Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9153
Gene name	Solute carrier family 28 member 2
Gene symbol	SLC28A2
Synonyms (NCBI Gene)	CNT2HCNT2HsT17153SPNT1
Chromosome	15
Chromosome location	15q21.1

215

Show/Hide all (215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT529452	hsa-miR-6782-3p	PAR-CLIP	22012620
MIRT529451	hsa-miR-208a-5p	PAR-CLIP	22012620
MIRT529450	hsa-miR-208b-5p	PAR-CLIP	22012620
MIRT529449	hsa-miR-4705	PAR-CLIP	22012620
MIRT529448	hsa-miR-4719	PAR-CLIP	22012620
MIRT529447	hsa-miR-3121-5p	PAR-CLIP	22012620
MIRT529446	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT529445	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT529452	hsa-miR-6782-3p	PAR-CLIP	22012620
MIRT529451	hsa-miR-208a-5p	PAR-CLIP	22012620
MIRT529450	hsa-miR-208b-5p	PAR-CLIP	22012620
MIRT529449	hsa-miR-4705	PAR-CLIP	22012620
MIRT529448	hsa-miR-4719	PAR-CLIP	22012620
MIRT529447	hsa-miR-3121-5p	PAR-CLIP	22012620
MIRT529446	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT529445	hsa-miR-450b-5p	PAR-CLIP	22012620
MIRT1358110	hsa-miR-1193	CLIP-seq
MIRT1358111	hsa-miR-1208	CLIP-seq
MIRT1358112	hsa-miR-122	CLIP-seq
MIRT1358113	hsa-miR-1225-3p	CLIP-seq
MIRT1358114	hsa-miR-1233	CLIP-seq
MIRT1358115	hsa-miR-2392	CLIP-seq
MIRT1358116	hsa-miR-3135b	CLIP-seq
MIRT1358117	hsa-miR-3152-3p	CLIP-seq
MIRT1358118	hsa-miR-3652	CLIP-seq
MIRT1358119	hsa-miR-3940-3p	CLIP-seq
MIRT1358120	hsa-miR-4252	CLIP-seq
MIRT1358121	hsa-miR-4420	CLIP-seq
MIRT1358122	hsa-miR-4430	CLIP-seq
MIRT1358123	hsa-miR-4438	CLIP-seq
MIRT1358124	hsa-miR-4454	CLIP-seq
MIRT1358125	hsa-miR-4634	CLIP-seq
MIRT1358126	hsa-miR-4662a-5p	CLIP-seq
MIRT1358127	hsa-miR-4676-5p	CLIP-seq
MIRT1358128	hsa-miR-4707-3p	CLIP-seq
MIRT1358129	hsa-miR-4797-5p	CLIP-seq
MIRT1358130	hsa-miR-483-5p	CLIP-seq
MIRT1358131	hsa-miR-5095	CLIP-seq
MIRT1358132	hsa-miR-575	CLIP-seq
MIRT1358133	hsa-miR-720	CLIP-seq
MIRT1358134	hsa-miR-892a	CLIP-seq
MIRT1358110	hsa-miR-1193	CLIP-seq
MIRT1358111	hsa-miR-1208	CLIP-seq
MIRT1921719	hsa-miR-129-5p	CLIP-seq
MIRT1358115	hsa-miR-2392	CLIP-seq
MIRT1921720	hsa-miR-3149	CLIP-seq
MIRT1358117	hsa-miR-3152-3p	CLIP-seq
MIRT1921721	hsa-miR-411	CLIP-seq
MIRT1358121	hsa-miR-4420	CLIP-seq
MIRT1358124	hsa-miR-4454	CLIP-seq
MIRT1358126	hsa-miR-4662a-5p	CLIP-seq
MIRT1358127	hsa-miR-4676-5p	CLIP-seq
MIRT1358128	hsa-miR-4707-3p	CLIP-seq
MIRT1921722	hsa-miR-4735-5p	CLIP-seq
MIRT1921723	hsa-miR-4775	CLIP-seq
MIRT1358130	hsa-miR-483-5p	CLIP-seq
MIRT1358132	hsa-miR-575	CLIP-seq
MIRT1921724	hsa-miR-590-3p	CLIP-seq
MIRT1358134	hsa-miR-892a	CLIP-seq
MIRT1358110	hsa-miR-1193	CLIP-seq
MIRT1358111	hsa-miR-1208	CLIP-seq
MIRT1358115	hsa-miR-2392	CLIP-seq
MIRT1358117	hsa-miR-3152-3p	CLIP-seq
MIRT1921721	hsa-miR-411	CLIP-seq
MIRT1358121	hsa-miR-4420	CLIP-seq
MIRT1358124	hsa-miR-4454	CLIP-seq
MIRT1358126	hsa-miR-4662a-5p	CLIP-seq
MIRT1358127	hsa-miR-4676-5p	CLIP-seq
MIRT1358128	hsa-miR-4707-3p	CLIP-seq
MIRT1358130	hsa-miR-483-5p	CLIP-seq
MIRT1358132	hsa-miR-575	CLIP-seq
MIRT1358134	hsa-miR-892a	CLIP-seq
MIRT1358110	hsa-miR-1193	CLIP-seq
MIRT1358111	hsa-miR-1208	CLIP-seq
MIRT1921719	hsa-miR-129-5p	CLIP-seq
