Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	93129
Gene name	ORAI calcium release-activated calcium modulator 3
Gene symbol	ORAI3
Synonyms (NCBI Gene)	TMEM142C
Chromosome	16
Chromosome location	16p11.2

212

Show/Hide all (212)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016774	hsa-miR-335-5p	Microarray	18185580
MIRT050737	hsa-miR-18a-5p	CLASH	23622248
MIRT1205143	hsa-miR-1	CLIP-seq
MIRT1205144	hsa-miR-1225-3p	CLIP-seq
MIRT1205145	hsa-miR-1233	CLIP-seq
MIRT1205146	hsa-miR-1292	CLIP-seq
MIRT1205147	hsa-miR-1321	CLIP-seq
MIRT1205148	hsa-miR-134	CLIP-seq
MIRT1205149	hsa-miR-139-5p	CLIP-seq
MIRT1205150	hsa-miR-1827	CLIP-seq
MIRT1205151	hsa-miR-186	CLIP-seq
MIRT1205152	hsa-miR-206	CLIP-seq
MIRT1205153	hsa-miR-2110	CLIP-seq
MIRT1205154	hsa-miR-2682	CLIP-seq
MIRT1205155	hsa-miR-299-3p	CLIP-seq
MIRT1205156	hsa-miR-3118	CLIP-seq
MIRT1205157	hsa-miR-3133	CLIP-seq
MIRT1205158	hsa-miR-3160-3p	CLIP-seq
MIRT1205159	hsa-miR-3164	CLIP-seq
MIRT1205160	hsa-miR-3192	CLIP-seq
MIRT1205161	hsa-miR-3202	CLIP-seq
MIRT1205162	hsa-miR-34a	CLIP-seq
MIRT1205163	hsa-miR-34c-5p	CLIP-seq
MIRT1205164	hsa-miR-3591-3p	CLIP-seq
MIRT1205165	hsa-miR-3612	CLIP-seq
MIRT1205166	hsa-miR-3672	CLIP-seq
MIRT1205167	hsa-miR-3677-5p	CLIP-seq
MIRT1205168	hsa-miR-3680	CLIP-seq
MIRT1205169	hsa-miR-3689a-3p	CLIP-seq
MIRT1205170	hsa-miR-3689c	CLIP-seq
MIRT1205171	hsa-miR-3975	CLIP-seq
MIRT1205172	hsa-miR-4252	CLIP-seq
MIRT1205173	hsa-miR-4271	CLIP-seq
MIRT1205174	hsa-miR-4292	CLIP-seq
MIRT1205175	hsa-miR-4300	CLIP-seq
MIRT1205176	hsa-miR-4308	CLIP-seq
MIRT1205177	hsa-miR-4324	CLIP-seq
MIRT1205178	hsa-miR-4327	CLIP-seq
MIRT1205179	hsa-miR-4419a	CLIP-seq
MIRT1205180	hsa-miR-4433	CLIP-seq
MIRT1205181	hsa-miR-4471	CLIP-seq
MIRT1205182	hsa-miR-4487	CLIP-seq
MIRT1205183	hsa-miR-449a	CLIP-seq
MIRT1205184	hsa-miR-449b	CLIP-seq
MIRT1205185	hsa-miR-449c	CLIP-seq
MIRT1205186	hsa-miR-4510	CLIP-seq
MIRT1205187	hsa-miR-4533	CLIP-seq
MIRT1205188	hsa-miR-4539	CLIP-seq
MIRT1205189	hsa-miR-4646-5p	CLIP-seq
MIRT1205190	hsa-miR-4648	CLIP-seq
MIRT1205191	hsa-miR-4654	CLIP-seq
MIRT1205192	hsa-miR-4668-3p	CLIP-seq
MIRT1205193	hsa-miR-4668-5p	CLIP-seq
MIRT1205194	hsa-miR-4680-5p	CLIP-seq
MIRT1205195	hsa-miR-4693-3p	CLIP-seq
MIRT1205196	hsa-miR-4701-5p	CLIP-seq
MIRT1205197	hsa-miR-4725-3p	CLIP-seq
MIRT1205198	hsa-miR-4728-5p	CLIP-seq
MIRT1205199	hsa-miR-4739	CLIP-seq
MIRT1205200	hsa-miR-4756-5p	CLIP-seq
MIRT1205201	hsa-miR-4767	CLIP-seq
MIRT1205202	hsa-miR-4769-5p	CLIP-seq
MIRT1205203	hsa-miR-4786-5p	CLIP-seq
MIRT1205204	hsa-miR-4795-5p	CLIP-seq
MIRT1205205	hsa-miR-4798-3p	CLIP-seq
MIRT1205206	hsa-miR-485-5p	CLIP-seq
MIRT1205207	hsa-miR-493	CLIP-seq
MIRT1205208	hsa-miR-520f	CLIP-seq
MIRT1205209	hsa-miR-541	CLIP-seq
MIRT1205210	hsa-miR-548v	CLIP-seq
MIRT1205211	hsa-miR-558	CLIP-seq
