Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9326
Gene name	Zinc finger HIT-type containing 3
Gene symbol	ZNHIT3
Synonyms (NCBI Gene)	Hit1PEHOTRIP3
Chromosome	17
Chromosome location	17q12

160

Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024305	hsa-miR-215-5p	Microarray	19074876
MIRT026564	hsa-miR-192-5p	Microarray	19074876
MIRT043888	hsa-miR-378a-3p	CLASH	23622248
MIRT449216	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT449214	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT449213	hsa-miR-144-5p	PAR-CLIP	22100165
MIRT449212	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT449211	hsa-miR-573	PAR-CLIP	22100165
MIRT449216	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT449214	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT449213	hsa-miR-144-5p	PAR-CLIP	22100165
MIRT449212	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT449211	hsa-miR-573	PAR-CLIP	22100165
MIRT1542923	hsa-miR-101	CLIP-seq
MIRT1542924	hsa-miR-1272	CLIP-seq
MIRT1542925	hsa-miR-1322	CLIP-seq
MIRT1542926	hsa-miR-141	CLIP-seq
MIRT1542927	hsa-miR-144	CLIP-seq
MIRT1542928	hsa-miR-200a	CLIP-seq
MIRT1542929	hsa-miR-2052	CLIP-seq
MIRT1542930	hsa-miR-2964a-5p	CLIP-seq
MIRT1542931	hsa-miR-4477a	CLIP-seq
MIRT1542932	hsa-miR-4796-5p	CLIP-seq
MIRT1542933	hsa-miR-548a-5p	CLIP-seq
MIRT1542934	hsa-miR-548ab	CLIP-seq
MIRT1542935	hsa-miR-548ac	CLIP-seq
MIRT1542936	hsa-miR-548ae	CLIP-seq
MIRT1542937	hsa-miR-548aj	CLIP-seq
MIRT1542938	hsa-miR-548ak	CLIP-seq
MIRT1542939	hsa-miR-548am	CLIP-seq
MIRT1542940	hsa-miR-548b-5p	CLIP-seq
MIRT1542941	hsa-miR-548c-5p	CLIP-seq
MIRT1542942	hsa-miR-548d-3p	CLIP-seq
MIRT1542943	hsa-miR-548d-5p	CLIP-seq
MIRT1542944	hsa-miR-548h	CLIP-seq
MIRT1542945	hsa-miR-548i	CLIP-seq
MIRT1542946	hsa-miR-548j	CLIP-seq
MIRT1542947	hsa-miR-548n	CLIP-seq
MIRT1542948	hsa-miR-548w	CLIP-seq
MIRT1542949	hsa-miR-548x	CLIP-seq
MIRT1542950	hsa-miR-548y	CLIP-seq
MIRT1542951	hsa-miR-548z	CLIP-seq
MIRT1542952	hsa-miR-559	CLIP-seq
MIRT1542953	hsa-miR-936	CLIP-seq
MIRT2163785	hsa-miR-136	CLIP-seq
MIRT2163786	hsa-miR-192	CLIP-seq
MIRT2163787	hsa-miR-215	CLIP-seq
MIRT2163788	hsa-miR-3064-3p	CLIP-seq
MIRT2163789	hsa-miR-346	CLIP-seq
MIRT2163790	hsa-miR-3691-3p	CLIP-seq
MIRT2163791	hsa-miR-4477b	CLIP-seq
MIRT2163792	hsa-miR-4715-3p	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT2163794	hsa-miR-4768-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT1542924	hsa-miR-1272	CLIP-seq
MIRT1542925	hsa-miR-1322	CLIP-seq
MIRT2163785	hsa-miR-136	CLIP-seq
MIRT1542926	hsa-miR-141	CLIP-seq
MIRT2382979	hsa-miR-15a	CLIP-seq
MIRT2382980	hsa-miR-15b	CLIP-seq
MIRT2382981	hsa-miR-16	CLIP-seq
MIRT2382982	hsa-miR-195	CLIP-seq
MIRT1542928	hsa-miR-200a	CLIP-seq
MIRT2382983	hsa-miR-2355-5p	CLIP-seq
MIRT1542930	hsa-miR-2964a-5p	CLIP-seq
MIRT2163788	hsa-miR-3064-3p	CLIP-seq
MIRT2382984	hsa-miR-3152-5p	CLIP-seq
MIRT2382985	hsa-miR-324-5p	CLIP-seq
MIRT2163789	hsa-miR-346	CLIP-seq
MIRT2382986	hsa-miR-3647-5p	CLIP-seq
MIRT2382987	hsa-miR-3670	CLIP-seq
MIRT2382988	hsa-miR-3690	CLIP-seq
MIRT2163790	hsa-miR-3691-3p	CLIP-seq
MIRT2382989	hsa-miR-424	CLIP-seq
MIRT2382990	hsa-miR-4254	CLIP-seq
MIRT2382991	hsa-miR-4261	CLIP-seq
MIRT2382992	hsa-miR-4323	CLIP-seq
MIRT1542931	hsa-miR-4477a	CLIP-seq
MIRT2163791	hsa-miR-4477b	CLIP-seq
