SLC16A6 (solute carrier family 16 member 6)

Gene

• Entrez ID: 9120
• Gene name: Solute carrier family 16 member 6
• Gene symbol: SLC16A6
• Synonyms (NCBI Gene): MCT6, MCT7
• Chromosome: 17
• Chromosome location: 17q24.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017473	hsa-miR-335-5p	Microarray	18185580
MIRT022486	hsa-miR-124-3p	Microarray	18668037
MIRT024746	hsa-miR-215-5p	Microarray	19074876
MIRT026327	hsa-miR-192-5p	Microarray	19074876
MIRT450011	hsa-miR-4282	HITS-CLIP	21572407
MIRT450010	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT450009	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT450008	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT699472	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT399048	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT699471	hsa-miR-4724-5p	HITS-CLIP	23313552
MIRT450010	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT699470	hsa-miR-8076	HITS-CLIP	23313552
MIRT699469	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT699468	hsa-miR-3688-3p	HITS-CLIP	23313552
MIRT699467	hsa-miR-4427	HITS-CLIP	23313552
MIRT699466	hsa-miR-643	HITS-CLIP	23313552
MIRT450009	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT699465	hsa-miR-6083	HITS-CLIP	23313552
MIRT467938	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT467937	hsa-miR-6502-3p	PAR-CLIP	23592263
MIRT467936	hsa-miR-4495	PAR-CLIP	23592263
MIRT467935	hsa-miR-3607-5p	PAR-CLIP	23592263
MIRT467934	hsa-miR-891b	PAR-CLIP	23592263
MIRT467933	hsa-miR-3152-3p	PAR-CLIP	23592263
MIRT467932	hsa-miR-3684	PAR-CLIP	23592263
MIRT450011	hsa-miR-4282	PAR-CLIP	22100165
MIRT450010	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT450009	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT450008	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT450011	hsa-miR-4282	HITS-CLIP	21572407
MIRT450010	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT450009	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT450008	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT699472	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT399048	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT699471	hsa-miR-4724-5p	HITS-CLIP	23313552
MIRT450010	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT699470	hsa-miR-8076	HITS-CLIP	23313552
MIRT699469	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT699468	hsa-miR-3688-3p	HITS-CLIP	23313552
MIRT699467	hsa-miR-4427	HITS-CLIP	23313552
MIRT699466	hsa-miR-643	HITS-CLIP	23313552
MIRT450009	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT699465	hsa-miR-6083	HITS-CLIP	23313552