MIRT1358115	hsa-miR-2392	CLIP-seq
MIRT1921720	hsa-miR-3149	CLIP-seq
MIRT1358117	hsa-miR-3152-3p	CLIP-seq
MIRT1921721	hsa-miR-411	CLIP-seq
MIRT1358121	hsa-miR-4420	CLIP-seq
MIRT1358124	hsa-miR-4454	CLIP-seq
MIRT1358126	hsa-miR-4662a-5p	CLIP-seq
MIRT1358127	hsa-miR-4676-5p	CLIP-seq
MIRT1358128	hsa-miR-4707-3p	CLIP-seq
MIRT1921722	hsa-miR-4735-5p	CLIP-seq
MIRT1921723	hsa-miR-4775	CLIP-seq
MIRT1358130	hsa-miR-483-5p	CLIP-seq
MIRT1358132	hsa-miR-575	CLIP-seq
MIRT1921724	hsa-miR-590-3p	CLIP-seq
MIRT1358134	hsa-miR-892a	CLIP-seq
MIRT1358110	hsa-miR-1193	CLIP-seq
MIRT1358111	hsa-miR-1208	CLIP-seq
MIRT1921719	hsa-miR-129-5p	CLIP-seq
MIRT1358115	hsa-miR-2392	CLIP-seq
MIRT1921720	hsa-miR-3149	CLIP-seq
MIRT1358117	hsa-miR-3152-3p	CLIP-seq
MIRT1921721	hsa-miR-411	CLIP-seq
MIRT1358121	hsa-miR-4420	CLIP-seq
MIRT1358124	hsa-miR-4454	CLIP-seq
MIRT1358126	hsa-miR-4662a-5p	CLIP-seq
MIRT1358127	hsa-miR-4676-5p	CLIP-seq
MIRT1358128	hsa-miR-4707-3p	CLIP-seq
MIRT1921723	hsa-miR-4775	CLIP-seq
MIRT1358130	hsa-miR-483-5p	CLIP-seq
MIRT1358132	hsa-miR-575	CLIP-seq
MIRT1921724	hsa-miR-590-3p	CLIP-seq
MIRT1358134	hsa-miR-892a	CLIP-seq
MIRT2106115	hsa-miR-106a	CLIP-seq
MIRT2106116	hsa-miR-106b	CLIP-seq
MIRT1358110	hsa-miR-1193	CLIP-seq
MIRT1358112	hsa-miR-122	CLIP-seq
MIRT2106117	hsa-miR-1234	CLIP-seq
MIRT2106118	hsa-miR-150	CLIP-seq
MIRT2106119	hsa-miR-17	CLIP-seq
MIRT2106120	hsa-miR-20a	CLIP-seq
MIRT2106121	hsa-miR-20b	CLIP-seq
MIRT2106122	hsa-miR-2276	CLIP-seq
MIRT1358115	hsa-miR-2392	CLIP-seq
MIRT2106123	hsa-miR-302a	CLIP-seq
MIRT2106124	hsa-miR-302b	CLIP-seq
MIRT2106125	hsa-miR-302c	CLIP-seq
MIRT2106126	hsa-miR-302d	CLIP-seq
MIRT2106127	hsa-miR-302e	CLIP-seq
MIRT1358116	hsa-miR-3135b	CLIP-seq
MIRT1358118	hsa-miR-3652	CLIP-seq
MIRT2106128	hsa-miR-372	CLIP-seq
MIRT2106129	hsa-miR-373	CLIP-seq
MIRT1358122	hsa-miR-4430	CLIP-seq
MIRT1358124	hsa-miR-4454	CLIP-seq
MIRT1358125	hsa-miR-4634	CLIP-seq
MIRT1358128	hsa-miR-4707-3p	CLIP-seq
MIRT2106130	hsa-miR-4731-5p	CLIP-seq
MIRT1358129	hsa-miR-4797-5p	CLIP-seq
MIRT2106131	hsa-miR-512-3p	CLIP-seq
MIRT2106132	hsa-miR-519d	CLIP-seq
MIRT2106133	hsa-miR-520a-3p	CLIP-seq
MIRT2106134	hsa-miR-520b	CLIP-seq
MIRT2106135	hsa-miR-520c-3p	CLIP-seq
MIRT2106136	hsa-miR-520d-3p	CLIP-seq
MIRT2106137	hsa-miR-520e	CLIP-seq
MIRT2106138	hsa-miR-520g	CLIP-seq
MIRT2106139	hsa-miR-520h	CLIP-seq
MIRT2106140	hsa-miR-639	CLIP-seq
MIRT1358133	hsa-miR-720	CLIP-seq
MIRT2106141	hsa-miR-93	CLIP-seq
MIRT2106115	hsa-miR-106a	CLIP-seq
MIRT2106116	hsa-miR-106b	CLIP-seq
MIRT1358110	hsa-miR-1193	CLIP-seq
MIRT1358111	hsa-miR-1208	CLIP-seq
MIRT1358112	hsa-miR-122	CLIP-seq
MIRT2106117	hsa-miR-1234	CLIP-seq
MIRT2106118	hsa-miR-150	CLIP-seq
MIRT2106119	hsa-miR-17	CLIP-seq
MIRT2106120	hsa-miR-20a	CLIP-seq
MIRT2106121	hsa-miR-20b	CLIP-seq
MIRT2106122	hsa-miR-2276	CLIP-seq
MIRT1358115	hsa-miR-2392	CLIP-seq
MIRT2106123	hsa-miR-302a	CLIP-seq
MIRT2106124	hsa-miR-302b	CLIP-seq
MIRT2106125	hsa-miR-302c	CLIP-seq
MIRT2106126	hsa-miR-302d	CLIP-seq
MIRT2106127	hsa-miR-302e	CLIP-seq
MIRT1358116	hsa-miR-3135b	CLIP-seq
MIRT1358117	hsa-miR-3152-3p	CLIP-seq
