GPR37L1 (G protein-coupled receptor 37 like 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 9283 |
| Gene name | G protein-coupled receptor 37 like 1 |
| Gene symbol | GPR37L1 |
| Synonyms (NCBI Gene) |
ET(B)R-LP-2ETBR-LP-2ETBRLP2
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| Chromosome | 1 |
| Chromosome location | 1q32.1 |
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miRNA
miRNA information provided by mirtarbase database.
300
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O60883 | ||||||||||
| Protein name | G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2) | ||||||||||
| Protein function | G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies hav | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149). {ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:9539149}. | ||||||||||
| Sequence |
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| Sequence length | 481 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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