Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9209
Gene name	LRR binding FLII interacting protein 2
Gene symbol	LRRFIP2
Synonyms (NCBI Gene)	HUFI-2
Chromosome	3
Chromosome location	3p22.2
Summary	The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded prote

232

Show/Hide all (232)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022838	hsa-miR-124-3p	Microarray	18668037
MIRT024927	hsa-miR-215-5p	Microarray	19074876
MIRT026617	hsa-miR-192-5p	Microarray	19074876
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT547551	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT547550	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT547549	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT547548	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT547545	hsa-miR-3163	PAR-CLIP	20371350
MIRT547543	hsa-miR-4719	PAR-CLIP	20371350
MIRT547542	hsa-miR-922	PAR-CLIP	20371350
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT547551	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT547550	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT547549	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT547548	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT547544	hsa-miR-577	PAR-CLIP	20371350
MIRT547545	hsa-miR-3163	PAR-CLIP	20371350
MIRT547543	hsa-miR-4719	PAR-CLIP	20371350
MIRT547542	hsa-miR-922	PAR-CLIP	20371350
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT547551	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT547550	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT547549	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT547548	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT547544	hsa-miR-577	PAR-CLIP	21572407
MIRT547545	hsa-miR-3163	PAR-CLIP	21572407
MIRT547543	hsa-miR-4719	PAR-CLIP	21572407
MIRT547542	hsa-miR-922	PAR-CLIP	21572407
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT547540	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT547551	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT547550	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT547549	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT547548	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT547544	hsa-miR-577	PAR-CLIP	21572407
MIRT547545	hsa-miR-3163	PAR-CLIP	21572407
MIRT547543	hsa-miR-4719	PAR-CLIP	21572407
MIRT547542	hsa-miR-922	PAR-CLIP	21572407
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT547540	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT547551	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT547550	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT547549	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT547548	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT547545	hsa-miR-3163	PAR-CLIP	20371350
MIRT547543	hsa-miR-4719	PAR-CLIP	20371350
MIRT547542	hsa-miR-922	PAR-CLIP	20371350
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT547551	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT547550	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT547549	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT547548	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT547544	hsa-miR-577	PAR-CLIP	20371350
MIRT547545	hsa-miR-3163	PAR-CLIP	20371350
MIRT547543	hsa-miR-4719	PAR-CLIP	20371350
MIRT547542	hsa-miR-922	PAR-CLIP	20371350
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT547551	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT547550	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT547549	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT547548	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT547544	hsa-miR-577	PAR-CLIP	21572407
MIRT547545	hsa-miR-3163	PAR-CLIP	21572407
MIRT547543	hsa-miR-4719	PAR-CLIP	21572407
