LRRFIP1 (LRR binding FLII interacting protein 1)

Gene

• Entrez ID: 9208
• Gene name: LRR binding FLII interacting protein 1
• Gene symbol: LRRFIP1
• Synonyms (NCBI Gene): FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP
• Chromosome: 2
• Chromosome location: 2q37.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001220	hsa-miR-21-5p	semi-qRT-PCR, Luciferase reporter assay, Western blot	19559015
MIRT001220	hsa-miR-21-5p	Luciferase reporter assay	19559015
MIRT001220	hsa-miR-21-5p	Luciferase reporter assay	19559015
MIRT001220	hsa-miR-21-5p	Luciferase reporter assay	19559015
MIRT005182	hsa-miR-30a-5p	pSILAC	18668040
MIRT024762	hsa-miR-215-5p	Microarray	19074876
MIRT025366	hsa-miR-34a-5p	Proteomics	21566225
MIRT025366	hsa-miR-34a-5p	Proteomics	21566225
MIRT026309	hsa-miR-192-5p	Microarray	19074876
MIRT005182	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT045426	hsa-miR-149-5p	CLASH	23622248
MIRT045105	hsa-miR-186-5p	CLASH	23622248
MIRT037289	hsa-miR-877-5p	CLASH	23622248
MIRT037048	hsa-miR-877-3p	CLASH	23622248
MIRT001220	hsa-miR-21-5p	Immunohistochemistry, Western blot	24690174
MIRT648109	hsa-miR-4267	HITS-CLIP	23824327
MIRT037048	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT648108	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT648107	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648106	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648105	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT648104	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT648103	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT648102	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT648101	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT648100	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT648098	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT648099	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT648097	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT648096	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT648095	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT440307	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440307	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT648109	hsa-miR-4267	HITS-CLIP	23824327
MIRT037048	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT648108	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT648107	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648106	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648105	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT648104	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT648103	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT648102	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT648101	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT648100	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT648098	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT648099	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT648097	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT648096	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT648095	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT1120793	hsa-miR-3674	CLIP-seq
MIRT1120794	hsa-miR-3935	CLIP-seq
MIRT1120795	hsa-miR-4659a-5p	CLIP-seq
MIRT1120796	hsa-miR-4659b-5p	CLIP-seq
MIRT1120797	hsa-miR-4724-5p	CLIP-seq
MIRT1120798	hsa-miR-4727-5p	CLIP-seq
