Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9100
Gene name	Ubiquitin specific peptidase 10
Gene symbol	USP10
Synonyms (NCBI Gene)	UBPO
Chromosome	16
Chromosome location	16q24.1
Summary	Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019670	hsa-miR-375	Microarray	20215506
MIRT022173	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT023247	hsa-miR-122-5p	Microarray	17612493
MIRT027416	hsa-miR-98-5p	Microarray	19088304
MIRT030377	hsa-miR-24-3p	Microarray	19748357
MIRT032235	hsa-let-7b-5p	Proteomics	18668040
MIRT050557	hsa-miR-20a-5p	CLASH	23622248
MIRT049080	hsa-miR-92a-3p	CLASH	23622248
MIRT047239	hsa-miR-181b-5p	CLASH	23622248
MIRT039563	hsa-miR-652-3p	CLASH	23622248
MIRT037849	hsa-miR-455-3p	CLASH	23622248
MIRT1477325	hsa-miR-103a	CLIP-seq
MIRT1477326	hsa-miR-107	CLIP-seq
MIRT1477327	hsa-miR-1252	CLIP-seq
MIRT1477328	hsa-miR-1253	CLIP-seq
MIRT1477329	hsa-miR-1258	CLIP-seq
MIRT1477330	hsa-miR-1273	CLIP-seq
MIRT1477331	hsa-miR-1273c	CLIP-seq
MIRT1477332	hsa-miR-1276	CLIP-seq
MIRT1477333	hsa-miR-1294	CLIP-seq
MIRT1477334	hsa-miR-129-5p	CLIP-seq
MIRT1477335	hsa-miR-1303	CLIP-seq
MIRT1477336	hsa-miR-1305	CLIP-seq
MIRT1477337	hsa-miR-132	CLIP-seq
MIRT1477338	hsa-miR-1324	CLIP-seq
MIRT1477339	hsa-miR-142-5p	CLIP-seq
MIRT1477340	hsa-miR-185	CLIP-seq
MIRT1477341	hsa-miR-203	CLIP-seq
MIRT1477342	hsa-miR-2113	CLIP-seq
MIRT1477343	hsa-miR-212	CLIP-seq
MIRT1477344	hsa-miR-2276	CLIP-seq
MIRT1477345	hsa-miR-2278	CLIP-seq
MIRT1477346	hsa-miR-3074-5p	CLIP-seq
MIRT1477347	hsa-miR-3115	CLIP-seq
MIRT1477348	hsa-miR-3123	CLIP-seq
MIRT1477349	hsa-miR-3143	CLIP-seq
MIRT1477350	hsa-miR-3162-5p	CLIP-seq
MIRT1477351	hsa-miR-3166	CLIP-seq
MIRT1477352	hsa-miR-3174	CLIP-seq
MIRT1477353	hsa-miR-3177-5p	CLIP-seq
MIRT1477354	hsa-miR-34c-3p	CLIP-seq
MIRT1477355	hsa-miR-3616-5p	CLIP-seq
MIRT1477356	hsa-miR-3647-5p	CLIP-seq
MIRT1477357	hsa-miR-3659	CLIP-seq
MIRT1477358	hsa-miR-3668	CLIP-seq
MIRT1477359	hsa-miR-3914	CLIP-seq
MIRT1477360	hsa-miR-3925-5p	CLIP-seq
MIRT1477361	hsa-miR-3942-3p	CLIP-seq
MIRT1477362	hsa-miR-421	CLIP-seq
MIRT1477363	hsa-miR-4263	CLIP-seq
MIRT1477364	hsa-miR-4264	CLIP-seq
MIRT1477365	hsa-miR-4282	CLIP-seq
MIRT1477366	hsa-miR-4306	CLIP-seq
MIRT1477367	hsa-miR-4307	CLIP-seq
MIRT1477368	hsa-miR-4310	CLIP-seq
MIRT1477369	hsa-miR-4311	CLIP-seq
MIRT1477370	hsa-miR-4316	CLIP-seq
MIRT1477371	hsa-miR-4428	CLIP-seq
MIRT1477372	hsa-miR-4468	CLIP-seq
MIRT1477373	hsa-miR-4477a	CLIP-seq
MIRT1477374	hsa-miR-4494	CLIP-seq
MIRT1477375	hsa-miR-4499	CLIP-seq
