Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	91862
Gene name	MARVEL domain containing 3
Gene symbol	MARVELD3
Synonyms (NCBI Gene)	MARVD3MRVLDC3
Chromosome	16
Chromosome location	16q22.2

213

Show/Hide all (213)

miRTarBase ID	miRNA	Experiments
MIRT1132905	hsa-miR-106a	CLIP-seq
MIRT1132906	hsa-miR-106b	CLIP-seq
MIRT1132907	hsa-miR-1178	CLIP-seq
MIRT1132908	hsa-miR-122	CLIP-seq
MIRT1132909	hsa-miR-125a-3p	CLIP-seq
MIRT1132910	hsa-miR-1297	CLIP-seq
MIRT1132911	hsa-miR-17	CLIP-seq
MIRT1132912	hsa-miR-1915	CLIP-seq
MIRT1132913	hsa-miR-20a	CLIP-seq
MIRT1132914	hsa-miR-20b	CLIP-seq
MIRT1132915	hsa-miR-26a	CLIP-seq
MIRT1132916	hsa-miR-26b	CLIP-seq
MIRT1132917	hsa-miR-302a	CLIP-seq
MIRT1132918	hsa-miR-302b	CLIP-seq
MIRT1132919	hsa-miR-302c	CLIP-seq
MIRT1132920	hsa-miR-302d	CLIP-seq
MIRT1132921	hsa-miR-302e	CLIP-seq
MIRT1132922	hsa-miR-3609	CLIP-seq
MIRT1132923	hsa-miR-3652	CLIP-seq
MIRT1132924	hsa-miR-372	CLIP-seq
MIRT1132925	hsa-miR-373	CLIP-seq
MIRT1132926	hsa-miR-378	CLIP-seq
MIRT1132927	hsa-miR-378b	CLIP-seq
MIRT1132928	hsa-miR-378c	CLIP-seq
MIRT1132929	hsa-miR-378d	CLIP-seq
MIRT1132930	hsa-miR-378e	CLIP-seq
MIRT1132931	hsa-miR-378f	CLIP-seq
MIRT1132932	hsa-miR-378h	CLIP-seq
MIRT1132933	hsa-miR-378i	CLIP-seq
MIRT1132934	hsa-miR-422a	CLIP-seq
MIRT1132935	hsa-miR-4312	CLIP-seq
MIRT1132936	hsa-miR-4430	CLIP-seq
MIRT1132937	hsa-miR-4465	CLIP-seq
MIRT1132938	hsa-miR-4501	CLIP-seq
MIRT1132939	hsa-miR-455-3p	CLIP-seq
MIRT1132940	hsa-miR-4653-3p	CLIP-seq
MIRT1132941	hsa-miR-4685-5p	CLIP-seq
MIRT1132942	hsa-miR-4686	CLIP-seq
MIRT1132943	hsa-miR-4709-3p	CLIP-seq
MIRT1132944	hsa-miR-4726-3p	CLIP-seq
MIRT1132945	hsa-miR-4731-5p	CLIP-seq
MIRT1132946	hsa-miR-4755-3p	CLIP-seq
MIRT1132947	hsa-miR-4757-5p	CLIP-seq
MIRT1132948	hsa-miR-4763-5p	CLIP-seq
MIRT1132949	hsa-miR-4772-3p	CLIP-seq
MIRT1132950	hsa-miR-4796-3p	CLIP-seq
MIRT1132951	hsa-miR-5095	CLIP-seq
MIRT1132952	hsa-miR-512-3p	CLIP-seq
MIRT1132953	hsa-miR-519d	CLIP-seq
MIRT1132954	hsa-miR-520a-3p	CLIP-seq
MIRT1132955	hsa-miR-520b	CLIP-seq
MIRT1132956	hsa-miR-520c-3p	CLIP-seq
MIRT1132957	hsa-miR-520d-3p	CLIP-seq
MIRT1132958	hsa-miR-520e	CLIP-seq
MIRT1132959	hsa-miR-548aa	CLIP-seq
MIRT1132960	hsa-miR-548ah	CLIP-seq
MIRT1132961	hsa-miR-570	CLIP-seq
MIRT1132962	hsa-miR-578	CLIP-seq
MIRT1132963	hsa-miR-581	CLIP-seq
MIRT1132964	hsa-miR-595	CLIP-seq
MIRT1132965	hsa-miR-628-5p	CLIP-seq
MIRT1132966	hsa-miR-93	CLIP-seq
MIRT1132967	hsa-miR-150	CLIP-seq
MIRT1551167	hsa-miR-4258	CLIP-seq
MIRT1551168	hsa-miR-4707-3p	CLIP-seq
MIRT1551169	hsa-miR-4735-5p	CLIP-seq
MIRT1551170	hsa-miR-4775	CLIP-seq
MIRT1551171	hsa-miR-4794	CLIP-seq
MIRT1551172	hsa-miR-590-3p	CLIP-seq
MIRT1132908	hsa-miR-122	CLIP-seq
MIRT2037918	hsa-miR-1587	CLIP-seq
MIRT2037919	hsa-miR-1908	CLIP-seq
MIRT2037920	hsa-miR-3135b	CLIP-seq
MIRT2037921	hsa-miR-3192	CLIP-seq
MIRT2037922	hsa-miR-3622a-3p	CLIP-seq
