Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9348
Gene name	N-deacetylase and N-sulfotransferase 3
Gene symbol	NDST3
Synonyms (NCBI Gene)	HSST3
Chromosome	4
Chromosome location	4q26
Summary	This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacet

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017221	hsa-miR-335-5p	Microarray	18185580
MIRT635660	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635659	hsa-miR-889-5p	HITS-CLIP	23824327
MIRT635658	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635657	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635656	hsa-miR-4459	HITS-CLIP	23824327
MIRT635655	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635654	hsa-miR-4267	HITS-CLIP	23824327
MIRT635653	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635651	hsa-miR-4268	HITS-CLIP	23824327
MIRT635652	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT635650	hsa-miR-7974	HITS-CLIP	23824327
MIRT635649	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT635648	hsa-miR-7977	HITS-CLIP	23824327
MIRT635647	hsa-miR-665	HITS-CLIP	23824327
MIRT635660	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635659	hsa-miR-889-5p	HITS-CLIP	23824327
MIRT635658	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635657	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635656	hsa-miR-4459	HITS-CLIP	23824327
MIRT635655	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635654	hsa-miR-4267	HITS-CLIP	23824327
MIRT635653	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635651	hsa-miR-4268	HITS-CLIP	23824327
MIRT635652	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT635650	hsa-miR-7974	HITS-CLIP	23824327
MIRT635649	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT635648	hsa-miR-7977	HITS-CLIP	23824327
MIRT635647	hsa-miR-665	HITS-CLIP	23824327
MIRT635660	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635659	hsa-miR-889-5p	HITS-CLIP	23824327
MIRT635658	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635657	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635656	hsa-miR-4459	HITS-CLIP	23824327
MIRT635655	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635654	hsa-miR-4267	HITS-CLIP	23824327
MIRT635653	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635651	hsa-miR-4268	HITS-CLIP	23824327
MIRT635652	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT635650	hsa-miR-7974	HITS-CLIP	23824327
MIRT635649	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT635648	hsa-miR-7977	HITS-CLIP	23824327
MIRT635647	hsa-miR-665	HITS-CLIP	23824327
MIRT635660	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635659	hsa-miR-889-5p	HITS-CLIP	23824327
MIRT635658	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635657	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635656	hsa-miR-4459	HITS-CLIP	23824327
MIRT635655	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635654	hsa-miR-4267	HITS-CLIP	23824327
MIRT635653	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635651	hsa-miR-4268	HITS-CLIP	23824327
MIRT635652	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT635650	hsa-miR-7974	HITS-CLIP	23824327
MIRT635649	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT635648	hsa-miR-7977	HITS-CLIP	23824327
MIRT635647	hsa-miR-665	HITS-CLIP	23824327
