Gene Gene information from NCBI Gene database.
Entrez ID 9122
Gene name Solute carrier family 16 member 4
Gene symbol SLC16A4
Synonyms (NCBI Gene)
MCT4MCT5
Chromosome 1
Chromosome location 1p13.3
miRNA miRNA information provided by mirtarbase database.
1088
miRTarBase ID miRNA Experiments Reference
MIRT018295 hsa-miR-335-5p Microarray 18185580
MIRT029757 hsa-miR-26b-5p Microarray 19088304
MIRT045889 hsa-miR-125b-5p CLASH 23622248
MIRT619201 hsa-miR-890 HITS-CLIP 23824327
MIRT619200 hsa-miR-6808-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 9425115
GO:0008028 Function Monocarboxylic acid transmembrane transporter activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603878 10925 ENSG00000168679
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15374
Protein name Monocarboxylate transporter 5 (MCT 5) (Monocarboxylate transporter 4) (MCT 4) (Solute carrier family 16 member 4)
Protein function Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies a
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07690 MFS_1 27 367 Major Facilitator Superfamily Family
PF07690 MFS_1 325 487 Major Facilitator Superfamily Family
Sequence
Sequence length 487
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 26525902, 26563366, 28206968, 29170050
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 25403912
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 28206968
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 31040927
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 29113201
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyps Adenomatous Polyposis BEFREE 31122841
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 30790227
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 26765963, 27623078
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 26213210
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 24077291
★☆☆☆☆
Found in Text Mining only