MAP3K13 (mitogen-activated protein kinase kinase kinase 13)

Gene

• Entrez ID: 9175
• Gene name: Mitogen-activated protein kinase kinase kinase 13
• Gene symbol: MAP3K13
• Synonyms (NCBI Gene): LZK, MEKK13, MLK
• Chromosome: 3
• Chromosome location: 3q27.2
• Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activ

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048810	hsa-miR-93-5p	CLASH	23622248
MIRT053440	hsa-miR-203a-3p	Microarray	23807165
MIRT735627	hsa-miR-204-3p	Luciferase reporter assay	31957920
MIRT1128368	hsa-miR-105	CLIP-seq
MIRT1128369	hsa-miR-106a	CLIP-seq
MIRT1128370	hsa-miR-106b	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128372	hsa-miR-1228	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT1128374	hsa-miR-128	CLIP-seq
MIRT1128375	hsa-miR-1293	CLIP-seq
MIRT1128376	hsa-miR-1301	CLIP-seq
MIRT1128377	hsa-miR-1304	CLIP-seq
MIRT1128378	hsa-miR-137	CLIP-seq
MIRT1128379	hsa-miR-142-5p	CLIP-seq
MIRT1128380	hsa-miR-145	CLIP-seq
MIRT1128381	hsa-miR-155	CLIP-seq
MIRT1128382	hsa-miR-17	CLIP-seq
MIRT1128383	hsa-miR-1827	CLIP-seq
MIRT1128384	hsa-miR-1912	CLIP-seq
MIRT1128385	hsa-miR-20a	CLIP-seq
MIRT1128386	hsa-miR-20b	CLIP-seq
MIRT1128387	hsa-miR-217	CLIP-seq
MIRT1128388	hsa-miR-2277-3p	CLIP-seq
MIRT1128389	hsa-miR-2467-5p	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128391	hsa-miR-30a	CLIP-seq
MIRT1128392	hsa-miR-30b	CLIP-seq
MIRT1128393	hsa-miR-30c	CLIP-seq
MIRT1128394	hsa-miR-30d	CLIP-seq
MIRT1128395	hsa-miR-30e	CLIP-seq
MIRT1128396	hsa-miR-3122	CLIP-seq
MIRT1128397	hsa-miR-3132	CLIP-seq
MIRT1128398	hsa-miR-3188	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128400	hsa-miR-329	CLIP-seq
MIRT1128401	hsa-miR-33a	CLIP-seq
MIRT1128402	hsa-miR-33b	CLIP-seq
MIRT1128403	hsa-miR-34a	CLIP-seq
MIRT1128404	hsa-miR-34c-5p	CLIP-seq
MIRT1128405	hsa-miR-3609	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT1128407	hsa-miR-3622a-3p	CLIP-seq
MIRT1128408	hsa-miR-3622b-3p	CLIP-seq
MIRT1128409	hsa-miR-362-3p	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT1128413	hsa-miR-3671	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128416	hsa-miR-3913-5p	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128418	hsa-miR-3937	CLIP-seq
MIRT1128419	hsa-miR-3975	CLIP-seq
MIRT1128420	hsa-miR-4264	CLIP-seq
MIRT1128421	hsa-miR-4278	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT1128423	hsa-miR-4326	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128426	hsa-miR-4436b-3p	CLIP-seq
MIRT1128427	hsa-miR-4451	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128429	hsa-miR-4475	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT1128431	hsa-miR-4480	CLIP-seq
MIRT1128432	hsa-miR-4483	CLIP-seq
MIRT1128433	hsa-miR-449a	CLIP-seq
MIRT1128434	hsa-miR-449b	CLIP-seq
MIRT1128435	hsa-miR-450a	CLIP-seq
MIRT1128436	hsa-miR-4645-3p	CLIP-seq
MIRT1128437	hsa-miR-4649-3p	CLIP-seq
MIRT1128438	hsa-miR-4651	CLIP-seq
MIRT1128439	hsa-miR-4660	CLIP-seq
MIRT1128440	hsa-miR-4694-3p	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT1128442	hsa-miR-4698	CLIP-seq
MIRT1128443	hsa-miR-4716-3p	CLIP-seq
MIRT1128444	hsa-miR-4719	CLIP-seq
MIRT1128445	hsa-miR-4722-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128447	hsa-miR-4762-5p	CLIP-seq
MIRT1128448	hsa-miR-4767	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT1128450	hsa-miR-4776-3p	CLIP-seq
MIRT1128451	hsa-miR-4796-3p	CLIP-seq
MIRT1128452	hsa-miR-4797-3p	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128455	hsa-miR-490-3p	CLIP-seq
MIRT1128456	hsa-miR-5047	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT1128459	hsa-miR-518a-5p	CLIP-seq
MIRT1128460	hsa-miR-519d	CLIP-seq
MIRT1128461	hsa-miR-520d-5p	CLIP-seq
MIRT1128462	hsa-miR-524-5p	CLIP-seq
