Gene Gene information from NCBI Gene database.
Entrez ID 9352
Gene name Thioredoxin like 1
Gene symbol TXNL1
Synonyms (NCBI Gene)
HEL-S-114TRP32TXL-1TXNLTxl
Chromosome 18
Chromosome location 18q21.31
miRNA miRNA information provided by mirtarbase database.
296
miRTarBase ID miRNA Experiments Reference
MIRT051069 hsa-miR-16-5p CLASH 23622248
MIRT050179 hsa-miR-26a-5p CLASH 23622248
MIRT724949 hsa-miR-6074 HITS-CLIP 19536157
MIRT724948 hsa-miR-141-5p HITS-CLIP 19536157
MIRT724947 hsa-miR-664a-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0000502 Component Proteasome complex IEA
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 9668102
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603049 12436 ENSG00000091164
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43396
Protein name Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)
Protein function Active thioredoxin with a redox potential of about -250 mV.
PDB 1GH2 , 1WWY , 9E8G , 9E8H , 9E8I , 9E8J , 9E8K , 9E8L , 9E8N , 9E8O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin 6 107 Thioredoxin Domain
PF06201 PITH 126 268 PITH domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 289
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 36230901 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 21290163
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 21290163 Associate
★☆☆☆☆
Found in Text Mining only
Coronary Arteriosclerosis Coronary Arteriosclerosis BEFREE 31227964
★☆☆☆☆
Found in Text Mining only
Leukemia, Myelocytic, Acute Leukemia BEFREE 7915211
★☆☆☆☆
Found in Text Mining only
Myocardial Ischemia Myocardial Ischemia BEFREE 31227964
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach neoplasms Pubtator 24525731 Associate
★☆☆☆☆
Found in Text Mining only