Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	90957
Gene name	DExH-box helicase 57
Gene symbol	DHX57
Synonyms (NCBI Gene)	DDX57
Chromosome	2
Chromosome location	2p22.1

Show/Hide all (95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001639	hsa-let-7b-5p	pSILAC	18668040
MIRT016202	hsa-miR-590-3p	Sequencing	20371350
MIRT023464	hsa-miR-23b-3p	Sequencing	20371350
MIRT027741	hsa-miR-98-5p	Microarray	19088304
MIRT001639	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT052544	hsa-let-7a-5p	CLASH	23622248
MIRT001639	hsa-let-7b-5p	CLASH	23622248
MIRT051721	hsa-let-7d-5p	CLASH	23622248
MIRT051546	hsa-let-7e-5p	CLASH	23622248
MIRT045910	hsa-miR-125b-5p	CLASH	23622248
MIRT038983	hsa-miR-15a-3p	CLASH	23622248
MIRT037449	hsa-miR-744-5p	CLASH	23622248
MIRT037095	hsa-miR-877-3p	CLASH	23622248
MIRT935720	hsa-miR-125a-3p	CLIP-seq
MIRT935721	hsa-miR-1273e	CLIP-seq
MIRT935722	hsa-miR-1915	CLIP-seq
MIRT935723	hsa-miR-320e	CLIP-seq
MIRT935724	hsa-miR-3646	CLIP-seq
MIRT935725	hsa-miR-3662	CLIP-seq
MIRT935726	hsa-miR-3665	CLIP-seq
MIRT935727	hsa-miR-4726-3p	CLIP-seq
MIRT935728	hsa-miR-4742-5p	CLIP-seq
MIRT935729	hsa-miR-4775	CLIP-seq
MIRT935730	hsa-miR-4792	CLIP-seq
MIRT935731	hsa-miR-610	CLIP-seq
MIRT935732	hsa-miR-629	CLIP-seq
MIRT1976980	hsa-miR-218	CLIP-seq
MIRT1976981	hsa-miR-3192	CLIP-seq
MIRT1976982	hsa-miR-3677-5p	CLIP-seq
MIRT1976983	hsa-miR-3926	CLIP-seq
MIRT1976984	hsa-miR-4731-5p	CLIP-seq
MIRT1976985	hsa-miR-548s	CLIP-seq
MIRT2212381	hsa-let-7a	CLIP-seq
MIRT2212382	hsa-let-7b	CLIP-seq
MIRT2212383	hsa-let-7c	CLIP-seq
MIRT2212384	hsa-let-7d	CLIP-seq
MIRT2212385	hsa-let-7e	CLIP-seq
MIRT2212386	hsa-let-7f	CLIP-seq
MIRT2212387	hsa-let-7g	CLIP-seq
MIRT2212388	hsa-let-7i	CLIP-seq
MIRT2212389	hsa-miR-3927	CLIP-seq
MIRT2212390	hsa-miR-4323	CLIP-seq
MIRT2212391	hsa-miR-4451	CLIP-seq
MIRT2212392	hsa-miR-4458	CLIP-seq
MIRT2212393	hsa-miR-4500	CLIP-seq
MIRT2212394	hsa-miR-98	CLIP-seq
MIRT2212381	hsa-let-7a	CLIP-seq
MIRT2212382	hsa-let-7b	CLIP-seq
MIRT2212383	hsa-let-7c	CLIP-seq
MIRT2212384	hsa-let-7d	CLIP-seq
MIRT2212385	hsa-let-7e	CLIP-seq
MIRT2212386	hsa-let-7f	CLIP-seq
MIRT2212387	hsa-let-7g	CLIP-seq
MIRT2212388	hsa-let-7i	CLIP-seq
MIRT2516055	hsa-miR-1207-3p	CLIP-seq
MIRT2516056	hsa-miR-146b-3p	CLIP-seq
MIRT2516057	hsa-miR-1587	CLIP-seq
MIRT2516058	hsa-miR-22	CLIP-seq
MIRT2516059	hsa-miR-3173-5p	CLIP-seq
MIRT2516060	hsa-miR-3189-3p	CLIP-seq
MIRT2516061	hsa-miR-3194-5p	CLIP-seq
MIRT2516062	hsa-miR-378g	CLIP-seq
MIRT2516063	hsa-miR-3918	CLIP-seq
MIRT2212389	hsa-miR-3927	CLIP-seq
MIRT2516064	hsa-miR-4268	CLIP-seq
MIRT2516065	hsa-miR-4292	CLIP-seq
MIRT2516066	hsa-miR-4312	CLIP-seq
MIRT2212390	hsa-miR-4323	CLIP-seq
MIRT2516067	hsa-miR-4437	CLIP-seq
MIRT2212391	hsa-miR-4451	CLIP-seq
MIRT2212392	hsa-miR-4458	CLIP-seq
MIRT2212393	hsa-miR-4500	CLIP-seq
MIRT2516068	hsa-miR-4640-5p	CLIP-seq
MIRT2516069	hsa-miR-4674	CLIP-seq
MIRT2516070	hsa-miR-4685-5p	CLIP-seq
MIRT2516071	hsa-miR-4691-5p	CLIP-seq
MIRT2516072	hsa-miR-4726-5p	CLIP-seq
MIRT2516073	hsa-miR-4733-3p	CLIP-seq
MIRT2516074	hsa-miR-635	CLIP-seq
MIRT2516075	hsa-miR-874	CLIP-seq
MIRT2212394	hsa-miR-98	CLIP-seq
MIRT2516056	hsa-miR-146b-3p	CLIP-seq
MIRT2516059	hsa-miR-3173-5p	CLIP-seq
MIRT2516062	hsa-miR-378g	CLIP-seq
MIRT2516063	hsa-miR-3918	CLIP-seq
MIRT2516064	hsa-miR-4268	CLIP-seq
MIRT2516065	hsa-miR-4292	CLIP-seq
MIRT2516067	hsa-miR-4437	CLIP-seq
MIRT2516068	hsa-miR-4640-5p	CLIP-seq
MIRT2516069	hsa-miR-4674	CLIP-seq
MIRT2516070	hsa-miR-4685-5p	CLIP-seq
MIRT2516071	hsa-miR-4691-5p	CLIP-seq
MIRT2516072	hsa-miR-4726-5p	CLIP-seq
MIRT2516073	hsa-miR-4733-3p	CLIP-seq
MIRT2516075	hsa-miR-874	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0045727	Process	Positive regulation of translation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070063	Function	RNA polymerase binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q6P158