MIRT1120799	hsa-miR-4769-3p	CLIP-seq
MIRT1120800	hsa-miR-488	CLIP-seq
MIRT1120801	hsa-miR-122	CLIP-seq
MIRT1120802	hsa-miR-124	CLIP-seq
MIRT1120803	hsa-miR-133a	CLIP-seq
MIRT1120804	hsa-miR-133b	CLIP-seq
MIRT1120805	hsa-miR-337-3p	CLIP-seq
MIRT1120806	hsa-miR-3652	CLIP-seq
MIRT1120807	hsa-miR-3714	CLIP-seq
MIRT1120808	hsa-miR-3910	CLIP-seq
MIRT1120809	hsa-miR-4430	CLIP-seq
MIRT1120810	hsa-miR-4438	CLIP-seq
MIRT1120811	hsa-miR-4505	CLIP-seq
MIRT1120812	hsa-miR-4797-5p	CLIP-seq
MIRT1120813	hsa-miR-506	CLIP-seq
MIRT1120814	hsa-miR-5095	CLIP-seq
MIRT1120815	hsa-miR-516b	CLIP-seq
MIRT1120816	hsa-let-7a	CLIP-seq
MIRT1120817	hsa-let-7b	CLIP-seq
MIRT1120818	hsa-let-7c	CLIP-seq
MIRT1120819	hsa-let-7d	CLIP-seq
MIRT1120820	hsa-let-7e	CLIP-seq
MIRT1120821	hsa-let-7f	CLIP-seq
MIRT1120822	hsa-let-7g	CLIP-seq
MIRT1120823	hsa-let-7i	CLIP-seq
MIRT1120824	hsa-miR-103b	CLIP-seq
MIRT1120825	hsa-miR-1184	CLIP-seq
MIRT1120826	hsa-miR-129-5p	CLIP-seq
MIRT1120827	hsa-miR-1303	CLIP-seq
MIRT1120828	hsa-miR-132	CLIP-seq
MIRT1120829	hsa-miR-1324	CLIP-seq
MIRT1120830	hsa-miR-154	CLIP-seq
MIRT1120831	hsa-miR-181a	CLIP-seq
MIRT1120832	hsa-miR-181b	CLIP-seq
MIRT1120833	hsa-miR-181c	CLIP-seq
MIRT1120834	hsa-miR-181d	CLIP-seq
MIRT1120835	hsa-miR-192	CLIP-seq
MIRT1120836	hsa-miR-194	CLIP-seq
MIRT1120837	hsa-miR-19a	CLIP-seq
MIRT1120838	hsa-miR-19b	CLIP-seq
MIRT1120839	hsa-miR-202	CLIP-seq
MIRT1120840	hsa-miR-212	CLIP-seq
MIRT1120841	hsa-miR-215	CLIP-seq
MIRT1120842	hsa-miR-3065-5p	CLIP-seq
MIRT1120843	hsa-miR-3074-3p	CLIP-seq
MIRT1120844	hsa-miR-3121-5p	CLIP-seq
MIRT1120845	hsa-miR-3149	CLIP-seq
MIRT1120846	hsa-miR-3160-5p	CLIP-seq
MIRT1120847	hsa-miR-3163	CLIP-seq
MIRT1120848	hsa-miR-33a	CLIP-seq
MIRT1120849	hsa-miR-33b	CLIP-seq
MIRT1120850	hsa-miR-3545-3p	CLIP-seq
MIRT1120851	hsa-miR-362-5p	CLIP-seq
MIRT1120852	hsa-miR-3662	CLIP-seq
MIRT1120853	hsa-miR-374a	CLIP-seq
MIRT1120854	hsa-miR-374b	CLIP-seq
MIRT1120855	hsa-miR-3942-3p	CLIP-seq
MIRT1120856	hsa-miR-4262	CLIP-seq
MIRT1120857	hsa-miR-4418	CLIP-seq
MIRT1120858	hsa-miR-4458	CLIP-seq
MIRT1120859	hsa-miR-4484	CLIP-seq
MIRT1120860	hsa-miR-4500	CLIP-seq
MIRT1120861	hsa-miR-450b-5p	CLIP-seq
MIRT1120862	hsa-miR-4517	CLIP-seq
MIRT1120863	hsa-miR-4680-5p	CLIP-seq
MIRT1120864	hsa-miR-4687-3p	CLIP-seq
MIRT1120865	hsa-miR-4699-3p	CLIP-seq
MIRT1120866	hsa-miR-4749-3p	CLIP-seq
MIRT1120867	hsa-miR-500b	CLIP-seq
MIRT1120868	hsa-miR-501-5p	CLIP-seq
MIRT1120869	hsa-miR-505	CLIP-seq
MIRT1120870	hsa-miR-507	CLIP-seq
MIRT1120871	hsa-miR-509-3-5p	CLIP-seq
MIRT1120872	hsa-miR-509-5p	CLIP-seq
MIRT1120873	hsa-miR-543	CLIP-seq
MIRT1120874	hsa-miR-548ag	CLIP-seq
MIRT1120875	hsa-miR-548ai	CLIP-seq
MIRT1120876	hsa-miR-548an	CLIP-seq
MIRT1120877	hsa-miR-552	CLIP-seq
MIRT1120878	hsa-miR-557	CLIP-seq
MIRT1120879	hsa-miR-590-3p	CLIP-seq
MIRT1120880	hsa-miR-643	CLIP-seq
MIRT1120881	hsa-miR-647	CLIP-seq
MIRT1120882	hsa-miR-758	CLIP-seq
MIRT1120883	hsa-miR-98	CLIP-seq
MIRT1120835	hsa-miR-192	CLIP-seq
MIRT1120836	hsa-miR-194	CLIP-seq
MIRT1120841	hsa-miR-215	CLIP-seq
MIRT2034229	hsa-miR-4289	CLIP-seq
MIRT1120879	hsa-miR-590-3p	CLIP-seq
MIRT1120824	hsa-miR-103b	CLIP-seq
MIRT1120825	hsa-miR-1184	CLIP-seq
MIRT1120801	hsa-miR-122	CLIP-seq
MIRT2264585	hsa-miR-1224-3p	CLIP-seq
MIRT2264586	hsa-miR-1260	CLIP-seq
MIRT2264587	hsa-miR-1260b	CLIP-seq
MIRT2264588	hsa-miR-1262	CLIP-seq
MIRT2264589	hsa-miR-1280	CLIP-seq
MIRT2264590	hsa-miR-1283	CLIP-seq
