Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	915
Gene name	CD3 delta subunit of T-cell receptor complex
Gene symbol	CD3D
Synonyms (NCBI Gene)	CD3-DELTACD3DELTAIMD19T3D
Chromosome	11
Chromosome location	11q23.3
Summary	The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four

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SNP ID	Visualize variation	Clinical significance	Consequence
rs111033580	G>A,T	Pathogenic, likely-benign	Synonymous variant, coding sequence variant, stop gained
rs111033581	G>T	Pathogenic	Stop gained, coding sequence variant, intron variant
rs730880296	C>T	Pathogenic	Intron variant
rs1591278347	C>T	Pathogenic	Coding sequence variant, stop gained

283

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miRTarBase ID	miRNA	Experiments	Reference
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT624400	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT624399	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT624398	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT624397	hsa-miR-4421	HITS-CLIP	23824327
MIRT624396	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT624395	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624394	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624393	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624392	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624391	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT624390	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT540608	hsa-miR-5588-3p	PAR-CLIP	21572407
MIRT540609	hsa-miR-2114-5p	PAR-CLIP	21572407
MIRT540607	hsa-miR-1228-3p	PAR-CLIP	21572407
MIRT540606	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT540605	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT540604	hsa-miR-4284	PAR-CLIP	21572407
MIRT540603	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT540602	hsa-miR-7977	PAR-CLIP	21572407
MIRT540601	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT540600	hsa-miR-3122	PAR-CLIP	21572407
MIRT540599	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT540598	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT540597	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT624398	hsa-miR-339-5p	PAR-CLIP	27292025
MIRT624397	hsa-miR-4421	PAR-CLIP	27292025
MIRT624396	hsa-miR-5699-3p	PAR-CLIP	27292025
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT672316	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT672315	hsa-miR-4673	HITS-CLIP	23824327
MIRT672314	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672313	hsa-miR-4640-5p	HITS-CLIP	23824327
MIRT672312	hsa-miR-4726-5p	HITS-CLIP	23824327
MIRT672311	hsa-miR-6508-3p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT672310	hsa-miR-6724-5p	HITS-CLIP	23824327
MIRT672309	hsa-miR-6773-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT634780	hsa-miR-4530	HITS-CLIP	23824327
MIRT634779	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT540604	hsa-miR-4284	HITS-CLIP	23824327
MIRT540603	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634778	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT634777	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT634776	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT634775	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT634774	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT634773	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT634772	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT540602	hsa-miR-7977	HITS-CLIP	23824327
MIRT634771	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT634770	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT634769	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT634768	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT634767	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT634766	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT634765	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT634764	hsa-miR-3689c	HITS-CLIP	23824327
MIRT634763	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT634762	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT540601	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT540600	hsa-miR-3122	HITS-CLIP	23824327
MIRT540599	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT540598	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT540597	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT624400	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT624399	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT624398	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT624397	hsa-miR-4421	HITS-CLIP	23824327
MIRT624396	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT624395	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624394	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624393	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624392	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624391	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT624390	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT540608	hsa-miR-5588-3p	PAR-CLIP	21572407
MIRT540609	hsa-miR-2114-5p	PAR-CLIP	21572407
MIRT540607	hsa-miR-1228-3p	PAR-CLIP	21572407
MIRT540606	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT540605	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT540604	hsa-miR-4284	PAR-CLIP	21572407
MIRT540603	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT540602	hsa-miR-7977	PAR-CLIP	21572407
MIRT540601	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT540600	hsa-miR-3122	PAR-CLIP	21572407
MIRT540599	hsa-miR-3913-5p	PAR-CLIP	21572407
MIRT540598	hsa-miR-887-5p	PAR-CLIP	21572407
MIRT540597	hsa-miR-6513-5p	PAR-CLIP	21572407
MIRT875233	hsa-miR-1185	CLIP-seq
MIRT875234	hsa-miR-3679-5p	CLIP-seq
MIRT875235	hsa-miR-4765	CLIP-seq
MIRT875236	hsa-miR-583	CLIP-seq
MIRT2196484	hsa-miR-3154	CLIP-seq
MIRT2196485	hsa-miR-451b	CLIP-seq
MIRT2196486	hsa-miR-4663	CLIP-seq
MIRT2196487	hsa-miR-647	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	NAS	29789755
GO:0002376	Process	Immune system process	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	IC	9485181
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	NAS	1831653
GO:0005886	Component	Plasma membrane	IDA	31461748
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IC	9485181
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0042101	Component	T cell receptor complex	IDA	8176201
GO:0042105	Component	Alpha-beta T cell receptor complex	IBA
GO:0042105	Component	Alpha-beta T cell receptor complex	IDA	9485181
GO:0042105	Component	Alpha-beta T cell receptor complex	IEA
GO:0042105	Component	Alpha-beta T cell receptor complex	IPI	31461748
GO:0042105	Component	Alpha-beta T cell receptor complex	ISS
GO:0042802	Function	Identical protein binding	IDA	14967045
GO:0045059	Process	Positive thymic T cell selection	IBA
GO:0045059	Process	Positive thymic T cell selection	IEA
GO:0045059	Process	Positive thymic T cell selection	ISS
GO:0046631	Process	Alpha-beta T cell activation	NAS	29789755
GO:0050852	Process	T cell receptor signaling pathway	NAS	29789755