MIRT2037923	hsa-miR-3622b-3p	CLIP-seq
MIRT1132923	hsa-miR-3652	CLIP-seq
MIRT2037924	hsa-miR-378g	CLIP-seq
MIRT2037925	hsa-miR-4300	CLIP-seq
MIRT1132936	hsa-miR-4430	CLIP-seq
MIRT2037926	hsa-miR-4492	CLIP-seq
MIRT2037927	hsa-miR-4498	CLIP-seq
MIRT2037928	hsa-miR-4656	CLIP-seq
MIRT2037929	hsa-miR-4675	CLIP-seq
MIRT2037930	hsa-miR-4741	CLIP-seq
MIRT2037931	hsa-miR-663	CLIP-seq
MIRT2037932	hsa-miR-762	CLIP-seq
MIRT2037933	hsa-miR-920	CLIP-seq
MIRT1132905	hsa-miR-106a	CLIP-seq
MIRT1132906	hsa-miR-106b	CLIP-seq
MIRT1132907	hsa-miR-1178	CLIP-seq
MIRT2267918	hsa-miR-1224-3p	CLIP-seq
MIRT1132967	hsa-miR-150	CLIP-seq
MIRT1132911	hsa-miR-17	CLIP-seq
MIRT1132912	hsa-miR-1915	CLIP-seq
MIRT1132913	hsa-miR-20a	CLIP-seq
MIRT1132914	hsa-miR-20b	CLIP-seq
MIRT2267919	hsa-miR-24	CLIP-seq
MIRT1132917	hsa-miR-302a	CLIP-seq
MIRT1132918	hsa-miR-302b	CLIP-seq
MIRT1132919	hsa-miR-302c	CLIP-seq
MIRT1132920	hsa-miR-302d	CLIP-seq
MIRT1132921	hsa-miR-302e	CLIP-seq
MIRT2037922	hsa-miR-3622a-3p	CLIP-seq
MIRT2037923	hsa-miR-3622b-3p	CLIP-seq
MIRT1132924	hsa-miR-372	CLIP-seq
MIRT1132925	hsa-miR-373	CLIP-seq
MIRT2267920	hsa-miR-4284	CLIP-seq
MIRT2267921	hsa-miR-4438	CLIP-seq
MIRT1132944	hsa-miR-4726-3p	CLIP-seq
MIRT1132945	hsa-miR-4731-5p	CLIP-seq
MIRT1132949	hsa-miR-4772-3p	CLIP-seq
MIRT1132951	hsa-miR-5095	CLIP-seq
MIRT1132952	hsa-miR-512-3p	CLIP-seq
MIRT1132953	hsa-miR-519d	CLIP-seq
MIRT1132954	hsa-miR-520a-3p	CLIP-seq
MIRT1132955	hsa-miR-520b	CLIP-seq
MIRT1132956	hsa-miR-520c-3p	CLIP-seq
MIRT1132957	hsa-miR-520d-3p	CLIP-seq
MIRT1132958	hsa-miR-520e	CLIP-seq
MIRT2267922	hsa-miR-520g	CLIP-seq
MIRT2267923	hsa-miR-520h	CLIP-seq
MIRT2267924	hsa-miR-607	CLIP-seq
MIRT1132966	hsa-miR-93	CLIP-seq
MIRT2037921	hsa-miR-3192	CLIP-seq
MIRT2037925	hsa-miR-4300	CLIP-seq
MIRT2037933	hsa-miR-920	CLIP-seq
MIRT2431021	hsa-miR-132	CLIP-seq
MIRT2431022	hsa-miR-146a	CLIP-seq
MIRT2431023	hsa-miR-146b-5p	CLIP-seq
MIRT2431024	hsa-miR-212	CLIP-seq
MIRT1132939	hsa-miR-455-3p	CLIP-seq
MIRT1132941	hsa-miR-4685-5p	CLIP-seq
MIRT2431025	hsa-miR-4712-3p	CLIP-seq
MIRT2431026	hsa-miR-4773	CLIP-seq
MIRT2431027	hsa-miR-589	CLIP-seq
MIRT2431021	hsa-miR-132	CLIP-seq
MIRT2431022	hsa-miR-146a	CLIP-seq
MIRT2431023	hsa-miR-146b-5p	CLIP-seq
MIRT2431024	hsa-miR-212	CLIP-seq
MIRT1132939	hsa-miR-455-3p	CLIP-seq
MIRT1132941	hsa-miR-4685-5p	CLIP-seq
MIRT2431025	hsa-miR-4712-3p	CLIP-seq
MIRT2431026	hsa-miR-4773	CLIP-seq
MIRT2431027	hsa-miR-589	CLIP-seq
MIRT2453753	hsa-miR-1273f	CLIP-seq
MIRT2453754	hsa-miR-139-3p	CLIP-seq
MIRT2453755	hsa-miR-3149	CLIP-seq
MIRT2453756	hsa-miR-3170	CLIP-seq
MIRT2453757	hsa-miR-411	CLIP-seq
MIRT2453758	hsa-miR-4294	CLIP-seq
MIRT2453759	hsa-miR-4423-5p	CLIP-seq
MIRT2453760	hsa-miR-4715-3p	CLIP-seq
MIRT1551169	hsa-miR-4735-5p	CLIP-seq
MIRT1551170	hsa-miR-4775	CLIP-seq
MIRT1551172	hsa-miR-590-3p	CLIP-seq
MIRT2453761	hsa-miR-720	CLIP-seq