MIRT1120828	hsa-miR-132	CLIP-seq
MIRT2264591	hsa-miR-1323	CLIP-seq
MIRT1120829	hsa-miR-1324	CLIP-seq
MIRT2264592	hsa-miR-135a	CLIP-seq
MIRT2264593	hsa-miR-135b	CLIP-seq
MIRT2264594	hsa-miR-150	CLIP-seq
MIRT1120831	hsa-miR-181a	CLIP-seq
MIRT1120832	hsa-miR-181b	CLIP-seq
MIRT1120833	hsa-miR-181c	CLIP-seq
MIRT1120834	hsa-miR-181d	CLIP-seq
MIRT2264595	hsa-miR-185	CLIP-seq
MIRT2264596	hsa-miR-1915	CLIP-seq
MIRT1120835	hsa-miR-192	CLIP-seq
MIRT1120836	hsa-miR-194	CLIP-seq
MIRT2264597	hsa-miR-198	CLIP-seq
MIRT1120837	hsa-miR-19a	CLIP-seq
MIRT1120838	hsa-miR-19b	CLIP-seq
MIRT2264598	hsa-miR-200b	CLIP-seq
MIRT2264599	hsa-miR-200c	CLIP-seq
MIRT1120840	hsa-miR-212	CLIP-seq
MIRT1120841	hsa-miR-215	CLIP-seq
MIRT2264600	hsa-miR-216b	CLIP-seq
MIRT2264601	hsa-miR-217	CLIP-seq
MIRT2264602	hsa-miR-2278	CLIP-seq
MIRT2264603	hsa-miR-299-5p	CLIP-seq
MIRT1120842	hsa-miR-3065-5p	CLIP-seq
MIRT2264604	hsa-miR-3120-5p	CLIP-seq
MIRT1120844	hsa-miR-3121-5p	CLIP-seq
MIRT2264605	hsa-miR-3135b	CLIP-seq
MIRT2264606	hsa-miR-3150a-5p	CLIP-seq
MIRT2264607	hsa-miR-3150b-5p	CLIP-seq
MIRT1120846	hsa-miR-3160-5p	CLIP-seq
MIRT1120847	hsa-miR-3163	CLIP-seq
MIRT2264608	hsa-miR-3183	CLIP-seq
MIRT2264609	hsa-miR-34a	CLIP-seq
MIRT2264610	hsa-miR-34c-5p	CLIP-seq
MIRT1120850	hsa-miR-3545-3p	CLIP-seq
MIRT2264611	hsa-miR-3616-5p	CLIP-seq
MIRT2264612	hsa-miR-3646	CLIP-seq
MIRT2264613	hsa-miR-3647-5p	CLIP-seq
MIRT1120806	hsa-miR-3652	CLIP-seq
MIRT1120852	hsa-miR-3662	CLIP-seq
MIRT2264614	hsa-miR-3663-3p	CLIP-seq
MIRT2264615	hsa-miR-3664-5p	CLIP-seq
MIRT2264616	hsa-miR-3671	CLIP-seq
MIRT2264617	hsa-miR-380	CLIP-seq
MIRT1120855	hsa-miR-3942-3p	CLIP-seq
MIRT1120856	hsa-miR-4262	CLIP-seq
MIRT2264618	hsa-miR-4263	CLIP-seq
MIRT2264619	hsa-miR-4269	CLIP-seq
MIRT2264620	hsa-miR-4275	CLIP-seq
MIRT2264621	hsa-miR-4276	CLIP-seq
MIRT2264622	hsa-miR-429	CLIP-seq
MIRT2264623	hsa-miR-4302	CLIP-seq
MIRT2264624	hsa-miR-4306	CLIP-seq
MIRT2264625	hsa-miR-4310	CLIP-seq
MIRT1120857	hsa-miR-4418	CLIP-seq
MIRT2264626	hsa-miR-4422	CLIP-seq
MIRT1120809	hsa-miR-4430	CLIP-seq
MIRT1120810	hsa-miR-4438	CLIP-seq
MIRT2264627	hsa-miR-4464	CLIP-seq
MIRT2264628	hsa-miR-4490	CLIP-seq
MIRT2264629	hsa-miR-4496	CLIP-seq
MIRT2264630	hsa-miR-449a	CLIP-seq
MIRT2264631	hsa-miR-449b	CLIP-seq
MIRT1120811	hsa-miR-4505	CLIP-seq
MIRT2264632	hsa-miR-4514	CLIP-seq
MIRT1120862	hsa-miR-4517	CLIP-seq
MIRT2264633	hsa-miR-4639-3p	CLIP-seq
MIRT2264634	hsa-miR-4644	CLIP-seq
MIRT2264635	hsa-miR-4645-5p	CLIP-seq
MIRT2264636	hsa-miR-4659a-3p	CLIP-seq
MIRT2264637	hsa-miR-4659b-3p	CLIP-seq
MIRT2264638	hsa-miR-4668-3p	CLIP-seq
MIRT2264639	hsa-miR-4670-3p	CLIP-seq
MIRT2264640	hsa-miR-4673	CLIP-seq
MIRT1120863	hsa-miR-4680-5p	CLIP-seq
MIRT1120864	hsa-miR-4687-3p	CLIP-seq
MIRT2264641	hsa-miR-4692	CLIP-seq
MIRT1120865	hsa-miR-4699-3p	CLIP-seq
MIRT2264642	hsa-miR-4701-3p	CLIP-seq
MIRT2264643	hsa-miR-4713-5p	CLIP-seq
MIRT2264644	hsa-miR-4723-3p	CLIP-seq
MIRT2264645	hsa-miR-4726-3p	CLIP-seq
MIRT2264646	hsa-miR-4732-5p	CLIP-seq
MIRT2264647	hsa-miR-4742-5p	CLIP-seq
MIRT2264648	hsa-miR-4748	CLIP-seq
MIRT1120866	hsa-miR-4749-3p	CLIP-seq
MIRT2264649	hsa-miR-4762-5p	CLIP-seq
MIRT2264650	hsa-miR-4773	CLIP-seq
MIRT2264651	hsa-miR-4795-5p	CLIP-seq
MIRT2264652	hsa-miR-4796-5p	CLIP-seq
MIRT2264653	hsa-miR-485-3p	CLIP-seq
MIRT2264654	hsa-miR-489	CLIP-seq
MIRT2264655	hsa-miR-495	CLIP-seq
MIRT1120869	hsa-miR-505	CLIP-seq
MIRT1120871	hsa-miR-509-3-5p	CLIP-seq
