Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	91608
Gene name	RAS like family 10 member B
Gene symbol	RASL10B
Synonyms (NCBI Gene)	RRP17VTS58635
Chromosome	17
Chromosome location	17q12

129

Show/Hide all (129)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043503	hsa-miR-331-3p	CLASH	23622248
MIRT039428	hsa-miR-421	CLASH	23622248
MIRT037118	hsa-miR-877-3p	CLASH	23622248
MIRT495291	hsa-miR-212-5p	PAR-CLIP	23708386
MIRT495290	hsa-miR-3926	PAR-CLIP	23708386
MIRT495289	hsa-miR-6069	PAR-CLIP	23708386
MIRT495288	hsa-miR-7156-3p	PAR-CLIP	23708386
MIRT495287	hsa-miR-548s	PAR-CLIP	23708386
MIRT495285	hsa-miR-4701-5p	PAR-CLIP	23708386
MIRT495286	hsa-miR-588	PAR-CLIP	23708386
MIRT495284	hsa-miR-4435	PAR-CLIP	23708386
MIRT495283	hsa-miR-3187-3p	PAR-CLIP	23708386
MIRT485155	hsa-miR-504-5p	PAR-CLIP	23592263
MIRT485153	hsa-miR-6732-3p	PAR-CLIP	23592263
MIRT485154	hsa-miR-4428	PAR-CLIP	23592263
MIRT485151	hsa-miR-4292	PAR-CLIP	23592263
MIRT485152	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT485150	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT485149	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT485147	hsa-miR-3656	PAR-CLIP	23592263
MIRT485148	hsa-miR-4533	PAR-CLIP	23592263
MIRT485146	hsa-miR-3202	PAR-CLIP	23592263
MIRT485145	hsa-miR-4434	PAR-CLIP	23592263
MIRT485144	hsa-miR-4516	PAR-CLIP	23592263
MIRT485143	hsa-miR-5703	PAR-CLIP	23592263
MIRT485142	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT485141	hsa-miR-6090	PAR-CLIP	23592263
MIRT485140	hsa-miR-4300	PAR-CLIP	23592263
MIRT485139	hsa-miR-5591-5p	PAR-CLIP	23592263
MIRT485138	hsa-miR-6726-5p	PAR-CLIP	23592263
MIRT485137	hsa-miR-920	PAR-CLIP	23592263
MIRT485136	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT485135	hsa-miR-6745	PAR-CLIP	23592263
MIRT485134	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT495291	hsa-miR-212-5p	PAR-CLIP	23708386
MIRT495290	hsa-miR-3926	PAR-CLIP	23708386
MIRT495289	hsa-miR-6069	PAR-CLIP	23708386
MIRT495288	hsa-miR-7156-3p	PAR-CLIP	23708386
MIRT495287	hsa-miR-548s	PAR-CLIP	23708386
MIRT495285	hsa-miR-4701-5p	PAR-CLIP	23708386
MIRT495286	hsa-miR-588	PAR-CLIP	23708386
MIRT495284	hsa-miR-4435	PAR-CLIP	23708386
MIRT495283	hsa-miR-3187-3p	PAR-CLIP	23708386
MIRT485155	hsa-miR-504-5p	PAR-CLIP	23592263
MIRT485153	hsa-miR-6732-3p	PAR-CLIP	23592263
MIRT485154	hsa-miR-4428	PAR-CLIP	23592263
MIRT485151	hsa-miR-4292	PAR-CLIP	23592263
MIRT485152	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT485150	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT485149	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT485147	hsa-miR-3656	PAR-CLIP	23592263
MIRT485148	hsa-miR-4533	PAR-CLIP	23592263
MIRT485146	hsa-miR-3202	PAR-CLIP	23592263
MIRT485145	hsa-miR-4434	PAR-CLIP	23592263
MIRT485144	hsa-miR-4516	PAR-CLIP	23592263
MIRT485143	hsa-miR-5703	PAR-CLIP	23592263
MIRT485142	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT485141	hsa-miR-6090	PAR-CLIP	23592263
MIRT485140	hsa-miR-4300	PAR-CLIP	23592263
MIRT485139	hsa-miR-5591-5p	PAR-CLIP	23592263
MIRT485138	hsa-miR-6726-5p	PAR-CLIP	23592263
MIRT485137	hsa-miR-920	PAR-CLIP	23592263
MIRT485136	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT485135	hsa-miR-6745	PAR-CLIP	23592263
MIRT485134	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT1292504	hsa-miR-1207-5p	CLIP-seq
MIRT1292505	hsa-miR-1294	CLIP-seq
MIRT1292506	hsa-miR-1321	CLIP-seq
MIRT1292507	hsa-miR-184	CLIP-seq
MIRT1292508	hsa-miR-1909	CLIP-seq
MIRT1292509	hsa-miR-2467-5p	CLIP-seq
