Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9328
Gene name	General transcription factor IIIC subunit 5
Gene symbol	GTF3C5
Synonyms (NCBI Gene)	TFIIIC63TFIIICepsilonTFiiiC2-63
Chromosome	9
Chromosome location	9q34.13

156

Show/Hide all (156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023140	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT025954	hsa-miR-7-5p	Sequencing	20371350
MIRT052437	hsa-let-7a-5p	CLASH	23622248
MIRT046697	hsa-miR-222-3p	CLASH	23622248
MIRT039525	hsa-miR-652-3p	CLASH	23622248
MIRT037096	hsa-miR-877-3p	CLASH	23622248
MIRT1037756	hsa-miR-1227	CLIP-seq
MIRT1037757	hsa-miR-2861	CLIP-seq
MIRT1037758	hsa-miR-299-5p	CLIP-seq
MIRT1037759	hsa-miR-3064-5p	CLIP-seq
MIRT1037760	hsa-miR-3180-5p	CLIP-seq
MIRT1037761	hsa-miR-3184	CLIP-seq
MIRT1037762	hsa-miR-320a	CLIP-seq
MIRT1037763	hsa-miR-320b	CLIP-seq
MIRT1037764	hsa-miR-320c	CLIP-seq
MIRT1037765	hsa-miR-320d	CLIP-seq
MIRT1037766	hsa-miR-3926	CLIP-seq
MIRT1037767	hsa-miR-423-5p	CLIP-seq
MIRT1037768	hsa-miR-4425	CLIP-seq
MIRT1037769	hsa-miR-4429	CLIP-seq
MIRT1037770	hsa-miR-450b-3p	CLIP-seq
MIRT1037771	hsa-miR-4687-3p	CLIP-seq
MIRT1037772	hsa-miR-4713-3p	CLIP-seq
MIRT1037773	hsa-miR-520a-5p	CLIP-seq
MIRT1037774	hsa-miR-525-5p	CLIP-seq
MIRT1037775	hsa-miR-548s	CLIP-seq
MIRT1037776	hsa-miR-553	CLIP-seq
MIRT1037777	hsa-miR-638	CLIP-seq
MIRT1037778	hsa-miR-663b	CLIP-seq
MIRT1037779	hsa-miR-769-3p	CLIP-seq
MIRT2007634	hsa-miR-124	CLIP-seq
MIRT2007635	hsa-miR-1293	CLIP-seq
MIRT2007636	hsa-miR-1296	CLIP-seq
MIRT2007637	hsa-miR-2467-5p	CLIP-seq
MIRT2007638	hsa-miR-3064-3p	CLIP-seq
MIRT2007639	hsa-miR-3150a-3p	CLIP-seq
MIRT2007640	hsa-miR-4286	CLIP-seq
MIRT2007641	hsa-miR-4318	CLIP-seq
MIRT2007642	hsa-miR-4483	CLIP-seq
MIRT2007643	hsa-miR-4484	CLIP-seq
MIRT2007644	hsa-miR-4497	CLIP-seq
MIRT2007645	hsa-miR-4509	CLIP-seq
MIRT2007646	hsa-miR-4512	CLIP-seq
MIRT2007647	hsa-miR-4649-5p	CLIP-seq
MIRT2007648	hsa-miR-4715-3p	CLIP-seq
MIRT2007649	hsa-miR-4786-5p	CLIP-seq
MIRT2007650	hsa-miR-506	CLIP-seq
MIRT1037773	hsa-miR-520a-5p	CLIP-seq
MIRT1037774	hsa-miR-525-5p	CLIP-seq
MIRT2007651	hsa-miR-548an	CLIP-seq
MIRT2007652	hsa-miR-591	CLIP-seq
MIRT1037778	hsa-miR-663b	CLIP-seq
MIRT2007653	hsa-miR-769-5p	CLIP-seq
MIRT2240259	hsa-miR-103a	CLIP-seq
MIRT2240260	hsa-miR-107	CLIP-seq
MIRT2240261	hsa-miR-1200	CLIP-seq
MIRT2240262	hsa-miR-1206	CLIP-seq
MIRT2240263	hsa-miR-1287	CLIP-seq
MIRT2007635	hsa-miR-1293	CLIP-seq
MIRT2240264	hsa-miR-140-3p	CLIP-seq
MIRT2240265	hsa-miR-1587	CLIP-seq
MIRT2240266	hsa-miR-15a	CLIP-seq
MIRT2240267	hsa-miR-15b	CLIP-seq
MIRT2240268	hsa-miR-16	CLIP-seq
MIRT2240269	hsa-miR-1827	CLIP-seq
MIRT2240270	hsa-miR-195	CLIP-seq
MIRT2007637	hsa-miR-2467-5p	CLIP-seq
MIRT1037757	hsa-miR-2861	CLIP-seq
MIRT2240271	hsa-miR-29a	CLIP-seq
MIRT2240272	hsa-miR-29b	CLIP-seq
MIRT2240273	hsa-miR-29c	CLIP-seq
MIRT1037759	hsa-miR-3064-5p	CLIP-seq
MIRT2240274	hsa-miR-3065-3p	CLIP-seq
MIRT2240275	hsa-miR-3176	CLIP-seq
MIRT1037762	hsa-miR-320a	CLIP-seq
MIRT1037763	hsa-miR-320b	CLIP-seq
MIRT1037764	hsa-miR-320c	CLIP-seq
MIRT1037765	hsa-miR-320d	CLIP-seq
MIRT2240276	hsa-miR-3652	CLIP-seq
MIRT2240277	hsa-miR-3663-5p	CLIP-seq
MIRT2240278	hsa-miR-378g	CLIP-seq
MIRT2240279	hsa-miR-3922-3p	CLIP-seq
MIRT1037766	hsa-miR-3926	CLIP-seq
MIRT2240280	hsa-miR-424	CLIP-seq
MIRT2240281	hsa-miR-4283	CLIP-seq
MIRT2007640	hsa-miR-4286	CLIP-seq
MIRT2240282	hsa-miR-4324	CLIP-seq
MIRT1037769	hsa-miR-4429	CLIP-seq