MIRT1205212	hsa-miR-588	CLIP-seq
MIRT1205213	hsa-miR-605	CLIP-seq
MIRT1205214	hsa-miR-613	CLIP-seq
MIRT1205215	hsa-miR-619	CLIP-seq
MIRT1205216	hsa-miR-634	CLIP-seq
MIRT1205217	hsa-miR-636	CLIP-seq
MIRT1205218	hsa-miR-650	CLIP-seq
MIRT1205219	hsa-miR-654-5p	CLIP-seq
MIRT1205220	hsa-miR-661	CLIP-seq
MIRT1205221	hsa-miR-665	CLIP-seq
MIRT1205222	hsa-miR-766	CLIP-seq
MIRT1205223	hsa-miR-769-5p	CLIP-seq
MIRT1205224	hsa-miR-920	CLIP-seq
MIRT1205225	hsa-miR-943	CLIP-seq
MIRT2059163	hsa-miR-1275	CLIP-seq
MIRT2059164	hsa-miR-128	CLIP-seq
MIRT1205148	hsa-miR-134	CLIP-seq
MIRT1205149	hsa-miR-139-5p	CLIP-seq
MIRT2059165	hsa-miR-2467-3p	CLIP-seq
MIRT1205156	hsa-miR-3118	CLIP-seq
MIRT2059166	hsa-miR-3150a-3p	CLIP-seq
MIRT1205158	hsa-miR-3160-3p	CLIP-seq
MIRT1205159	hsa-miR-3164	CLIP-seq
MIRT2059167	hsa-miR-3175	CLIP-seq
MIRT1205169	hsa-miR-3689a-3p	CLIP-seq
MIRT1205170	hsa-miR-3689c	CLIP-seq
MIRT1205171	hsa-miR-3975	CLIP-seq
MIRT1205173	hsa-miR-4271	CLIP-seq
MIRT1205175	hsa-miR-4300	CLIP-seq
MIRT1205176	hsa-miR-4308	CLIP-seq
MIRT2059168	hsa-miR-4447	CLIP-seq
MIRT2059169	hsa-miR-4472	CLIP-seq
MIRT1205182	hsa-miR-4487	CLIP-seq
MIRT2059170	hsa-miR-4525	CLIP-seq
MIRT1205189	hsa-miR-4646-5p	CLIP-seq
MIRT2059171	hsa-miR-4665-5p	CLIP-seq
MIRT2059172	hsa-miR-4723-5p	CLIP-seq
MIRT1205197	hsa-miR-4725-3p	CLIP-seq
MIRT1205198	hsa-miR-4728-5p	CLIP-seq
MIRT2059173	hsa-miR-4747-5p	CLIP-seq
MIRT1205206	hsa-miR-485-5p	CLIP-seq
MIRT2059174	hsa-miR-491-5p	CLIP-seq
MIRT1205209	hsa-miR-541	CLIP-seq
MIRT1205210	hsa-miR-548v	CLIP-seq
MIRT1205211	hsa-miR-558	CLIP-seq
MIRT2059175	hsa-miR-625	CLIP-seq
MIRT1205219	hsa-miR-654-5p	CLIP-seq
MIRT1205220	hsa-miR-661	CLIP-seq
MIRT1205224	hsa-miR-920	CLIP-seq
MIRT2059176	hsa-miR-939	CLIP-seq
MIRT1205225	hsa-miR-943	CLIP-seq
MIRT1205144	hsa-miR-1225-3p	CLIP-seq
MIRT1205145	hsa-miR-1233	CLIP-seq
MIRT2287266	hsa-miR-1283	CLIP-seq
MIRT2287267	hsa-miR-3153	CLIP-seq
MIRT2287268	hsa-miR-329	CLIP-seq
MIRT2287269	hsa-miR-3613-3p	CLIP-seq
MIRT2287270	hsa-miR-3614-5p	CLIP-seq
MIRT2287271	hsa-miR-362-3p	CLIP-seq
MIRT1205166	hsa-miR-3672	CLIP-seq
MIRT1205168	hsa-miR-3680	CLIP-seq
MIRT2287272	hsa-miR-4261	CLIP-seq
MIRT2287273	hsa-miR-4287	CLIP-seq
MIRT1205175	hsa-miR-4300	CLIP-seq
MIRT1205180	hsa-miR-4433	CLIP-seq
MIRT2287274	hsa-miR-4469	CLIP-seq
MIRT2287275	hsa-miR-4494	CLIP-seq
MIRT1205189	hsa-miR-4646-5p	CLIP-seq
MIRT1205193	hsa-miR-4668-5p	CLIP-seq
MIRT2287276	hsa-miR-4685-3p	CLIP-seq
MIRT1205203	hsa-miR-4786-5p	CLIP-seq
MIRT1205205	hsa-miR-4798-3p	CLIP-seq
MIRT1205220	hsa-miR-661	CLIP-seq
MIRT1205221	hsa-miR-665	CLIP-seq
MIRT1205223	hsa-miR-769-5p	CLIP-seq
MIRT1205224	hsa-miR-920	CLIP-seq
MIRT1205143	hsa-miR-1	CLIP-seq
MIRT1205152	hsa-miR-206	CLIP-seq
MIRT1205155	hsa-miR-299-3p	CLIP-seq
MIRT1205167	hsa-miR-3677-5p	CLIP-seq
MIRT1205172	hsa-miR-4252	CLIP-seq