MIRT1477376	hsa-miR-450b-5p	CLIP-seq
MIRT1477377	hsa-miR-4511	CLIP-seq
MIRT1477378	hsa-miR-4528	CLIP-seq
MIRT1477379	hsa-miR-4641	CLIP-seq
MIRT1477380	hsa-miR-4644	CLIP-seq
MIRT1477381	hsa-miR-4649-5p	CLIP-seq
MIRT1477382	hsa-miR-4658	CLIP-seq
MIRT1477383	hsa-miR-4668-3p	CLIP-seq
MIRT1477384	hsa-miR-4670-3p	CLIP-seq
MIRT1477385	hsa-miR-4672	CLIP-seq
MIRT1477386	hsa-miR-4705	CLIP-seq
MIRT1477387	hsa-miR-4709-5p	CLIP-seq
MIRT1477388	hsa-miR-4768-5p	CLIP-seq
MIRT1477389	hsa-miR-4771	CLIP-seq
MIRT1477390	hsa-miR-4772-3p	CLIP-seq
MIRT1477391	hsa-miR-4797-3p	CLIP-seq
MIRT1477392	hsa-miR-4799-5p	CLIP-seq
MIRT1477393	hsa-miR-505	CLIP-seq
MIRT1477394	hsa-miR-507	CLIP-seq
MIRT1477395	hsa-miR-518a-5p	CLIP-seq
MIRT1477396	hsa-miR-527	CLIP-seq
MIRT1477397	hsa-miR-543	CLIP-seq
MIRT1477398	hsa-miR-548b-3p	CLIP-seq
MIRT1477399	hsa-miR-548g	CLIP-seq
MIRT1477400	hsa-miR-549	CLIP-seq
MIRT1477401	hsa-miR-557	CLIP-seq
MIRT1477402	hsa-miR-561	CLIP-seq
MIRT1477403	hsa-miR-573	CLIP-seq
MIRT1477404	hsa-miR-574-5p	CLIP-seq
MIRT1477405	hsa-miR-576-5p	CLIP-seq
MIRT1477406	hsa-miR-583	CLIP-seq
MIRT1477407	hsa-miR-599	CLIP-seq
MIRT1477408	hsa-miR-622	CLIP-seq
MIRT1477409	hsa-miR-629	CLIP-seq
MIRT1477410	hsa-miR-634	CLIP-seq
MIRT1477411	hsa-miR-891b	CLIP-seq
MIRT1477412	hsa-miR-892a	CLIP-seq
MIRT1477413	hsa-miR-922	CLIP-seq
MIRT1477414	hsa-miR-944	CLIP-seq
MIRT1477325	hsa-miR-103a	CLIP-seq
MIRT1477326	hsa-miR-107	CLIP-seq
MIRT1477328	hsa-miR-1253	CLIP-seq
MIRT1477332	hsa-miR-1276	CLIP-seq
MIRT1477333	hsa-miR-1294	CLIP-seq
MIRT1477335	hsa-miR-1303	CLIP-seq
MIRT1477336	hsa-miR-1305	CLIP-seq
MIRT1477337	hsa-miR-132	CLIP-seq
MIRT1477338	hsa-miR-1324	CLIP-seq
MIRT1477339	hsa-miR-142-5p	CLIP-seq
MIRT2143757	hsa-miR-149	CLIP-seq
MIRT1477341	hsa-miR-203	CLIP-seq
MIRT1477343	hsa-miR-212	CLIP-seq
MIRT1477344	hsa-miR-2276	CLIP-seq
MIRT1477345	hsa-miR-2278	CLIP-seq
MIRT2143758	hsa-miR-24	CLIP-seq
MIRT1477347	hsa-miR-3115	CLIP-seq
MIRT1477348	hsa-miR-3123	CLIP-seq
MIRT1477349	hsa-miR-3143	CLIP-seq
MIRT2143759	hsa-miR-3145-5p	CLIP-seq
MIRT2143760	hsa-miR-3161	CLIP-seq
MIRT1477351	hsa-miR-3166	CLIP-seq
MIRT1477352	hsa-miR-3174	CLIP-seq
MIRT1477353	hsa-miR-3177-5p	CLIP-seq
MIRT2143761	hsa-miR-3178	CLIP-seq
MIRT1477357	hsa-miR-3659	CLIP-seq
MIRT1477358	hsa-miR-3668	CLIP-seq
MIRT2143762	hsa-miR-3910	CLIP-seq
MIRT1477360	hsa-miR-3925-5p	CLIP-seq
MIRT1477361	hsa-miR-3942-3p	CLIP-seq
MIRT2143763	hsa-miR-4284	CLIP-seq
MIRT1477368	hsa-miR-4310	CLIP-seq
MIRT1477369	hsa-miR-4311	CLIP-seq
MIRT1477370	hsa-miR-4316	CLIP-seq
