DIRAS3 (DIRAS family GTPase 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 9077
Gene name DIRAS family GTPase 3
Gene symbol DIRAS3
Synonyms (NCBI Gene)
ARHINOEY2
Chromosome 1
Chromosome location 1p31.3
Summary This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in ma
miRNA miRNA information provided by mirtarbase database.
44
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (44)
miRTarBase ID miRNA Experiments Reference
MIRT006018 hsa-miR-221-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21071579
MIRT006019 hsa-miR-222-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21071579
MIRT006018 hsa-miR-221-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21071579
MIRT006019 hsa-miR-222-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21071579
MIRT006018 hsa-miR-221-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21071579
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
E2F1 Repression 16158053;16638845;16757345;17230502
E2F4 Repression 16158053;16638845;16757345;17230502
HDAC9 Repression 16158053
STAT3 Unknown 23604529
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9874798
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 9874798
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
605193 687 ENSG00000162595
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95661
Protein name GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI)
PDB 6NAZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 39 → 201 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.
Sequence
Sequence length 229
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, HEPATOCELLULAR — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIRAS3-related disorder Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (59)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 29156798
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 11914599, 12499268, 12874023, 16158053, 17230502, 19482475, 21244707, 23801152, 24676336, 25193278, 9874798
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 19482475, 25560175, 9874798 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 23801152, 23871723 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 23247805
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Ovarian Epithelial Epithelial ovarian carcinoma Pubtator 36805591 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 38169324 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 15475444, 15785748, 24879154, 25077680, 29368982, 30620384
★★★★★
★☆☆☆☆
Found in Text Mining only
Diabetic Cardiomyopathies Diabetic cardiomyopathy BEFREE 27903964
★★★★★
★☆☆☆☆
Found in Text Mining only
Dwarfism Dwarfism BEFREE 30916492
★★★★★
★☆☆☆☆
Found in Text Mining only