MIRT2163792	hsa-miR-4715-3p	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT2382993	hsa-miR-4774-3p	CLIP-seq
MIRT2382994	hsa-miR-4793-5p	CLIP-seq
MIRT1542932	hsa-miR-4796-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT2382995	hsa-miR-497	CLIP-seq
MIRT2382996	hsa-miR-875-3p	CLIP-seq
MIRT1542926	hsa-miR-141	CLIP-seq
MIRT1542928	hsa-miR-200a	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT1542924	hsa-miR-1272	CLIP-seq
MIRT1542925	hsa-miR-1322	CLIP-seq
MIRT2163786	hsa-miR-192	CLIP-seq
MIRT2163787	hsa-miR-215	CLIP-seq
MIRT2382983	hsa-miR-2355-5p	CLIP-seq
MIRT1542930	hsa-miR-2964a-5p	CLIP-seq
MIRT2382984	hsa-miR-3152-5p	CLIP-seq
MIRT2673489	hsa-miR-3192	CLIP-seq
MIRT2382985	hsa-miR-324-5p	CLIP-seq
MIRT2382986	hsa-miR-3647-5p	CLIP-seq
MIRT2673490	hsa-miR-3663-5p	CLIP-seq
MIRT2382987	hsa-miR-3670	CLIP-seq
MIRT2382988	hsa-miR-3690	CLIP-seq
MIRT2382990	hsa-miR-4254	CLIP-seq
MIRT2382991	hsa-miR-4261	CLIP-seq
MIRT2673491	hsa-miR-4314	CLIP-seq
MIRT2382992	hsa-miR-4323	CLIP-seq
MIRT2673492	hsa-miR-4419a	CLIP-seq
MIRT2673493	hsa-miR-4433	CLIP-seq
MIRT2673494	hsa-miR-4484	CLIP-seq
MIRT2673495	hsa-miR-4510	CLIP-seq
MIRT2673496	hsa-miR-4514	CLIP-seq
MIRT2673497	hsa-miR-4527	CLIP-seq
MIRT2673498	hsa-miR-4646-5p	CLIP-seq
MIRT2673499	hsa-miR-4661-5p	CLIP-seq
MIRT2673500	hsa-miR-4690-5p	CLIP-seq
MIRT2673501	hsa-miR-4692	CLIP-seq
MIRT2673502	hsa-miR-4736	CLIP-seq
MIRT2163793	hsa-miR-4764-3p	CLIP-seq
MIRT2382993	hsa-miR-4774-3p	CLIP-seq
MIRT2382994	hsa-miR-4793-5p	CLIP-seq
MIRT1542932	hsa-miR-4796-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT2673503	hsa-miR-548an	CLIP-seq
MIRT1542947	hsa-miR-548n	CLIP-seq
MIRT2673504	hsa-miR-657	CLIP-seq
MIRT2673505	hsa-miR-665	CLIP-seq
MIRT2382996	hsa-miR-875-3p	CLIP-seq
MIRT2673506	hsa-miR-940	CLIP-seq
MIRT2163786	hsa-miR-192	CLIP-seq
MIRT2163787	hsa-miR-215	CLIP-seq
MIRT2382983	hsa-miR-2355-5p	CLIP-seq
MIRT2382984	hsa-miR-3152-5p	CLIP-seq
MIRT2673489	hsa-miR-3192	CLIP-seq
MIRT2382985	hsa-miR-324-5p	CLIP-seq
MIRT2673490	hsa-miR-3663-5p	CLIP-seq
MIRT2382987	hsa-miR-3670	CLIP-seq
MIRT2382988	hsa-miR-3690	CLIP-seq
MIRT2382990	hsa-miR-4254	CLIP-seq
MIRT2382991	hsa-miR-4261	CLIP-seq
MIRT2673491	hsa-miR-4314	CLIP-seq
MIRT2382992	hsa-miR-4323	CLIP-seq
MIRT2673492	hsa-miR-4419a	CLIP-seq
MIRT2673494	hsa-miR-4484	CLIP-seq
MIRT2673495	hsa-miR-4510	CLIP-seq
MIRT2673496	hsa-miR-4514	CLIP-seq
MIRT2673497	hsa-miR-4527	CLIP-seq
MIRT2673498	hsa-miR-4646-5p	CLIP-seq
MIRT2673499	hsa-miR-4661-5p	CLIP-seq
MIRT2673500	hsa-miR-4690-5p	CLIP-seq
MIRT2673501	hsa-miR-4692	CLIP-seq
MIRT2673502	hsa-miR-4736	CLIP-seq
MIRT2382993	hsa-miR-4774-3p	CLIP-seq
MIRT2382994	hsa-miR-4793-5p	CLIP-seq
MIRT2163795	hsa-miR-494	CLIP-seq
MIRT2673503	hsa-miR-548an	CLIP-seq
MIRT2673504	hsa-miR-657	CLIP-seq
MIRT2382996	hsa-miR-875-3p	CLIP-seq
MIRT2673506	hsa-miR-940	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000492	Process	Box C/D snoRNP assembly	IBA
GO:0005515	Function	Protein binding	IPI	25170085, 28335020, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	28335020
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	28335020
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	7776974
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046966	Function	Nuclear thyroid hormone receptor binding	TAS	7776974
GO:0070761	Component	Pre-snoRNP complex	IBA

