Gene Gene information from NCBI Gene database.
Entrez ID 90865
Gene name Interleukin 33
Gene symbol IL33
Synonyms (NCBI Gene)
C9orf26DVS27IL1F11NF-HEVNFEHEV
Chromosome 9
Chromosome location 9p24.1
Summary The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript vari
miRNA miRNA information provided by mirtarbase database.
350
miRTarBase ID miRNA Experiments Reference
MIRT017750 hsa-miR-335-5p Microarray 18185580
MIRT736393 hsa-miR-524-3p Western blottingMicroarrayqRT-PCR 31990904
MIRT756199 hsa-miR-181a-5p Luciferase reporter assayWestern blottingqRT-PCR 34978772
MIRT1064883 hsa-miR-331-3p CLIP-seq
MIRT1064884 hsa-miR-3660 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
83
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 17185418
GO:0001819 Process Positive regulation of cytokine production IBA
GO:0002112 Function Interleukin-33 receptor binding IEA
GO:0002281 Process Macrophage activation involved in immune response IEA
GO:0002282 Process Microglial cell activation involved in immune response IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608678 16028 ENSG00000137033
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95760
Protein name Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
Protein function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). Involved in the maturation of Th2 cells inducing the secretion
PDB 2KLL , 4KC3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15095 IL33 5 268 Interleukin 33 Family
Tissue specificity TISSUE SPECIFICITY: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269|PubMed:12819012}.
Sequence
Sequence length 270
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Necroptosis
Cytosolic DNA-sensing pathway
Influenza A
  PIP3 activates AKT signaling
Ub-specific processing proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
21
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTHRITIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATOPIC ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute intermittent porphyria Intermittent Porphyria BEFREE 28373582, 31287532
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 23418608
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 27120577, 29499051, 30964341
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 29499051
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 22819319
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 25324197, 27120577
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 25324197
★☆☆☆☆
Found in Text Mining only
Adrenoleukodystrophy Adrenoleukodystrophy BEFREE 28870670, 30478965
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 26755704, 27701734
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 19037964, 22233535, 22460070, 26428949, 26489077, 28412624, 28857184, 29790007, 30301503, 30556842, 31043056, 31173279
★☆☆☆☆
Found in Text Mining only