Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9265
Gene name	Cytohesin 3
Gene symbol	CYTH3
Synonyms (NCBI Gene)	ARNO3GRP1PSCD3cytohesin-3
Chromosome	7
Chromosome location	7p22.1
Summary	This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckst

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018199	hsa-miR-335-5p	Microarray	18185580
MIRT044672	hsa-miR-320a	CLASH	23622248
MIRT488784	hsa-miR-1281	PAR-CLIP	23592263
MIRT488783	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488782	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT488781	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT488779	hsa-miR-449a	PAR-CLIP	23592263
MIRT488780	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT488778	hsa-miR-548au-3p	PAR-CLIP	23592263
MIRT488777	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT488776	hsa-miR-891a-3p	PAR-CLIP	23592263
MIRT488784	hsa-miR-1281	PAR-CLIP	23592263
MIRT488783	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488782	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT488781	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT488779	hsa-miR-449a	PAR-CLIP	23592263
MIRT488780	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT488778	hsa-miR-548au-3p	PAR-CLIP	23592263
MIRT488777	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT488776	hsa-miR-891a-3p	PAR-CLIP	23592263
MIRT922235	hsa-let-7a	CLIP-seq
MIRT922236	hsa-let-7b	CLIP-seq
MIRT922237	hsa-let-7c	CLIP-seq
MIRT922238	hsa-let-7d	CLIP-seq
MIRT922239	hsa-let-7e	CLIP-seq
MIRT922240	hsa-let-7f	CLIP-seq
MIRT922241	hsa-let-7g	CLIP-seq
MIRT922242	hsa-let-7i	CLIP-seq
MIRT922243	hsa-miR-1257	CLIP-seq
MIRT922244	hsa-miR-1271	CLIP-seq
MIRT922245	hsa-miR-1289	CLIP-seq
MIRT922246	hsa-miR-1304	CLIP-seq
MIRT922247	hsa-miR-140-3p	CLIP-seq
MIRT922248	hsa-miR-144	CLIP-seq
MIRT922249	hsa-miR-182	CLIP-seq
MIRT922250	hsa-miR-198	CLIP-seq
MIRT922251	hsa-miR-202	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT922253	hsa-miR-22	CLIP-seq
MIRT922254	hsa-miR-24	CLIP-seq
MIRT922255	hsa-miR-29a	CLIP-seq
MIRT922256	hsa-miR-29b	CLIP-seq
MIRT922257	hsa-miR-29c	CLIP-seq
MIRT922258	hsa-miR-3065-3p	CLIP-seq
MIRT922259	hsa-miR-3198	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT922261	hsa-miR-3619-3p	CLIP-seq
MIRT922262	hsa-miR-3622b-5p	CLIP-seq
MIRT922263	hsa-miR-3657	CLIP-seq
MIRT922264	hsa-miR-3685	CLIP-seq
MIRT922265	hsa-miR-384	CLIP-seq
MIRT922266	hsa-miR-3973	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922268	hsa-miR-4254	CLIP-seq
MIRT922269	hsa-miR-4284	CLIP-seq
MIRT922270	hsa-miR-4294	CLIP-seq
MIRT922271	hsa-miR-4309	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT922273	hsa-miR-4424	CLIP-seq
MIRT922274	hsa-miR-4433	CLIP-seq
MIRT922275	hsa-miR-4458	CLIP-seq
MIRT922276	hsa-miR-4500	CLIP-seq
MIRT922277	hsa-miR-4642	CLIP-seq
MIRT922278	hsa-miR-4648	CLIP-seq
MIRT922279	hsa-miR-4653-3p	CLIP-seq
MIRT922280	hsa-miR-4654	CLIP-seq
MIRT922281	hsa-miR-4659a-5p	CLIP-seq
MIRT922282	hsa-miR-4659b-5p	CLIP-seq
MIRT922283	hsa-miR-4668-5p	CLIP-seq
MIRT922284	hsa-miR-4669	CLIP-seq