MIRT1477372	hsa-miR-4468	CLIP-seq
MIRT1477378	hsa-miR-4528	CLIP-seq
MIRT1477379	hsa-miR-4641	CLIP-seq
MIRT1477382	hsa-miR-4658	CLIP-seq
MIRT2143764	hsa-miR-4659a-3p	CLIP-seq
MIRT2143765	hsa-miR-4659b-3p	CLIP-seq
MIRT1477385	hsa-miR-4672	CLIP-seq
MIRT1477386	hsa-miR-4705	CLIP-seq
MIRT1477387	hsa-miR-4709-5p	CLIP-seq
MIRT2143766	hsa-miR-4729	CLIP-seq
MIRT2143767	hsa-miR-4744	CLIP-seq
MIRT2143768	hsa-miR-4764-3p	CLIP-seq
MIRT1477390	hsa-miR-4772-3p	CLIP-seq
MIRT2143769	hsa-miR-4778-3p	CLIP-seq
MIRT1477397	hsa-miR-543	CLIP-seq
MIRT1477402	hsa-miR-561	CLIP-seq
MIRT1477404	hsa-miR-574-5p	CLIP-seq
MIRT2143770	hsa-miR-582-3p	CLIP-seq
MIRT1477406	hsa-miR-583	CLIP-seq
MIRT1477408	hsa-miR-622	CLIP-seq
MIRT2143771	hsa-miR-676	CLIP-seq
MIRT2143772	hsa-miR-892b	CLIP-seq
MIRT1477413	hsa-miR-922	CLIP-seq
MIRT1477325	hsa-miR-103a	CLIP-seq
MIRT1477326	hsa-miR-107	CLIP-seq
MIRT1477328	hsa-miR-1253	CLIP-seq
MIRT1477332	hsa-miR-1276	CLIP-seq
MIRT1477333	hsa-miR-1294	CLIP-seq
MIRT1477335	hsa-miR-1303	CLIP-seq
MIRT1477338	hsa-miR-1324	CLIP-seq
MIRT1477339	hsa-miR-142-5p	CLIP-seq
MIRT1477344	hsa-miR-2276	CLIP-seq
MIRT1477345	hsa-miR-2278	CLIP-seq
MIRT1477348	hsa-miR-3123	CLIP-seq
MIRT1477349	hsa-miR-3143	CLIP-seq
MIRT1477351	hsa-miR-3166	CLIP-seq
MIRT1477352	hsa-miR-3174	CLIP-seq
MIRT1477353	hsa-miR-3177-5p	CLIP-seq
MIRT2143761	hsa-miR-3178	CLIP-seq
MIRT1477355	hsa-miR-3616-5p	CLIP-seq
MIRT1477356	hsa-miR-3647-5p	CLIP-seq
MIRT1477357	hsa-miR-3659	CLIP-seq
MIRT1477358	hsa-miR-3668	CLIP-seq
MIRT2143762	hsa-miR-3910	CLIP-seq
MIRT1477360	hsa-miR-3925-5p	CLIP-seq
MIRT1477361	hsa-miR-3942-3p	CLIP-seq
MIRT1477362	hsa-miR-421	CLIP-seq
MIRT1477364	hsa-miR-4264	CLIP-seq
MIRT1477367	hsa-miR-4307	CLIP-seq
MIRT1477368	hsa-miR-4310	CLIP-seq
MIRT1477369	hsa-miR-4311	CLIP-seq
MIRT1477370	hsa-miR-4316	CLIP-seq
MIRT1477372	hsa-miR-4468	CLIP-seq
MIRT2364048	hsa-miR-4486	CLIP-seq
MIRT2364049	hsa-miR-4509	CLIP-seq
MIRT1477382	hsa-miR-4658	CLIP-seq
MIRT1477386	hsa-miR-4705	CLIP-seq
MIRT1477387	hsa-miR-4709-5p	CLIP-seq
MIRT2143767	hsa-miR-4744	CLIP-seq
MIRT1477388	hsa-miR-4768-5p	CLIP-seq
MIRT1477390	hsa-miR-4772-3p	CLIP-seq
MIRT1477391	hsa-miR-4797-3p	CLIP-seq
MIRT1477393	hsa-miR-505	CLIP-seq
MIRT1477397	hsa-miR-543	CLIP-seq
MIRT1477402	hsa-miR-561	CLIP-seq
MIRT1477403	hsa-miR-573	CLIP-seq
MIRT1477404	hsa-miR-574-5p	CLIP-seq
MIRT1477406	hsa-miR-583	CLIP-seq
MIRT2143771	hsa-miR-676	CLIP-seq
MIRT1477413	hsa-miR-922	CLIP-seq
MIRT2657781	hsa-miR-1246	CLIP-seq
MIRT1477329	hsa-miR-1258	CLIP-seq