MIRT467938	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT467937	hsa-miR-6502-3p	PAR-CLIP	23592263
MIRT467936	hsa-miR-4495	PAR-CLIP	23592263
MIRT467935	hsa-miR-3607-5p	PAR-CLIP	23592263
MIRT467934	hsa-miR-891b	PAR-CLIP	23592263
MIRT467933	hsa-miR-3152-3p	PAR-CLIP	23592263
MIRT467932	hsa-miR-3684	PAR-CLIP	23592263
MIRT450011	hsa-miR-4282	PAR-CLIP	22100165
MIRT450010	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT450009	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT450008	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT1353103	hsa-miR-106a	CLIP-seq
MIRT1353104	hsa-miR-106b	CLIP-seq
MIRT1353105	hsa-miR-1238	CLIP-seq
MIRT1353106	hsa-miR-125a-5p	CLIP-seq
MIRT1353107	hsa-miR-125b	CLIP-seq
MIRT1353108	hsa-miR-1264	CLIP-seq
MIRT1353109	hsa-miR-137	CLIP-seq
MIRT1353110	hsa-miR-139-5p	CLIP-seq
MIRT1353111	hsa-miR-148a	CLIP-seq
MIRT1353112	hsa-miR-148b	CLIP-seq
MIRT1353113	hsa-miR-152	CLIP-seq
MIRT1353114	hsa-miR-15a	CLIP-seq
MIRT1353115	hsa-miR-15b	CLIP-seq
MIRT1353116	hsa-miR-16	CLIP-seq
MIRT1353117	hsa-miR-17	CLIP-seq
MIRT1353118	hsa-miR-181a	CLIP-seq
MIRT1353119	hsa-miR-181b	CLIP-seq
MIRT1353120	hsa-miR-181c	CLIP-seq
MIRT1353121	hsa-miR-181d	CLIP-seq
MIRT1353122	hsa-miR-195	CLIP-seq
MIRT1353123	hsa-miR-20a	CLIP-seq
MIRT1353124	hsa-miR-20b	CLIP-seq
MIRT1353125	hsa-miR-219-1-3p	CLIP-seq
MIRT1353126	hsa-miR-2276	CLIP-seq
MIRT1353127	hsa-miR-23a	CLIP-seq
MIRT1353128	hsa-miR-23b	CLIP-seq
MIRT1353129	hsa-miR-23c	CLIP-seq
MIRT1353130	hsa-miR-2467-3p	CLIP-seq
MIRT1353131	hsa-miR-302a	CLIP-seq
MIRT1353132	hsa-miR-302b	CLIP-seq
MIRT1353133	hsa-miR-302c	CLIP-seq
MIRT1353134	hsa-miR-302d	CLIP-seq
MIRT1353135	hsa-miR-302e	CLIP-seq
MIRT1353136	hsa-miR-3117-5p	CLIP-seq
MIRT1353137	hsa-miR-3128	CLIP-seq
MIRT1353138	hsa-miR-3143	CLIP-seq
MIRT1353139	hsa-miR-3173-3p	CLIP-seq
MIRT1353140	hsa-miR-3609	CLIP-seq
MIRT1353141	hsa-miR-361-3p	CLIP-seq
MIRT1353142	hsa-miR-3678-3p	CLIP-seq
MIRT1353143	hsa-miR-3679-3p	CLIP-seq
MIRT1353144	hsa-miR-372	CLIP-seq
MIRT1353145	hsa-miR-373	CLIP-seq
MIRT1353146	hsa-miR-376a	CLIP-seq
MIRT1353147	hsa-miR-376b	CLIP-seq
MIRT1353148	hsa-miR-3919	CLIP-seq
MIRT1353149	hsa-miR-412	CLIP-seq
MIRT1353150	hsa-miR-424	CLIP-seq
MIRT1353151	hsa-miR-4252	CLIP-seq
MIRT1353152	hsa-miR-4262	CLIP-seq
MIRT1353153	hsa-miR-4272	CLIP-seq
MIRT1353154	hsa-miR-4276	CLIP-seq
MIRT1353155	hsa-miR-4307	CLIP-seq
MIRT1353156	hsa-miR-4319	CLIP-seq
MIRT1353157	hsa-miR-4330	CLIP-seq
MIRT1353158	hsa-miR-4426	CLIP-seq
MIRT1353159	hsa-miR-4446-5p	CLIP-seq
MIRT1353160	hsa-miR-4534	CLIP-seq
MIRT1353161	hsa-miR-4647	CLIP-seq
MIRT1353162	hsa-miR-4662b	CLIP-seq
MIRT1353163	hsa-miR-4670-3p	CLIP-seq