MIRT1120814	hsa-miR-5095	CLIP-seq
MIRT1120872	hsa-miR-509-5p	CLIP-seq
MIRT2264656	hsa-miR-511	CLIP-seq
MIRT2264657	hsa-miR-514	CLIP-seq
MIRT2264658	hsa-miR-514b-3p	CLIP-seq
MIRT2264659	hsa-miR-515-3p	CLIP-seq
MIRT1120815	hsa-miR-516b	CLIP-seq
MIRT2264660	hsa-miR-519e	CLIP-seq
MIRT2264661	hsa-miR-520d-5p	CLIP-seq
MIRT2264662	hsa-miR-524-5p	CLIP-seq
MIRT2264663	hsa-miR-532-3p	CLIP-seq
MIRT1120873	hsa-miR-543	CLIP-seq
MIRT1120874	hsa-miR-548ag	CLIP-seq
MIRT1120875	hsa-miR-548ai	CLIP-seq
MIRT2264664	hsa-miR-548l	CLIP-seq
MIRT2264665	hsa-miR-548o	CLIP-seq
MIRT2264666	hsa-miR-573	CLIP-seq
MIRT2264667	hsa-miR-576-5p	CLIP-seq
MIRT2264668	hsa-miR-600	CLIP-seq
MIRT1120880	hsa-miR-643	CLIP-seq
MIRT1120881	hsa-miR-647	CLIP-seq
MIRT2264669	hsa-miR-648	CLIP-seq
MIRT2264670	hsa-miR-654-3p	CLIP-seq
MIRT1120882	hsa-miR-758	CLIP-seq
MIRT2264671	hsa-miR-767-3p	CLIP-seq
MIRT2264672	hsa-miR-802	CLIP-seq
MIRT2264673	hsa-miR-936	CLIP-seq
MIRT2264674	hsa-miR-943	CLIP-seq
MIRT2264597	hsa-miR-198	CLIP-seq
MIRT1120806	hsa-miR-3652	CLIP-seq
MIRT1120809	hsa-miR-4430	CLIP-seq
MIRT2264635	hsa-miR-4645-5p	CLIP-seq
MIRT2264640	hsa-miR-4673	CLIP-seq
MIRT1120812	hsa-miR-4797-5p	CLIP-seq
MIRT2563525	hsa-miR-1273e	CLIP-seq
MIRT2563526	hsa-miR-1273g	CLIP-seq
MIRT2563527	hsa-miR-1276	CLIP-seq
MIRT2563528	hsa-miR-128	CLIP-seq
MIRT2264592	hsa-miR-135a	CLIP-seq
MIRT2264593	hsa-miR-135b	CLIP-seq
MIRT2563529	hsa-miR-145	CLIP-seq
MIRT2563530	hsa-miR-1825	CLIP-seq
MIRT2563531	hsa-miR-188-5p	CLIP-seq
MIRT2563532	hsa-miR-199a-5p	CLIP-seq
MIRT2563533	hsa-miR-199b-5p	CLIP-seq
MIRT2563534	hsa-miR-2052	CLIP-seq
MIRT2563535	hsa-miR-2113	CLIP-seq
MIRT2563536	hsa-miR-3180-5p	CLIP-seq
MIRT2563537	hsa-miR-3607-3p	CLIP-seq
MIRT2563538	hsa-miR-3692	CLIP-seq
MIRT2563539	hsa-miR-4311	CLIP-seq
MIRT2563540	hsa-miR-4313	CLIP-seq
MIRT2563541	hsa-miR-4423-5p	CLIP-seq
MIRT2264638	hsa-miR-4668-3p	CLIP-seq
MIRT1120797	hsa-miR-4724-5p	CLIP-seq
MIRT2563542	hsa-miR-4778-3p	CLIP-seq
MIRT2563543	hsa-miR-548c-3p	CLIP-seq
MIRT2563544	hsa-miR-579	CLIP-seq
MIRT2563545	hsa-miR-583	CLIP-seq
MIRT2563546	hsa-miR-599	CLIP-seq
MIRT2563547	hsa-miR-605	CLIP-seq
MIRT2563548	hsa-miR-924	CLIP-seq
MIRT2563525	hsa-miR-1273e	CLIP-seq
MIRT2563526	hsa-miR-1273g	CLIP-seq
MIRT2563528	hsa-miR-128	CLIP-seq
MIRT2264592	hsa-miR-135a	CLIP-seq
MIRT2264593	hsa-miR-135b	CLIP-seq
MIRT2563529	hsa-miR-145	CLIP-seq
MIRT2563530	hsa-miR-1825	CLIP-seq
MIRT2563532	hsa-miR-199a-5p	CLIP-seq
MIRT2563533	hsa-miR-199b-5p	CLIP-seq
MIRT2563534	hsa-miR-2052	CLIP-seq
MIRT2563535	hsa-miR-2113	CLIP-seq
MIRT2563536	hsa-miR-3180-5p	CLIP-seq
MIRT2563538	hsa-miR-3692	CLIP-seq
MIRT2563540	hsa-miR-4313	CLIP-seq
MIRT2563546	hsa-miR-599	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	14522076
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	14522076
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	14522076
GO:0003677	Function	DNA binding	IDA	23099021
GO:0003677	Function	DNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	TAS	9671805
GO:0005515	Function	Protein binding	IPI	9671805, 10366446, 25416956, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9671805
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	TAS	9671805
GO:0005886	Component	Plasma membrane	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0042803	Function	Protein homodimerization activity	IDA	23099021
GO:0045296	Function	Cadherin binding	HDA	25468996

