Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9240
Gene name	PNMA family member 1
Gene symbol	PNMA1
Synonyms (NCBI Gene)	MA1
Chromosome	14
Chromosome location	14q24.3
Summary	This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identifi

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Show/Hide all (167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT726919	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726918	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726916	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726917	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726915	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT1244897	hsa-miR-1299	CLIP-seq
MIRT1244898	hsa-miR-132	CLIP-seq
MIRT1244899	hsa-miR-148a	CLIP-seq
MIRT1244900	hsa-miR-148b	CLIP-seq
MIRT1244901	hsa-miR-152	CLIP-seq
MIRT1244902	hsa-miR-212	CLIP-seq
MIRT1244903	hsa-miR-30a	CLIP-seq
MIRT1244904	hsa-miR-30b	CLIP-seq
MIRT1244905	hsa-miR-30c	CLIP-seq
MIRT1244906	hsa-miR-30d	CLIP-seq
MIRT1244907	hsa-miR-30e	CLIP-seq
MIRT1244908	hsa-miR-3149	CLIP-seq
MIRT1244909	hsa-miR-33a	CLIP-seq
MIRT1244910	hsa-miR-33b	CLIP-seq
MIRT1244911	hsa-miR-361-5p	CLIP-seq
MIRT1244912	hsa-miR-3667-3p	CLIP-seq
MIRT1244913	hsa-miR-3671	CLIP-seq
MIRT1244914	hsa-miR-410	CLIP-seq
MIRT1244915	hsa-miR-4275	CLIP-seq
MIRT1244916	hsa-miR-4426	CLIP-seq
MIRT1244917	hsa-miR-4647	CLIP-seq
MIRT1244918	hsa-miR-4662b	CLIP-seq
MIRT1244919	hsa-miR-539	CLIP-seq
MIRT1244920	hsa-miR-548c-3p	CLIP-seq
MIRT1244921	hsa-miR-548g	CLIP-seq
MIRT1244922	hsa-miR-561	CLIP-seq
MIRT1244923	hsa-miR-568	CLIP-seq
MIRT1244924	hsa-miR-582-3p	CLIP-seq
MIRT1244925	hsa-miR-584	CLIP-seq
MIRT1244926	hsa-miR-607	CLIP-seq
MIRT1244927	hsa-miR-875-3p	CLIP-seq
MIRT1244928	hsa-miR-885-5p	CLIP-seq
MIRT2072467	hsa-miR-1250	CLIP-seq
MIRT2072468	hsa-miR-1272	CLIP-seq
MIRT2072469	hsa-miR-1275	CLIP-seq
MIRT2072470	hsa-miR-1322	CLIP-seq
MIRT2072471	hsa-miR-181a	CLIP-seq
MIRT2072472	hsa-miR-181b	CLIP-seq
MIRT2072473	hsa-miR-181c	CLIP-seq
MIRT2072474	hsa-miR-181d	CLIP-seq
MIRT2072475	hsa-miR-1972	CLIP-seq
MIRT2072476	hsa-miR-203	CLIP-seq
MIRT2072477	hsa-miR-2277-3p	CLIP-seq
MIRT2072478	hsa-miR-23a	CLIP-seq
MIRT2072479	hsa-miR-23b	CLIP-seq
MIRT2072480	hsa-miR-23c	CLIP-seq
MIRT2072481	hsa-miR-2964a-5p	CLIP-seq
MIRT1244903	hsa-miR-30a	CLIP-seq
MIRT1244904	hsa-miR-30b	CLIP-seq
MIRT1244905	hsa-miR-30c	CLIP-seq
MIRT1244906	hsa-miR-30d	CLIP-seq
MIRT1244907	hsa-miR-30e	CLIP-seq
MIRT2072482	hsa-miR-3190	CLIP-seq
MIRT1244909	hsa-miR-33a	CLIP-seq
MIRT1244910	hsa-miR-33b	CLIP-seq
MIRT2072483	hsa-miR-3613-3p	CLIP-seq
MIRT2072484	hsa-miR-3653	CLIP-seq
MIRT2072485	hsa-miR-3676	CLIP-seq
MIRT2072486	hsa-miR-3907	CLIP-seq
MIRT2072487	hsa-miR-3911	CLIP-seq
MIRT2072488	hsa-miR-3920	CLIP-seq
