PDCD5 (programmed cell death 5)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 9141
Gene name Programmed cell death 5
Gene symbol PDCD5
Synonyms (NCBI Gene)
TFAR19
Chromosome 19
Chromosome location 19q13.11
Summary This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA
miRNA miRNA information provided by mirtarbase database.
11
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT044914 hsa-miR-186-5p CLASH 23622248
MIRT044914 hsa-miR-186-5p CLASH 23622248
MIRT039944 hsa-miR-615-3p CLASH 23622248
MIRT1219446 hsa-miR-1468 CLIP-seq
MIRT1219447 hsa-miR-3168 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
KLF9 Activation 24173774
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 24012345, 24375412, 32296183
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 24012345
GO:0005737 Component Cytoplasm HDA 16791210
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
604583 8764 ENSG00000105185
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14737
Protein name Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)
Protein function May function in the process of apoptosis.
PDB 1YYB , 2CRU , 2K6B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01984 dsDNA_bind 9 → 114 Double-stranded DNA-binding domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta.
Sequence
Sequence length 125
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SYSTEMIC LUPUS ERYTHEMATOSUS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (62)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 16247177
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16549820, 25109624
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 29588416
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 17468978, 29228993
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis Pubtator 31282065 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 18695908
★★★★★
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma LHGDN 18695908
★★★★★
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 29588416
★★★★★
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 24012345
★★★★★
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 31281315
★★★★★
★☆☆☆☆
Found in Text Mining only