Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	92291
Gene name	Calpain 13
Gene symbol	CAPN13
Synonyms (NCBI Gene)	-
Chromosome	2
Chromosome location	2p23.1
Summary	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018063	hsa-miR-335-5p	Microarray	18185580
MIRT019322	hsa-miR-148b-3p	Microarray	17612493
MIRT648576	hsa-miR-3919	HITS-CLIP	23824327
MIRT648575	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT648574	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648573	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT648572	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT648571	hsa-miR-549a	HITS-CLIP	23824327
MIRT648570	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT648569	hsa-miR-1260a	HITS-CLIP	23824327
MIRT648568	hsa-miR-1260b	HITS-CLIP	23824327
MIRT648567	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT648566	hsa-miR-4279	HITS-CLIP	23824327
MIRT648565	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT648564	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT648576	hsa-miR-3919	HITS-CLIP	23824327
MIRT648575	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT648574	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648573	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT648572	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT648571	hsa-miR-549a	HITS-CLIP	23824327
MIRT648570	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT648569	hsa-miR-1260a	HITS-CLIP	23824327
MIRT648568	hsa-miR-1260b	HITS-CLIP	23824327
MIRT648567	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT648566	hsa-miR-4279	HITS-CLIP	23824327
MIRT648565	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT648564	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT441015	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT441015	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT648576	hsa-miR-3919	HITS-CLIP	23824327
MIRT648575	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT648574	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648573	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT648572	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT648571	hsa-miR-549a	HITS-CLIP	23824327
MIRT648570	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT648569	hsa-miR-1260a	HITS-CLIP	23824327
MIRT648568	hsa-miR-1260b	HITS-CLIP	23824327
MIRT648567	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT648566	hsa-miR-4279	HITS-CLIP	23824327
MIRT648565	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT648564	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT648576	hsa-miR-3919	HITS-CLIP	23824327
MIRT648575	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT648574	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT648573	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT648572	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT648571	hsa-miR-549a	HITS-CLIP	23824327
MIRT648570	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT648569	hsa-miR-1260a	HITS-CLIP	23824327
MIRT648568	hsa-miR-1260b	HITS-CLIP	23824327
MIRT648567	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT648566	hsa-miR-4279	HITS-CLIP	23824327
MIRT648565	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT648564	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT861877	hsa-miR-106a	CLIP-seq
MIRT861878	hsa-miR-106b	CLIP-seq
MIRT861879	hsa-miR-17	CLIP-seq
MIRT861880	hsa-miR-20a	CLIP-seq
MIRT861881	hsa-miR-20b	CLIP-seq
MIRT861882	hsa-miR-302a	CLIP-seq
MIRT861883	hsa-miR-302b	CLIP-seq
MIRT861884	hsa-miR-302c	CLIP-seq
MIRT861885	hsa-miR-302d	CLIP-seq
MIRT861886	hsa-miR-302e	CLIP-seq
MIRT861887	hsa-miR-372	CLIP-seq
MIRT861888	hsa-miR-373	CLIP-seq
MIRT861889	hsa-miR-4299	CLIP-seq
MIRT861890	hsa-miR-4330	CLIP-seq
MIRT861891	hsa-miR-4427	CLIP-seq
MIRT861892	hsa-miR-4652-5p	CLIP-seq
MIRT861893	hsa-miR-4733-5p	CLIP-seq
MIRT861894	hsa-miR-519d	CLIP-seq
MIRT861895	hsa-miR-520a-3p	CLIP-seq
MIRT861896	hsa-miR-520b	CLIP-seq
MIRT861897	hsa-miR-520c-3p	CLIP-seq
MIRT861898	hsa-miR-520d-3p	CLIP-seq
MIRT861899	hsa-miR-520e	CLIP-seq
MIRT861900	hsa-miR-520g	CLIP-seq
MIRT861901	hsa-miR-520h	CLIP-seq
MIRT861902	hsa-miR-542-3p	CLIP-seq
MIRT861903	hsa-miR-582-3p	CLIP-seq
MIRT861904	hsa-miR-93	CLIP-seq

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GO ID	Ontology	Definition	Evidence
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA

MIM	HGNC	e!Ensembl
610228	16663	ENSG00000162949

Q6MZZ7

Protein name

Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13)

Protein function

Probable non-lysosomal thiol-protease.

PDB

2I7A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00648	Peptidase_C2	35 → 331	Calpain family cysteine protease	Family
PF01067	Calpain_III	354 → 474	Calpain large subunit, domain III	Domain

Tissue specificity

TISSUE SPECIFICITY: Weakly expressed in lung and testis. Weakly or not expressed in other tissues. {ECO:0000269|PubMed:11675017}.

Sequence

MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNV
IWKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSH
QYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQA
MENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPR
KSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGN
TAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE
KFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRIFLKMPDS
DRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSL
DECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTD
FLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEM
EWMSLVMYN

Sequence length

669

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OROPHARYNX CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	32079541	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	26399219	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	26399219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	26399219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	20591971	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CAPN13 (calpain 13)