BPY2 (basic charge Y-linked 2)

Gene

• Entrez ID: 9083
• Gene name: Basic charge Y-linked 2
• Gene symbol: BPY2
• Synonyms (NCBI Gene): BPY2A, VCY2, VCY2A
• Chromosome: Y
• Chromosome location: Yq11.223
• Summary: This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nea

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017713	hsa-miR-335-5p	Microarray	18185580
MIRT823953	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14627543
GO:0005634	Component	Nucleus	IDA	12724276
GO:0007283	Process	Spermatogenesis	IMP	12724276
GO:0007338	Process	Single fertilization	TAS	9381176
GO:0032399	Function	HECT domain binding	IPI	12207887

Other IDs

• MIM: 400013
• HGNC: 13508
• e!Ensembl: ENSG00000183753

Interactions View interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SPERMATOGENIC FAILURE, NONOBSTRUCTIVE, Y-LINKED	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPERMATOGENIC FAILURE, Y-LINKED, 2	—	ClinVar, HPO ClinVar, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	25711770		★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	BEFREE	12207887		★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	Pubtator	16491273	Associate	★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	25711770		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25711770		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	10737540, 11743352		★☆☆☆☆ Found in Text Mining only
Oligospermia	Oligospermia	BEFREE	12207887, 12724276		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	10737540, 11743352		★☆☆☆☆ Found in Text Mining only
Spermatogenic Failure, Nonobstructive, Y-Linked	Nonobstructive Spermatogenic Failure, Y-Linked	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VACTERL Association	VACTERL Association	BEFREE	31315107		★☆☆☆☆ Found in Text Mining only