MIRT1205175	hsa-miR-4300	CLIP-seq
MIRT1205189	hsa-miR-4646-5p	CLIP-seq
MIRT1205190	hsa-miR-4648	CLIP-seq
MIRT1205191	hsa-miR-4654	CLIP-seq
MIRT1205196	hsa-miR-4701-5p	CLIP-seq
MIRT1205202	hsa-miR-4769-5p	CLIP-seq
MIRT1205204	hsa-miR-4795-5p	CLIP-seq
MIRT1205212	hsa-miR-588	CLIP-seq
MIRT1205214	hsa-miR-613	CLIP-seq
MIRT1205222	hsa-miR-766	CLIP-seq
MIRT1205224	hsa-miR-920	CLIP-seq
MIRT2287266	hsa-miR-1283	CLIP-seq
MIRT2287269	hsa-miR-3613-3p	CLIP-seq
MIRT2455712	hsa-miR-4684-5p	CLIP-seq
MIRT2287266	hsa-miR-1283	CLIP-seq
MIRT2287269	hsa-miR-3613-3p	CLIP-seq
MIRT2455712	hsa-miR-4684-5p	CLIP-seq
MIRT2287266	hsa-miR-1283	CLIP-seq
MIRT1205146	hsa-miR-1292	CLIP-seq
MIRT1205162	hsa-miR-34a	CLIP-seq
MIRT1205163	hsa-miR-34c-5p	CLIP-seq
MIRT2287269	hsa-miR-3613-3p	CLIP-seq
MIRT2585487	hsa-miR-4269	CLIP-seq
MIRT2585488	hsa-miR-4436b-3p	CLIP-seq
MIRT2585489	hsa-miR-4455	CLIP-seq
MIRT1205181	hsa-miR-4471	CLIP-seq
MIRT2585490	hsa-miR-4489	CLIP-seq
MIRT1205183	hsa-miR-449a	CLIP-seq
MIRT1205184	hsa-miR-449b	CLIP-seq
MIRT2585491	hsa-miR-4514	CLIP-seq
MIRT1205189	hsa-miR-4646-5p	CLIP-seq
MIRT2455712	hsa-miR-4684-5p	CLIP-seq
MIRT2585492	hsa-miR-4692	CLIP-seq
MIRT2585493	hsa-miR-4742-5p	CLIP-seq
MIRT2585494	hsa-miR-4761-3p	CLIP-seq
MIRT1205203	hsa-miR-4786-5p	CLIP-seq
MIRT1205220	hsa-miR-661	CLIP-seq
MIRT2585495	hsa-miR-767-5p	CLIP-seq
MIRT1205223	hsa-miR-769-5p	CLIP-seq
MIRT2287266	hsa-miR-1283	CLIP-seq
MIRT1205146	hsa-miR-1292	CLIP-seq
MIRT1205162	hsa-miR-34a	CLIP-seq
MIRT1205163	hsa-miR-34c-5p	CLIP-seq
MIRT2287269	hsa-miR-3613-3p	CLIP-seq
MIRT2585487	hsa-miR-4269	CLIP-seq
MIRT2585488	hsa-miR-4436b-3p	CLIP-seq
MIRT1205181	hsa-miR-4471	CLIP-seq
MIRT2585490	hsa-miR-4489	CLIP-seq
MIRT1205183	hsa-miR-449a	CLIP-seq
MIRT1205184	hsa-miR-449b	CLIP-seq
MIRT2585491	hsa-miR-4514	CLIP-seq
MIRT1205189	hsa-miR-4646-5p	CLIP-seq
MIRT2455712	hsa-miR-4684-5p	CLIP-seq
MIRT2585492	hsa-miR-4692	CLIP-seq
MIRT2585493	hsa-miR-4742-5p	CLIP-seq
MIRT2585494	hsa-miR-4761-3p	CLIP-seq
MIRT1205203	hsa-miR-4786-5p	CLIP-seq
MIRT1205220	hsa-miR-661	CLIP-seq
MIRT2585495	hsa-miR-767-5p	CLIP-seq
MIRT1205223	hsa-miR-769-5p	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002115	Process	Store-operated calcium entry	IBA
GO:0002115	Process	Store-operated calcium entry	IDA	19182790, 32415068
GO:0002115	Process	Store-operated calcium entry	IEA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	17442569, 19887627, 20418871, 24954132, 32415068
GO:0005886	Component	Plasma membrane	IDA	32415068
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0015279	Function	Store-operated calcium channel activity	IBA
GO:0015279	Function	Store-operated calcium channel activity	IDA	17442569, 19182790, 32415068
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
610930	28185	ENSG00000175938