MIRT1128463	hsa-miR-527	CLIP-seq
MIRT1128464	hsa-miR-542-3p	CLIP-seq
MIRT1128465	hsa-miR-544b	CLIP-seq
MIRT1128466	hsa-miR-548a-3p	CLIP-seq
MIRT1128467	hsa-miR-548aa	CLIP-seq
MIRT1128468	hsa-miR-548ag	CLIP-seq
MIRT1128469	hsa-miR-548ah	CLIP-seq
MIRT1128470	hsa-miR-548ai	CLIP-seq
MIRT1128471	hsa-miR-548e	CLIP-seq
MIRT1128472	hsa-miR-548f	CLIP-seq
MIRT1128473	hsa-miR-566	CLIP-seq
MIRT1128474	hsa-miR-607	CLIP-seq
MIRT1128475	hsa-miR-608	CLIP-seq
MIRT1128476	hsa-miR-621	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128480	hsa-miR-93	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT1128374	hsa-miR-128	CLIP-seq
MIRT1128377	hsa-miR-1304	CLIP-seq
MIRT1128389	hsa-miR-2467-5p	CLIP-seq
MIRT1128398	hsa-miR-3188	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128419	hsa-miR-3975	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128483	hsa-miR-4464	CLIP-seq
MIRT1128484	hsa-miR-4476	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128485	hsa-miR-4748	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT1128377	hsa-miR-1304	CLIP-seq
MIRT1128487	hsa-miR-223	CLIP-seq
MIRT1128389	hsa-miR-2467-5p	CLIP-seq
MIRT1128398	hsa-miR-3188	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128419	hsa-miR-3975	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT1128488	hsa-miR-548ac	CLIP-seq
MIRT1128489	hsa-miR-548ae	CLIP-seq
MIRT1128490	hsa-miR-548aj	CLIP-seq
MIRT1128491	hsa-miR-548am	CLIP-seq
MIRT1128492	hsa-miR-548d-3p	CLIP-seq
MIRT1128493	hsa-miR-548x	CLIP-seq
MIRT1128494	hsa-miR-548z	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT1128495	hsa-miR-935	CLIP-seq
MIRT1128383	hsa-miR-1827	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128396	hsa-miR-3122	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128416	hsa-miR-3913-5p	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT1128437	hsa-miR-4649-3p	CLIP-seq
MIRT2036489	hsa-miR-4667-5p	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT2036490	hsa-miR-4700-5p	CLIP-seq
MIRT1128445	hsa-miR-4722-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128448	hsa-miR-4767	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT2036491	hsa-miR-520g	CLIP-seq
MIRT2036492	hsa-miR-520h	CLIP-seq
MIRT2036493	hsa-miR-548p	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT1128473	hsa-miR-566	CLIP-seq
MIRT2036494	hsa-miR-637	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT2266760	hsa-miR-4256	CLIP-seq
MIRT1128440	hsa-miR-4694-3p	CLIP-seq
MIRT1128442	hsa-miR-4698	CLIP-seq
MIRT2266761	hsa-miR-4778-5p	CLIP-seq
MIRT1128461	hsa-miR-520d-5p	CLIP-seq
MIRT1128462	hsa-miR-524-5p	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT2266762	hsa-miR-185	CLIP-seq
MIRT2266763	hsa-miR-3156-5p	CLIP-seq
MIRT2266764	hsa-miR-3163	CLIP-seq
MIRT2266765	hsa-miR-3180-5p	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT2266767	hsa-miR-4306	CLIP-seq
MIRT2266768	hsa-miR-432	CLIP-seq
MIRT1128423	hsa-miR-4326	CLIP-seq
MIRT2266769	hsa-miR-4644	CLIP-seq
MIRT2266770	hsa-miR-4695-3p	CLIP-seq
MIRT2266771	hsa-miR-520a-5p	CLIP-seq
MIRT2266772	hsa-miR-525-5p	CLIP-seq
MIRT2266773	hsa-miR-526b	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT2438497	hsa-miR-1260	CLIP-seq
MIRT2438498	hsa-miR-1260b	CLIP-seq
MIRT2438499	hsa-miR-188-3p	CLIP-seq
MIRT2438500	hsa-miR-3156-3p	CLIP-seq
MIRT2266765	hsa-miR-3180-5p	CLIP-seq
MIRT2438501	hsa-miR-3192	CLIP-seq
MIRT2438502	hsa-miR-4301	CLIP-seq
MIRT2438503	hsa-miR-4314	CLIP-seq
MIRT2438504	hsa-miR-4646-5p	CLIP-seq
MIRT2438505	hsa-miR-4747-5p	CLIP-seq
MIRT2266771	hsa-miR-520a-5p	CLIP-seq
MIRT2266772	hsa-miR-525-5p	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2566337	hsa-miR-1183	CLIP-seq
MIRT2566338	hsa-miR-3124-3p	CLIP-seq