MIRT635660	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635659	hsa-miR-889-5p	HITS-CLIP	23824327
MIRT635658	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635657	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635656	hsa-miR-4459	HITS-CLIP	23824327
MIRT635655	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635654	hsa-miR-4267	HITS-CLIP	23824327
MIRT635653	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635651	hsa-miR-4268	HITS-CLIP	23824327
MIRT635652	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT635650	hsa-miR-7974	HITS-CLIP	23824327
MIRT635649	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT635648	hsa-miR-7977	HITS-CLIP	23824327
MIRT635647	hsa-miR-665	HITS-CLIP	23824327
MIRT635660	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635659	hsa-miR-889-5p	HITS-CLIP	23824327
MIRT635658	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635657	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635656	hsa-miR-4459	HITS-CLIP	23824327
MIRT635655	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635654	hsa-miR-4267	HITS-CLIP	23824327
MIRT635653	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635651	hsa-miR-4268	HITS-CLIP	23824327
MIRT635652	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT635650	hsa-miR-7974	HITS-CLIP	23824327
MIRT635649	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT635648	hsa-miR-7977	HITS-CLIP	23824327
MIRT635647	hsa-miR-665	HITS-CLIP	23824327
MIRT1178447	hsa-let-7a	CLIP-seq
MIRT1178448	hsa-let-7b	CLIP-seq
MIRT1178449	hsa-let-7c	CLIP-seq
MIRT1178450	hsa-let-7d	CLIP-seq
MIRT1178451	hsa-let-7e	CLIP-seq
MIRT1178452	hsa-let-7f	CLIP-seq
MIRT1178453	hsa-let-7g	CLIP-seq
MIRT1178454	hsa-let-7i	CLIP-seq
MIRT1178455	hsa-miR-1200	CLIP-seq
MIRT1178456	hsa-miR-1228	CLIP-seq
MIRT1178457	hsa-miR-1257	CLIP-seq
MIRT1178458	hsa-miR-1262	CLIP-seq
MIRT1178459	hsa-miR-1283	CLIP-seq
MIRT1178460	hsa-miR-1293	CLIP-seq
MIRT1178461	hsa-miR-1305	CLIP-seq
MIRT1178462	hsa-miR-15a	CLIP-seq
MIRT1178463	hsa-miR-15b	CLIP-seq
MIRT1178464	hsa-miR-16	CLIP-seq
MIRT1178465	hsa-miR-1827	CLIP-seq
MIRT1178466	hsa-miR-195	CLIP-seq
MIRT1178467	hsa-miR-199a-3p	CLIP-seq
MIRT1178468	hsa-miR-199b-3p	CLIP-seq
MIRT1178469	hsa-miR-202	CLIP-seq
MIRT1178470	hsa-miR-216a	CLIP-seq
MIRT1178471	hsa-miR-216b	CLIP-seq
MIRT1178472	hsa-miR-25	CLIP-seq
MIRT1178473	hsa-miR-27a	CLIP-seq
MIRT1178474	hsa-miR-27b	CLIP-seq
MIRT1178475	hsa-miR-3065-3p	CLIP-seq
MIRT1178476	hsa-miR-3129-5p	CLIP-seq
MIRT1178477	hsa-miR-3160-3p	CLIP-seq
MIRT1178478	hsa-miR-3163	CLIP-seq
MIRT1178479	hsa-miR-3174	CLIP-seq
MIRT1178480	hsa-miR-32	CLIP-seq
MIRT1178481	hsa-miR-338-5p	CLIP-seq
MIRT1178482	hsa-miR-34b	CLIP-seq
MIRT1178483	hsa-miR-3614-5p	CLIP-seq
MIRT1178484	hsa-miR-3618	CLIP-seq
MIRT1178485	hsa-miR-363	CLIP-seq
MIRT1178486	hsa-miR-367	CLIP-seq
MIRT1178487	hsa-miR-3672	CLIP-seq
MIRT1178488	hsa-miR-3692	CLIP-seq
MIRT1178489	hsa-miR-3913-3p	CLIP-seq
MIRT1178490	hsa-miR-3915	CLIP-seq
MIRT1178491	hsa-miR-3928	CLIP-seq
MIRT1178492	hsa-miR-3929	CLIP-seq
MIRT1178493	hsa-miR-410	CLIP-seq
MIRT1178494	hsa-miR-424	CLIP-seq
MIRT1178495	hsa-miR-4275	CLIP-seq
MIRT1178496	hsa-miR-4307	CLIP-seq
MIRT1178497	hsa-miR-4324	CLIP-seq
MIRT1178498	hsa-miR-4325	CLIP-seq
MIRT1178499	hsa-miR-4419b	CLIP-seq
MIRT1178500	hsa-miR-4433	CLIP-seq
MIRT1178501	hsa-miR-4458	CLIP-seq
MIRT1178502	hsa-miR-4464	CLIP-seq
