Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	91687
Gene name	Centromere protein L
Gene symbol	CENPL
Synonyms (NCBI Gene)	C1orf155CENP-LdJ383J4.3
Chromosome	1
Chromosome location	1q25.1
Summary	CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[sup

227

Show/Hide all (227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT693632	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT693631	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT693630	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693629	hsa-miR-8063	HITS-CLIP	23313552
MIRT693628	hsa-miR-4698	HITS-CLIP	23313552
MIRT693627	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT693626	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693625	hsa-miR-4421	HITS-CLIP	23313552
MIRT693624	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT693623	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT693622	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT693621	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT693620	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT693619	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT693618	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693617	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693616	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693615	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693614	hsa-miR-612	HITS-CLIP	23313552
MIRT693613	hsa-miR-6860	HITS-CLIP	23313552
MIRT693612	hsa-miR-4725-5p	HITS-CLIP	23313552
MIRT693611	hsa-miR-661	HITS-CLIP	23313552
MIRT693610	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693609	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693608	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT646627	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT646626	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT646625	hsa-miR-3163	HITS-CLIP	23824327
MIRT646624	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT646623	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT646622	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT646621	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT646619	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT646620	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT646618	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT693632	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT693631	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT693630	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693629	hsa-miR-8063	HITS-CLIP	23313552
MIRT693628	hsa-miR-4698	HITS-CLIP	23313552
MIRT693627	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT693626	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693625	hsa-miR-4421	HITS-CLIP	23313552
MIRT693624	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT693623	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT693622	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT693621	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT693620	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT693619	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT693618	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693617	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693616	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693615	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693614	hsa-miR-612	HITS-CLIP	23313552
MIRT693613	hsa-miR-6860	HITS-CLIP	23313552
MIRT693612	hsa-miR-4725-5p	HITS-CLIP	23313552
MIRT693611	hsa-miR-661	HITS-CLIP	23313552
MIRT693610	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693609	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693608	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT646627	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT646626	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT646625	hsa-miR-3163	HITS-CLIP	23824327