MIRT1353164	hsa-miR-4682	CLIP-seq
MIRT1353165	hsa-miR-4691-5p	CLIP-seq
MIRT1353166	hsa-miR-4704-3p	CLIP-seq
MIRT1353167	hsa-miR-4720-5p	CLIP-seq
MIRT1353168	hsa-miR-4729	CLIP-seq
MIRT1353169	hsa-miR-4772-3p	CLIP-seq
MIRT1353170	hsa-miR-4795-5p	CLIP-seq
MIRT1353171	hsa-miR-4796-3p	CLIP-seq
MIRT1353172	hsa-miR-4799-3p	CLIP-seq
MIRT1353173	hsa-miR-497	CLIP-seq
MIRT1353174	hsa-miR-512-3p	CLIP-seq
MIRT1353175	hsa-miR-519d	CLIP-seq
MIRT1353176	hsa-miR-520a-3p	CLIP-seq
MIRT1353177	hsa-miR-520b	CLIP-seq
MIRT1353178	hsa-miR-520c-3p	CLIP-seq
MIRT1353179	hsa-miR-520d-3p	CLIP-seq
MIRT1353180	hsa-miR-520e	CLIP-seq
MIRT1353181	hsa-miR-539	CLIP-seq
MIRT1353182	hsa-miR-543	CLIP-seq
MIRT1353183	hsa-miR-548ah	CLIP-seq
MIRT1353184	hsa-miR-548c-3p	CLIP-seq
MIRT1353185	hsa-miR-548u	CLIP-seq
MIRT1353186	hsa-miR-571	CLIP-seq
MIRT1353187	hsa-miR-579	CLIP-seq
MIRT1353188	hsa-miR-591	CLIP-seq
MIRT1353189	hsa-miR-616	CLIP-seq
MIRT1353190	hsa-miR-645	CLIP-seq
MIRT1353191	hsa-miR-654-3p	CLIP-seq
MIRT1353192	hsa-miR-7	CLIP-seq
MIRT1353193	hsa-miR-875-5p	CLIP-seq
MIRT1353194	hsa-miR-93	CLIP-seq
MIRT1353195	hsa-miR-935	CLIP-seq
MIRT1353196	hsa-miR-1244	CLIP-seq
MIRT1353197	hsa-miR-1297	CLIP-seq
MIRT1353198	hsa-miR-1324	CLIP-seq
MIRT1353111	hsa-miR-148a	CLIP-seq
MIRT1353112	hsa-miR-148b	CLIP-seq
MIRT1353113	hsa-miR-152	CLIP-seq
MIRT1353199	hsa-miR-2053	CLIP-seq
MIRT1353130	hsa-miR-2467-3p	CLIP-seq
MIRT1353200	hsa-miR-26a	CLIP-seq
MIRT1353201	hsa-miR-26b	CLIP-seq
MIRT1353202	hsa-miR-3180-5p	CLIP-seq
MIRT1353203	hsa-miR-338-3p	CLIP-seq
MIRT1353204	hsa-miR-3646	CLIP-seq
MIRT1353142	hsa-miR-3678-3p	CLIP-seq
MIRT1353148	hsa-miR-3919	CLIP-seq
MIRT1353151	hsa-miR-4252	CLIP-seq
MIRT1353154	hsa-miR-4276	CLIP-seq
MIRT1353205	hsa-miR-4326	CLIP-seq
MIRT1353206	hsa-miR-4465	CLIP-seq
MIRT1353207	hsa-miR-4530	CLIP-seq
MIRT1353208	hsa-miR-4640-3p	CLIP-seq
MIRT1353209	hsa-miR-4681	CLIP-seq
MIRT1353210	hsa-miR-4803	CLIP-seq
MIRT1353181	hsa-miR-539	CLIP-seq
MIRT1353187	hsa-miR-579	CLIP-seq
MIRT1353211	hsa-miR-593	CLIP-seq
MIRT1353212	hsa-miR-630	CLIP-seq
MIRT2104553	hsa-miR-1284	CLIP-seq
MIRT2104554	hsa-miR-142-3p	CLIP-seq
MIRT1353136	hsa-miR-3117-5p	CLIP-seq
MIRT2104555	hsa-miR-3157-3p	CLIP-seq
MIRT2104556	hsa-miR-3942-5p	CLIP-seq
MIRT2104557	hsa-miR-4290	CLIP-seq
MIRT2104558	hsa-miR-4666-5p	CLIP-seq
MIRT2104559	hsa-miR-4667-3p	CLIP-seq
MIRT2104560	hsa-miR-4703-5p	CLIP-seq
MIRT2104561	hsa-miR-548a-3p	CLIP-seq
MIRT2104562	hsa-miR-548e	CLIP-seq
MIRT2104563	hsa-miR-548f	CLIP-seq
MIRT2104564	hsa-miR-600	CLIP-seq
MIRT2104565	hsa-miR-648	CLIP-seq
MIRT2104566	hsa-miR-874	CLIP-seq
MIRT1353130	hsa-miR-2467-3p	CLIP-seq
