Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9263
Gene name	Serine/threonine kinase 17a
Gene symbol	STK17A
Synonyms (NCBI Gene)	DRAK1
Chromosome	7
Chromosome location	7p13
Summary	This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

233

Show/Hide all (233)

miRTarBase ID	miRNA	Experiments	Reference
MIRT647688	hsa-miR-6783-5p	HITS-CLIP	23824327
MIRT647687	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT647686	hsa-miR-8060	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT647685	hsa-miR-6824-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT450061	hsa-miR-1250-3p	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446830	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446829	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446828	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446827	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446826	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446825	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446824	hsa-miR-3920	PAR-CLIP	22100165
MIRT446823	hsa-miR-29a-5p	PAR-CLIP	22100165
MIRT446822	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT446820	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT735374	hsa-miR-411-5p	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	31746360
MIRT647688	hsa-miR-6783-5p	HITS-CLIP	23824327
MIRT647687	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT647686	hsa-miR-8060	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT647685	hsa-miR-6824-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT450061	hsa-miR-1250-3p	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446830	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446829	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446828	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446827	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446826	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446825	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446824	hsa-miR-3920	PAR-CLIP	22100165
MIRT446823	hsa-miR-29a-5p	PAR-CLIP	22100165
MIRT446822	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT446820	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT1397277	hsa-miR-1208	CLIP-seq
MIRT1397278	hsa-miR-125a-3p	CLIP-seq
MIRT1397279	hsa-miR-1262	CLIP-seq
MIRT1397280	hsa-miR-1286	CLIP-seq
MIRT1397281	hsa-miR-1302	CLIP-seq
MIRT1397282	hsa-miR-18a	CLIP-seq
MIRT1397283	hsa-miR-18b	CLIP-seq
MIRT1397284	hsa-miR-214	CLIP-seq
MIRT1397285	hsa-miR-3120-3p	CLIP-seq
MIRT1397286	hsa-miR-3122	CLIP-seq
MIRT1397287	hsa-miR-3143	CLIP-seq
MIRT1397288	hsa-miR-3151	CLIP-seq
MIRT1397289	hsa-miR-3169	CLIP-seq
MIRT1397290	hsa-miR-3187-3p	CLIP-seq
MIRT1397291	hsa-miR-34c-3p	CLIP-seq
MIRT1397292	hsa-miR-3619-5p	CLIP-seq
MIRT1397293	hsa-miR-3688-5p	CLIP-seq
MIRT1397294	hsa-miR-377	CLIP-seq
MIRT1397295	hsa-miR-3913-5p	CLIP-seq
MIRT1397296	hsa-miR-3942-5p	CLIP-seq
MIRT1397297	hsa-miR-3945	CLIP-seq
MIRT1397298	hsa-miR-4257	CLIP-seq
MIRT1397299	hsa-miR-4298	CLIP-seq
MIRT1397300	hsa-miR-4318	CLIP-seq
MIRT1397301	hsa-miR-4435	CLIP-seq
MIRT1397302	hsa-miR-4447	CLIP-seq
MIRT1397303	hsa-miR-4472	CLIP-seq
MIRT1397304	hsa-miR-4515	CLIP-seq
MIRT1397305	hsa-miR-4539	CLIP-seq
MIRT1397306	hsa-miR-4672	CLIP-seq
MIRT1397307	hsa-miR-4701-3p	CLIP-seq
MIRT1397308	hsa-miR-4701-5p	CLIP-seq
MIRT1397309	hsa-miR-4703-5p	CLIP-seq
MIRT1397310	hsa-miR-4724-5p	CLIP-seq
MIRT1397311	hsa-miR-4735-3p	CLIP-seq
MIRT1397312	hsa-miR-486-3p	CLIP-seq
MIRT1397313	hsa-miR-491-5p	CLIP-seq
MIRT1397314	hsa-miR-543	CLIP-seq
MIRT1397315	hsa-miR-548ac	CLIP-seq
MIRT1397316	hsa-miR-548ae	CLIP-seq
MIRT1397317	hsa-miR-548aj	CLIP-seq
MIRT1397318	hsa-miR-548am	CLIP-seq
MIRT1397319	hsa-miR-548d-3p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT1397321	hsa-miR-548x	CLIP-seq
MIRT1397322	hsa-miR-548z	CLIP-seq
MIRT1397323	hsa-miR-552	CLIP-seq
MIRT1397324	hsa-miR-588	CLIP-seq
MIRT1397325	hsa-miR-618	CLIP-seq
MIRT1397326	hsa-miR-656	CLIP-seq
MIRT1397327	hsa-miR-761	CLIP-seq
MIRT2118981	hsa-miR-1297	CLIP-seq
MIRT2118982	hsa-miR-26a	CLIP-seq
MIRT2118983	hsa-miR-26b	CLIP-seq
MIRT2118984	hsa-miR-4465	CLIP-seq
MIRT2118985	hsa-miR-466	CLIP-seq
MIRT2118986	hsa-miR-4719	CLIP-seq
MIRT2118981	hsa-miR-1297	CLIP-seq
MIRT2341289	hsa-miR-145	CLIP-seq
MIRT2118982	hsa-miR-26a	CLIP-seq
MIRT2118983	hsa-miR-26b	CLIP-seq
MIRT1397290	hsa-miR-3187-3p	CLIP-seq
MIRT1397298	hsa-miR-4257	CLIP-seq
MIRT1397301	hsa-miR-4435	CLIP-seq
MIRT2341290	hsa-miR-4436b-5p	CLIP-seq
MIRT2118984	hsa-miR-4465	CLIP-seq
MIRT2341291	hsa-miR-4666-5p	CLIP-seq
MIRT1397308	hsa-miR-4701-5p	CLIP-seq
MIRT2341292	hsa-miR-4712-5p	CLIP-seq
MIRT2341293	hsa-miR-4755-3p	CLIP-seq
MIRT2341294	hsa-miR-4795-5p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT1397324	hsa-miR-588	CLIP-seq
MIRT2341295	hsa-miR-770-5p	CLIP-seq
MIRT2440858	hsa-miR-514	CLIP-seq
MIRT2440859	hsa-miR-514b-3p	CLIP-seq
MIRT2440860	hsa-miR-599	CLIP-seq
MIRT2635198	hsa-miR-1207-5p	CLIP-seq
MIRT2635199	hsa-miR-1909	CLIP-seq
MIRT2635200	hsa-miR-1912	CLIP-seq
MIRT2635201	hsa-miR-3126-5p	CLIP-seq