MIRT2657782	hsa-miR-1266	CLIP-seq
MIRT1477336	hsa-miR-1305	CLIP-seq
MIRT1477337	hsa-miR-132	CLIP-seq
MIRT1477342	hsa-miR-2113	CLIP-seq
MIRT1477343	hsa-miR-212	CLIP-seq
MIRT1477344	hsa-miR-2276	CLIP-seq
MIRT2143758	hsa-miR-24	CLIP-seq
MIRT1477346	hsa-miR-3074-5p	CLIP-seq
MIRT1477347	hsa-miR-3115	CLIP-seq
MIRT2657783	hsa-miR-3134	CLIP-seq
MIRT1477349	hsa-miR-3143	CLIP-seq
MIRT2143759	hsa-miR-3145-5p	CLIP-seq
MIRT2657784	hsa-miR-3163	CLIP-seq
MIRT1477353	hsa-miR-3177-5p	CLIP-seq
MIRT2657785	hsa-miR-3613-3p	CLIP-seq
MIRT2657786	hsa-miR-3664-3p	CLIP-seq
MIRT2657787	hsa-miR-3672	CLIP-seq
MIRT1477359	hsa-miR-3914	CLIP-seq
MIRT1477361	hsa-miR-3942-3p	CLIP-seq
MIRT1477363	hsa-miR-4263	CLIP-seq
MIRT1477364	hsa-miR-4264	CLIP-seq
MIRT1477365	hsa-miR-4282	CLIP-seq
MIRT2143763	hsa-miR-4284	CLIP-seq
MIRT1477367	hsa-miR-4307	CLIP-seq
MIRT1477368	hsa-miR-4310	CLIP-seq
MIRT2657788	hsa-miR-4436b-5p	CLIP-seq
MIRT2657789	hsa-miR-4450	CLIP-seq
MIRT2657790	hsa-miR-4463	CLIP-seq
MIRT1477373	hsa-miR-4477a	CLIP-seq
MIRT2657791	hsa-miR-4477b	CLIP-seq
MIRT2364049	hsa-miR-4509	CLIP-seq
MIRT2657792	hsa-miR-4518	CLIP-seq
MIRT2657793	hsa-miR-4534	CLIP-seq
MIRT2657794	hsa-miR-4667-5p	CLIP-seq
MIRT1477383	hsa-miR-4668-3p	CLIP-seq
MIRT2657795	hsa-miR-4700-5p	CLIP-seq
MIRT1477387	hsa-miR-4709-5p	CLIP-seq
MIRT2657796	hsa-miR-4719	CLIP-seq
MIRT2143766	hsa-miR-4729	CLIP-seq
MIRT2657797	hsa-miR-4760-3p	CLIP-seq
MIRT2657798	hsa-miR-4762-5p	CLIP-seq
MIRT2143768	hsa-miR-4764-3p	CLIP-seq
MIRT1477388	hsa-miR-4768-5p	CLIP-seq
MIRT1477390	hsa-miR-4772-3p	CLIP-seq
MIRT1477391	hsa-miR-4797-3p	CLIP-seq
MIRT1477392	hsa-miR-4799-5p	CLIP-seq
MIRT2657799	hsa-miR-5096	CLIP-seq
MIRT2657800	hsa-miR-513a-3p	CLIP-seq
MIRT2657801	hsa-miR-513b	CLIP-seq
MIRT1477397	hsa-miR-543	CLIP-seq
MIRT2657802	hsa-miR-548ae	CLIP-seq
MIRT2657803	hsa-miR-548aj	CLIP-seq
MIRT2657804	hsa-miR-548am	CLIP-seq
MIRT2657805	hsa-miR-548t	CLIP-seq
MIRT2657806	hsa-miR-548x	CLIP-seq
MIRT1477405	hsa-miR-576-5p	CLIP-seq
MIRT2657807	hsa-miR-577	CLIP-seq
MIRT2657808	hsa-miR-579	CLIP-seq
MIRT2657809	hsa-miR-595	CLIP-seq
MIRT1477407	hsa-miR-599	CLIP-seq
MIRT1477408	hsa-miR-622	CLIP-seq
MIRT1477409	hsa-miR-629	CLIP-seq
MIRT1477410	hsa-miR-634	CLIP-seq
MIRT2657810	hsa-miR-664	CLIP-seq
MIRT2657811	hsa-miR-873	CLIP-seq
MIRT1477411	hsa-miR-891b	CLIP-seq
MIRT1477414	hsa-miR-944	CLIP-seq
MIRT2657781	hsa-miR-1246	CLIP-seq
MIRT1477329	hsa-miR-1258	CLIP-seq
MIRT2657782	hsa-miR-1266	CLIP-seq
MIRT1477336	hsa-miR-1305	CLIP-seq
MIRT1477337	hsa-miR-132	CLIP-seq