Protein name

Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57)

Protein function

Probable ATP-binding RNA helicase.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05773	RWD	246 → 419	RWD domain	Domain
PF18044	zf-CCCH_4	303 → 324	CCCH-type zinc finger	Domain
PF00270	DEAD	548 → 709	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	828 → 969	Helicase conserved C-terminal domain	Family
PF04408	HA2	1036 → 1174	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	1213 → 1312	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain

Sequence

MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGGGGGGGGGGGGGNRKASSRIWDD
GDDFCIFSESRRPSRPSNSNISKGESRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQE
QDADAGSERGLSGEEEDDEPDCCNDERYWPAGQEPSLVPDLDPLEYAGLASVEPYVPEFT
VSPFAVQKLSRYGFNTERCQAVLRMCDGDVGASLEHLLTQCFSETFGERMKISEAVNQIS
LDECMEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSRFRKSKPKESTKNVQEN
SLEICKFYLKGNCKFGSKCRFKHEVPPNQIVGRIERSVDDSHLNAIEDASFLYELEIRFS
KDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYDKALTFAETSEPVVYSLITLLEEESE
IVKLLTNTHHKYSDPPVNFLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEKASESEES
DEDDGPAPVIVENESYVNLKKKISKRYDWQAKSVHAENGKICKQFRMKQASRQFQSILQE
RQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQ
PRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQ
GVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITI
PGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLS
LHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVD
GKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFV
KPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQ
RKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSV
FSRLIEPPHTDSLRASKIRLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRC
LDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVR
ASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATG
EEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDG
YVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRG
EFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIISTIV
KLVTTQ

Sequence length

1386

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DHX57-related disorder	Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Azoospermia	Azoospermia	Pubtator	36945018	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	29233017	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DHX57 (DExH-box helicase 57)