MIRT1358118	hsa-miR-3652	CLIP-seq
MIRT2106128	hsa-miR-372	CLIP-seq
MIRT2106129	hsa-miR-373	CLIP-seq
MIRT1921721	hsa-miR-411	CLIP-seq
MIRT1358121	hsa-miR-4420	CLIP-seq
MIRT1358122	hsa-miR-4430	CLIP-seq
MIRT1358123	hsa-miR-4438	CLIP-seq
MIRT1358124	hsa-miR-4454	CLIP-seq
MIRT1358125	hsa-miR-4634	CLIP-seq
MIRT1358126	hsa-miR-4662a-5p	CLIP-seq
MIRT1358127	hsa-miR-4676-5p	CLIP-seq
MIRT1358128	hsa-miR-4707-3p	CLIP-seq
MIRT2106130	hsa-miR-4731-5p	CLIP-seq
MIRT1358129	hsa-miR-4797-5p	CLIP-seq
MIRT1358130	hsa-miR-483-5p	CLIP-seq
MIRT1358131	hsa-miR-5095	CLIP-seq
MIRT2106131	hsa-miR-512-3p	CLIP-seq
MIRT2106132	hsa-miR-519d	CLIP-seq
MIRT2106133	hsa-miR-520a-3p	CLIP-seq
MIRT2106134	hsa-miR-520b	CLIP-seq
MIRT2106135	hsa-miR-520c-3p	CLIP-seq
MIRT2106136	hsa-miR-520d-3p	CLIP-seq
MIRT2106137	hsa-miR-520e	CLIP-seq
MIRT2106138	hsa-miR-520g	CLIP-seq
MIRT2106139	hsa-miR-520h	CLIP-seq
MIRT1358132	hsa-miR-575	CLIP-seq
MIRT2106140	hsa-miR-639	CLIP-seq
MIRT1358133	hsa-miR-720	CLIP-seq
MIRT1358134	hsa-miR-892a	CLIP-seq
MIRT2106141	hsa-miR-93	CLIP-seq
MIRT2106122	hsa-miR-2276	CLIP-seq
MIRT1358125	hsa-miR-4634	CLIP-seq
MIRT2106140	hsa-miR-639	CLIP-seq
MIRT1358133	hsa-miR-720	CLIP-seq
MIRT1358112	hsa-miR-122	CLIP-seq
MIRT1921719	hsa-miR-129-5p	CLIP-seq
MIRT2106122	hsa-miR-2276	CLIP-seq
MIRT1358116	hsa-miR-3135b	CLIP-seq
MIRT1921720	hsa-miR-3149	CLIP-seq
MIRT1358118	hsa-miR-3652	CLIP-seq
MIRT1358122	hsa-miR-4430	CLIP-seq
MIRT1358125	hsa-miR-4634	CLIP-seq
MIRT1921722	hsa-miR-4735-5p	CLIP-seq
MIRT1921723	hsa-miR-4775	CLIP-seq
MIRT1921724	hsa-miR-590-3p	CLIP-seq
MIRT2106140	hsa-miR-639	CLIP-seq
MIRT1358133	hsa-miR-720	CLIP-seq
MIRT2106122	hsa-miR-2276	CLIP-seq
MIRT1358125	hsa-miR-4634	CLIP-seq
MIRT2106140	hsa-miR-639	CLIP-seq
MIRT1358133	hsa-miR-720	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001895	Process	Retina homeostasis	IBA
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IDA	10087507
GO:0005337	Function	Nucleoside transmembrane transporter activity	IEA
GO:0005345	Function	Purine nucleobase transmembrane transporter activity	IDA	22492015
GO:0005415	Function	Nucleoside:sodium symporter activity	IBA
GO:0005415	Function	Nucleoside:sodium symporter activity	IDA	10087507
GO:0005415	Function	Nucleoside:sodium symporter activity	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	9435697
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	9435697
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0006836	Process	Neurotransmitter transport	IDA	10087507
GO:0006855	Process	Xenobiotic transmembrane transport	TAS
GO:0012506	Component	Vesicle membrane	ISS
GO:0015211	Function	Purine nucleoside transmembrane transporter activity	IBA
GO:0015211	Function	Purine nucleoside transmembrane transporter activity	IDA	10087507
GO:0015211	Function	Purine nucleoside transmembrane transporter activity	TAS	9435697
GO:0015213	Function	Uridine transmembrane transporter activity	IDA	10087507, 22492015
GO:0015389	Function	Pyrimidine- and adenosine-specific:sodium symporter activity	IDA	10087507
GO:0015855	Process	Pyrimidine nucleobase transport	IEA
