
MIRT2655941	hsa-miR-377	CLIP-seq
MIRT2141182	hsa-miR-378g	CLIP-seq
MIRT1469553	hsa-miR-3913-3p	CLIP-seq
MIRT1469557	hsa-miR-3944-5p	CLIP-seq
MIRT1469559	hsa-miR-421	CLIP-seq
MIRT1469560	hsa-miR-424	CLIP-seq
MIRT2141184	hsa-miR-425	CLIP-seq
MIRT2655943	hsa-miR-4254	CLIP-seq
MIRT2655944	hsa-miR-4279	CLIP-seq
MIRT1469564	hsa-miR-4310	CLIP-seq
MIRT2141187	hsa-miR-4328	CLIP-seq
MIRT2655945	hsa-miR-4423-5p	CLIP-seq
MIRT2655946	hsa-miR-4443	CLIP-seq
MIRT2655947	hsa-miR-4463	CLIP-seq
MIRT2655948	hsa-miR-4468	CLIP-seq
MIRT2655949	hsa-miR-4476	CLIP-seq
MIRT2655950	hsa-miR-4477a	CLIP-seq
MIRT2141191	hsa-miR-4484	CLIP-seq
MIRT2141192	hsa-miR-4486	CLIP-seq
MIRT2655951	hsa-miR-4494	CLIP-seq
MIRT2362171	hsa-miR-4495	CLIP-seq
MIRT2655952	hsa-miR-4496	CLIP-seq
MIRT2655953	hsa-miR-4517	CLIP-seq
MIRT2655954	hsa-miR-452	CLIP-seq
MIRT2655955	hsa-miR-4540	CLIP-seq
MIRT2655956	hsa-miR-4652-3p	CLIP-seq
MIRT2655957	hsa-miR-4676-3p	CLIP-seq
MIRT1469571	hsa-miR-4690-5p	CLIP-seq
MIRT2655959	hsa-miR-4698	CLIP-seq
MIRT2655960	hsa-miR-4703-3p	CLIP-seq
MIRT2655962	hsa-miR-4705	CLIP-seq
MIRT1469572	hsa-miR-4709-3p	CLIP-seq
MIRT1469573	hsa-miR-4709-5p	CLIP-seq
MIRT2655963	hsa-miR-4711-3p	CLIP-seq
MIRT1469574	hsa-miR-4711-5p	CLIP-seq
MIRT2655964	hsa-miR-4714-3p	CLIP-seq
MIRT2655965	hsa-miR-4720-5p	CLIP-seq
MIRT2655966	hsa-miR-4729	CLIP-seq
MIRT2655968	hsa-miR-4774-3p	CLIP-seq
MIRT2655969	hsa-miR-4791	CLIP-seq
MIRT2655970	hsa-miR-4796-3p	CLIP-seq
MIRT2655971	hsa-miR-4799-3p	CLIP-seq
MIRT1469582	hsa-miR-489	CLIP-seq
MIRT2655973	hsa-miR-490-5p	CLIP-seq
MIRT1469584	hsa-miR-497	CLIP-seq
MIRT2141202	hsa-miR-499-3p	CLIP-seq
MIRT2141203	hsa-miR-499a-3p	CLIP-seq
MIRT2141204	hsa-miR-506	CLIP-seq
MIRT2141206	hsa-miR-5096	CLIP-seq
MIRT2141208	hsa-miR-526b	CLIP-seq
MIRT1469589	hsa-miR-539	CLIP-seq
MIRT2141210	hsa-miR-543	CLIP-seq
MIRT1469590	hsa-miR-548ac	CLIP-seq
MIRT2141146	hsa-miR-548an	CLIP-seq
MIRT1469591	hsa-miR-548d-3p	CLIP-seq
MIRT2141222	hsa-miR-548l	CLIP-seq
MIRT2655974	hsa-miR-548n	CLIP-seq
MIRT2655975	hsa-miR-548u	CLIP-seq
MIRT1469592	hsa-miR-548z	CLIP-seq
MIRT2655976	hsa-miR-554	CLIP-seq
MIRT2141228	hsa-miR-578	CLIP-seq
MIRT2141229	hsa-miR-579	CLIP-seq
MIRT1469598	hsa-miR-603	CLIP-seq
MIRT2655978	hsa-miR-607	CLIP-seq
MIRT2141230	hsa-miR-612	CLIP-seq
MIRT2141231	hsa-miR-613	CLIP-seq
MIRT2141232	hsa-miR-640	CLIP-seq
MIRT2655979	hsa-miR-650	CLIP-seq
MIRT2655980	hsa-miR-651	CLIP-seq
MIRT2655981	hsa-miR-656	CLIP-seq
MIRT2141233	hsa-miR-660	CLIP-seq
MIRT1469601	hsa-miR-663	CLIP-seq
MIRT2141234	hsa-miR-668	CLIP-seq
MIRT1469602	hsa-miR-7	CLIP-seq
MIRT2441591	hsa-miR-767-5p	CLIP-seq
MIRT1469496	hsa-miR-874	CLIP-seq
MIRT2655982	hsa-miR-885-5p	CLIP-seq
MIRT2655983	hsa-miR-921	CLIP-seq
MIRT2655985	hsa-miR-99a	CLIP-seq
MIRT2655986	hsa-miR-99b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IEA
GO:0000151	Component	Ubiquitin ligase complex	TAS	10089879
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	21903422, 22119785, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	10089879
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IBA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IEA
GO:0036503	Process	ERAD pathway	IBA
GO:0036503	Process	ERAD pathway	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 603753
• HGNC: 12499
• e!Ensembl: ENSG00000110344