MIRT2240283	hsa-miR-4430	CLIP-seq
MIRT2007642	hsa-miR-4483	CLIP-seq
MIRT2240284	hsa-miR-4489	CLIP-seq
MIRT2240285	hsa-miR-4492	CLIP-seq
MIRT2240286	hsa-miR-4498	CLIP-seq
MIRT2240287	hsa-miR-4505	CLIP-seq
MIRT2007647	hsa-miR-4649-5p	CLIP-seq
MIRT2240288	hsa-miR-4656	CLIP-seq
MIRT2240289	hsa-miR-4675	CLIP-seq
MIRT1037771	hsa-miR-4687-3p	CLIP-seq
MIRT2240290	hsa-miR-4699-3p	CLIP-seq
MIRT2240291	hsa-miR-4731-5p	CLIP-seq
MIRT2240292	hsa-miR-4741	CLIP-seq
MIRT2007649	hsa-miR-4786-5p	CLIP-seq
MIRT2240293	hsa-miR-4793-5p	CLIP-seq
MIRT2240294	hsa-miR-497	CLIP-seq
MIRT2240295	hsa-miR-544b	CLIP-seq
MIRT1037775	hsa-miR-548s	CLIP-seq
MIRT2007652	hsa-miR-591	CLIP-seq
MIRT2240296	hsa-miR-661	CLIP-seq
MIRT1037778	hsa-miR-663b	CLIP-seq
MIRT2240297	hsa-miR-762	CLIP-seq
MIRT2007653	hsa-miR-769-5p	CLIP-seq
MIRT2240298	hsa-miR-892b	CLIP-seq
MIRT2450876	hsa-miR-193a-3p	CLIP-seq
MIRT2450877	hsa-miR-193b	CLIP-seq
MIRT2240275	hsa-miR-3176	CLIP-seq
MIRT2240279	hsa-miR-3922-3p	CLIP-seq
MIRT2240281	hsa-miR-4283	CLIP-seq
MIRT2450878	hsa-miR-4463	CLIP-seq
MIRT2240284	hsa-miR-4489	CLIP-seq
MIRT2240296	hsa-miR-661	CLIP-seq
MIRT1037778	hsa-miR-663b	CLIP-seq
MIRT2240264	hsa-miR-140-3p	CLIP-seq
MIRT2450876	hsa-miR-193a-3p	CLIP-seq
MIRT2450877	hsa-miR-193b	CLIP-seq
MIRT2007637	hsa-miR-2467-5p	CLIP-seq
MIRT2240275	hsa-miR-3176	CLIP-seq
MIRT2240279	hsa-miR-3922-3p	CLIP-seq
MIRT2240281	hsa-miR-4283	CLIP-seq
MIRT2007640	hsa-miR-4286	CLIP-seq
MIRT2450878	hsa-miR-4463	CLIP-seq
MIRT2240284	hsa-miR-4489	CLIP-seq
MIRT2007647	hsa-miR-4649-5p	CLIP-seq
MIRT2007649	hsa-miR-4786-5p	CLIP-seq
MIRT2007652	hsa-miR-591	CLIP-seq
MIRT2240296	hsa-miR-661	CLIP-seq
MIRT1037778	hsa-miR-663b	CLIP-seq
MIRT2007653	hsa-miR-769-5p	CLIP-seq
MIRT2240264	hsa-miR-140-3p	CLIP-seq
MIRT2450876	hsa-miR-193a-3p	CLIP-seq
MIRT2450877	hsa-miR-193b	CLIP-seq
MIRT2682194	hsa-miR-22	CLIP-seq
MIRT2007637	hsa-miR-2467-5p	CLIP-seq
MIRT2240275	hsa-miR-3176	CLIP-seq
MIRT2240279	hsa-miR-3922-3p	CLIP-seq
MIRT2682195	hsa-miR-4267	CLIP-seq
MIRT2240281	hsa-miR-4283	CLIP-seq
MIRT2007640	hsa-miR-4286	CLIP-seq
MIRT2450878	hsa-miR-4463	CLIP-seq
MIRT2240284	hsa-miR-4489	CLIP-seq
MIRT2007647	hsa-miR-4649-5p	CLIP-seq
MIRT2682196	hsa-miR-4712-3p	CLIP-seq
MIRT2007649	hsa-miR-4786-5p	CLIP-seq
MIRT2007652	hsa-miR-591	CLIP-seq
MIRT2240296	hsa-miR-661	CLIP-seq
MIRT1037778	hsa-miR-663b	CLIP-seq
MIRT2007653	hsa-miR-769-5p	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000127	Component	Transcription factor TFIIIC complex	IBA
GO:0000127	Component	Transcription factor TFIIIC complex	IDA	17409385
GO:0000127	Component	Transcription factor TFIIIC complex	IEA
GO:0000995	Function	RNA polymerase III general transcription initiation factor activity	IDA	17409385
GO:0001002	Function	RNA polymerase III type 1 promoter sequence-specific DNA binding	IBA
GO:0001003	Function	RNA polymerase III type 2 promoter sequence-specific DNA binding	IBA
GO:0003677	Function	DNA binding	IC	17409385
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17409385, 25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006383	Process	Transcription by RNA polymerase III	IC	17409385
GO:0006384	Process	Transcription initiation at RNA polymerase III promoter	IEA
GO:0035914	Process	Skeletal muscle cell differentiation	IEA
GO:0042791	Process	5S class rRNA transcription by RNA polymerase III	IC	17409385
GO:0042797	Process	TRNA transcription by RNA polymerase III	IC	17409385

