Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	92745
Gene name	Solute carrier family 38 member 5
Gene symbol	SLC38A5
Synonyms (NCBI Gene)	JM24SN2SNAT5pp7194
Chromosome	X
Chromosome location	Xp11.23
Summary	The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino

164

Show/Hide all (164)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001413	hsa-miR-16-5p	pSILAC	18668040
MIRT020892	hsa-miR-155-5p	Proteomics	18668040
MIRT022809	hsa-miR-124-3p	Microarray	18668037
MIRT028564	hsa-miR-30a-5p	Proteomics	18668040
MIRT001413	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT032417	hsa-let-7b-5p	Proteomics	18668040
MIRT618757	hsa-miR-5193	HITS-CLIP	21572407
MIRT618756	hsa-miR-660-3p	HITS-CLIP	21572407
MIRT618755	hsa-miR-877-3p	HITS-CLIP	21572407
MIRT645277	hsa-miR-3176	HITS-CLIP	21572407
MIRT645276	hsa-miR-3922-3p	HITS-CLIP	21572407
MIRT628651	hsa-miR-6791-3p	HITS-CLIP	21572407
MIRT628650	hsa-miR-6829-3p	HITS-CLIP	21572407
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	21572407
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	21572407
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	21572407
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	21572407
MIRT618748	hsa-miR-1281	HITS-CLIP	21572407
MIRT618757	hsa-miR-5193	HITS-CLIP	23824327
MIRT618756	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT645277	hsa-miR-3176	HITS-CLIP	23824327
MIRT645276	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT628651	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT628650	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT618748	hsa-miR-1281	HITS-CLIP	23824327
MIRT645280	hsa-miR-6890-5p	HITS-CLIP	23824327
MIRT645279	hsa-miR-4733-3p	HITS-CLIP	23824327
MIRT618757	hsa-miR-5193	HITS-CLIP	23824327
MIRT618756	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT645278	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT645277	hsa-miR-3176	HITS-CLIP	23824327
MIRT645276	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT645275	hsa-miR-3661	HITS-CLIP	23824327
MIRT645274	hsa-miR-631	HITS-CLIP	23824327
MIRT628651	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT628650	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT645273	hsa-miR-492	HITS-CLIP	23824327
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT645272	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT618753	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT618752	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT618751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT645271	hsa-miR-3170	HITS-CLIP	23824327
MIRT645270	hsa-miR-6855-5p	HITS-CLIP	23824327
MIRT618749	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT618748	hsa-miR-1281	HITS-CLIP	23824327
MIRT618757	hsa-miR-5193	HITS-CLIP	23824327
MIRT618756	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT628651	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT628650	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT618748	hsa-miR-1281	HITS-CLIP	23824327
MIRT618757	hsa-miR-5193	HITS-CLIP	23824327
MIRT618756	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT618753	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT618752	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT618751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618749	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT618748	hsa-miR-1281	HITS-CLIP	23824327
MIRT618757	hsa-miR-5193	HITS-CLIP	23824327
MIRT618756	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT618753	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT618752	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT618751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618749	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT618748	hsa-miR-1281	HITS-CLIP	23824327
MIRT574989	hsa-miR-5193	HITS-CLIP	21572407
MIRT574988	hsa-miR-660-3p	HITS-CLIP	21572407
MIRT618755	hsa-miR-877-3p	HITS-CLIP	21572407
MIRT645277	hsa-miR-3176	HITS-CLIP	21572407
MIRT645276	hsa-miR-3922-3p	HITS-CLIP	21572407
MIRT574987	hsa-miR-6791-3p	HITS-CLIP	21572407
MIRT574986	hsa-miR-6829-3p	HITS-CLIP	21572407
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	21572407
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	21572407
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	21572407
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	21572407
MIRT574985	hsa-miR-1281	HITS-CLIP	21572407
MIRT574989	hsa-miR-5193	HITS-CLIP	23824327
MIRT574988	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT645277	hsa-miR-3176	HITS-CLIP	23824327
MIRT645276	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT574987	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT574986	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT574985	hsa-miR-1281	HITS-CLIP	23824327
MIRT645280	hsa-miR-6890-5p	HITS-CLIP	23824327
MIRT645279	hsa-miR-4733-3p	HITS-CLIP	23824327
MIRT574989	hsa-miR-5193	HITS-CLIP	23824327
MIRT574988	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT645278	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT645277	hsa-miR-3176	HITS-CLIP	23824327
MIRT645276	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT645275	hsa-miR-3661	HITS-CLIP	23824327
MIRT645274	hsa-miR-631	HITS-CLIP	23824327
MIRT574987	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT574986	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT645273	hsa-miR-492	HITS-CLIP	23824327
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT645272	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT618753	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT618752	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT618751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT645271	hsa-miR-3170	HITS-CLIP	23824327
MIRT645270	hsa-miR-6855-5p	HITS-CLIP	23824327
MIRT618749	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT574985	hsa-miR-1281	HITS-CLIP	23824327
MIRT574989	hsa-miR-5193	HITS-CLIP	23824327
MIRT574988	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT574987	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT574986	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT628649	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT628648	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT628647	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT574985	hsa-miR-1281	HITS-CLIP	23824327
MIRT574989	hsa-miR-5193	HITS-CLIP	23824327
MIRT574988	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT618753	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT618752	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT618751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618749	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT574985	hsa-miR-1281	HITS-CLIP	23824327
MIRT574989	hsa-miR-5193	HITS-CLIP	23824327
MIRT574988	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT618755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618754	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT618753	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT618752	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT618751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618750	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618749	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT574985	hsa-miR-1281	HITS-CLIP	23824327
MIRT2107664	hsa-miR-3660	CLIP-seq
MIRT2107665	hsa-miR-4526	CLIP-seq
MIRT2107666	hsa-miR-4779	CLIP-seq
MIRT2107667	hsa-miR-549	CLIP-seq

Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005290	Function	L-histidine transmembrane transporter activity	IMP	11243884
GO:0005290	Function	L-histidine transmembrane transporter activity	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006865	Process	Amino acid transport	TAS
GO:0006867	Process	Asparagine transport	IEA
GO:0006868	Process	Glutamine transport	IBA
GO:0006868	Process	Glutamine transport	IMP	11243884
GO:0006868	Process	Glutamine transport	ISS
GO:0015171	Function	Amino acid transmembrane transporter activity	TAS
GO:0015182	Function	L-asparagine transmembrane transporter activity	IMP	11243884
GO:0015186	Function	L-glutamine transmembrane transporter activity	IBA
GO:0015186	Function	L-glutamine transmembrane transporter activity	IMP	11243884
GO:0015186	Function	L-glutamine transmembrane transporter activity	ISS
GO:0015187	Function	Glycine transmembrane transporter activity	IBA
GO:0015187	Function	Glycine transmembrane transporter activity	IMP	11243884
GO:0015194	Function	L-serine transmembrane transporter activity	IMP	11243884
GO:0015194	Function	L-serine transmembrane transporter activity	ISS
GO:0015804	Process	Neutral amino acid transport	IDA	11243884
GO:0015816	Process	Glycine transport	IBA
GO:0015816	Process	Glycine transport	IMP	11243884
GO:0015825	Process	L-serine transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0022858	Function	Alanine transmembrane transporter activity	IMP	11243884
GO:0032329	Process	Serine transport	IBA
GO:0032329	Process	Serine transport	IMP	11243884
GO:0032973	Process	Amino acid export across plasma membrane	ISS
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0089709	Process	L-histidine transmembrane transport	IBA
GO:0089709	Process	L-histidine transmembrane transport	IMP	11243884
GO:0089709	Process	L-histidine transmembrane transport	ISS
GO:0089718	Process	Amino acid import across plasma membrane	ISS
GO:0140830	Function	L-glutamine, sodium:proton antiporter activity	IEA
GO:0140830	Function	L-glutamine, sodium:proton antiporter activity	ISS
GO:0140893	Function	Neutral amino acid, sodium:proton antiporter activity	IDA	11243884
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1903713	Process	Asparagine transmembrane transport	IMP	11243884
GO:1903803	Process	L-glutamine import across plasma membrane	IEA
GO:1903803	Process	L-glutamine import across plasma membrane	ISS
GO:1903812	Process	L-serine import across plasma membrane	ISS
GO:1904557	Process	L-alanine transmembrane transport	IMP	11243884

MIM	HGNC	e!Ensembl
300649	18070	ENSG00000017483

Q8WUX1

Protein name

Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)

Protein function

Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01490	Aa_trans	46 → 460	Transmembrane amino acid transporter protein	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in stomach, brain, liver, lung and intestinal tract. {ECO:0000269|PubMed:11243884}.

Sequence

MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNA
IMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFG
PAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVL
IILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPS
QGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGA
MFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRA
LQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIF
YLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH

Sequence length

472

Interactions

View interactions

	KEGG		Reactome
	GABAergic synapse		Amino acid transport across the plasma membrane

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormality of neuronal migration	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALFORMATIONS OF CORTICAL DEVELOPMENT, GROUP II	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SLC38A5-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anaplastic astrocytoma	Anaplastic Astrocytoma	BEFREE	15094455		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	12381519	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29954738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29954738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Enteritis	Enteritis	BEFREE	29271063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	15094455		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	15094455		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	17333282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	LHGDN	17333282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	15094455		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	17333282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29954738		★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC38A5 (solute carrier family 38 member 5)