MIRT2072489	hsa-miR-4262	CLIP-seq
MIRT2072490	hsa-miR-4276	CLIP-seq
MIRT2072491	hsa-miR-4302	CLIP-seq
MIRT2072492	hsa-miR-4525	CLIP-seq
MIRT2072493	hsa-miR-4539	CLIP-seq
MIRT2072494	hsa-miR-4650-5p	CLIP-seq
MIRT2072495	hsa-miR-4665-5p	CLIP-seq
MIRT2072496	hsa-miR-4666-5p	CLIP-seq
MIRT2072497	hsa-miR-4723-5p	CLIP-seq
MIRT2072498	hsa-miR-4755-3p	CLIP-seq
MIRT2072499	hsa-miR-5096	CLIP-seq
MIRT2072500	hsa-miR-510	CLIP-seq
MIRT2072501	hsa-miR-512-5p	CLIP-seq
MIRT2072502	hsa-miR-513b	CLIP-seq
MIRT2072503	hsa-miR-576-3p	CLIP-seq
MIRT2072504	hsa-miR-590-3p	CLIP-seq
MIRT2072505	hsa-miR-625	CLIP-seq
MIRT2072506	hsa-miR-720	CLIP-seq
MIRT2072467	hsa-miR-1250	CLIP-seq
MIRT2299577	hsa-miR-1256	CLIP-seq
MIRT1244897	hsa-miR-1299	CLIP-seq
MIRT2299578	hsa-miR-1305	CLIP-seq
MIRT2299579	hsa-miR-1914	CLIP-seq
MIRT2072476	hsa-miR-203	CLIP-seq
MIRT2299580	hsa-miR-22	CLIP-seq
MIRT1244903	hsa-miR-30a	CLIP-seq
MIRT1244904	hsa-miR-30b	CLIP-seq
MIRT1244905	hsa-miR-30c	CLIP-seq
MIRT1244906	hsa-miR-30d	CLIP-seq
MIRT1244907	hsa-miR-30e	CLIP-seq
MIRT2299581	hsa-miR-3130-3p	CLIP-seq
MIRT2072482	hsa-miR-3190	CLIP-seq
MIRT2299582	hsa-miR-320a	CLIP-seq
MIRT2299583	hsa-miR-320b	CLIP-seq
MIRT2299584	hsa-miR-320c	CLIP-seq
MIRT2299585	hsa-miR-320d	CLIP-seq
MIRT1244909	hsa-miR-33a	CLIP-seq
MIRT1244910	hsa-miR-33b	CLIP-seq
MIRT2299586	hsa-miR-3607-3p	CLIP-seq
MIRT1244911	hsa-miR-361-5p	CLIP-seq
MIRT2072484	hsa-miR-3653	CLIP-seq
MIRT1244912	hsa-miR-3667-3p	CLIP-seq
MIRT2299587	hsa-miR-3667-5p	CLIP-seq
MIRT1244913	hsa-miR-3671	CLIP-seq
MIRT2299588	hsa-miR-3686	CLIP-seq
MIRT2072486	hsa-miR-3907	CLIP-seq
MIRT2072487	hsa-miR-3911	CLIP-seq
MIRT1244915	hsa-miR-4275	CLIP-seq
MIRT2072490	hsa-miR-4276	CLIP-seq
MIRT2072491	hsa-miR-4302	CLIP-seq
MIRT2299589	hsa-miR-4327	CLIP-seq
MIRT2299590	hsa-miR-4429	CLIP-seq
MIRT2299591	hsa-miR-451b	CLIP-seq
MIRT2299592	hsa-miR-4527	CLIP-seq
MIRT2072493	hsa-miR-4539	CLIP-seq
MIRT2072494	hsa-miR-4650-5p	CLIP-seq
MIRT2299593	hsa-miR-4662a-5p	CLIP-seq
MIRT2072496	hsa-miR-4666-5p	CLIP-seq
MIRT2299594	hsa-miR-4676-5p	CLIP-seq
MIRT2299595	hsa-miR-4677-3p	CLIP-seq
MIRT2299596	hsa-miR-4679	CLIP-seq
MIRT2299597	hsa-miR-4696	CLIP-seq
MIRT2299598	hsa-miR-4720-5p	CLIP-seq
MIRT2299599	hsa-miR-4724-5p	CLIP-seq
MIRT2299600	hsa-miR-4742-3p	CLIP-seq
MIRT2072498	hsa-miR-4755-3p	CLIP-seq
MIRT2299601	hsa-miR-4773	CLIP-seq
MIRT2299602	hsa-miR-4793-3p	CLIP-seq
MIRT2299603	hsa-miR-4797-3p	CLIP-seq
MIRT2299604	hsa-miR-4799-3p	CLIP-seq
MIRT2072500	hsa-miR-510	CLIP-seq
MIRT2072501	hsa-miR-512-5p	CLIP-seq
MIRT1244920	hsa-miR-548c-3p	CLIP-seq
MIRT1244921	hsa-miR-548g	CLIP-seq
MIRT2299605	hsa-miR-548n	CLIP-seq
MIRT2299606	hsa-miR-562	CLIP-seq
MIRT2299607	hsa-miR-575	CLIP-seq
MIRT1244924	hsa-miR-582-3p	CLIP-seq
MIRT1244925	hsa-miR-584	CLIP-seq