MIRT2694789	hsa-miR-138	CLIP-seq
MIRT1477342	hsa-miR-2113	CLIP-seq
MIRT1477343	hsa-miR-212	CLIP-seq
MIRT1477344	hsa-miR-2276	CLIP-seq
MIRT2143758	hsa-miR-24	CLIP-seq
MIRT1477346	hsa-miR-3074-5p	CLIP-seq
MIRT1477347	hsa-miR-3115	CLIP-seq
MIRT2657783	hsa-miR-3134	CLIP-seq
MIRT1477349	hsa-miR-3143	CLIP-seq
MIRT2143759	hsa-miR-3145-5p	CLIP-seq
MIRT2657784	hsa-miR-3163	CLIP-seq
MIRT2694790	hsa-miR-3168	CLIP-seq
MIRT1477353	hsa-miR-3177-5p	CLIP-seq
MIRT2657785	hsa-miR-3613-3p	CLIP-seq
MIRT1477355	hsa-miR-3616-5p	CLIP-seq
MIRT1477356	hsa-miR-3647-5p	CLIP-seq
MIRT2657786	hsa-miR-3664-3p	CLIP-seq
MIRT2657787	hsa-miR-3672	CLIP-seq
MIRT1477359	hsa-miR-3914	CLIP-seq
MIRT1477361	hsa-miR-3942-3p	CLIP-seq
MIRT1477363	hsa-miR-4263	CLIP-seq
MIRT1477364	hsa-miR-4264	CLIP-seq
MIRT1477365	hsa-miR-4282	CLIP-seq
MIRT2143763	hsa-miR-4284	CLIP-seq
MIRT1477367	hsa-miR-4307	CLIP-seq
MIRT1477368	hsa-miR-4310	CLIP-seq
MIRT2657788	hsa-miR-4436b-5p	CLIP-seq
MIRT2657789	hsa-miR-4450	CLIP-seq
MIRT2657790	hsa-miR-4463	CLIP-seq
MIRT1477373	hsa-miR-4477a	CLIP-seq
MIRT2657791	hsa-miR-4477b	CLIP-seq
MIRT2364049	hsa-miR-4509	CLIP-seq
MIRT1477377	hsa-miR-4511	CLIP-seq
MIRT2657792	hsa-miR-4518	CLIP-seq
MIRT2657793	hsa-miR-4534	CLIP-seq
MIRT2657794	hsa-miR-4667-5p	CLIP-seq
MIRT1477383	hsa-miR-4668-3p	CLIP-seq
MIRT2657795	hsa-miR-4700-5p	CLIP-seq
MIRT1477387	hsa-miR-4709-5p	CLIP-seq
MIRT2657796	hsa-miR-4719	CLIP-seq
MIRT2143766	hsa-miR-4729	CLIP-seq
MIRT2657797	hsa-miR-4760-3p	CLIP-seq
MIRT2657798	hsa-miR-4762-5p	CLIP-seq
MIRT2143768	hsa-miR-4764-3p	CLIP-seq
MIRT1477388	hsa-miR-4768-5p	CLIP-seq
MIRT1477390	hsa-miR-4772-3p	CLIP-seq
MIRT1477391	hsa-miR-4797-3p	CLIP-seq
MIRT1477392	hsa-miR-4799-5p	CLIP-seq
MIRT2657799	hsa-miR-5096	CLIP-seq
MIRT2657800	hsa-miR-513a-3p	CLIP-seq
MIRT2657801	hsa-miR-513b	CLIP-seq
MIRT1477397	hsa-miR-543	CLIP-seq
MIRT2657802	hsa-miR-548ae	CLIP-seq
MIRT2657803	hsa-miR-548aj	CLIP-seq
MIRT2657804	hsa-miR-548am	CLIP-seq
MIRT1477398	hsa-miR-548b-3p	CLIP-seq
MIRT2694791	hsa-miR-548q	CLIP-seq
MIRT2657805	hsa-miR-548t	CLIP-seq
MIRT2657806	hsa-miR-548x	CLIP-seq
MIRT1477403	hsa-miR-573	CLIP-seq
MIRT1477405	hsa-miR-576-5p	CLIP-seq
MIRT2657807	hsa-miR-577	CLIP-seq
MIRT2657808	hsa-miR-579	CLIP-seq
MIRT2657809	hsa-miR-595	CLIP-seq
MIRT1477407	hsa-miR-599	CLIP-seq
MIRT1477408	hsa-miR-622	CLIP-seq
MIRT1477409	hsa-miR-629	CLIP-seq
MIRT1477410	hsa-miR-634	CLIP-seq
MIRT2657810	hsa-miR-664	CLIP-seq
MIRT2657811	hsa-miR-873	CLIP-seq
MIRT1477411	hsa-miR-891b	CLIP-seq
MIRT1477414	hsa-miR-944	CLIP-seq

