GLP2R (glucagon like peptide 2 receptor)

Gene

• Entrez ID: 9340
• Gene name: Glucagon like peptide 2 receptor
• Gene symbol: GLP2R
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomita

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT696128	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT696127	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT696126	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT696125	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696124	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT696123	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT696122	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696121	hsa-miR-3926	HITS-CLIP	23313552
MIRT696120	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT696119	hsa-miR-548s	HITS-CLIP	23313552
MIRT682518	hsa-miR-15a-5p	HITS-CLIP	23706177
MIRT682517	hsa-miR-15b-5p	HITS-CLIP	23706177
MIRT682516	hsa-miR-16-5p	HITS-CLIP	23706177
MIRT682515	hsa-miR-195-5p	HITS-CLIP	23706177
MIRT682514	hsa-miR-424-5p	HITS-CLIP	23706177
MIRT682513	hsa-miR-497-5p	HITS-CLIP	23706177
MIRT682512	hsa-miR-6838-5p	HITS-CLIP	23706177
MIRT682511	hsa-miR-503-5p	HITS-CLIP	23706177
MIRT682510	hsa-miR-646	HITS-CLIP	23706177
MIRT682509	hsa-miR-4310	HITS-CLIP	23706177
MIRT682508	hsa-miR-7157-5p	HITS-CLIP	23706177
MIRT682507	hsa-miR-103a-3p	HITS-CLIP	23706177
MIRT682506	hsa-miR-107	HITS-CLIP	23706177
MIRT682505	hsa-miR-4524a-5p	HITS-CLIP	23706177
MIRT682504	hsa-miR-4524b-5p	HITS-CLIP	23706177
MIRT682503	hsa-miR-4662a-5p	HITS-CLIP	23706177
MIRT682502	hsa-miR-513b-5p	HITS-CLIP	23706177
MIRT629966	hsa-miR-524-3p	HITS-CLIP	23824327
MIRT629965	hsa-miR-525-3p	HITS-CLIP	23824327
MIRT629964	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT629963	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT629962	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT629961	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT629960	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT629959	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT629958	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT629957	hsa-miR-7977	HITS-CLIP	23824327
MIRT629956	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT629955	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT629954	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT629953	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT629952	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT629951	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT629950	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT629949	hsa-miR-3689c	HITS-CLIP	23824327
MIRT629948	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT629947	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT629946	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT629945	hsa-miR-3122	HITS-CLIP	23824327
MIRT629944	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT629943	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT629942	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT531905	hsa-miR-5692a	PAR-CLIP	22012620
MIRT531904	hsa-miR-4712-3p	PAR-CLIP	22012620
MIRT531903	hsa-miR-139-5p	PAR-CLIP	22012620
MIRT531902	hsa-miR-548aw	PAR-CLIP	22012620
MIRT531901	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT531900	hsa-miR-527	PAR-CLIP	22012620
MIRT531899	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT450446	hsa-miR-5582-5p	PAR-CLIP	22100165
MIRT450445	hsa-miR-4269	PAR-CLIP	22100165
MIRT450444	hsa-miR-6715b-5p	PAR-CLIP	22100165
MIRT450443	hsa-miR-3913-3p	PAR-CLIP	22100165
MIRT450442	hsa-miR-489-3p	PAR-CLIP	22100165
MIRT450441	hsa-miR-1273e	PAR-CLIP	22100165
MIRT450441	hsa-miR-1273e	PAR-CLIP	27292025
MIRT629953	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT629953	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT629962	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT629962	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT629952	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT629952	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT629951	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT629951	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT629950	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT629950	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT629949	hsa-miR-3689c	PAR-CLIP	27292025
MIRT629949	hsa-miR-3689c	PAR-CLIP	27292025
MIRT629961	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT629961	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT629948	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT629948	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT629947	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT629947	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT629960	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT629960	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT629958	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT629958	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT629959	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT629959	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT629963	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT629963	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT696128	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT696127	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT696126	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT696125	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696124	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT696123	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT696122	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696121	hsa-miR-3926	HITS-CLIP	23313552
MIRT696120	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT696119	hsa-miR-548s	HITS-CLIP	23313552
MIRT682518	hsa-miR-15a-5p	HITS-CLIP	23706177
MIRT682517	hsa-miR-15b-5p	HITS-CLIP	23706177
MIRT682516	hsa-miR-16-5p	HITS-CLIP	23706177
MIRT682515	hsa-miR-195-5p	HITS-CLIP	23706177
MIRT682514	hsa-miR-424-5p	HITS-CLIP	23706177
MIRT682513	hsa-miR-497-5p	HITS-CLIP	23706177
MIRT682512	hsa-miR-6838-5p	HITS-CLIP	23706177
MIRT682511	hsa-miR-503-5p	HITS-CLIP	23706177
MIRT682510	hsa-miR-646	HITS-CLIP	23706177
MIRT682509	hsa-miR-4310	HITS-CLIP	23706177
MIRT682508	hsa-miR-7157-5p	HITS-CLIP	23706177
MIRT682507	hsa-miR-103a-3p	HITS-CLIP	23706177
MIRT682506	hsa-miR-107	HITS-CLIP	23706177
MIRT682505	hsa-miR-4524a-5p	HITS-CLIP	23706177
MIRT682504	hsa-miR-4524b-5p	HITS-CLIP	23706177
MIRT682503	hsa-miR-4662a-5p	HITS-CLIP	23706177
MIRT682502	hsa-miR-513b-5p	HITS-CLIP	23706177
MIRT629966	hsa-miR-524-3p	HITS-CLIP	23824327
MIRT629965	hsa-miR-525-3p	HITS-CLIP	23824327
MIRT629964	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT629963	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT629962	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT629961	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT629960	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT629959	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT629958	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT629957	hsa-miR-7977	HITS-CLIP	23824327
MIRT629956	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT629955	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT629954	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT629953	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT629952	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT629951	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT629950	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT629949	hsa-miR-3689c	HITS-CLIP	23824327
MIRT629948	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT629947	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT629946	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT629945	hsa-miR-3122	HITS-CLIP	23824327
MIRT629944	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT629943	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT629942	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT531905	hsa-miR-5692a	PAR-CLIP	22012620
MIRT531904	hsa-miR-4712-3p	PAR-CLIP	22012620
MIRT531903	hsa-miR-139-5p	PAR-CLIP	22012620
MIRT531902	hsa-miR-548aw	PAR-CLIP	22012620
MIRT531901	hsa-miR-518a-5p	PAR-CLIP	22012620
MIRT531900	hsa-miR-527	PAR-CLIP	22012620
MIRT531899	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT450446	hsa-miR-5582-5p	PAR-CLIP	22100165
MIRT450445	hsa-miR-4269	PAR-CLIP	22100165
MIRT450444	hsa-miR-6715b-5p	PAR-CLIP	22100165
MIRT450443	hsa-miR-3913-3p	PAR-CLIP	22100165
MIRT450442	hsa-miR-489-3p	PAR-CLIP	22100165
MIRT450441	hsa-miR-1273e	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9990065
GO:0004967	Function	Glucagon receptor activity	IBA
GO:0004967	Function	Glucagon receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9990065
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	9990065
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	9990065
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9990065
GO:0017046	Function	Peptide hormone binding	IBA
GO:0071377	Process	Cellular response to glucagon stimulus	IEA

