Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	92259
Gene name	Alpha-ketoglutarate dehydrogenase subunit 4
Gene symbol	KGD4
Synonyms (NCBI Gene)	DC47MRP-S36MRPS36
Chromosome	5
Chromosome location	5q13.2

108

Show/Hide all (108)

miRTarBase ID	miRNA	Experiments
MIRT1160439	hsa-miR-106a	CLIP-seq
MIRT1160440	hsa-miR-106b	CLIP-seq
MIRT1160441	hsa-miR-1257	CLIP-seq
MIRT1160442	hsa-miR-17	CLIP-seq
MIRT1160443	hsa-miR-20a	CLIP-seq
MIRT1160444	hsa-miR-20b	CLIP-seq
MIRT1160445	hsa-miR-3123	CLIP-seq
MIRT1160446	hsa-miR-3145-5p	CLIP-seq
MIRT1160447	hsa-miR-3609	CLIP-seq
MIRT1160448	hsa-miR-3611	CLIP-seq
MIRT1160449	hsa-miR-3688-3p	CLIP-seq
MIRT1160450	hsa-miR-3925-3p	CLIP-seq
MIRT1160451	hsa-miR-4477a	CLIP-seq
MIRT1160452	hsa-miR-4712-5p	CLIP-seq
MIRT1160453	hsa-miR-4796-3p	CLIP-seq
MIRT1160454	hsa-miR-508-5p	CLIP-seq
MIRT1160455	hsa-miR-519d	CLIP-seq
MIRT1160456	hsa-miR-548a-5p	CLIP-seq
MIRT1160457	hsa-miR-548ab	CLIP-seq
MIRT1160458	hsa-miR-548ah	CLIP-seq
MIRT1160459	hsa-miR-548ak	CLIP-seq
MIRT1160460	hsa-miR-548b-5p	CLIP-seq
MIRT1160461	hsa-miR-548c-5p	CLIP-seq
MIRT1160462	hsa-miR-548d-5p	CLIP-seq
MIRT1160463	hsa-miR-548h	CLIP-seq
MIRT1160464	hsa-miR-548i	CLIP-seq
MIRT1160465	hsa-miR-548j	CLIP-seq
MIRT1160466	hsa-miR-548m	CLIP-seq
MIRT1160467	hsa-miR-548w	CLIP-seq
MIRT1160468	hsa-miR-548y	CLIP-seq
MIRT1160469	hsa-miR-559	CLIP-seq
MIRT1160470	hsa-miR-579	CLIP-seq
MIRT1160471	hsa-miR-582-5p	CLIP-seq
MIRT1160472	hsa-miR-616	CLIP-seq
MIRT1160473	hsa-miR-7	CLIP-seq
MIRT1160474	hsa-miR-770-5p	CLIP-seq
MIRT1160475	hsa-miR-889	CLIP-seq
MIRT1160476	hsa-miR-93	CLIP-seq
MIRT1160466	hsa-miR-548m	CLIP-seq
MIRT1160470	hsa-miR-579	CLIP-seq
MIRT1160471	hsa-miR-582-5p	CLIP-seq
MIRT1160475	hsa-miR-889	CLIP-seq
MIRT2275181	hsa-miR-4720-3p	CLIP-seq
MIRT2275182	hsa-miR-4804-3p	CLIP-seq
MIRT2275183	hsa-miR-548g	CLIP-seq
MIRT2275184	hsa-miR-548u	CLIP-seq
MIRT1160439	hsa-miR-106a	CLIP-seq
MIRT1160440	hsa-miR-106b	CLIP-seq
MIRT1160442	hsa-miR-17	CLIP-seq
MIRT1160443	hsa-miR-20a	CLIP-seq
MIRT1160444	hsa-miR-20b	CLIP-seq
MIRT2574189	hsa-miR-3115	CLIP-seq
MIRT1160447	hsa-miR-3609	CLIP-seq
MIRT2574190	hsa-miR-4643	CLIP-seq
MIRT2574191	hsa-miR-466	CLIP-seq
MIRT2574192	hsa-miR-4789-3p	CLIP-seq
MIRT1160453	hsa-miR-4796-3p	CLIP-seq
MIRT2574193	hsa-miR-513a-3p	CLIP-seq
MIRT1160455	hsa-miR-519d	CLIP-seq
MIRT1160456	hsa-miR-548a-5p	CLIP-seq
MIRT1160457	hsa-miR-548ab	CLIP-seq
MIRT1160458	hsa-miR-548ah	CLIP-seq
MIRT1160459	hsa-miR-548ak	CLIP-seq
MIRT1160460	hsa-miR-548b-5p	CLIP-seq
MIRT1160461	hsa-miR-548c-5p	CLIP-seq
MIRT1160462	hsa-miR-548d-5p	CLIP-seq
MIRT1160463	hsa-miR-548h	CLIP-seq
MIRT1160464	hsa-miR-548i	CLIP-seq
MIRT1160465	hsa-miR-548j	CLIP-seq
MIRT1160467	hsa-miR-548w	CLIP-seq
MIRT1160468	hsa-miR-548y	CLIP-seq