MIM	HGNC	e!Ensembl
186790	1673	ENSG00000167286

P04234

Protein name

T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)

Protein function

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell

PDB

1XIW , 6JXR , 7FJD , 7FJE , 7FJF , 7PHR , 8ES7 , 8ES8 , 8ES9 , 8JC0 , 8JCB , 8TW4 , 8TW6 , 8WXE , 8WY0 , 8WYI , 8YC0 , 9BBC , 9C3E , 9CI8 , 9CIA , 9CQ4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16680	Ig_4	30 → 104	T-cell surface glycoprotein CD3 delta chain	Domain
PF02189	ITAM	146 → 165	Immunoreceptor tyrosine-based activation motif	Motif

Tissue specificity

TISSUE SPECIFICITY: CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells. {ECO:0000269|PubMed:1372642}.

Sequence

MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDL
GKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLAL
GVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

Sequence length

171

Interactions

View interactions

	KEGG		Reactome
	Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Chagas disease Measles Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Primary immunodeficiency		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
CD3D-related disorder	Likely pathogenic; Pathogenic	rs730880296	RCV003398816	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Immunodeficiency 19	Pathogenic; Likely pathogenic	rs1180673589, rs1341165259, rs2134058885, rs730880296, rs111033580, rs111033581, rs2496878055, rs1311932817, rs2496872144, rs767884151, rs1262227887, rs2496878023, rs2496870461, rs1172098673, rs1591278347	RCV001389381 RCV001970739 RCV002016082 RCV000157634 RCV000083294 View all (10 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Severe combined immunodeficiency disease	Pathogenic	rs2496872976	RCV003487261	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BILIARY CIRRHOSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATITIS, ALLERGIC CONTACT	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Immunodeficiency 104	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IMMUNODEFICIENCY 19, SEVERE COMBINED	—	CTD, HPO CTD, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, BILIARY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CHOLANGITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE COMBINED IMMUNODEFICIENCY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (70)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	1834326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia Aplastic	Aplastic anemia	Pubtator	22401598	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anorexia	Anorexia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	36311761	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bare Lymphocyte Syndrome	Bare Lymphocyte Syndrome	CTD_human_DG	15546002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Biliary cirrhosis	Biliary cirrhosis	CTD_human_DG	18422935		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Biliary Cirrhosis, Primary, 1	Biliary cirrhosis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	29484035	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26174627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33350431, 34572592	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	28258914	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37386390	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	21422001	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	21422001, 36733486	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	36802116	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Palsy	Cerebral palsy	Pubtator	29484035	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	31914842	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31914842, 34975867	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Common Variable Immunodeficiency	Common variable immunodeficiency	Pubtator	31921117	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	20155851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis, Allergic Contact	Dermatitis	CTD_human_DG	17597826		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus	Diabetes mellitus	Pubtator	36187128	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	1982251		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	34555062	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	40697415	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Exfoliative dermatitis	Exfoliative Dermatitis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Exudative vitreoretinopathy 1	Exudative vitreoretinopathy	Pubtator	1415220	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatigue Syndrome Chronic	Fatigue syndrome	Pubtator	36284352	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29254160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29254160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	35090306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	35712757	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
IMMUNODEFICIENCY 19	Immunodeficiency	CLINVAR_DG	14602880, 15546002, 21883749, 21926461, 22039266, 23336327, 24290291, 25344390, 27807805		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
IMMUNODEFICIENCY 19	Immunodeficiency	BEFREE	15640687		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
IMMUNODEFICIENCY 19	Immunodeficiency	CTD_human_DG			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
IMMUNODEFICIENCY 19	Immunodeficiency	GENOMICS_ENGLAND_DG			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	31921117	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	1834326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphopenia	Lymphopenia	BEFREE	23590417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphopenia	Lymphopenia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26174627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	30885360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	2456698, 30885360, 31114346		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	8181865		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	21669053	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	37274867	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	9781639		★★★★★ ★☆☆☆☆ Found in Text Mining only
Omenn Syndrome	Omenn Syndrome	CTD_human_DG	15546002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Otitis Media	Otitis media	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	37841886	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	27494091		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Recurrent otitis media	Otitis media	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	31842801		★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary Biliary Cholangitis	Biliary Cholangitis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	39377750	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	20133891		★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe Combined Immunodeficiency	Severe combined immunodeficiency disease	LHGDN	14602880		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe Combined Immunodeficiency	Severe combined immunodeficiency disease	CTD_human_DG	15546002		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe Combined Immunodeficiency	Severe combined immunodeficiency	Pubtator	15546002, 24288697, 35303369	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe Combined Immunodeficiency	Severe combined immunodeficiency disease	BEFREE	16264327, 23590417, 24288697		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe Combined Immunodeficiency	Severe combined immunodeficiency disease	GENOMICS_ENGLAND_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sjogren's Syndrome	Sjogren syndrome	Pubtator	15880807, 34367157	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32831060, 35712757	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta	Severe combined immunodeficiency disease	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	30885360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroiditis Autoimmune	Thyroiditis	Pubtator	31921117	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	33901225, 35090306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CD3D (CD3 delta subunit of T-cell receptor complex)