MIM	HGNC	e!Ensembl
604500	12309	ENSG00000273611

Q15649

Protein name

Zinc finger HIT domain-containing protein 3 (HNF-4a coactivator) (Thyroid hormone receptor interactor 3) (Thyroid receptor-interacting protein 3) (TR-interacting protein 3) (TRIP-3)

PDB

2YQQ , 5L85

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04438	zf-HIT	7 → 36	HIT zinc finger	Domain

Sequence

MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTK
TVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLGESATLRSLLLNPHLRQLMVNLDQG
EDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES

Sequence length

155

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
PEHO syndrome	Likely pathogenic	rs148890852	RCV000490627	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAYER-ROKITANSKY-KUSTER SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAYER-ROKITANSKY-KUSTER-HAUSER SYNDROME	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ZNHIT3-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (34)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acquired porencephaly	Acquired Porencephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	28639078		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	28639078	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthrogryposis	Arthrogryposis multiplex congenita	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrophy/Degeneration affecting the brainstem	Brainstem Atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebellar atrophy	Cerebellar atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral cortical atrophy	Cerebral cortical atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	35843310	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	17656577	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Macrotia	Macrotia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	GENOMICS_ENGLAND_DG	28335020		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pachygyria	Pachygyria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
PEHO syndrome	PEHO Syndrome	BEFREE	28335020, 31048081, 31536827		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PEHO syndrome	PEHO Syndrome	UNIPROT_DG	28335020		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PEHO syndrome	PEHO Syndrome	ORPHANET_DG	28335020		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PEHO syndrome	PEHO Syndrome	GENOMICS_ENGLAND_DG	28335020		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PEHO syndrome	PEHO Syndrome	Orphanet			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PEHO syndrome	Peho syndrome	Pubtator	31048081, 35843310	Associate	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PEHO syndrome	PEHO Syndrome	CTD_human_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PEHO syndrome	PEHO Syndrome	CLINVAR_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Polymicrogyria	Polymicrogyria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Porencephalic cyst	Porencephalic cyst	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	LHGDN	19149918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy-like syndrome	Progressive Encephalopathy With Edema, Hypsarrhythmia, And Optic Atrophy-Like Syndrome	BEFREE	12949965, 31048081		★★★★★ ★☆☆☆☆ Found in Text Mining only
Progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy-like syndrome	Progressive Encephalopathy With Edema, Hypsarrhythmia, And Optic Atrophy-Like Syndrome	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
West Syndrome	West Syndrome	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
X-linked infantile spasms	Spasms X-Linked	BEFREE	26917597		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNHIT3 (zinc finger HIT-type containing 3)