MIRT922285	hsa-miR-4685-5p	CLIP-seq
MIRT922286	hsa-miR-4687-3p	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922289	hsa-miR-4769-3p	CLIP-seq
MIRT922290	hsa-miR-4769-5p	CLIP-seq
MIRT922291	hsa-miR-4776-5p	CLIP-seq
MIRT922292	hsa-miR-4799-5p	CLIP-seq
MIRT922293	hsa-miR-485-5p	CLIP-seq
MIRT922294	hsa-miR-495	CLIP-seq
MIRT922295	hsa-miR-499-3p	CLIP-seq
MIRT922296	hsa-miR-499a-3p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT922298	hsa-miR-512-5p	CLIP-seq
MIRT922299	hsa-miR-548k	CLIP-seq
MIRT922300	hsa-miR-581	CLIP-seq
MIRT922301	hsa-miR-592	CLIP-seq
MIRT922302	hsa-miR-599	CLIP-seq
MIRT922303	hsa-miR-619	CLIP-seq
MIRT922304	hsa-miR-665	CLIP-seq
MIRT922305	hsa-miR-802	CLIP-seq
MIRT922306	hsa-miR-96	CLIP-seq
MIRT922307	hsa-miR-98	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT738349	hsa-miR-1285	CLIP-seq
MIRT738348	hsa-miR-3187-5p	CLIP-seq
MIRT738350	hsa-miR-612	CLIP-seq
MIRT1973145	hsa-miR-1268	CLIP-seq
MIRT1973146	hsa-miR-1268b	CLIP-seq
MIRT922247	hsa-miR-140-3p	CLIP-seq
MIRT1973147	hsa-miR-153	CLIP-seq
MIRT1973148	hsa-miR-1915	CLIP-seq
MIRT922250	hsa-miR-198	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT1973149	hsa-miR-2277-3p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT1973150	hsa-miR-34a	CLIP-seq
MIRT1973151	hsa-miR-3612	CLIP-seq
MIRT922263	hsa-miR-3657	CLIP-seq
MIRT1973152	hsa-miR-3937	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT922273	hsa-miR-4424	CLIP-seq
MIRT922274	hsa-miR-4433	CLIP-seq
MIRT1973153	hsa-miR-4443	CLIP-seq
MIRT1973154	hsa-miR-4463	CLIP-seq
MIRT1973155	hsa-miR-448	CLIP-seq
MIRT1973156	hsa-miR-449b	CLIP-seq
MIRT1973157	hsa-miR-4508	CLIP-seq
MIRT1973158	hsa-miR-4514	CLIP-seq
MIRT922279	hsa-miR-4653-3p	CLIP-seq
MIRT922284	hsa-miR-4669	CLIP-seq
MIRT922285	hsa-miR-4685-5p	CLIP-seq
MIRT922286	hsa-miR-4687-3p	CLIP-seq
MIRT1973159	hsa-miR-4692	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT1973160	hsa-miR-4726-3p	CLIP-seq
MIRT1973161	hsa-miR-4767	CLIP-seq
MIRT922293	hsa-miR-485-5p	CLIP-seq
MIRT1973162	hsa-miR-490-5p	CLIP-seq
MIRT922295	hsa-miR-499-3p	CLIP-seq
MIRT922296	hsa-miR-499a-3p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT1973163	hsa-miR-549	CLIP-seq
MIRT922301	hsa-miR-592	CLIP-seq
MIRT922302	hsa-miR-599	CLIP-seq
MIRT1973164	hsa-miR-650	CLIP-seq
MIRT922304	hsa-miR-665	CLIP-seq
MIRT1973165	hsa-miR-7	CLIP-seq
MIRT1973166	hsa-miR-744	CLIP-seq
MIRT922235	hsa-let-7a	CLIP-seq
MIRT922236	hsa-let-7b	CLIP-seq
MIRT922237	hsa-let-7c	CLIP-seq
MIRT922238	hsa-let-7d	CLIP-seq
MIRT922239	hsa-let-7e	CLIP-seq
MIRT922240	hsa-let-7f	CLIP-seq
MIRT922241	hsa-let-7g	CLIP-seq
MIRT922242	hsa-let-7i	CLIP-seq
MIRT2208846	hsa-miR-1254	CLIP-seq
MIRT922243	hsa-miR-1257	CLIP-seq
MIRT922244	hsa-miR-1271	CLIP-seq
MIRT922246	hsa-miR-1304	CLIP-seq
MIRT922247	hsa-miR-140-3p	CLIP-seq
MIRT922248	hsa-miR-144	CLIP-seq
MIRT2208847	hsa-miR-148a	CLIP-seq
MIRT2208848	hsa-miR-148b	CLIP-seq
MIRT2208849	hsa-miR-152	CLIP-seq
MIRT2208850	hsa-miR-1539	CLIP-seq
MIRT2208851	hsa-miR-15a	CLIP-seq
MIRT2208852	hsa-miR-15b	CLIP-seq