Protein

• UniProt ID: Q14139
• Protein name: Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)
• Protein function: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin
• PDB: 1WGM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10408	Ufd2P_core	330 → 972	Ubiquitin elongating factor core	Family
  PF04564	U-box	988 → 1060	U-box domain	Domain

• Sequence:

  MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDE
  FDYSVAEISRSFRSQQEICEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMA
  VELEDQDWLDMSNVEQALFARLLLQDPGNHLINMTSSTTLNLSADRDAGERHIFCYLYSC
  FQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGA
  HFEDVTEFLEEVIEALILDEEVRTFPEVMIPVFDILLGRIKDLELCQILLYAYLDILLYF
  TRQKDMAKVFVEYIQPKDPTNGQMYQKTLLGVILSISCLLKTPGVVENHGYFLNPSRSSP
  QEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILSWLGNCLHANAGRTKIWANQ
  MPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCALKELNDEERKIKNV
  HMRGLDKETCLIPAVQEPKFPQNYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQ
  VAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAI
  GNEGSQPIELTFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFADDILETSADSLEHVLHF
  ITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPNPLVSSVFHRKRVFCNFQYAPQLAE
  ALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDTYRESIKDLADYASKNLEAMN
  PPLFLRFLNLLMNDAIFLLDEAIQYLSKIKIQQIEKDRGEWDSLTPEARREKEAGLQMFG
  QLARFHNIMSNETIGTLAFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKD
  FSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNM
  IMAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIA
  RHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQLE

• Sequence length: 1066

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Neurodevelopmental disorder	Likely pathogenic	rs2496959742	RCV002789993	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder with hypotonia and gross motor and speech delay	Pathogenic; Likely pathogenic	rs2134089305, rs748926976, rs2496943725, rs1565532385	RCV001787244 RCV001787245 RCV003233439 RCV001787106	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
UBE4A-related disorder	Pathogenic	rs2134092709	RCV001808204	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOSOMAL RECESSIVE NON-SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, Orphanet Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	17822919, 34965472	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	11080474	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35136024	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	18069675		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	30663414		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Hyperlipoproteinemias	Hyperlipoproteinemia	Pubtator	3705062	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	27862841		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	28963376		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16386891		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12700669		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	12700669, 15019985		★☆☆☆☆ Found in Text Mining only
Osteogenesis Imperfecta Type IV	Osteogenesis imperfecta	Pubtator	3705062	Stimulate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	27862841		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27862841	Inhibit	★☆☆☆☆ Found in Text Mining only
Scleroderma	Scleroderma	BEFREE	15611659		★☆☆☆☆ Found in Text Mining only
Sleep Apnea Obstructive	Sleep apnea	Pubtator	15879419	Associate	★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	15611659		★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	28963376		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	28963376		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	28963376	Associate	★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	18069675		★☆☆☆☆ Found in Text Mining only