MIRT2104567	hsa-miR-3973	CLIP-seq
MIRT2104568	hsa-miR-520g	CLIP-seq
MIRT2104569	hsa-miR-520h	CLIP-seq
MIRT1353103	hsa-miR-106a	CLIP-seq
MIRT1353104	hsa-miR-106b	CLIP-seq
MIRT1353196	hsa-miR-1244	CLIP-seq
MIRT1353106	hsa-miR-125a-5p	CLIP-seq
MIRT1353107	hsa-miR-125b	CLIP-seq
MIRT1353108	hsa-miR-1264	CLIP-seq
MIRT1353198	hsa-miR-1324	CLIP-seq
MIRT2328985	hsa-miR-147	CLIP-seq
MIRT1353117	hsa-miR-17	CLIP-seq
MIRT1353123	hsa-miR-20a	CLIP-seq
MIRT1353124	hsa-miR-20b	CLIP-seq
MIRT1353125	hsa-miR-219-1-3p	CLIP-seq
MIRT1353130	hsa-miR-2467-3p	CLIP-seq
MIRT1353131	hsa-miR-302a	CLIP-seq
MIRT1353132	hsa-miR-302b	CLIP-seq
MIRT1353133	hsa-miR-302c	CLIP-seq
MIRT1353134	hsa-miR-302d	CLIP-seq
MIRT1353135	hsa-miR-302e	CLIP-seq
MIRT2328986	hsa-miR-3149	CLIP-seq
MIRT2328987	hsa-miR-3177-5p	CLIP-seq
MIRT1353140	hsa-miR-3609	CLIP-seq
MIRT1353142	hsa-miR-3678-3p	CLIP-seq
MIRT1353143	hsa-miR-3679-3p	CLIP-seq
MIRT1353144	hsa-miR-372	CLIP-seq
MIRT1353145	hsa-miR-373	CLIP-seq
MIRT1353155	hsa-miR-4307	CLIP-seq
MIRT1353156	hsa-miR-4319	CLIP-seq
MIRT2328988	hsa-miR-4433	CLIP-seq
MIRT1353159	hsa-miR-4446-5p	CLIP-seq
MIRT2328989	hsa-miR-4459	CLIP-seq
MIRT2328990	hsa-miR-4468	CLIP-seq
MIRT2328991	hsa-miR-4659a-3p	CLIP-seq
MIRT2328992	hsa-miR-4659b-3p	CLIP-seq
MIRT1353164	hsa-miR-4682	CLIP-seq
MIRT2328993	hsa-miR-4768-3p	CLIP-seq
MIRT1353171	hsa-miR-4796-3p	CLIP-seq
MIRT1353174	hsa-miR-512-3p	CLIP-seq
MIRT1353175	hsa-miR-519d	CLIP-seq
MIRT1353176	hsa-miR-520a-3p	CLIP-seq
MIRT1353177	hsa-miR-520b	CLIP-seq
MIRT1353178	hsa-miR-520c-3p	CLIP-seq
MIRT1353179	hsa-miR-520d-3p	CLIP-seq
MIRT1353180	hsa-miR-520e	CLIP-seq
MIRT1353183	hsa-miR-548ah	CLIP-seq
MIRT1353186	hsa-miR-571	CLIP-seq
MIRT1353187	hsa-miR-579	CLIP-seq
MIRT2328994	hsa-miR-581	CLIP-seq
MIRT1353190	hsa-miR-645	CLIP-seq
MIRT1353194	hsa-miR-93	CLIP-seq
MIRT2440434	hsa-miR-221	CLIP-seq
MIRT2440435	hsa-miR-222	CLIP-seq
MIRT2440436	hsa-miR-548v	CLIP-seq
MIRT2328986	hsa-miR-3149	CLIP-seq
MIRT2459497	hsa-miR-3686	CLIP-seq
MIRT2459498	hsa-miR-4778-5p	CLIP-seq
MIRT2459499	hsa-miR-568	CLIP-seq
MIRT2104553	hsa-miR-1284	CLIP-seq
MIRT2623469	hsa-miR-134	CLIP-seq
MIRT2104554	hsa-miR-142-3p	CLIP-seq
MIRT1353136	hsa-miR-3117-5p	CLIP-seq
MIRT2623470	hsa-miR-3118	CLIP-seq
MIRT2623471	hsa-miR-3145-5p	CLIP-seq
MIRT2104555	hsa-miR-3157-3p	CLIP-seq
MIRT2623472	hsa-miR-3164	CLIP-seq
MIRT2623473	hsa-miR-3613-3p	CLIP-seq
MIRT2104556	hsa-miR-3942-5p	CLIP-seq
MIRT2104557	hsa-miR-4290	CLIP-seq
MIRT2104558	hsa-miR-4666-5p	CLIP-seq
MIRT2104559	hsa-miR-4667-3p	CLIP-seq
MIRT2104560	hsa-miR-4703-5p	CLIP-seq
MIRT2104561	hsa-miR-548a-3p	CLIP-seq
MIRT2104562	hsa-miR-548e	CLIP-seq