MIRT646624	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT646623	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT646622	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT646621	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT646619	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT646620	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT646618	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT884988	hsa-miR-1202	CLIP-seq
MIRT884989	hsa-miR-1290	CLIP-seq
MIRT884990	hsa-miR-197	CLIP-seq
MIRT884991	hsa-miR-199a-3p	CLIP-seq
MIRT884992	hsa-miR-199b-3p	CLIP-seq
MIRT884993	hsa-miR-3123	CLIP-seq
MIRT884994	hsa-miR-3129-5p	CLIP-seq
MIRT884995	hsa-miR-3154	CLIP-seq
MIRT884996	hsa-miR-3179	CLIP-seq
MIRT884997	hsa-miR-3184	CLIP-seq
MIRT884998	hsa-miR-3925-5p	CLIP-seq
MIRT884999	hsa-miR-3936	CLIP-seq
MIRT885000	hsa-miR-3972	CLIP-seq
MIRT885001	hsa-miR-423-5p	CLIP-seq
MIRT885002	hsa-miR-4277	CLIP-seq
MIRT885003	hsa-miR-4450	CLIP-seq
MIRT885004	hsa-miR-4716-5p	CLIP-seq
MIRT885005	hsa-miR-4781-3p	CLIP-seq
MIRT885006	hsa-miR-5096	CLIP-seq
MIRT885007	hsa-miR-936	CLIP-seq
MIRT885008	hsa-miR-105	CLIP-seq
MIRT884988	hsa-miR-1202	CLIP-seq
MIRT884989	hsa-miR-1290	CLIP-seq
MIRT885009	hsa-miR-129-5p	CLIP-seq
MIRT885010	hsa-miR-1304	CLIP-seq
MIRT885011	hsa-miR-1343	CLIP-seq
MIRT885012	hsa-miR-1827	CLIP-seq
MIRT885013	hsa-miR-3176	CLIP-seq
MIRT884997	hsa-miR-3184	CLIP-seq
MIRT885014	hsa-miR-3662	CLIP-seq
MIRT885015	hsa-miR-3663-5p	CLIP-seq
MIRT885016	hsa-miR-3922-3p	CLIP-seq
MIRT885000	hsa-miR-3972	CLIP-seq
MIRT885001	hsa-miR-423-5p	CLIP-seq
MIRT885002	hsa-miR-4277	CLIP-seq
MIRT885017	hsa-miR-4311	CLIP-seq
MIRT885018	hsa-miR-4427	CLIP-seq
MIRT885003	hsa-miR-4450	CLIP-seq
MIRT885019	hsa-miR-4452	CLIP-seq
MIRT885020	hsa-miR-4635	CLIP-seq
MIRT885021	hsa-miR-4680-3p	CLIP-seq
MIRT885022	hsa-miR-4720-3p	CLIP-seq
MIRT885023	hsa-miR-4757-5p	CLIP-seq
MIRT885024	hsa-miR-4762-3p	CLIP-seq
MIRT885025	hsa-miR-4804-3p	CLIP-seq
MIRT885026	hsa-miR-548m	CLIP-seq
MIRT885027	hsa-miR-640	CLIP-seq
MIRT1962457	hsa-miR-552	CLIP-seq
MIRT885008	hsa-miR-105	CLIP-seq
MIRT1962458	hsa-miR-1184	CLIP-seq
MIRT1962459	hsa-miR-122	CLIP-seq
MIRT885011	hsa-miR-1343	CLIP-seq
MIRT1962460	hsa-miR-24	CLIP-seq
MIRT1962461	hsa-miR-3135b	CLIP-seq
MIRT885013	hsa-miR-3176	CLIP-seq
MIRT1962462	hsa-miR-3652	CLIP-seq
MIRT885016	hsa-miR-3922-3p	CLIP-seq
MIRT1962463	hsa-miR-4284	CLIP-seq
MIRT1962464	hsa-miR-4418	CLIP-seq
MIRT1962465	hsa-miR-4423-5p	CLIP-seq
MIRT1962466	hsa-miR-4430	CLIP-seq
MIRT885019	hsa-miR-4452	CLIP-seq
MIRT885023	hsa-miR-4757-5p	CLIP-seq
MIRT1962467	hsa-miR-509-3-5p	CLIP-seq
MIRT1962468	hsa-miR-509-5p	CLIP-seq
MIRT885027	hsa-miR-640	CLIP-seq
MIRT2198855	hsa-miR-106a	CLIP-seq
MIRT2198856	hsa-miR-106b	CLIP-seq
MIRT1962458	hsa-miR-1184	CLIP-seq
MIRT2198857	hsa-miR-1287	CLIP-seq
MIRT2198858	hsa-miR-17	CLIP-seq
MIRT2198859	hsa-miR-20a	CLIP-seq
MIRT2198860	hsa-miR-20b	CLIP-seq
MIRT1962460	hsa-miR-24	CLIP-seq
MIRT2198861	hsa-miR-302a	CLIP-seq
MIRT2198862	hsa-miR-302b	CLIP-seq
MIRT2198863	hsa-miR-302c	CLIP-seq
MIRT2198864	hsa-miR-302d	CLIP-seq
MIRT2198865	hsa-miR-302e	CLIP-seq
MIRT1962461	hsa-miR-3135b	CLIP-seq
MIRT2198866	hsa-miR-372	CLIP-seq
MIRT2198867	hsa-miR-373	CLIP-seq
MIRT2198868	hsa-miR-3908	CLIP-seq
MIRT2198869	hsa-miR-3942-5p	CLIP-seq
MIRT1962463	hsa-miR-4284	CLIP-seq
MIRT2198870	hsa-miR-4291	CLIP-seq
MIRT2198871	hsa-miR-4310	CLIP-seq
MIRT1962464	hsa-miR-4418	CLIP-seq
MIRT2198872	hsa-miR-4423-3p	CLIP-seq
MIRT2198873	hsa-miR-4703-5p	CLIP-seq
MIRT2198874	hsa-miR-4753-3p	CLIP-seq
MIRT2198875	hsa-miR-4766-3p	CLIP-seq
MIRT1962467	hsa-miR-509-3-5p	CLIP-seq
MIRT1962468	hsa-miR-509-5p	CLIP-seq
MIRT2198876	hsa-miR-512-3p	CLIP-seq
MIRT2198877	hsa-miR-519d	CLIP-seq