Other IDs

• MIM: 603659
• HGNC: 4325
• e!Ensembl: ENSG00000065325

Protein

• UniProt ID: O95838
• Protein name: Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R)
• Protein function: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
• PDB: 7D68
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02793	HRM	93 → 162	Hormone receptor domain	Family
  PF00002	7tm_2	175 → 432	7 transmembrane receptor (Secretin family)	Family

• Sequence:

  MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
  IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
  YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL
  MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS
  KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW
  PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK
  ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI
  QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKK
  LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM
  ANTMEEILEESEI

• Sequence length: 553

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Apraxias	Apraxia	Pubtator	27120335	Associate	★☆☆☆☆ Found in Text Mining only
Cholecystitis	Cholecystitis	BEFREE	30137354		★☆☆☆☆ Found in Text Mining only
Cholelithiasis	Cholelithiasis	BEFREE	30137354		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	24875097		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21948569, 37076536	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	28514806		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	28514806		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	33544567	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	28514806		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	22951144		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	28337026, 31666597		★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	36313769	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28337026, 31666597		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	32936762	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	28566273, 33414548	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28514806		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	28566273		★☆☆☆☆ Found in Text Mining only
Enteritis	Enteritis	BEFREE	22253424		★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	30052880		★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	BEFREE	22951144		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	30452417		★☆☆☆☆ Found in Text Mining only
Intestinal Neoplasms	Intestinal Neoplasms	BEFREE	18829546		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35027025	Associate	★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	28580281		★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic syndrome	Pubtator	32936762	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18829546, 22951144		★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	30578967		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	32986861	Associate	★☆☆☆☆ Found in Text Mining only
Obesity, Morbid	Obesity	BEFREE	28337026		★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	30409537		★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	30052880		★☆☆☆☆ Found in Text Mining only