Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9330
Gene name	General transcription factor IIIC subunit 3
Gene symbol	GTF3C3
Synonyms (NCBI Gene)	NEDFBSTFIIIC102TFIIICgammaTFiiiC2-102
Chromosome	2
Chromosome location	2q33.1
Summary	The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encod

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025544	hsa-miR-34a-5p	Proteomics	21566225
MIRT031970	hsa-miR-16-5p	Proteomics	18668040
MIRT047868	hsa-miR-30c-5p	CLASH	23622248
MIRT042107	hsa-miR-484	CLASH	23622248
MIRT649535	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT649533	hsa-miR-1321	HITS-CLIP	23824327
MIRT649532	hsa-miR-4739	HITS-CLIP	23824327
MIRT649531	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT649530	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT649529	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT649528	hsa-miR-3162-5p	HITS-CLIP	23824327
MIRT649527	hsa-miR-623	HITS-CLIP	23824327
MIRT649526	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT649525	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT649524	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT649523	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT649522	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT649535	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT649533	hsa-miR-1321	HITS-CLIP	23824327
MIRT649532	hsa-miR-4739	HITS-CLIP	23824327
MIRT649531	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT649530	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT649529	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT649528	hsa-miR-3162-5p	HITS-CLIP	23824327
MIRT649527	hsa-miR-623	HITS-CLIP	23824327
MIRT649526	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT649525	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT649524	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT649523	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT649522	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1037692	hsa-miR-101	CLIP-seq
MIRT1037693	hsa-miR-144	CLIP-seq
MIRT1037694	hsa-miR-3692	CLIP-seq
MIRT1037695	hsa-miR-369-3p	CLIP-seq
MIRT1037696	hsa-miR-374a	CLIP-seq
MIRT1037697	hsa-miR-374b	CLIP-seq
MIRT1037698	hsa-miR-4731-3p	CLIP-seq
MIRT1037699	hsa-miR-4801	CLIP-seq
MIRT1037700	hsa-miR-936	CLIP-seq
MIRT1549419	hsa-miR-3150a-5p	CLIP-seq
MIRT1549420	hsa-miR-3150b-5p	CLIP-seq
MIRT1549421	hsa-miR-340	CLIP-seq
MIRT1549422	hsa-miR-4275	CLIP-seq
MIRT1549423	hsa-miR-494	CLIP-seq
MIRT1037692	hsa-miR-101	CLIP-seq
MIRT2007578	hsa-miR-1183	CLIP-seq
MIRT2007579	hsa-miR-1273d	CLIP-seq
MIRT1037693	hsa-miR-144	CLIP-seq
MIRT2007580	hsa-miR-1587	CLIP-seq
MIRT2007581	hsa-miR-2113	CLIP-seq
MIRT2007582	hsa-miR-3177-5p	CLIP-seq
MIRT2007583	hsa-miR-4264	CLIP-seq
MIRT2007584	hsa-miR-4455	CLIP-seq
MIRT2007585	hsa-miR-4492	CLIP-seq
MIRT2007586	hsa-miR-4498	CLIP-seq
MIRT2007587	hsa-miR-4505	CLIP-seq
MIRT2007588	hsa-miR-4637	CLIP-seq
MIRT2007589	hsa-miR-4656	CLIP-seq
MIRT2007590	hsa-miR-4674	CLIP-seq
MIRT2007591	hsa-miR-4675	CLIP-seq
MIRT2007592	hsa-miR-4693-5p	CLIP-seq
MIRT2007593	hsa-miR-4694-5p	CLIP-seq
MIRT2007594	hsa-miR-4741	CLIP-seq
MIRT2007595	hsa-miR-4777-3p	CLIP-seq
MIRT2007596	hsa-miR-4797-3p	CLIP-seq
MIRT2007597	hsa-miR-548ae	CLIP-seq
MIRT2007598	hsa-miR-548aj	CLIP-seq
MIRT2007599	hsa-miR-548am	CLIP-seq
MIRT2007600	hsa-miR-548x	CLIP-seq
MIRT2007601	hsa-miR-561	CLIP-seq
MIRT2007602	hsa-miR-599	CLIP-seq
MIRT2007603	hsa-miR-609	CLIP-seq
MIRT2007604	hsa-miR-762	CLIP-seq
MIRT2007605	hsa-miR-935	CLIP-seq
MIRT1037700	hsa-miR-936	CLIP-seq
MIRT2240205	hsa-miR-3662	CLIP-seq
MIRT2240206	hsa-miR-488	CLIP-seq
MIRT2437515	hsa-miR-2117	CLIP-seq
MIRT2437516	hsa-miR-22	CLIP-seq
MIRT2437517	hsa-miR-3194-3p	CLIP-seq
MIRT2437518	hsa-miR-377	CLIP-seq
MIRT2007583	hsa-miR-4264	CLIP-seq
MIRT2437519	hsa-miR-4273	CLIP-seq
MIRT2437520	hsa-miR-4746-3p	CLIP-seq
MIRT2437521	hsa-miR-4769-3p	CLIP-seq
MIRT2007596	hsa-miR-4797-3p	CLIP-seq
MIRT2437522	hsa-miR-646	CLIP-seq
MIRT2543864	hsa-miR-1276	CLIP-seq
MIRT2543865	hsa-miR-1292	CLIP-seq
MIRT2543866	hsa-miR-1305	CLIP-seq
MIRT2437515	hsa-miR-2117	CLIP-seq
MIRT2437516	hsa-miR-22	CLIP-seq
MIRT2543867	hsa-miR-3124-3p	CLIP-seq
MIRT2543868	hsa-miR-3156-3p	CLIP-seq
MIRT2437517	hsa-miR-3194-3p	CLIP-seq
MIRT2437518	hsa-miR-377	CLIP-seq
MIRT2543869	hsa-miR-3913-3p	CLIP-seq
MIRT2543870	hsa-miR-421	CLIP-seq
MIRT2007583	hsa-miR-4264	CLIP-seq
MIRT2437519	hsa-miR-4273	CLIP-seq
MIRT2543871	hsa-miR-4301	CLIP-seq
MIRT2543872	hsa-miR-4311	CLIP-seq
MIRT2543873	hsa-miR-4471	CLIP-seq
MIRT2437521	hsa-miR-4769-3p	CLIP-seq
MIRT2007596	hsa-miR-4797-3p	CLIP-seq
MIRT2543874	hsa-miR-489	CLIP-seq
MIRT2543875	hsa-miR-511	CLIP-seq
MIRT2543876	hsa-miR-583	CLIP-seq
MIRT2437522	hsa-miR-646	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000127	Component	Transcription factor TFIIIC complex	IBA
GO:0000127	Component	Transcription factor TFIIIC complex	IDA	17409385
GO:0000995	Function	RNA polymerase III general transcription initiation factor activity	IDA	17409385
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IC	17409385
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17314511, 17500595, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006383	Process	Transcription by RNA polymerase III	IBA
GO:0006383	Process	Transcription by RNA polymerase III	IC	17409385
GO:0006383	Process	Transcription by RNA polymerase III	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0042791	Process	5S class rRNA transcription by RNA polymerase III	IC	17409385
GO:0042797	Process	TRNA transcription by RNA polymerase III	IC	17409385