MIRT2566339	hsa-miR-4725-5p	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT2566340	hsa-miR-504	CLIP-seq
MIRT1128391	hsa-miR-30a	CLIP-seq
MIRT1128392	hsa-miR-30b	CLIP-seq
MIRT1128393	hsa-miR-30c	CLIP-seq
MIRT1128394	hsa-miR-30d	CLIP-seq
MIRT1128395	hsa-miR-30e	CLIP-seq
MIRT2566338	hsa-miR-3124-3p	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2566341	hsa-miR-4775	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT1128467	hsa-miR-548aa	CLIP-seq
MIRT2566342	hsa-miR-579	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2566342	hsa-miR-579	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128369	hsa-miR-106a	CLIP-seq
MIRT1128370	hsa-miR-106b	CLIP-seq
MIRT2566337	hsa-miR-1183	CLIP-seq
MIRT2684476	hsa-miR-1224-3p	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128372	hsa-miR-1228	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT2684477	hsa-miR-1271	CLIP-seq
MIRT2684478	hsa-miR-1273d	CLIP-seq
MIRT2684479	hsa-miR-1273f	CLIP-seq
MIRT1128374	hsa-miR-128	CLIP-seq
MIRT2684480	hsa-miR-1286	CLIP-seq
MIRT2684481	hsa-miR-1295	CLIP-seq
MIRT2684482	hsa-miR-1303	CLIP-seq
MIRT1128379	hsa-miR-142-5p	CLIP-seq
MIRT1128380	hsa-miR-145	CLIP-seq
MIRT1128382	hsa-miR-17	CLIP-seq
MIRT2684483	hsa-miR-182	CLIP-seq
MIRT1128383	hsa-miR-1827	CLIP-seq
MIRT2684484	hsa-miR-187	CLIP-seq
MIRT2684485	hsa-miR-188-5p	CLIP-seq
MIRT2684486	hsa-miR-208a	CLIP-seq
MIRT2684487	hsa-miR-208b	CLIP-seq
MIRT1128385	hsa-miR-20a	CLIP-seq
MIRT1128386	hsa-miR-20b	CLIP-seq
MIRT2684488	hsa-miR-2116	CLIP-seq
MIRT2684489	hsa-miR-2278	CLIP-seq
MIRT1128391	hsa-miR-30a	CLIP-seq
MIRT1128392	hsa-miR-30b	CLIP-seq
MIRT1128393	hsa-miR-30c	CLIP-seq
MIRT1128394	hsa-miR-30d	CLIP-seq
MIRT1128395	hsa-miR-30e	CLIP-seq
MIRT2684490	hsa-miR-3117-5p	CLIP-seq
MIRT1128396	hsa-miR-3122	CLIP-seq
MIRT2566338	hsa-miR-3124-3p	CLIP-seq
MIRT2684491	hsa-miR-3138	CLIP-seq
MIRT2684492	hsa-miR-3140-3p	CLIP-seq
MIRT2684493	hsa-miR-3157-5p	CLIP-seq
MIRT2438501	hsa-miR-3192	CLIP-seq
MIRT2684494	hsa-miR-324-5p	CLIP-seq
MIRT1128400	hsa-miR-329	CLIP-seq
MIRT2684495	hsa-miR-337-3p	CLIP-seq
MIRT2684496	hsa-miR-3607-3p	CLIP-seq
MIRT1128405	hsa-miR-3609	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT2684497	hsa-miR-3618	CLIP-seq
MIRT1128407	hsa-miR-3622a-3p	CLIP-seq
MIRT1128408	hsa-miR-3622b-3p	CLIP-seq
MIRT1128409	hsa-miR-362-3p	CLIP-seq
MIRT2684498	hsa-miR-3646	CLIP-seq
MIRT2684499	hsa-miR-3647-3p	CLIP-seq
MIRT2684500	hsa-miR-3662	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT2684501	hsa-miR-3667-3p	CLIP-seq
MIRT1128413	hsa-miR-3671	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2684502	hsa-miR-3686	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT2684503	hsa-miR-3689d	CLIP-seq
MIRT2684504	hsa-miR-3692	CLIP-seq
MIRT1128416	hsa-miR-3913-5p	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128418	hsa-miR-3937	CLIP-seq
MIRT2684505	hsa-miR-4254	CLIP-seq
MIRT2684506	hsa-miR-4260	CLIP-seq
MIRT2684507	hsa-miR-4263	CLIP-seq
MIRT2684508	hsa-miR-4273	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT2684509	hsa-miR-4283	CLIP-seq
MIRT2684510	hsa-miR-4308	CLIP-seq
MIRT2684511	hsa-miR-4310	CLIP-seq
MIRT2684512	hsa-miR-4330	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT2684513	hsa-miR-4432	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT2684514	hsa-miR-4489	CLIP-seq
MIRT2684515	hsa-miR-4495	CLIP-seq
MIRT2684516	hsa-miR-4514	CLIP-seq
MIRT2684517	hsa-miR-4519	CLIP-seq
MIRT2684518	hsa-miR-4534	CLIP-seq
MIRT2684519	hsa-miR-4536	CLIP-seq
MIRT1128436	hsa-miR-4645-3p	CLIP-seq
MIRT1128437	hsa-miR-4649-3p	CLIP-seq
MIRT2684520	hsa-miR-4652-5p	CLIP-seq
MIRT2684521	hsa-miR-4662a-3p	CLIP-seq
MIRT2684522	hsa-miR-4662a-5p	CLIP-seq
MIRT2684523	hsa-miR-4668-3p	CLIP-seq
MIRT2684524	hsa-miR-4676-5p	CLIP-seq
