Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9183
Gene name	Zw10 kinetochore protein
Gene symbol	ZW10
Synonyms (NCBI Gene)	HZW10KNTC1AP
Chromosome	11
Chromosome location	11q23.2
Summary	This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [

100

Show/Hide all (100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046629	hsa-miR-222-3p	CLASH	23622248
MIRT040820	hsa-miR-18a-3p	CLASH	23622248
MIRT1544246	hsa-miR-3136-3p	CLIP-seq
MIRT1544247	hsa-miR-3926	CLIP-seq
MIRT1544248	hsa-miR-3978	CLIP-seq
MIRT1544249	hsa-miR-4287	CLIP-seq
MIRT1544250	hsa-miR-4667-3p	CLIP-seq
MIRT1544251	hsa-miR-4685-3p	CLIP-seq
MIRT1544252	hsa-miR-4691-5p	CLIP-seq
MIRT1544253	hsa-miR-4700-3p	CLIP-seq
MIRT1544254	hsa-miR-4753-5p	CLIP-seq
MIRT1544255	hsa-miR-486-5p	CLIP-seq
MIRT1544256	hsa-miR-5095	CLIP-seq
MIRT1544257	hsa-miR-663b	CLIP-seq
MIRT1544247	hsa-miR-3926	CLIP-seq
MIRT1544254	hsa-miR-4753-5p	CLIP-seq
MIRT2383382	hsa-miR-4721	CLIP-seq
MIRT2673800	hsa-miR-1238	CLIP-seq
MIRT2673801	hsa-miR-1264	CLIP-seq
MIRT2673802	hsa-miR-1296	CLIP-seq
MIRT2673803	hsa-miR-1299	CLIP-seq
MIRT2673804	hsa-miR-150	CLIP-seq
MIRT2673805	hsa-miR-15a	CLIP-seq
MIRT2673806	hsa-miR-15b	CLIP-seq
MIRT2673807	hsa-miR-16	CLIP-seq
MIRT2673808	hsa-miR-195	CLIP-seq
MIRT2673809	hsa-miR-197	CLIP-seq
MIRT2673810	hsa-miR-1972	CLIP-seq
MIRT2673811	hsa-miR-208a	CLIP-seq
MIRT2673812	hsa-miR-208b	CLIP-seq
MIRT2673813	hsa-miR-2116	CLIP-seq
MIRT2673814	hsa-miR-219-2-3p	CLIP-seq
MIRT2673815	hsa-miR-2861	CLIP-seq
MIRT2673816	hsa-miR-2964a-3p	CLIP-seq
MIRT2673817	hsa-miR-3182	CLIP-seq
MIRT2673818	hsa-miR-3607-3p	CLIP-seq
MIRT2673819	hsa-miR-3686	CLIP-seq
MIRT2673820	hsa-miR-3690	CLIP-seq
MIRT2673821	hsa-miR-424	CLIP-seq
MIRT2673822	hsa-miR-4254	CLIP-seq
MIRT2673823	hsa-miR-4277	CLIP-seq
MIRT2673824	hsa-miR-4426	CLIP-seq
MIRT2673825	hsa-miR-4438	CLIP-seq
MIRT2673826	hsa-miR-4459	CLIP-seq
MIRT2673827	hsa-miR-4475	CLIP-seq
MIRT2673828	hsa-miR-4477b	CLIP-seq
MIRT2673829	hsa-miR-4512	CLIP-seq
MIRT2673830	hsa-miR-4645-3p	CLIP-seq
MIRT2673831	hsa-miR-4647	CLIP-seq
MIRT2673832	hsa-miR-4649-5p	CLIP-seq
MIRT2673833	hsa-miR-4659a-3p	CLIP-seq
MIRT2673834	hsa-miR-4659b-3p	CLIP-seq
MIRT2673835	hsa-miR-4662b	CLIP-seq
MIRT2673836	hsa-miR-4713-5p	CLIP-seq
MIRT2383382	hsa-miR-4721	CLIP-seq
MIRT2673837	hsa-miR-497	CLIP-seq
MIRT1544256	hsa-miR-5095	CLIP-seq
MIRT2673838	hsa-miR-532-3p	CLIP-seq
MIRT2673839	hsa-miR-548aa	CLIP-seq
MIRT2673840	hsa-miR-665	CLIP-seq
MIRT2673841	hsa-miR-671-5p	CLIP-seq
MIRT2673842	hsa-miR-760	CLIP-seq
MIRT2673843	hsa-miR-875-3p	CLIP-seq
MIRT2673800	hsa-miR-1238	CLIP-seq
MIRT2673801	hsa-miR-1264	CLIP-seq
MIRT2673802	hsa-miR-1296	CLIP-seq
MIRT2673804	hsa-miR-150	CLIP-seq
MIRT2673809	hsa-miR-197	CLIP-seq
MIRT2673810	hsa-miR-1972	CLIP-seq
MIRT2673811	hsa-miR-208a	CLIP-seq
MIRT2673812	hsa-miR-208b	CLIP-seq
MIRT2673813	hsa-miR-2116	CLIP-seq
MIRT2673814	hsa-miR-219-2-3p	CLIP-seq
MIRT2673815	hsa-miR-2861	CLIP-seq
MIRT2673816	hsa-miR-2964a-3p	CLIP-seq
MIRT2673817	hsa-miR-3182	CLIP-seq
MIRT2673818	hsa-miR-3607-3p	CLIP-seq
MIRT2673819	hsa-miR-3686	CLIP-seq
MIRT2673820	hsa-miR-3690	CLIP-seq
MIRT2673822	hsa-miR-4254	CLIP-seq
MIRT2673823	hsa-miR-4277	CLIP-seq
MIRT2673824	hsa-miR-4426	CLIP-seq
MIRT2673825	hsa-miR-4438	CLIP-seq
MIRT2673826	hsa-miR-4459	CLIP-seq
MIRT2673827	hsa-miR-4475	CLIP-seq
MIRT2673828	hsa-miR-4477b	CLIP-seq
MIRT2673829	hsa-miR-4512	CLIP-seq
MIRT2673830	hsa-miR-4645-3p	CLIP-seq
MIRT2673831	hsa-miR-4647	CLIP-seq
MIRT2673832	hsa-miR-4649-5p	CLIP-seq
MIRT2673833	hsa-miR-4659a-3p	CLIP-seq
MIRT2673834	hsa-miR-4659b-3p	CLIP-seq
MIRT2673835	hsa-miR-4662b	CLIP-seq
MIRT2673836	hsa-miR-4713-5p	CLIP-seq
MIRT2383382	hsa-miR-4721	CLIP-seq
MIRT1544256	hsa-miR-5095	CLIP-seq
MIRT2673838	hsa-miR-532-3p	CLIP-seq
MIRT2673839	hsa-miR-548aa	CLIP-seq
MIRT2673840	hsa-miR-665	CLIP-seq
MIRT2673842	hsa-miR-760	CLIP-seq

Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	IDA	11146660
GO:0000132	Process	Establishment of mitotic spindle orientation	IMP	19468067
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	11682612, 15485811, 15824131, 19229290, 19468067
GO:0000776	Component	Kinetochore	IEA
GO:0000922	Component	Spindle pole	IDA	11146660
GO:0005515	Function	Protein binding	IPI	11146660, 12686595, 15029241, 15272311, 15485811, 15824131, 16354670, 16571679, 16732327, 19468067, 20462495, 24056303, 28514442, 30970241, 33961781
GO:0005634	Component	Nucleus	IDA	15485811
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	15029241
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005811	Component	Lipid droplet	IDA	30970241
GO:0005811	Component	Lipid droplet	IEA
GO:0005819	Component	Spindle	IEA
GO:0005828	Component	Kinetochore microtubule	IDA	11146660
GO:0005828	Component	Kinetochore microtubule	NAS	28320825
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	15029241
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	NAS	15029241
GO:0007030	Process	Golgi organization	IGI	20163571
GO:0007030	Process	Golgi organization	IMP	20163571
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	19468067
GO:0007094	Process	Mitotic spindle assembly checkpoint signaling	IBA
GO:0007094	Process	Mitotic spindle assembly checkpoint signaling	IDA	11146660
GO:0007094	Process	Mitotic spindle assembly checkpoint signaling	IMP	15824131
GO:0007096	Process	Regulation of exit from mitosis	IDA	11146660
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0019237	Function	Centromeric DNA binding	TAS	9700164
GO:0034501	Process	Protein localization to kinetochore	IMP	19468067
GO:0051301	Process	Cell division	IEA
GO:0051321	Process	Meiotic cell cycle	TAS	9298984
GO:0051988	Process	Regulation of attachment of spindle microtubules to kinetochore	NAS	28320825
GO:0065003	Process	Protein-containing complex assembly	IDA	11146660
GO:0070939	Component	Dsl1/NZR complex	IDA	20462495
GO:0070939	Component	Dsl1/NZR complex	IPI	20462495
GO:1990423	Component	RZZ complex	IBA
GO:1990423	Component	RZZ complex	IDA	20462495
GO:1990423	Component	RZZ complex	IPI	25849506

MIM	HGNC	e!Ensembl
603954	13194	ENSG00000086827

O43264

Protein name

Centromere/kinetochore protein zw10 homolog

Protein function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machin

PDB

7QPG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06248	Zw10	9 → 564	Centromere/kinetochore Zw10	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MASFVTEVLAHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLI
TQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQLQEFSTAIE
EYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEE
WQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSK
LKSFGQMLLKYILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVL
EVLQKQLLDLPLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQ
YEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIH
NTVKIIPDSKINVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRIS
ESVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAI
HHNNCMYIAHHLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGEL
LERLSSARNFSNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTA
ISEVIGKITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKW
MPFKELMMMLQASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK

Sequence length

779

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOSARCOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anorexia Nervosa	Anorexia	BEFREE	30519816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anorexia Nervosa	Anorexia nervosa	Pubtator	30519816	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	34675265	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30198401	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	29615843		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	30642433	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	30642433	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	30198401	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30642433	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	30198401	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	29615843		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	CTD_human_DG	14767549		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteosarcoma	Osteosarcoma	BEFREE	29560129		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Roberts-SC phocomelia syndrome	Roberts-SC Phocomelia Syndrome	BEFREE	15094189		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZW10 (zw10 kinetochore protein)