MIRT2453753	hsa-miR-1273f	CLIP-seq
MIRT2453755	hsa-miR-3149	CLIP-seq
MIRT2453756	hsa-miR-3170	CLIP-seq
MIRT2453757	hsa-miR-411	CLIP-seq
MIRT2453760	hsa-miR-4715-3p	CLIP-seq
MIRT1551169	hsa-miR-4735-5p	CLIP-seq
MIRT1551170	hsa-miR-4775	CLIP-seq
MIRT1551172	hsa-miR-590-3p	CLIP-seq
MIRT1132908	hsa-miR-122	CLIP-seq
MIRT2567551	hsa-miR-129-5p	CLIP-seq
MIRT2037918	hsa-miR-1587	CLIP-seq
MIRT2037919	hsa-miR-1908	CLIP-seq
MIRT2037920	hsa-miR-3135b	CLIP-seq
MIRT2453755	hsa-miR-3149	CLIP-seq
MIRT2037922	hsa-miR-3622a-3p	CLIP-seq
MIRT2037923	hsa-miR-3622b-3p	CLIP-seq
MIRT1132923	hsa-miR-3652	CLIP-seq
MIRT2037924	hsa-miR-378g	CLIP-seq
MIRT1551167	hsa-miR-4258	CLIP-seq
MIRT1132936	hsa-miR-4430	CLIP-seq
MIRT2267921	hsa-miR-4438	CLIP-seq
MIRT2037926	hsa-miR-4492	CLIP-seq
MIRT2037927	hsa-miR-4498	CLIP-seq
MIRT2037928	hsa-miR-4656	CLIP-seq
MIRT2037929	hsa-miR-4675	CLIP-seq
MIRT1551168	hsa-miR-4707-3p	CLIP-seq
MIRT1551169	hsa-miR-4735-5p	CLIP-seq
MIRT2037930	hsa-miR-4741	CLIP-seq
MIRT1551170	hsa-miR-4775	CLIP-seq
MIRT1551171	hsa-miR-4794	CLIP-seq
MIRT1132951	hsa-miR-5095	CLIP-seq
MIRT1551172	hsa-miR-590-3p	CLIP-seq
MIRT2037931	hsa-miR-663	CLIP-seq
MIRT2037932	hsa-miR-762	CLIP-seq
MIRT1132908	hsa-miR-122	CLIP-seq
MIRT2567551	hsa-miR-129-5p	CLIP-seq
MIRT2037918	hsa-miR-1587	CLIP-seq
MIRT2037919	hsa-miR-1908	CLIP-seq
MIRT2037920	hsa-miR-3135b	CLIP-seq
MIRT2453755	hsa-miR-3149	CLIP-seq
MIRT2037922	hsa-miR-3622a-3p	CLIP-seq
MIRT2037923	hsa-miR-3622b-3p	CLIP-seq
MIRT1132923	hsa-miR-3652	CLIP-seq
MIRT2037924	hsa-miR-378g	CLIP-seq
MIRT1132936	hsa-miR-4430	CLIP-seq
MIRT2037926	hsa-miR-4492	CLIP-seq
MIRT2037927	hsa-miR-4498	CLIP-seq
MIRT2037928	hsa-miR-4656	CLIP-seq
MIRT2037929	hsa-miR-4675	CLIP-seq
MIRT1551169	hsa-miR-4735-5p	CLIP-seq
MIRT2037930	hsa-miR-4741	CLIP-seq
MIRT1551170	hsa-miR-4775	CLIP-seq
MIRT1551171	hsa-miR-4794	CLIP-seq
MIRT1551172	hsa-miR-590-3p	CLIP-seq
MIRT2037931	hsa-miR-663	CLIP-seq
MIRT2037932	hsa-miR-762	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20164257
GO:0005923	Component	Bicellular tight junction	IDA	20028514, 20164257
GO:0005923	Component	Bicellular tight junction	IEA
GO:0006970	Process	Response to osmotic stress	IMP	24567356
GO:0010633	Process	Negative regulation of epithelial cell migration	IMP	24567356
GO:0016020	Component	Membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IDA	20164257
GO:0031435	Function	Mitogen-activated protein kinase kinase kinase binding	IDA	24567356
GO:0045216	Process	Cell-cell junction organization	IMP	20164257
GO:0046329	Process	Negative regulation of JNK cascade	IMP	24567356
GO:0050680	Process	Negative regulation of epithelial cell proliferation	IMP	24567356
GO:0070161	Component	Anchoring junction	IEA
GO:0070830	Process	Bicellular tight junction assembly	IMP	20164257
GO:1902414	Process	Protein localization to cell junction	IMP	24567356