MIRT1292510	hsa-miR-3188	CLIP-seq
MIRT1292511	hsa-miR-3616-3p	CLIP-seq
MIRT1292512	hsa-miR-3619-3p	CLIP-seq
MIRT1292513	hsa-miR-3975	CLIP-seq
MIRT1292514	hsa-miR-4257	CLIP-seq
MIRT1292515	hsa-miR-4284	CLIP-seq
MIRT1292516	hsa-miR-4316	CLIP-seq
MIRT1292517	hsa-miR-4419a	CLIP-seq
MIRT1292518	hsa-miR-4436b-3p	CLIP-seq
MIRT1292519	hsa-miR-4510	CLIP-seq
MIRT1292520	hsa-miR-4677-3p	CLIP-seq
MIRT1292521	hsa-miR-4736	CLIP-seq
MIRT1292522	hsa-miR-4739	CLIP-seq
MIRT1292523	hsa-miR-4756-5p	CLIP-seq
MIRT1292524	hsa-miR-4763-3p	CLIP-seq
MIRT1292525	hsa-miR-485-5p	CLIP-seq
MIRT1292526	hsa-miR-939	CLIP-seq
MIRT2086902	hsa-miR-1253	CLIP-seq
MIRT2086903	hsa-miR-1268	CLIP-seq
MIRT2086904	hsa-miR-1268b	CLIP-seq
MIRT2086905	hsa-miR-1299	CLIP-seq
MIRT2086906	hsa-miR-139-3p	CLIP-seq
MIRT1292509	hsa-miR-2467-5p	CLIP-seq
MIRT2086907	hsa-miR-378g	CLIP-seq
MIRT1292514	hsa-miR-4257	CLIP-seq
MIRT2086908	hsa-miR-4258	CLIP-seq
MIRT2086909	hsa-miR-4437	CLIP-seq
MIRT2086910	hsa-miR-4531	CLIP-seq
MIRT2086911	hsa-miR-4651	CLIP-seq
MIRT2086912	hsa-miR-4674	CLIP-seq
MIRT2086913	hsa-miR-4782-5p	CLIP-seq
MIRT2086914	hsa-miR-483-5p	CLIP-seq
MIRT2086915	hsa-miR-516b	CLIP-seq
MIRT2086916	hsa-miR-585	CLIP-seq
MIRT2086917	hsa-miR-592	CLIP-seq
MIRT2086918	hsa-miR-597	CLIP-seq
MIRT2086919	hsa-miR-608	CLIP-seq
MIRT2086920	hsa-miR-642b	CLIP-seq
MIRT2086921	hsa-miR-661	CLIP-seq
MIRT1292504	hsa-miR-1207-5p	CLIP-seq
MIRT1292507	hsa-miR-184	CLIP-seq
MIRT2311821	hsa-miR-1915	CLIP-seq
MIRT2311822	hsa-miR-194	CLIP-seq
MIRT2311823	hsa-miR-3184	CLIP-seq
MIRT2311824	hsa-miR-345	CLIP-seq
MIRT1292512	hsa-miR-3619-3p	CLIP-seq
MIRT2311825	hsa-miR-383	CLIP-seq
MIRT2311826	hsa-miR-423-5p	CLIP-seq
MIRT2311827	hsa-miR-4493	CLIP-seq
MIRT2311828	hsa-miR-4645-3p	CLIP-seq
MIRT2311829	hsa-miR-4688	CLIP-seq
MIRT2311830	hsa-miR-4726-3p	CLIP-seq
MIRT2311831	hsa-miR-4733-3p	CLIP-seq
MIRT1292521	hsa-miR-4736	CLIP-seq
MIRT1292524	hsa-miR-4763-3p	CLIP-seq
MIRT2311832	hsa-miR-4786-3p	CLIP-seq
MIRT2311833	hsa-miR-617	CLIP-seq
MIRT2311834	hsa-miR-671-5p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003050	Process	Regulation of systemic arterial blood pressure by atrial natriuretic peptide	IEA
GO:0003050	Process	Regulation of systemic arterial blood pressure by atrial natriuretic peptide	ISS
GO:0003924	Function	GTPase activity	IEA
GO:0003925	Function	G protein activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005525	Function	GTP binding	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0090277	Process	Positive regulation of peptide hormone secretion	IEA
GO:0090277	Process	Positive regulation of peptide hormone secretion	ISS

MIM	HGNC	e!Ensembl
612128	30295	ENSG00000270885

Q96S79

Protein name

Ras-like protein family member 10B (EC 3.6.5.2) (Ras-like protein VTS58635) (Ras-related protein 17) (RRP17)

Protein function

May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	6 → 178	Ras family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas. {ECO:0000269|PubMed:17984325}.

Sequence

MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF
PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE
TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA
RCKHVHAALRFQGALRRNRCAIM

Sequence length

203

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30016783	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	30016783	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543		★★★★★ ★☆☆☆☆ Found in Text Mining only

RASL10B (RAS like family 10 member B)