MIRT2198878	hsa-miR-520a-3p	CLIP-seq
MIRT2198879	hsa-miR-520b	CLIP-seq
MIRT2198880	hsa-miR-520c-3p	CLIP-seq
MIRT2198881	hsa-miR-520d-3p	CLIP-seq
MIRT2198882	hsa-miR-520e	CLIP-seq
MIRT2198883	hsa-miR-520g	CLIP-seq
MIRT2198884	hsa-miR-520h	CLIP-seq
MIRT2198885	hsa-miR-93	CLIP-seq
MIRT2385937	hsa-miR-1976	CLIP-seq
MIRT2385938	hsa-miR-4279	CLIP-seq
MIRT2385939	hsa-miR-450b-3p	CLIP-seq
MIRT2385940	hsa-miR-455-5p	CLIP-seq
MIRT2385941	hsa-miR-4713-3p	CLIP-seq
MIRT2385942	hsa-miR-638	CLIP-seq
MIRT2385943	hsa-miR-769-3p	CLIP-seq
MIRT1962459	hsa-miR-122	CLIP-seq
MIRT885012	hsa-miR-1827	CLIP-seq
MIRT1962461	hsa-miR-3135b	CLIP-seq
MIRT1962462	hsa-miR-3652	CLIP-seq
MIRT1962465	hsa-miR-4423-5p	CLIP-seq
MIRT1962466	hsa-miR-4430	CLIP-seq
MIRT2501655	hsa-miR-4715-3p	CLIP-seq
MIRT1962458	hsa-miR-1184	CLIP-seq
MIRT1962459	hsa-miR-122	CLIP-seq
MIRT1962460	hsa-miR-24	CLIP-seq
MIRT1962461	hsa-miR-3135b	CLIP-seq
MIRT1962462	hsa-miR-3652	CLIP-seq
MIRT1962463	hsa-miR-4284	CLIP-seq
MIRT1962464	hsa-miR-4418	CLIP-seq
MIRT1962465	hsa-miR-4423-5p	CLIP-seq
MIRT1962466	hsa-miR-4430	CLIP-seq
MIRT2501655	hsa-miR-4715-3p	CLIP-seq
MIRT2501656	hsa-miR-4742-3p	CLIP-seq
MIRT2501657	hsa-miR-4803	CLIP-seq
MIRT1962467	hsa-miR-509-3-5p	CLIP-seq
MIRT1962468	hsa-miR-509-5p	CLIP-seq
MIRT1962458	hsa-miR-1184	CLIP-seq
MIRT1962459	hsa-miR-122	CLIP-seq
MIRT885012	hsa-miR-1827	CLIP-seq
MIRT884991	hsa-miR-199a-3p	CLIP-seq
MIRT884992	hsa-miR-199b-3p	CLIP-seq
MIRT1962460	hsa-miR-24	CLIP-seq
MIRT884993	hsa-miR-3123	CLIP-seq
MIRT884994	hsa-miR-3129-5p	CLIP-seq
MIRT1962461	hsa-miR-3135b	CLIP-seq
MIRT884995	hsa-miR-3154	CLIP-seq
MIRT884996	hsa-miR-3179	CLIP-seq
MIRT1962462	hsa-miR-3652	CLIP-seq
MIRT884998	hsa-miR-3925-5p	CLIP-seq
MIRT884999	hsa-miR-3936	CLIP-seq
MIRT1962463	hsa-miR-4284	CLIP-seq
MIRT1962464	hsa-miR-4418	CLIP-seq
MIRT1962465	hsa-miR-4423-5p	CLIP-seq
MIRT1962466	hsa-miR-4430	CLIP-seq
MIRT2501655	hsa-miR-4715-3p	CLIP-seq
MIRT2501656	hsa-miR-4742-3p	CLIP-seq
MIRT2501657	hsa-miR-4803	CLIP-seq
MIRT1962467	hsa-miR-509-3-5p	CLIP-seq
MIRT1962468	hsa-miR-509-5p	CLIP-seq
MIRT885007	hsa-miR-936	CLIP-seq
MIRT2678015	hsa-miR-944	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000939	Component	Inner kinetochore	IPI	36085283
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	36085283
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	NAS	36085283

MIM	HGNC	e!Ensembl
611503	17879	ENSG00000120334

Q8N0S6

Protein name

Centromere protein L (CENP-L) (Interphase centromere complex protein 33)

Protein function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesiz

PDB

7PKN , 7QOO , 7R5S , 7R5V , 7XHN , 7XHO , 7YWX , 7YYH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13092	CENP-L	177 → 324	Kinetochore complex Sim4 subunit Fta1	Family

Sequence

MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVD
PQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVI
FSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTC
LPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFL
WSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLS
ATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE

Sequence length

344

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	34341433	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34457090, 34607313, 36572856, 37914022	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	36572856	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	36572856	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	21548129	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	36572856	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Seckel syndrome 1	Seckel syndrome	Pubtator	21548129	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36572856	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CENPL (centromere protein L)