MIRT1160469	hsa-miR-559	CLIP-seq
MIRT2574194	hsa-miR-587	CLIP-seq
MIRT1160476	hsa-miR-93	CLIP-seq
MIRT1160439	hsa-miR-106a	CLIP-seq
MIRT1160440	hsa-miR-106b	CLIP-seq
MIRT2685361	hsa-miR-147	CLIP-seq
MIRT1160442	hsa-miR-17	CLIP-seq
MIRT1160443	hsa-miR-20a	CLIP-seq
MIRT1160444	hsa-miR-20b	CLIP-seq
MIRT2685362	hsa-miR-218	CLIP-seq
MIRT2574189	hsa-miR-3115	CLIP-seq
MIRT2685363	hsa-miR-3140-3p	CLIP-seq
MIRT1160447	hsa-miR-3609	CLIP-seq
MIRT2685364	hsa-miR-4289	CLIP-seq
MIRT2574190	hsa-miR-4643	CLIP-seq
MIRT2574191	hsa-miR-466	CLIP-seq
MIRT2574192	hsa-miR-4789-3p	CLIP-seq
MIRT1160453	hsa-miR-4796-3p	CLIP-seq
MIRT2574193	hsa-miR-513a-3p	CLIP-seq
MIRT1160455	hsa-miR-519d	CLIP-seq
MIRT1160456	hsa-miR-548a-5p	CLIP-seq
MIRT1160457	hsa-miR-548ab	CLIP-seq
MIRT1160458	hsa-miR-548ah	CLIP-seq
MIRT1160459	hsa-miR-548ak	CLIP-seq
MIRT1160460	hsa-miR-548b-5p	CLIP-seq
MIRT1160461	hsa-miR-548c-5p	CLIP-seq
MIRT1160462	hsa-miR-548d-5p	CLIP-seq
MIRT1160463	hsa-miR-548h	CLIP-seq
MIRT1160464	hsa-miR-548i	CLIP-seq
MIRT1160465	hsa-miR-548j	CLIP-seq
MIRT1160467	hsa-miR-548w	CLIP-seq
MIRT1160468	hsa-miR-548y	CLIP-seq
MIRT1160469	hsa-miR-559	CLIP-seq
MIRT2574194	hsa-miR-587	CLIP-seq
MIRT2685365	hsa-miR-633	CLIP-seq
MIRT2685366	hsa-miR-636	CLIP-seq
MIRT1160476	hsa-miR-93	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006099	Process	Tricarboxylic acid cycle	ISO
GO:0006103	Process	2-oxoglutarate metabolic process	IBA
GO:0006103	Process	2-oxoglutarate metabolic process	IEA
GO:0006103	Process	2-oxoglutarate metabolic process	ISO
GO:0006103	Process	2-oxoglutarate metabolic process	ISS
GO:0030674	Function	Protein-macromolecule adaptor activity	IEA
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IBA
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IEA
GO:0045252	Component	Oxoglutarate dehydrogenase complex	ISO
GO:0045252	Component	Oxoglutarate dehydrogenase complex	ISS

MIM	HGNC	e!Ensembl
611996	16631	ENSG00000134056

P82909

Protein name

Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4)

Protein function

Molecular adapter that is necessary to form a stable 2-oxoglutarate dehydrogenase enzyme complex (OGDHC). Enables the specific recruitment of E3 subunit to E2 subunit in the 2-oxoglutarate dehydrogenase complex (OGDHC). {ECO:0000250|UniProtKB:Q9

Family and domains

Sequence

MMGSKMASASRVVQVVKPHTPLIRFPDRRDNPKPNVSEALRSAGLPSHSSVISQHSKGSK
SPDLLMYQGPPDTAEIIKTLPQKYRRKLVSQEEMEFIQRGGPE

Sequence length

103

Interactions

View interactions

	Reactome
			Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LEIGH SYNDROME	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	22102698	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KGD4 (alpha-ketoglutarate dehydrogenase subunit 4)