MIRT2684525	hsa-miR-4677-5p	CLIP-seq
MIRT2684526	hsa-miR-4691-3p	CLIP-seq
MIRT2684527	hsa-miR-4692	CLIP-seq
MIRT1128440	hsa-miR-4694-3p	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT2684528	hsa-miR-4704-5p	CLIP-seq
MIRT1128444	hsa-miR-4719	CLIP-seq
MIRT1128445	hsa-miR-4722-5p	CLIP-seq
MIRT2566339	hsa-miR-4725-5p	CLIP-seq
MIRT2684529	hsa-miR-4727-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT2684530	hsa-miR-4755-3p	CLIP-seq
MIRT1128447	hsa-miR-4762-5p	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT2684531	hsa-miR-4769-3p	CLIP-seq
MIRT2684532	hsa-miR-4780	CLIP-seq
MIRT2684533	hsa-miR-4786-3p	CLIP-seq
MIRT1128451	hsa-miR-4796-3p	CLIP-seq
MIRT2684534	hsa-miR-4802-5p	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128455	hsa-miR-490-3p	CLIP-seq
MIRT2684535	hsa-miR-495	CLIP-seq
MIRT2684536	hsa-miR-499-5p	CLIP-seq
MIRT2684537	hsa-miR-500a	CLIP-seq
MIRT2566340	hsa-miR-504	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT1128460	hsa-miR-519d	CLIP-seq
MIRT1128465	hsa-miR-544b	CLIP-seq
MIRT1128466	hsa-miR-548a-3p	CLIP-seq
MIRT1128469	hsa-miR-548ah	CLIP-seq
MIRT2684538	hsa-miR-548c-3p	CLIP-seq
MIRT1128471	hsa-miR-548e	CLIP-seq
MIRT1128472	hsa-miR-548f	CLIP-seq
MIRT2036493	hsa-miR-548p	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT2684539	hsa-miR-552	CLIP-seq
MIRT2684540	hsa-miR-555	CLIP-seq
MIRT1128473	hsa-miR-566	CLIP-seq
MIRT2684541	hsa-miR-575	CLIP-seq
MIRT1128474	hsa-miR-607	CLIP-seq
MIRT2684542	hsa-miR-623	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT2684543	hsa-miR-767-3p	CLIP-seq
MIRT1128480	hsa-miR-93	CLIP-seq
MIRT2684544	hsa-miR-934	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT2684545	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9353328
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	11726277
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	11726277, 12492477
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006468	Process	Protein phosphorylation	IDA	9353328, 11726277
GO:0007254	Process	JNK cascade	IBA
GO:0007254	Process	JNK cascade	IDA	9353328, 11726277
GO:0007254	Process	JNK cascade	IEA
GO:0007254	Process	JNK cascade	ISS
GO:0014042	Process	Positive regulation of neuron maturation	IEA
GO:0014042	Process	Positive regulation of neuron maturation	ISS
GO:0016020	Component	Membrane	IDA	9353328
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019899	Function	Enzyme binding	IPI	12492477
GO:0019901	Function	Protein kinase binding	ISS	9353328
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042802	Function	Identical protein binding	IPI	11163770
GO:0042803	Function	Protein homodimerization activity	IDA	11163770
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IEA
GO:0043539	Function	Protein serine/threonine kinase activator activity	ISS
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0045773	Process	Positive regulation of axon extension	ISS
GO:0046777	Process	Protein autophosphorylation	IDA	9353328
GO:0046872	Function	Metal ion binding	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	12492477
GO:0051403	Process	Stress-activated MAPK cascade	IBA
GO:0051403	Process	Stress-activated MAPK cascade	IDA	11726277
GO:0060255	Process	Regulation of macromolecule metabolic process	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:0106137	Function	IkappaB kinase complex binding	IDA	12492477
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0150012	Process	Positive regulation of neuron projection arborization	IEA
GO:0150012	Process	Positive regulation of neuron projection arborization	ISS
GO:1905492	Process	Positive regulation of branching morphogenesis of a nerve	IEA
GO:1905492	Process	Positive regulation of branching morphogenesis of a nerve	ISS