GO:0015860	Process	Purine nucleoside transmembrane transport	IDA	10087507
GO:0015860	Process	Purine nucleoside transmembrane transport	TAS	9435697
GO:0015862	Process	Uridine transmembrane transport	IDA	10087507, 22492015
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9435697
GO:0016327	Component	Apicolateral plasma membrane	IDA	35307651
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0030135	Component	Coated vesicle	ISS
GO:0031526	Component	Brush border membrane	ISS
GO:0032238	Process	Adenosine transport	IDA	10087507
GO:0035340	Process	Inosine transport	IDA	10087507
GO:0045117	Process	Azole transmembrane transport	ISS
GO:0072531	Process	Pyrimidine-containing compound transmembrane transport	IDA	10087507, 22492015
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1901474	Function	Azole transmembrane transporter activity	ISS
GO:1901642	Process	Nucleoside transmembrane transport	IBA
GO:1901642	Process	Nucleoside transmembrane transport	IDA	10087507, 22492015
GO:1901642	Process	Nucleoside transmembrane transport	IEA
GO:1904823	Process	Purine nucleobase transmembrane transport	IDA	22492015

MIM	HGNC	e!Ensembl
606208	11002	ENSG00000137860

O43868

Protein name

Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2)

Protein function

Sodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:1008

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01773	Nucleos_tra2_N	178 → 251	Na+ dependent nucleoside transporter N-terminus	Family
PF07670	Gate	258 → 358	Nucleoside recognition	Domain
PF07662	Nucleos_tra2_C	361 → 585	Na+ dependent nucleoside transporter C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain (PubMed:9435697). Weak expression in lung (PubMed:9435697). In testis, primarily localized to the apicolateral membranes of Serto

Sequence

MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA

Sequence length

658

Interactions

View interactions

	Reactome
			Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anemia	Anemia	BEFREE	21346688, 23195617, 26071337		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	33646276, 34850851	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30076612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30076612	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36244249	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gout	Gout	Pubtator	30679935	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	21266914		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperuricemia	Hyperuricemia	BEFREE	29379442		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperuricemia	Hyperuricemia	Pubtator	30679935	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	19487253	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lipodystrophy	Lipodystrophy	LHGDN	17926640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	35053305	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30076612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	20028759	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	29701127		★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC28A2 (solute carrier family 28 member 2)