Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9349
Gene name	Ribosomal protein L23
Gene symbol	RPL23
Synonyms (NCBI Gene)	L23rpL17uL14
Chromosome	17
Chromosome location	17q12
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (29)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022730	hsa-miR-124-3p	Microarray	18668037
MIRT047046	hsa-miR-183-5p	CLASH	23622248
MIRT041095	hsa-miR-503-5p	CLASH	23622248
MIRT041095	hsa-miR-503-5p	CLASH	23622248
MIRT039746	hsa-miR-615-3p	CLASH	23622248
MIRT052822	hsa-miR-3200-3p	CLASH	23622248
MIRT514899	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT514898	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514897	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT514896	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT514895	hsa-miR-5095	PAR-CLIP	23446348
MIRT514894	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514893	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT514899	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT514898	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514897	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT514896	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT514895	hsa-miR-5095	PAR-CLIP	23446348
MIRT514894	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514893	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT2318586	hsa-miR-1243	CLIP-seq
MIRT2318587	hsa-miR-3654	CLIP-seq
MIRT2318588	hsa-miR-4434	CLIP-seq
MIRT2318589	hsa-miR-4506	CLIP-seq
MIRT2318590	hsa-miR-4516	CLIP-seq
MIRT2318591	hsa-miR-4531	CLIP-seq
MIRT2318592	hsa-miR-520d-5p	CLIP-seq
MIRT2318593	hsa-miR-524-5p	CLIP-seq
MIRT2318594	hsa-miR-629	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19160485
GO:0001223	Function	Transcription coactivator binding	IPI	19160485
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	15314173, 16189514, 17110929, 17310983, 25416956, 30021884, 32296183, 33961781, 35271311
GO:0005654	Component	Nucleoplasm	IDA	15314173
GO:0005730	Component	Nucleolus	IDA	15314173, 19160485
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	15314173
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	NAS	1874450
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006610	Process	Ribosomal protein import into nucleus	NAS	1874450
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	19160485
GO:0010628	Process	Positive regulation of gene expression	IMP	15314173
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15314173
GO:0032986	Process	Protein-DNA complex disassembly	IDA	19160485
GO:0032991	Component	Protein-containing complex	IDA	19160485
GO:0032991	Component	Protein-containing complex	IMP	15314173
GO:0045202	Component	Synapse	IEA
GO:0050821	Process	Protein stabilization	IMP	15314173, 19160485
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070180	Function	Large ribosomal subunit rRNA binding	IBA
GO:0070314	Process	G1 to G0 transition	IMP	19160485
GO:0072717	Process	Cellular response to actinomycin D	IMP	15314173
GO:1901798	Process	Positive regulation of signal transduction by p53 class mediator	IMP	15314173
GO:1903450	Process	Regulation of G1 to G0 transition	IMP	15314173
GO:1904667	Process	Negative regulation of ubiquitin protein ligase activity	IDA	15314173
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990948	Function	Ubiquitin ligase inhibitor activity	IDA	15314173
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IDA	15314173

MIM	HGNC	e!Ensembl
603662	10316	ENSG00000125691

P62829

Protein name

Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23)

Protein function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00238	Ribosomal_L14	20 → 140	Ribosomal protein L14p/L23e	Domain

Sequence

MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDM
VMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGP
VAKECADLWPRIASNAGSIA

Sequence length

140

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	GENOMICS_ENGLAND_DG	28297620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Reactive	Reactive arthritis	Pubtator	8790600	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atypical Hemolytic Uremic Syndrome	Hemolytic uremic syndrome	Pubtator	37373158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	8790600		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30546434		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26044651		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36341526	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	31603917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Focal glomerulosclerosis	Glomerulosclerosis	BEFREE	28158993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Focal Segmental Glomerulosclerosis, Not Otherwise Specified	Focal segmental glomerulosclerosis	BEFREE	28158993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Infertility Male	Male infertility	Pubtator	36369953	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Macular dystrophy, corneal type 1	Macular corneal dystrophy	BEFREE	28158993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30546434		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	15149863, 20020415, 23933826		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20020415		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucopolysaccharidoses	Mucopolysaccharidosis	Pubtator	35456399	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	22580751, 28539603		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	28539603	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20020415, 26044651, 29991511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Sarcoma	Pubtator	40016701	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	15149863, 20020415, 23933826		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	15149863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Venous Thromboembolism	Venous thromboembolism	Pubtator	29620629	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPL23 (ribosomal protein L23)