MIRT547542	hsa-miR-922	PAR-CLIP	21572407
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT547540	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT547552	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT547551	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT547550	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT547549	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT547548	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT547547	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT547546	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT547544	hsa-miR-577	PAR-CLIP	21572407
MIRT547545	hsa-miR-3163	PAR-CLIP	21572407
MIRT547543	hsa-miR-4719	PAR-CLIP	21572407
MIRT547542	hsa-miR-922	PAR-CLIP	21572407
MIRT547541	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT547540	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT1120884	hsa-miR-1296	CLIP-seq
MIRT1120885	hsa-miR-1910	CLIP-seq
MIRT1120886	hsa-miR-196a	CLIP-seq
MIRT1120887	hsa-miR-196b	CLIP-seq
MIRT1120888	hsa-miR-2114	CLIP-seq
MIRT1120889	hsa-miR-296-5p	CLIP-seq
MIRT1120890	hsa-miR-3927	CLIP-seq
MIRT1120891	hsa-miR-412	CLIP-seq
MIRT1120892	hsa-miR-4512	CLIP-seq
MIRT1120893	hsa-miR-455-3p	CLIP-seq
MIRT1120894	hsa-miR-4659a-3p	CLIP-seq
MIRT1120895	hsa-miR-4659b-3p	CLIP-seq
MIRT1120896	hsa-miR-4726-3p	CLIP-seq
MIRT1120897	hsa-miR-592	CLIP-seq
MIRT1120898	hsa-miR-597	CLIP-seq
MIRT1120899	hsa-miR-599	CLIP-seq
MIRT1120900	hsa-miR-642a	CLIP-seq
MIRT1120901	hsa-miR-1298	CLIP-seq
MIRT1120902	hsa-miR-1304	CLIP-seq
MIRT1120903	hsa-miR-15a	CLIP-seq
MIRT1120904	hsa-miR-15b	CLIP-seq
MIRT1120905	hsa-miR-16	CLIP-seq
MIRT1120906	hsa-miR-195	CLIP-seq
MIRT1120907	hsa-miR-3120-3p	CLIP-seq
MIRT1120908	hsa-miR-3185	CLIP-seq
MIRT1120909	hsa-miR-3692	CLIP-seq
MIRT1120910	hsa-miR-424	CLIP-seq
MIRT1120911	hsa-miR-4709-3p	CLIP-seq
MIRT1120912	hsa-miR-497	CLIP-seq
MIRT1120913	hsa-miR-624	CLIP-seq
MIRT1120914	hsa-miR-629	CLIP-seq
MIRT1120902	hsa-miR-1304	CLIP-seq
MIRT1120908	hsa-miR-3185	CLIP-seq
MIRT1120915	hsa-miR-3940-5p	CLIP-seq
MIRT1120916	hsa-miR-4507	CLIP-seq
MIRT1120911	hsa-miR-4709-3p	CLIP-seq
MIRT1120914	hsa-miR-629	CLIP-seq
MIRT1120917	hsa-miR-711	CLIP-seq
MIRT1120901	hsa-miR-1298	CLIP-seq
MIRT2034230	hsa-miR-2964a-3p	CLIP-seq
MIRT2034231	hsa-miR-4691-5p	CLIP-seq
MIRT1120901	hsa-miR-1298	CLIP-seq
MIRT1120903	hsa-miR-15a	CLIP-seq
MIRT1120904	hsa-miR-15b	CLIP-seq
MIRT1120905	hsa-miR-16	CLIP-seq
MIRT1120906	hsa-miR-195	CLIP-seq
MIRT1120907	hsa-miR-3120-3p	CLIP-seq
MIRT2264675	hsa-miR-3663-3p	CLIP-seq
MIRT1120909	hsa-miR-3692	CLIP-seq
MIRT1120910	hsa-miR-424	CLIP-seq
MIRT2264676	hsa-miR-4264	CLIP-seq
MIRT2264677	hsa-miR-4276	CLIP-seq
MIRT2264678	hsa-miR-4649-3p	CLIP-seq
MIRT2264679	hsa-miR-4797-3p	CLIP-seq
MIRT1120912	hsa-miR-497	CLIP-seq
MIRT1120913	hsa-miR-624	CLIP-seq
MIRT2563549	hsa-miR-101	CLIP-seq
MIRT2563550	hsa-miR-1207-3p	CLIP-seq
MIRT2563551	hsa-miR-1269	CLIP-seq
MIRT2563552	hsa-miR-1269b	CLIP-seq
MIRT2563553	hsa-miR-1283	CLIP-seq
MIRT2563554	hsa-miR-1288	CLIP-seq
MIRT2563555	hsa-miR-1323	CLIP-seq
MIRT2563556	hsa-miR-1827	CLIP-seq
MIRT2563557	hsa-miR-2110	CLIP-seq
MIRT2563558	hsa-miR-3065-5p	CLIP-seq
MIRT2563559	hsa-miR-30a	CLIP-seq
MIRT2563560	hsa-miR-30b	CLIP-seq
MIRT2563561	hsa-miR-30c	CLIP-seq
MIRT2563562	hsa-miR-30d	CLIP-seq
MIRT2563563	hsa-miR-30e	CLIP-seq
MIRT2563564	hsa-miR-3148	CLIP-seq
MIRT2563565	hsa-miR-371b-5p	CLIP-seq
MIRT2563566	hsa-miR-3936	CLIP-seq
MIRT2563567	hsa-miR-4271	CLIP-seq
MIRT2563568	hsa-miR-4275	CLIP-seq
MIRT2563569	hsa-miR-4515	CLIP-seq
MIRT2563570	hsa-miR-4667-5p	CLIP-seq
MIRT2563571	hsa-miR-4668-5p	CLIP-seq
MIRT2563572	hsa-miR-4700-5p	CLIP-seq
MIRT2563573	hsa-miR-4725-3p	CLIP-seq
MIRT2563574	hsa-miR-4731-5p	CLIP-seq
MIRT2563575	hsa-miR-4740-5p	CLIP-seq