Other IDs

• MIM: 604915
• HGNC: 6852
• e!Ensembl: ENSG00000073803

Protein

• UniProt ID: O43283
• Protein name: Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)
• Protein function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07714	PK_Tyr_Ser-Thr	168 → 407	Protein tyrosine and serine/threonine kinase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO:0000269|PubMed:9353328}.
• Sequence:

  MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV
  HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF
  SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
  AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
  LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
  SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
  IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE
  TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
  NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH
  KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
  DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG
  QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP
  WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE
  FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
  SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
  SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH
  YSSATW

• Sequence length: 966

Pathways

KEGG:

MAPK signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	26625115	Associate	★☆☆☆☆ Found in Text Mining only
Breast adenocarcinoma	Breast Adenocarcinoma	CGI_DG			★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28507808, 9150946		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CGI_DG			★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23902710, 38003265	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32525024, 35311629	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35508649	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	11549352		★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	28760853		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	34654328	Associate	★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	11549352		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31186535		★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	28760853		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26918941, 28507808		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CGI_DG			★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26918941, 27655071, 28760853		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	28507808		★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28760853, 31186535		★☆☆☆☆ Found in Text Mining only
Paragangliomas 3	Paraganglioma	Pubtator	34654328	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	19691116, 21815648		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	28760853		★☆☆☆☆ Found in Text Mining only