Gene Gene information from NCBI Gene database.
Entrez ID 91746
Gene name YTH N6-methyladenosine RNA binding protein C1
Gene symbol YTHDC1
Synonyms (NCBI Gene)
YT521YT521-B
Chromosome 4
Chromosome location 4q13.2
miRNA miRNA information provided by mirtarbase database.
904
miRTarBase ID miRNA Experiments Reference
MIRT023492 hsa-miR-1-3p Proteomics 18668040
MIRT027037 hsa-miR-103a-3p Sequencing 20371350
MIRT027989 hsa-miR-93-5p Sequencing 20371350
MIRT031105 hsa-miR-19b-3p Sequencing 20371350
MIRT031379 hsa-miR-16-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IBA
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IEA
GO:0000398 Process MRNA splicing, via spliceosome IBA
GO:0001701 Process In utero embryonic development IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617283 30626 ENSG00000083896
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96MU7
Protein name YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)
Protein function Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and
PDB 2YUD , 4R3H , 4R3I , 6RT4 , 6RT5 , 6RT6 , 6RT7 , 6SYZ , 6SZ1 , 6SZ2 , 6SZ3 , 6SZL , 6SZN , 6SZR , 6SZT , 6SZX , 6SZY , 6T01 , 6T02 , 6T03 , 6T04 , 6T05 , 6T06 , 6T07 , 6T08 , 6T09 , 6T0A , 6T0C , 6T0D , 6T0O , 6T0X , 6T0Z , 6T10 , 6T11 , 6T12 , 6WE8 , 6WE9 , 6WEA , 6YKE , 6YKI , 6YKJ , 6YKZ , 6YL0 , 6YL8 , 6YL9 , 6YM2 , 6YM8 , 6YNI , 6YNJ , 6YNK , 6YNL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04146 YTH 355 432 YT521-B-like domain Domain
PF04146 YTH 431 493 YT521-B-like domain Domain
Sequence
MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQ
KPSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSS
ASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG
SDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE
EEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKE
RKRARGISPIVFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLI
KSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESH
HGGSPIHWVL
PAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEI
ELECGTQLCLLFP
PDESIDLYQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDY
DIHNSRKKPRIDYPPEFHQRPGYLKDPRYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMG
PPPPWQGMPPYPGMEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRV
DDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRG
ERGRYRR
Sequence length 727
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDER GenCC
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
YTHDC1-related disorder Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of rectum Adenocarcinoma Of Rectum BEFREE 31396313
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 33725886 Inhibit
★☆☆☆☆
Found in Text Mining only
Aortic Dissection Aortic dissection Pubtator 36819785 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 35502895 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 20686370 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 32631107, 34221187 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 34747720, 37400994 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 35974388 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 36050747 Associate
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy Pubtator 37041267 Associate
★☆☆☆☆
Found in Text Mining only