Q9BRQ5

Protein name

Protein orai-3 (Transmembrane protein 142C)

Protein function

Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:16807233, PubMed:17442569, PubMed:1918

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07856	Orai-1	46 → 276	Mediator of CRAC channel activity	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in both naive and effector T helper cells with higher levels in effector cells. {ECO:0000269|PubMed:20354224}.

Sequence

MKGGEGDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAK
LKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLL
PHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAP
LDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGP
GWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQAV

Sequence length

295

Interactions

View interactions

	KEGG
	Calcium signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (30)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	24058448		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	33568645	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	33568645	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	33568645	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	20683915, 22827285, 23266555, 29323264, 30216788, 30754719		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20395295, 23266555, 29323264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	33798603	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	30943377		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30988334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	30543678	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastro-enteropancreatic neuroendocrine tumor	Digestive system neuroendocrine neoplasm	BEFREE	29507531		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30988334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	31541223		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	20004786		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	20683915, 22827285, 23266555, 29323264, 30216788, 30754719		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24240085, 31475744		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23266555, 26017146, 30216788		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24058448, 26445441		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24058448		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	30754719		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oropharyngeal Neoplasms	Oropharyngeal neoplasm	Pubtator	37759448	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	33798603	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pleural Diseases	Pleural diseases	Pubtator	27835593	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	35669690	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	24240085, 31475744		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	24240085	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26445441, 40189057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	30943377	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary fibrosis	Pubtator	36128650	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	37759448	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ORAI3 (ORAI calcium release-activated calcium modulator 3)