MIM	HGNC	e!Ensembl
614094	30525	ENSG00000140832

Q96A59

Protein name

MARVEL domain-containing protein 3

Protein function

As a component of tight junctions, plays a role in paracellular ion conductivity.

Family and domains

Sequence

MEDPSGAREPRARPRERDPGRRPHPDQGRTHDRPRDRPGDPRRKRSSDGNRRRDGDRDPE
RDQERDGNRDRNRDRERERERERDPDRGPRRDTHRDAGPRAGEHGVWEKPRQSRTRDGAR
GLTWDAAAPPGPAPWEAPEPPQPQRKGDPGRRRPESEPPSERYLPSTPRPGREEVEYYQS
EAEGLLECHKCKYLCTGRACCQMLEVLLNLLILACSSVSYSSTGGYTGITSLGGIYYYQF
GGAYSGFDGADGEKAQQLDVQFYQLKLPMVTVAMACSGALTALCCLFVAMGVLRVPWHCP
LLLVTEGLLDMLIAGGYIPALYFYFHYLSAAYGSPVCKERQALYQSKGYSGFGCSFHGAD
IGAGIFAALGIVVFALGAVLAIKGYRKVRKLKEKPAEMFEF

Sequence length

401

Interactions

View interactions

	KEGG
	Tight junction

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	24398667		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34338154	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	24398667		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	24398667	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	24398667		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	21763689		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	21763689		★★★★★ ★☆☆☆☆ Found in Text Mining only

MARVELD3 (MARVEL domain containing 3)