MIRT1178503	hsa-miR-4478	CLIP-seq
MIRT1178504	hsa-miR-4483	CLIP-seq
MIRT1178505	hsa-miR-4487	CLIP-seq
MIRT1178506	hsa-miR-4500	CLIP-seq
MIRT1178507	hsa-miR-4524	CLIP-seq
MIRT1178508	hsa-miR-4649-3p	CLIP-seq
MIRT1178509	hsa-miR-4659a-3p	CLIP-seq
MIRT1178510	hsa-miR-4659b-3p	CLIP-seq
MIRT1178511	hsa-miR-4668-3p	CLIP-seq
MIRT1178512	hsa-miR-4701-3p	CLIP-seq
MIRT1178513	hsa-miR-4709-3p	CLIP-seq
MIRT1178514	hsa-miR-4717-5p	CLIP-seq
MIRT1178515	hsa-miR-4722-5p	CLIP-seq
MIRT1178516	hsa-miR-4748	CLIP-seq
MIRT1178517	hsa-miR-4761-5p	CLIP-seq
MIRT1178518	hsa-miR-485-5p	CLIP-seq
MIRT1178519	hsa-miR-489	CLIP-seq
MIRT1178520	hsa-miR-497	CLIP-seq
MIRT1178521	hsa-miR-500a	CLIP-seq
MIRT1178522	hsa-miR-501-5p	CLIP-seq
MIRT1178523	hsa-miR-503	CLIP-seq
MIRT1178524	hsa-miR-505	CLIP-seq
MIRT1178525	hsa-miR-508-5p	CLIP-seq
MIRT1178526	hsa-miR-513a-5p	CLIP-seq
MIRT1178527	hsa-miR-514	CLIP-seq
MIRT1178528	hsa-miR-514b-3p	CLIP-seq
MIRT1178529	hsa-miR-544b	CLIP-seq
MIRT1178530	hsa-miR-548n	CLIP-seq
MIRT1178531	hsa-miR-548t	CLIP-seq
MIRT1178532	hsa-miR-558	CLIP-seq
MIRT1178533	hsa-miR-567	CLIP-seq
MIRT1178534	hsa-miR-579	CLIP-seq
MIRT1178535	hsa-miR-617	CLIP-seq
MIRT1178536	hsa-miR-646	CLIP-seq
MIRT1178537	hsa-miR-658	CLIP-seq
MIRT1178538	hsa-miR-661	CLIP-seq
MIRT1178539	hsa-miR-766	CLIP-seq
MIRT1178540	hsa-miR-921	CLIP-seq
MIRT1178541	hsa-miR-92a	CLIP-seq
MIRT1178542	hsa-miR-92b	CLIP-seq
MIRT1178543	hsa-miR-940	CLIP-seq
MIRT1178544	hsa-miR-98	CLIP-seq
MIRT1178456	hsa-miR-1228	CLIP-seq
MIRT1178458	hsa-miR-1262	CLIP-seq
MIRT1178459	hsa-miR-1283	CLIP-seq
MIRT1178465	hsa-miR-1827	CLIP-seq
MIRT1178467	hsa-miR-199a-3p	CLIP-seq
MIRT1178468	hsa-miR-199b-3p	CLIP-seq
MIRT2051661	hsa-miR-24	CLIP-seq
MIRT1178472	hsa-miR-25	CLIP-seq
MIRT2051662	hsa-miR-3127-5p	CLIP-seq
MIRT1178476	hsa-miR-3129-5p	CLIP-seq
MIRT1178477	hsa-miR-3160-3p	CLIP-seq
MIRT1178480	hsa-miR-32	CLIP-seq
MIRT2051663	hsa-miR-337-3p	CLIP-seq
MIRT1178481	hsa-miR-338-5p	CLIP-seq
MIRT1178482	hsa-miR-34b	CLIP-seq
MIRT1178483	hsa-miR-3614-5p	CLIP-seq
MIRT1178484	hsa-miR-3618	CLIP-seq
MIRT2051664	hsa-miR-3622b-5p	CLIP-seq
MIRT1178485	hsa-miR-363	CLIP-seq
MIRT1178486	hsa-miR-367	CLIP-seq
MIRT2051665	hsa-miR-3685	CLIP-seq
MIRT1178488	hsa-miR-3692	CLIP-seq
MIRT2051666	hsa-miR-384	CLIP-seq
MIRT2051667	hsa-miR-3918	CLIP-seq
MIRT1178492	hsa-miR-3929	CLIP-seq
MIRT1178493	hsa-miR-410	CLIP-seq
MIRT2051668	hsa-miR-4253	CLIP-seq
MIRT2051669	hsa-miR-4284	CLIP-seq
MIRT1178498	hsa-miR-4325	CLIP-seq
MIRT2051670	hsa-miR-4328	CLIP-seq
MIRT1178499	hsa-miR-4419b	CLIP-seq
MIRT1178500	hsa-miR-4433	CLIP-seq
MIRT1178503	hsa-miR-4478	CLIP-seq
MIRT1178505	hsa-miR-4487	CLIP-seq
MIRT1178508	hsa-miR-4649-3p	CLIP-seq
MIRT1178512	hsa-miR-4701-3p	CLIP-seq
MIRT1178515	hsa-miR-4722-5p	CLIP-seq
MIRT2051671	hsa-miR-4761-3p	CLIP-seq
MIRT1178517	hsa-miR-4761-5p	CLIP-seq
MIRT1178518	hsa-miR-485-5p	CLIP-seq
MIRT1178525	hsa-miR-508-5p	CLIP-seq
MIRT1178532	hsa-miR-558	CLIP-seq
MIRT2051672	hsa-miR-562	CLIP-seq
MIRT1178534	hsa-miR-579	CLIP-seq
MIRT2051673	hsa-miR-607	CLIP-seq
MIRT1178537	hsa-miR-658	CLIP-seq
MIRT1178538	hsa-miR-661	CLIP-seq
MIRT1178539	hsa-miR-766	CLIP-seq
MIRT1178541	hsa-miR-92a	CLIP-seq
MIRT1178542	hsa-miR-92b	CLIP-seq
MIRT1178543	hsa-miR-940	CLIP-seq
MIRT1178456	hsa-miR-1228	CLIP-seq
MIRT1178458	hsa-miR-1262	CLIP-seq
MIRT1178460	hsa-miR-1293	CLIP-seq