MIRT2208853	hsa-miR-16	CLIP-seq
MIRT922249	hsa-miR-182	CLIP-seq
MIRT1973148	hsa-miR-1915	CLIP-seq
MIRT2208854	hsa-miR-195	CLIP-seq
MIRT922250	hsa-miR-198	CLIP-seq
MIRT922251	hsa-miR-202	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT1973149	hsa-miR-2277-3p	CLIP-seq
MIRT2208855	hsa-miR-3116	CLIP-seq
MIRT2208856	hsa-miR-3120-3p	CLIP-seq
MIRT2208857	hsa-miR-3150a-3p	CLIP-seq
MIRT2208858	hsa-miR-3175	CLIP-seq
MIRT2208859	hsa-miR-3194-3p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT1973150	hsa-miR-34a	CLIP-seq
MIRT2208860	hsa-miR-3614-3p	CLIP-seq
MIRT922261	hsa-miR-3619-3p	CLIP-seq
MIRT922262	hsa-miR-3622b-5p	CLIP-seq
MIRT922263	hsa-miR-3657	CLIP-seq
MIRT2208861	hsa-miR-3660	CLIP-seq
MIRT2208862	hsa-miR-3663-5p	CLIP-seq
MIRT2208863	hsa-miR-370	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT2208864	hsa-miR-424	CLIP-seq
MIRT922268	hsa-miR-4254	CLIP-seq
MIRT2208865	hsa-miR-4276	CLIP-seq
MIRT2208866	hsa-miR-4325	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT739460	hsa-miR-4327	CLIP-seq
MIRT922273	hsa-miR-4424	CLIP-seq
MIRT922274	hsa-miR-4433	CLIP-seq
MIRT922275	hsa-miR-4458	CLIP-seq
MIRT1973156	hsa-miR-449b	CLIP-seq
MIRT922276	hsa-miR-4500	CLIP-seq
MIRT2208867	hsa-miR-4526	CLIP-seq
MIRT2208868	hsa-miR-4633-3p	CLIP-seq
MIRT922277	hsa-miR-4642	CLIP-seq
MIRT922279	hsa-miR-4653-3p	CLIP-seq
MIRT922284	hsa-miR-4669	CLIP-seq
MIRT922286	hsa-miR-4687-3p	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT2208869	hsa-miR-4716-3p	CLIP-seq
MIRT1973160	hsa-miR-4726-3p	CLIP-seq
MIRT922289	hsa-miR-4769-3p	CLIP-seq
MIRT922291	hsa-miR-4776-5p	CLIP-seq
MIRT922293	hsa-miR-485-5p	CLIP-seq
MIRT2208870	hsa-miR-491-5p	CLIP-seq
MIRT2208871	hsa-miR-497	CLIP-seq
MIRT2208872	hsa-miR-502-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT2208873	hsa-miR-516b	CLIP-seq
MIRT2208874	hsa-miR-545	CLIP-seq
MIRT2208875	hsa-miR-548a-3p	CLIP-seq
MIRT2208876	hsa-miR-548e	CLIP-seq
MIRT2208877	hsa-miR-548f	CLIP-seq
MIRT2208878	hsa-miR-574-3p	CLIP-seq
MIRT2208879	hsa-miR-579	CLIP-seq
MIRT922300	hsa-miR-581	CLIP-seq
MIRT922301	hsa-miR-592	CLIP-seq
MIRT922302	hsa-miR-599	CLIP-seq
MIRT2208880	hsa-miR-646	CLIP-seq
MIRT922304	hsa-miR-665	CLIP-seq
MIRT2208881	hsa-miR-888	CLIP-seq
MIRT2208882	hsa-miR-939	CLIP-seq
MIRT922306	hsa-miR-96	CLIP-seq
MIRT922307	hsa-miR-98	CLIP-seq
MIRT922252	hsa-miR-205	CLIP-seq
MIRT1973150	hsa-miR-34a	CLIP-seq
MIRT2208861	hsa-miR-3660	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922272	hsa-miR-4326	CLIP-seq
MIRT1973156	hsa-miR-449b	CLIP-seq
MIRT2208867	hsa-miR-4526	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT1973149	hsa-miR-2277-3p	CLIP-seq
MIRT922260	hsa-miR-323-3p	CLIP-seq
MIRT2436757	hsa-miR-3682-5p	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922287	hsa-miR-4699-3p	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT2436758	hsa-miR-550b	CLIP-seq
MIRT922267	hsa-miR-421	CLIP-seq
MIRT922288	hsa-miR-4709-5p	CLIP-seq
MIRT922297	hsa-miR-508-5p	CLIP-seq
MIRT2512640	hsa-miR-1245b-5p	CLIP-seq
MIRT2512641	hsa-miR-2110	CLIP-seq
MIRT2512642	hsa-miR-3142	CLIP-seq