MIRT2635202	hsa-miR-3607-5p	CLIP-seq
MIRT2635203	hsa-miR-3646	CLIP-seq
MIRT2635204	hsa-miR-3650	CLIP-seq
MIRT2635205	hsa-miR-3659	CLIP-seq
MIRT2635206	hsa-miR-3677-5p	CLIP-seq
MIRT2635207	hsa-miR-3689d	CLIP-seq
MIRT2635208	hsa-miR-3925-5p	CLIP-seq
MIRT2635209	hsa-miR-3926	CLIP-seq
MIRT2635210	hsa-miR-3942-3p	CLIP-seq
MIRT2635211	hsa-miR-3976	CLIP-seq
MIRT1397298	hsa-miR-4257	CLIP-seq
MIRT2635212	hsa-miR-4419a	CLIP-seq
MIRT2635213	hsa-miR-4510	CLIP-seq
MIRT2635214	hsa-miR-4658	CLIP-seq
MIRT2635215	hsa-miR-4696	CLIP-seq
MIRT2635216	hsa-miR-4723-5p	CLIP-seq
MIRT2635217	hsa-miR-4736	CLIP-seq
MIRT2341293	hsa-miR-4755-3p	CLIP-seq
MIRT2635218	hsa-miR-4763-3p	CLIP-seq
MIRT2635219	hsa-miR-4773	CLIP-seq
MIRT2341294	hsa-miR-4795-5p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT2635220	hsa-miR-574-5p	CLIP-seq
MIRT2635221	hsa-miR-646	CLIP-seq
MIRT2692233	hsa-miR-1206	CLIP-seq
MIRT2692234	hsa-miR-130a	CLIP-seq
MIRT2692235	hsa-miR-130b	CLIP-seq
MIRT2692236	hsa-miR-219-1-3p	CLIP-seq
MIRT2692237	hsa-miR-2467-3p	CLIP-seq
MIRT2692238	hsa-miR-301a	CLIP-seq
MIRT2692239	hsa-miR-301b	CLIP-seq
MIRT2635201	hsa-miR-3126-5p	CLIP-seq
MIRT2692240	hsa-miR-3179	CLIP-seq
MIRT2635203	hsa-miR-3646	CLIP-seq
MIRT2635204	hsa-miR-3650	CLIP-seq
MIRT2635205	hsa-miR-3659	CLIP-seq
MIRT2692241	hsa-miR-3666	CLIP-seq
MIRT2635206	hsa-miR-3677-5p	CLIP-seq
MIRT2692242	hsa-miR-3678-3p	CLIP-seq
MIRT2635207	hsa-miR-3689d	CLIP-seq
MIRT2692243	hsa-miR-376a	CLIP-seq
MIRT2692244	hsa-miR-376b	CLIP-seq
MIRT2635209	hsa-miR-3926	CLIP-seq
MIRT2692245	hsa-miR-4295	CLIP-seq
MIRT2635212	hsa-miR-4419a	CLIP-seq
MIRT2692246	hsa-miR-4475	CLIP-seq
MIRT2635213	hsa-miR-4510	CLIP-seq
MIRT2692247	hsa-miR-454	CLIP-seq
MIRT2635214	hsa-miR-4658	CLIP-seq
MIRT2692248	hsa-miR-4671-3p	CLIP-seq
MIRT2692249	hsa-miR-4682	CLIP-seq
MIRT2635216	hsa-miR-4723-5p	CLIP-seq
MIRT2341293	hsa-miR-4755-3p	CLIP-seq
MIRT2341294	hsa-miR-4795-5p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT2692250	hsa-miR-571	CLIP-seq
MIRT2635220	hsa-miR-574-5p	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9786912
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IDA	9786912
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9786912
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0006468	Process	Protein phosphorylation	IDA	9786912
GO:0006915	Process	Apoptotic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	9786912
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	21489989
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000271	Process	Positive regulation of fibroblast apoptotic process	IEA
GO:2000271	Process	Positive regulation of fibroblast apoptotic process	IMP	9786912
GO:2000377	Process	Regulation of reactive oxygen species metabolic process	IMP	21489989

MIM	HGNC	e!Ensembl
604726	11395	ENSG00000164543

Q9UEE5

Protein name

Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1)

Protein function

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

PDB

7QUE , 7QUF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	62 → 321	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9786912}.

Sequence

MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS
LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW
VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR
DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI
SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT
LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE
TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY

Sequence length

414

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PATELLAR TENDINITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	18302252	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	31746360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	31746360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30655319		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30655319	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	24312360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	24312360	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	24312360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	24312360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	24312360	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	37370186	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	23860322		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	33955523	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24312360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	31746360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Memory Disorders	Memory disorders	Pubtator	18302252	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18558287, 25531329, 30655319		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	25531329		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	33955523	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	24403257, 31746360, 35194034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

STK17A (serine/threonine kinase 17a)