MIRT2563576	hsa-miR-4788	CLIP-seq
MIRT2563577	hsa-miR-548ac	CLIP-seq
MIRT2563578	hsa-miR-548ae	CLIP-seq
MIRT2563579	hsa-miR-548aj	CLIP-seq
MIRT2563580	hsa-miR-548am	CLIP-seq
MIRT2563581	hsa-miR-548d-3p	CLIP-seq
MIRT2563582	hsa-miR-548o	CLIP-seq
MIRT2563583	hsa-miR-548x	CLIP-seq
MIRT2563584	hsa-miR-548z	CLIP-seq
MIRT1120897	hsa-miR-592	CLIP-seq
MIRT1120898	hsa-miR-597	CLIP-seq
MIRT1120899	hsa-miR-599	CLIP-seq
MIRT2563585	hsa-miR-888	CLIP-seq
MIRT2563549	hsa-miR-101	CLIP-seq
MIRT2563550	hsa-miR-1207-3p	CLIP-seq
MIRT2563551	hsa-miR-1269	CLIP-seq
MIRT2563552	hsa-miR-1269b	CLIP-seq
MIRT2563553	hsa-miR-1283	CLIP-seq
MIRT2563554	hsa-miR-1288	CLIP-seq
MIRT2563555	hsa-miR-1323	CLIP-seq
MIRT2563556	hsa-miR-1827	CLIP-seq
MIRT2563557	hsa-miR-2110	CLIP-seq
MIRT2563559	hsa-miR-30a	CLIP-seq
MIRT2563560	hsa-miR-30b	CLIP-seq
MIRT2563561	hsa-miR-30c	CLIP-seq
MIRT2563562	hsa-miR-30d	CLIP-seq
MIRT2563563	hsa-miR-30e	CLIP-seq
MIRT2563564	hsa-miR-3148	CLIP-seq
MIRT2563565	hsa-miR-371b-5p	CLIP-seq
MIRT2563567	hsa-miR-4271	CLIP-seq
MIRT2563568	hsa-miR-4275	CLIP-seq
MIRT2563569	hsa-miR-4515	CLIP-seq
MIRT2563570	hsa-miR-4667-5p	CLIP-seq
MIRT2563571	hsa-miR-4668-5p	CLIP-seq
MIRT2563572	hsa-miR-4700-5p	CLIP-seq
MIRT2563573	hsa-miR-4725-3p	CLIP-seq
MIRT2563574	hsa-miR-4731-5p	CLIP-seq
MIRT2563575	hsa-miR-4740-5p	CLIP-seq
MIRT2563576	hsa-miR-4788	CLIP-seq
MIRT2563577	hsa-miR-548ac	CLIP-seq
MIRT2563578	hsa-miR-548ae	CLIP-seq
MIRT2563579	hsa-miR-548aj	CLIP-seq
MIRT2563580	hsa-miR-548am	CLIP-seq
MIRT2563581	hsa-miR-548d-3p	CLIP-seq
MIRT2563582	hsa-miR-548o	CLIP-seq
MIRT2563583	hsa-miR-548x	CLIP-seq
MIRT2563584	hsa-miR-548z	CLIP-seq
MIRT2563585	hsa-miR-888	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10366446, 15677333, 25416956, 25910212, 31515488, 33961781
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030275	Function	LRR domain binding	IPI	10366446

MIM	HGNC	e!Ensembl
614043	6703	ENSG00000093167

Q9Y608

Protein name

Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)

Protein function

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09738	LRRFIP	31 → 145	LRRFIP family	Family
PF09738	LRRFIP	290 → 460	LRRFIP family	Family
PF09738	LRRFIP	457 → 646	LRRFIP family	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:10366446}.

Sequence

MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY
SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSR
LSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDP
LATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFT
NDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQY
AENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGR
YMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE
NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETL
LWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSH
EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR
NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR
YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ
Q

Sequence length

721

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	23240038, 32828126	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	21712435, 21785361	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Nonpolyposis Colorectal Cancer	Colorectal Cancer	BEFREE	21785361		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lynch Syndrome	Lynch Syndrome	BEFREE	21785361		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19188145		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	34371182	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	18353764	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36307405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LRRFIP2 (LRR binding FLII interacting protein 2)