Show/Hide all (55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002039	Function	P53 binding	IPI	20096447
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	21962518
GO:0004843	Function	Cysteine-type deubiquitinase activity	IBA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IDA	20096447, 21962518, 31981475, 34348161, 34469731
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IMP	19398555, 25861989
GO:0004843	Function	Cysteine-type deubiquitinase activity	TAS
GO:0005515	Function	Protein binding	IPI	19398555, 19615732, 21455491, 21962518, 23279204, 24270572, 24845384, 24981860, 25416956, 25861989, 27022092, 29892012, 31515488, 32296183, 32302570, 32814053, 33495715, 33961781, 34799561, 34901782, 35156780, 35271311, 36012204, 36279435
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20096447, 24845384
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	20096447
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	IDA	19398555
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006281	Process	DNA repair	IEA
GO:0006338	Process	Chromatin remodeling	IDA	23892288, 37023208
GO:0006508	Process	Proteolysis	IEA
GO:0006513	Process	Protein monoubiquitination	IDA	34348161
GO:0006914	Process	Autophagy	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	25861989
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0010506	Process	Regulation of autophagy	IBA
GO:0010506	Process	Regulation of autophagy	IDA	21962518
GO:0016579	Process	Protein deubiquitination	IDA	20096447
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016579	Process	Protein deubiquitination	IMP	19398555, 24845384, 25861989
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0019985	Process	Translesion synthesis	TAS
GO:0022626	Component	Cytosolic ribosome	IDA	34348161, 34469731
GO:0030330	Process	DNA damage response, signal transduction by p53 class mediator	IBA
GO:0030330	Process	DNA damage response, signal transduction by p53 class mediator	IMP	20096447
GO:0031647	Process	Regulation of protein stability	IBA
GO:0032991	Component	Protein-containing complex	IDA	25861989
GO:0034063	Process	Stress granule assembly	IDA	32302570, 32302571
GO:0035520	Process	Monoubiquitinated protein deubiquitination	IDA	34348161, 34469731
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IMP	25861989
GO:0044325	Function	Transmembrane transporter binding	IDA	19398555
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0062030	Process	Negative regulation of stress granule assembly	IDA	27022092, 32302570
GO:0071347	Process	Cellular response to interleukin-1	IMP	25861989
GO:0072344	Process	Rescue of stalled ribosome	IDA	31981475, 34348161, 34469731
GO:0140678	Function	Molecular function inhibitor activity	IDA	27022092, 32302570
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IDA	34348161

MIM	HGNC	e!Ensembl
609818	12608	ENSG00000103194

Q14694

Protein name

Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)

Protein function

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability:

PDB

7XHF , 8TH6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07145	PAM2	78 → 95	Ataxin-2 C-terminal region	Motif
PF00443	UCH	415 → 792	Ubiquitin carboxyl-terminal hydrolase	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11439350}.

Sequence

MALHSPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFG
VDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGS
ALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGH
ANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAG
QPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATN
GVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYV
ETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINK
GNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPK
PRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEML
NLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQT
PITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYT
TKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPG
VKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVK
PTAERTAYLLYYRRVDLL

Sequence length

798

Interactions

View interactions

	Reactome
			Termination of translesion DNA synthesis Ub-specific processing proteases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OCULAR SARCOIDOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

USP10 (ubiquitin specific peptidase 10)