MIM	HGNC	e!Ensembl
604890	4668	ENSG00000148308

Q9Y5Q8

Protein name

General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon)

Protein function

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

PDB

8CLK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17682	Tau95_N	25 → 132	Tau95 Triple barrel domain	Domain
PF09734	Tau95	167 → 322	RNA polymerase III transcription factor (TF)IIIC subunit HTH domain	Family

Sequence

MAAEAADLGLGAAVPVELRRERRMVCVEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKRL
ELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRQKGVLGTEAHSEVTFDMEILGIISTI
YKFQGMSDFQYLAVHTEAGGKHTSMYDKVLMLRPEKEAFFHQELPLYIPPPIFSRLDAPV
DYFYRPETQHREGYNNPPISGENLIGLSRARRPHNAIFVNFEDEEVPKQPLEAAAQTWRR
VCTNPVDRKVEEELRKLFDIRPIWSRNAVKANISVHPDKLKVLLPFIAYYMITGPWRSLW
IRFGYDPRKNPDAKIYQVLDFRIRCGMKHGYAPSDLPVKAKRSTYNYSLPITVKKTSSQL
VTMHDLKQGLGPSGTSGARKPASSKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQK
IIHRNDGAENSCTERDGWCLPKTSDELRDTMSLMIRQTIRSKRPALFSSSAKADGGKEQL
TYESGEDEEDEEEEEEEEEDFKPSDGSENEMETEILDYV

Sequence length

519

Interactions

View interactions

	Reactome
			RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEMORRHAGIC DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multisystem developmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THROMBOCYTOPENIA 4	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cardiovascular Diseases	Cardiovascular disease	Pubtator	36419110	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GTF3C5 (general transcription factor IIIC subunit 5)