MIM	HGNC	e!Ensembl
604888	4666	ENSG00000119041

Q9Y5Q9

Protein name

General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma)

Protein function

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

PDB

8CLK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13181	TPR_8	220 → 250	Tetratricopeptide repeat	Repeat
PF13181	TPR_8	456 → 487	Tetratricopeptide repeat	Repeat
PF13181	TPR_8	811 → 842	Tetratricopeptide repeat	Repeat

Sequence

MSGFSPELIDYLEGKISFEEFERRREERKTREKKSLQEKGKLSAEENPDDSEVPSSSGIN
STKSQDKDVNEGETSDGVRKSVHKVFASMLGENEDDEEEEEEEEEEEEEEETPEQPTAGD
VFVLEMVLNRETKKMMKEKRPRSKLPRALRGLMGEANIRFARGEREEAILMCMEIIRQAP
LAYEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCY
TKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYRRILNLLSPSDGERFMQLARDMAKSY
YEANDVTSAINIIDEAFSKHQGLVSMEDVNIAAELYISNKQYDKALEIITDFSGIVLEKK
TSEEGTSEENKAPENVTCTIPDGVPIDITVKLMVCLVHLNILEPLNPLLTTLVEQNPEDM
GDLYLDVAEAFLDVGEYNSALPLLSALVCSERYNLAVVWLRHAECLKALGYMERAAESYG
KVVDLAPLHLDARISLSTLQQQLGQPEKALEALEPMYDPDTLAQDANAAQQELKLLLHRS
TLLFSQGKMYGYVDTLLTMLAMLLKVAMNRAQVCLISSSKSGERHLYLIKVSRDKISDSN
DQESANCDAKAIFAVLTSVLTKDDWWNLLLKAIYSLCDLSRFQEAELLVDSSLEYYSFYD
DRQKRKELEYFGLSAAILDKNFRKAYNYIRIMVMENVNKPQLWNIFNQVTMHSQDVRHHR
FCLRLMLKNPENHALCVLNGHNAFVSGSFKHALGQYVQAFRTHPDEPLYSFCIGLTFIHM
ASQKYVLRRHALIVQGFSFLNRYLSLRGPCQESFYNLGRGLHQLGLIHLAIHYYQKALEL
PPLVVEGIELDQLDLRRDIAYNLSLIYQSSGNTGMAQTLLYTYCSI

Sequence length

886

Interactions

View interactions

	Reactome
			RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Chromosome 2q32-q33 deletion syndrome	Likely pathogenic	rs2469013541	RCV004527537	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures	Likely pathogenic	rs2469013541	RCV005412662	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EARLY INFANTILE EPILEPTIC ENCEPHALOPATHY WITH SUPPRESSION BURSTS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GENETIC DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GTF3C3-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Brain Diseases	Brain disease	Pubtator	30552426	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	30552426	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epileptic Encephalopathy Early Infantile 3	Developmental and epileptic encephalopathy	Pubtator	30552426	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	GENOMICS_ENGLAND_DG	30552426		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	30552426		★★★★★ ★☆☆☆☆ Found in Text Mining only

GTF3C3 (general transcription factor IIIC subunit 3)