Other IDs

• MIM: 603256
• HGNC: 6702
• e!Ensembl: ENSG00000124831

Protein

• UniProt ID: Q32MZ4
• Protein name: Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein)
• Protein function: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA re
• PDB: 4H22
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09738	LRRFIP	23 → 353	LRRFIP family	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:9671805, ECO:0000269|PubMed:9705290}.
• Sequence:

  MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRR
  SRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS
  GDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ
  LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA
  LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS
  EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG
  TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT
  ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE
  AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT
  QNEPLDMKEPDEEKSDQQGEALDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT
  DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG
  DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS
  EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE
  PGHFNPESREDTRGGNEKGKSKEDCTMS

• Sequence length: 808

Pathways

Reactome:

Signaling by cytosolic FGFR1 fusion mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Signaling by FGFR1 in disease

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autism Spectrum Disorder	Autism	Pubtator	36938998	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	30709060		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23181716	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24761896	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26047573, 27171439		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	16520390, 30709060		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	22750095		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	39596218	Associate	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	28717191		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	34385509	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	BEFREE	19559015, 24690174		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	25904638, 35338570	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	19559015, 24690174		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35338570	Associate	★☆☆☆☆ Found in Text Mining only
Intrahepatic Cholangiocarcinoma	Intrahepatic Cholangiocarcinoma	BEFREE	31545502		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	24761896		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	24761896		★☆☆☆☆ Found in Text Mining only
Lung Diseases, Interstitial	Lung Diseases	BEFREE	30886067		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26047573, 27171439		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26047573		★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	40420163	Associate	★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	20833976		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19389625		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30709060		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Papillary craniopharyngioma	Papillary Craniopharyngioma	BEFREE	21140450		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36601001	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	27271164		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	28717191		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASDB_DG	21795503		★★☆☆☆ Found in Text Mining + Unknown/Other Associations