MOB1B (MOB kinase activator 1B)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 92597
Gene name MOB kinase activator 1B
Gene symbol MOB1B
Synonyms (NCBI Gene)
MATS2MOB4AMOBKL1A
Chromosome 4
Chromosome location 4q13.3
Summary The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been
miRNA miRNA information provided by mirtarbase database.
333
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (333)
miRTarBase ID miRNA Experiments Reference
MIRT022073 hsa-miR-128-3p Microarray 17612493
MIRT025196 hsa-miR-181a-5p Sequencing 20371350
MIRT032390 hsa-let-7b-5p Proteomics 18668040
MIRT050791 hsa-miR-17-5p CLASH 23622248
MIRT050791 hsa-miR-17-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (19)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19739119, 22863277, 24255178, 24366813, 25416956, 28514442, 32296183, 32707033, 33961781
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 15067004
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
609282 29801 ENSG00000173542
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7L9L4
Protein name MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A)
Protein function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03637 Mob1_phocein 33 → 204 Mob1/phocein family Family
Tissue specificity TISSUE SPECIFICITY: Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}.
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Hippo signaling pathway
Hippo signaling pathway - multiple species 		  Signaling by Hippo
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (6)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (4)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Endometrial Neoplasms Endometrial neoplasm Pubtator 36445107 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Malnutrition Malnutrition BEFREE 23143302
★★★★★
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 23143302
★★★★★
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 36445107 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only