MIRT2072504	hsa-miR-590-3p	CLIP-seq
MIRT1244926	hsa-miR-607	CLIP-seq
MIRT2299608	hsa-miR-619	CLIP-seq
MIRT2072506	hsa-miR-720	CLIP-seq
MIRT1244927	hsa-miR-875-3p	CLIP-seq
MIRT1244928	hsa-miR-885-5p	CLIP-seq
MIRT2299609	hsa-miR-889	CLIP-seq
MIRT2072494	hsa-miR-4650-5p	CLIP-seq
MIRT2072475	hsa-miR-1972	CLIP-seq
MIRT2596290	hsa-miR-3065-5p	CLIP-seq
MIRT2072483	hsa-miR-3613-3p	CLIP-seq
MIRT2072494	hsa-miR-4650-5p	CLIP-seq
MIRT2072496	hsa-miR-4666-5p	CLIP-seq
MIRT2072500	hsa-miR-510	CLIP-seq
MIRT2072501	hsa-miR-512-5p	CLIP-seq
MIRT2072504	hsa-miR-590-3p	CLIP-seq
MIRT2072475	hsa-miR-1972	CLIP-seq
MIRT2072494	hsa-miR-4650-5p	CLIP-seq
MIRT2072496	hsa-miR-4666-5p	CLIP-seq
MIRT2072500	hsa-miR-510	CLIP-seq
MIRT2072501	hsa-miR-512-5p	CLIP-seq
MIRT2072504	hsa-miR-590-3p	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002437	Process	Inflammatory response to antigenic stimulus	IEA
GO:0002437	Process	Inflammatory response to antigenic stimulus	ISS	15201193
GO:0005515	Function	Protein binding	IPI	14676191, 16169070, 21516116, 21653829, 25416956, 25910212, 26871637, 27107012, 28514442, 29892012, 31515488, 32296183, 33961781, 36217029
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA	10050892
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	10050892
GO:0043065	Process	Positive regulation of apoptotic process	ISS

MIM	HGNC	e!Ensembl
604010	9158	ENSG00000176903

Q8ND90

Protein name

Paraneoplastic antigen Ma1 (37 kDa neuronal protein) (Neuron- and testis-specific protein 1)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14893	PNMA	1 → 325	PNMA	Family

Tissue specificity

TISSUE SPECIFICITY: Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells. {ECO:0000269|PubMed:10050892, ECO:0000269|PubMed:19366867}.

Sequence

MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVSYRMLGRMFWREEN
AKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVA
RVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPW
LEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSV
ESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANH
SGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF

Sequence length

353

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Brain Stem Neoplasms	Brain stem neoplasms	Pubtator	12933950	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	12933950	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	30243081	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30243081	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	31381571	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
CNS disorder	CNS Disorder	BEFREE	15201193		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30243081		★★★★★ ★☆☆☆☆ Found in Text Mining only

PNMA1 (PNMA family member 1)