MIRT1178465	hsa-miR-1827	CLIP-seq
MIRT1178470	hsa-miR-216a	CLIP-seq
MIRT1178471	hsa-miR-216b	CLIP-seq
MIRT1178472	hsa-miR-25	CLIP-seq
MIRT1178477	hsa-miR-3160-3p	CLIP-seq
MIRT1178478	hsa-miR-3163	CLIP-seq
MIRT2280716	hsa-miR-3165	CLIP-seq
MIRT1178480	hsa-miR-32	CLIP-seq
MIRT1178482	hsa-miR-34b	CLIP-seq
MIRT1178483	hsa-miR-3614-5p	CLIP-seq
MIRT1178485	hsa-miR-363	CLIP-seq
MIRT1178486	hsa-miR-367	CLIP-seq
MIRT1178492	hsa-miR-3929	CLIP-seq
MIRT2280717	hsa-miR-4311	CLIP-seq
MIRT1178498	hsa-miR-4325	CLIP-seq
MIRT1178499	hsa-miR-4419b	CLIP-seq
MIRT1178500	hsa-miR-4433	CLIP-seq
MIRT1178503	hsa-miR-4478	CLIP-seq
MIRT1178504	hsa-miR-4483	CLIP-seq
MIRT1178505	hsa-miR-4487	CLIP-seq
MIRT1178508	hsa-miR-4649-3p	CLIP-seq
MIRT1178512	hsa-miR-4701-3p	CLIP-seq
MIRT1178515	hsa-miR-4722-5p	CLIP-seq
MIRT1178517	hsa-miR-4761-5p	CLIP-seq
MIRT2280718	hsa-miR-4775	CLIP-seq
MIRT1178518	hsa-miR-485-5p	CLIP-seq
MIRT1178525	hsa-miR-508-5p	CLIP-seq
MIRT1178532	hsa-miR-558	CLIP-seq
MIRT1178537	hsa-miR-658	CLIP-seq
MIRT1178538	hsa-miR-661	CLIP-seq
MIRT1178539	hsa-miR-766	CLIP-seq
MIRT1178541	hsa-miR-92a	CLIP-seq
MIRT1178542	hsa-miR-92b	CLIP-seq
MIRT1178543	hsa-miR-940	CLIP-seq
MIRT1178458	hsa-miR-1262	CLIP-seq
MIRT1178471	hsa-miR-216b	CLIP-seq
MIRT1178477	hsa-miR-3160-3p	CLIP-seq
MIRT2391462	hsa-miR-3675-3p	CLIP-seq
MIRT1178500	hsa-miR-4433	CLIP-seq
MIRT1178505	hsa-miR-4487	CLIP-seq
MIRT1178512	hsa-miR-4701-3p	CLIP-seq
MIRT1178525	hsa-miR-508-5p	CLIP-seq
MIRT1178532	hsa-miR-558	CLIP-seq
MIRT1178538	hsa-miR-661	CLIP-seq
MIRT1178539	hsa-miR-766	CLIP-seq
MIRT1178465	hsa-miR-1827	CLIP-seq
MIRT1178477	hsa-miR-3160-3p	CLIP-seq
MIRT1178482	hsa-miR-34b	CLIP-seq
MIRT1178483	hsa-miR-3614-5p	CLIP-seq
MIRT1178505	hsa-miR-4487	CLIP-seq
MIRT1178515	hsa-miR-4722-5p	CLIP-seq
MIRT1178532	hsa-miR-558	CLIP-seq
MIRT1178537	hsa-miR-658	CLIP-seq
MIRT1178543	hsa-miR-940	CLIP-seq
MIRT2579211	hsa-miR-10a	CLIP-seq
MIRT2579212	hsa-miR-10b	CLIP-seq
MIRT1178456	hsa-miR-1228	CLIP-seq
MIRT1178465	hsa-miR-1827	CLIP-seq
MIRT1178477	hsa-miR-3160-3p	CLIP-seq
MIRT2579213	hsa-miR-339-5p	CLIP-seq
MIRT1178482	hsa-miR-34b	CLIP-seq
MIRT1178483	hsa-miR-3614-5p	CLIP-seq
MIRT1178505	hsa-miR-4487	CLIP-seq
MIRT1178515	hsa-miR-4722-5p	CLIP-seq
MIRT1178532	hsa-miR-558	CLIP-seq
MIRT1178537	hsa-miR-658	CLIP-seq
MIRT2579214	hsa-miR-668	CLIP-seq
MIRT1178543	hsa-miR-940	CLIP-seq
MIRT1178465	hsa-miR-1827	CLIP-seq
MIRT1178477	hsa-miR-3160-3p	CLIP-seq
MIRT1178482	hsa-miR-34b	CLIP-seq
MIRT1178483	hsa-miR-3614-5p	CLIP-seq
MIRT1178505	hsa-miR-4487	CLIP-seq
MIRT1178515	hsa-miR-4722-5p	CLIP-seq
MIRT1178532	hsa-miR-558	CLIP-seq
MIRT1178537	hsa-miR-658	CLIP-seq
MIRT1178543	hsa-miR-940	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IBA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IDA	9915799
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IEA
GO:0015016	Function	Heparan sulfate N-sulfotransferase activity	IBA
GO:0015016	Function	Heparan sulfate N-sulfotransferase activity	IDA	9915799
GO:0015016	Function	Heparan sulfate N-sulfotransferase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019213	Function	Deacetylase activity	IBA
GO:0019213	Function	Deacetylase activity	IEA
GO:0030210	Process	Heparin proteoglycan biosynthetic process	IEA
GO:0102140	Function	Heparan sulfate N-deacetylase activity	IDA	9915799