MIRT2208857	hsa-miR-3150a-3p	CLIP-seq
MIRT2512643	hsa-miR-3189-3p	CLIP-seq
MIRT2512644	hsa-miR-4450	CLIP-seq
MIRT2512640	hsa-miR-1245b-5p	CLIP-seq
MIRT2512641	hsa-miR-2110	CLIP-seq
MIRT2512642	hsa-miR-3142	CLIP-seq
MIRT2208857	hsa-miR-3150a-3p	CLIP-seq
MIRT2512643	hsa-miR-3189-3p	CLIP-seq
MIRT2512644	hsa-miR-4450	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001726	Component	Ruffle	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	9707577, 23940353
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 28514442, 32296183, 33961781
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	9742223, 23940353
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	9742223
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	17398095
GO:0005886	Component	Plasma membrane	IEA
GO:0005912	Component	Adherens junction	IEA
GO:0005912	Component	Adherens junction	ISS
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	ISS
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0032012	Process	Regulation of ARF protein signal transduction	IEA
GO:0045785	Process	Positive regulation of cell adhesion	IEA
GO:0048193	Process	Golgi vesicle transport	IMP	9707577
GO:0070161	Component	Anchoring junction	IEA
GO:0090162	Process	Establishment of epithelial cell polarity	IEA
GO:0090162	Process	Establishment of epithelial cell polarity	ISS

MIM	HGNC	e!Ensembl
605081	9504	ENSG00000008256

O43739

Protein name

Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)

Protein function

Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:O08967, ECO:0000269|PubMed:239

PDB

4KAX , 6U3E , 6U3G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01369	Sec7	66 → 248	Sec7 domain	Domain
PF00169	PH	265 → 381	PH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Almost absent from liver, thymus and peripheral blood lymphocytes.

Sequence

MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEE
SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYL
GERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCN
PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLY
ESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYT
TDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYR
ISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

Sequence length

400

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Endocytosis Pathogenic Escherichia coli infection Shigellosis Salmonella infection		Intra-Golgi traffic

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CIRCADIAN RHYTHM SLEEP DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	19377877	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24966920	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	GWASCAT_DG	31113495		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	24966920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	28611183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24966920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	35958598	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CYTH3 (cytohesin 3)