Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	91156
Gene name	Immunoglobulin like and fibronectin type III domain containing 1
Gene symbol	IGFN1
Synonyms (NCBI Gene)	EEF1A2BP1
Chromosome	1
Chromosome location	1q32.1

Show/Hide all (51)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023081	hsa-miR-124-3p	Microarray	18668037
MIRT2014744	hsa-miR-3612	CLIP-seq
MIRT2014745	hsa-miR-3689d	CLIP-seq
MIRT2014746	hsa-miR-4287	CLIP-seq
MIRT2014747	hsa-miR-4290	CLIP-seq
MIRT2014748	hsa-miR-4443	CLIP-seq
MIRT2014749	hsa-miR-4459	CLIP-seq
MIRT2014750	hsa-miR-4667-3p	CLIP-seq
MIRT2014751	hsa-miR-4685-3p	CLIP-seq
MIRT2014752	hsa-miR-4780	CLIP-seq
MIRT2014753	hsa-miR-485-5p	CLIP-seq
MIRT2014754	hsa-miR-623	CLIP-seq
MIRT2014755	hsa-miR-650	CLIP-seq
MIRT2014756	hsa-miR-665	CLIP-seq
MIRT2247033	hsa-miR-639	CLIP-seq
MIRT2389304	hsa-miR-365	CLIP-seq
MIRT2014746	hsa-miR-4287	CLIP-seq
MIRT2014747	hsa-miR-4290	CLIP-seq
MIRT2389305	hsa-miR-4659a-3p	CLIP-seq
MIRT2389306	hsa-miR-4659b-3p	CLIP-seq
MIRT2014750	hsa-miR-4667-3p	CLIP-seq
MIRT2014751	hsa-miR-4685-3p	CLIP-seq
MIRT2014752	hsa-miR-4780	CLIP-seq
MIRT2014754	hsa-miR-623	CLIP-seq
MIRT2451644	hsa-miR-1470	CLIP-seq
MIRT2451645	hsa-miR-24	CLIP-seq
MIRT2451646	hsa-miR-337-5p	CLIP-seq
MIRT2014750	hsa-miR-4667-3p	CLIP-seq
MIRT2451647	hsa-miR-4690-3p	CLIP-seq
MIRT2550610	hsa-miR-1	CLIP-seq
MIRT2550611	hsa-miR-206	CLIP-seq
MIRT2389304	hsa-miR-365	CLIP-seq
MIRT2550612	hsa-miR-3673	CLIP-seq
MIRT2014746	hsa-miR-4287	CLIP-seq
MIRT2014747	hsa-miR-4290	CLIP-seq
MIRT2014750	hsa-miR-4667-3p	CLIP-seq
MIRT2014751	hsa-miR-4685-3p	CLIP-seq
MIRT2014752	hsa-miR-4780	CLIP-seq
MIRT2550613	hsa-miR-613	CLIP-seq
MIRT2014754	hsa-miR-623	CLIP-seq
MIRT2550610	hsa-miR-1	CLIP-seq
MIRT2550611	hsa-miR-206	CLIP-seq
MIRT2389304	hsa-miR-365	CLIP-seq
MIRT2550612	hsa-miR-3673	CLIP-seq
MIRT2014746	hsa-miR-4287	CLIP-seq
MIRT2014747	hsa-miR-4290	CLIP-seq
MIRT2014750	hsa-miR-4667-3p	CLIP-seq
MIRT2014751	hsa-miR-4685-3p	CLIP-seq
MIRT2014752	hsa-miR-4780	CLIP-seq
MIRT2550613	hsa-miR-613	CLIP-seq
MIRT2014754	hsa-miR-623	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0030018	Component	Z disc	IEA
GO:0030018	Component	Z disc	ISS

MIM	HGNC	e!Ensembl
617309	24607	ENSG00000163395

Q86VF2

Protein name

Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	29 → 120	Immunoglobulin I-set domain	Domain
PF18362	THB	166 → 199	Tri-helix bundle domain	Domain
PF07679	I-set	456 → 541	Immunoglobulin I-set domain	Domain
PF07679	I-set	548 → 640	Immunoglobulin I-set domain	Domain
PF00041	fn3	645 → 730	Fibronectin type III domain	Domain
PF00041	fn3	745 → 830	Fibronectin type III domain	Domain
PF00041	fn3	846 → 931	Fibronectin type III domain	Domain
PF07679	I-set	949 → 1037	Immunoglobulin I-set domain	Domain
PF00041	fn3	1042 → 1126	Fibronectin type III domain	Domain
PF07679	I-set	1157 → 1246	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in skeletal muscle. {ECO:0000269|PubMed:15385448}.

Sequence

MAGKLRKSHIPGVSIWQLVEEIPEGCSTPDFEQKPVTSALPEGKNAVFRAVVCGEPRPEV
RWQNSKGDLSDSSKYKISSSPGSKEHVLQINKLTGEDTDLYRCTAVNAYGEAACSVRLTV
IEVGFRKNRKRHREPQEDLRKELMDFRKLLKKRAPPAPKKKMDLEQIWQLLMTADRKDYE
KICLKYGIVDYRGMLRRLQEMKKEQEDKMAQYINTISSLRHIRVTKDGNAKFDLELDLKD
SQSKIYLYKDGEMIPYGFNNQTKHCLRRLGKRYEFQIQDLRPEDSGIYQVKVEDAVVFST
ELEASAIPPRVVVPLAETHCEEQGDAVFECTLSSPCPSAAWHFRHRLLHPSDKYEVYVSP
DGLTHRLVVRGARFSDMGPYSLGTGLYTSSAWLVVEAGKDKDLQSTSADHKLQSRRSGKD
GRLDIYGERRDATRSSTSRYKPGTGSFSKDAQGPMGHFSQGLADMEVQPGEAATLSCTLT
SDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTFVAGDQQSEATLTV
QDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAAWRKDGAEVVGSSDREAQVD
LGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQGPMEVQDCHRAG
VCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEPGRKYTFRVR
AVTSEGAGEALESEEILVAPEALPKAPSAPAILSASSQGITLTWTAPRGPGSAHILGYLI
ERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEPGPPSDAVFARD
PMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSLQWLPCHVGTVP
VTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFLVDSSTKDLLTV
KVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVTVTKDGLTQLLIPVAGLSDSGLYTVV
LRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPGTVTAEWEPSPDEAQDVPLHYAVFTR
SSAHGPWHEAADRIHTNRFTLLGILPGHEYHFRVVAKNELGASKPSDTSQPWCIPRQRDR
FTVKAPCYREPDLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGN
PAVYSTDLLGVCSLTIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEPST

Sequence length

1251

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTROCYTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	28027327, 30335789	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	30335789, 39331921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30335789		★★★★★ ★☆☆☆☆ Found in Text Mining only
Exudative age-related macular degeneration	Exudative Macular Degeneration	BEFREE	29323771		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35456975	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35456975	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30335789		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36484990	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

IGFN1 (immunoglobulin like and fibronectin type III domain containing 1)