MIRT2104563	hsa-miR-548f	CLIP-seq
MIRT2104564	hsa-miR-600	CLIP-seq
MIRT2104565	hsa-miR-648	CLIP-seq
MIRT2104566	hsa-miR-874	CLIP-seq
MIRT1353136	hsa-miR-3117-5p	CLIP-seq
MIRT2104555	hsa-miR-3157-3p	CLIP-seq
MIRT2104557	hsa-miR-4290	CLIP-seq
MIRT2104559	hsa-miR-4667-3p	CLIP-seq
MIRT2104561	hsa-miR-548a-3p	CLIP-seq
MIRT2104562	hsa-miR-548e	CLIP-seq
MIRT2104563	hsa-miR-548f	CLIP-seq
MIRT2104564	hsa-miR-600	CLIP-seq
MIRT2104566	hsa-miR-874	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005368	Function	Taurine transmembrane transporter activity	ISS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9425115
GO:0008028	Function	Monocarboxylic acid transmembrane transporter activity	IBA
GO:0008028	Function	Monocarboxylic acid transmembrane transporter activity	TAS	9425115
GO:0015711	Process	Organic anion transport	IEA
GO:0015718	Process	Monocarboxylic acid transport	TAS	9425115
GO:0015734	Process	Taurine transmembrane transport	IEA
GO:0015849	Process	Organic acid transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9425115
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 603880
• HGNC: 10927
• e!Ensembl: ENSG00000108932

Protein

• UniProt ID: O15403
• Protein name: Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6)
• Protein function: Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather lo
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07690	MFS_1	31 → 437	Major Facilitator Superfamily	Family

• Sequence:

  MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN
  SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVA
  IGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWR
  YSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDS
  GVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALF
  GLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY
  IELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSS
  AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMGLCQ
  HHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEHRVHVQMEPV

• Sequence length: 523

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	28971779		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23555315, 35257743	Associate	★☆☆☆☆ Found in Text Mining only
Endometrioma	Endometrioma	CTD_human_DG	20864642		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	CTD_human_DG	20864642		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	28971779		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	35257743	Associate	★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	32232919	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21861841		★☆☆☆☆ Found in Text Mining only