MIM	HGNC	e!Ensembl
603950	7682	ENSG00000164100

O95803

Protein name

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan su

Protein function

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated hepa

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12062	HSNSD	20 → 506	heparan sulfate-N-deacetylase	Family
PF00685	Sulfotransfer_1	595 → 858	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle. {ECO:0000269|PubMed:9915799}.

Sequence

MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPY
QLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVL
IDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGF
PFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKT
PENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLS
LDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEE
EDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKKFALEHGIPTDMGYAV
APHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLF
THTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANF
VKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLV
IGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVT
TDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFS
FYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVM
DEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLS
SYYRDHNVELSKLLHKLGQPLPSWLRQELQKVR

Sequence length

873

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways		HS-GAG biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATOCONUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	36135988	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	36135988	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	24253340, 26731438		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	24253340		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	24253340, 36135988	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33836688	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	36135988	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	34284545	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Liver neoplasm	Pubtator	36135988	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	29140583		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	29140583		★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	36135988	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	24253340, 25139529, 26731438, 29140583		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	24253340, 25139529		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	Pubtator	24253340, 36135988	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Unipolar Depression	Mental Depression	BEFREE	29140583		★★★★★ ★☆☆☆☆ Found in Text Mining only

NDST3 (N-deacetylase and N-sulfotransferase 3)