ERI1 (exoribonuclease 1)

Gene

• Entrez ID: 90459
• Gene name: Exoribonuclease 1
• Gene symbol: ERI1
• Synonyms (NCBI Gene): 3'HEXO, HEXO, HXAL, SEMDGC, SEMDGS, THEX1
• Chromosome: 8
• Chromosome location: 8p23.1

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1563322318	A>-	Likely-pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020545	hsa-miR-155-5p	Proteomics	18668040
MIRT047993	hsa-miR-30c-5p	CLASH	23622248
MIRT650237	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT650236	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT650235	hsa-miR-544a	HITS-CLIP	23824327
MIRT650234	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT537634	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT537633	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT537632	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT537631	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT537630	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT537629	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT537628	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT537627	hsa-miR-3664-5p	PAR-CLIP	22012620
MIRT402602	hsa-miR-548p	PAR-CLIP	22012620
MIRT537626	hsa-miR-221-5p	PAR-CLIP	22012620
MIRT537625	hsa-miR-8073	PAR-CLIP	22012620
MIRT537624	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT537623	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT537622	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT537621	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT537620	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT537619	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT537618	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT537617	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT537616	hsa-miR-208a-3p	PAR-CLIP	22012620
MIRT447888	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT447886	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT447885	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT650237	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT650236	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT650235	hsa-miR-544a	HITS-CLIP	23824327
MIRT650234	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT537634	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT537633	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT537632	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT537631	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT537630	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT537629	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT537628	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT537627	hsa-miR-3664-5p	PAR-CLIP	22012620
MIRT402602	hsa-miR-548p	PAR-CLIP	22012620
MIRT537626	hsa-miR-221-5p	PAR-CLIP	22012620
MIRT537625	hsa-miR-8073	PAR-CLIP	22012620
MIRT537624	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT537623	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT537622	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT537621	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT537620	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT537619	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT537618	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT537617	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT537616	hsa-miR-208a-3p	PAR-CLIP	22012620
MIRT447888	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT447886	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT447885	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT969007	hsa-miR-106a	CLIP-seq
MIRT969008	hsa-miR-106b	CLIP-seq
MIRT969009	hsa-miR-1206	CLIP-seq
MIRT969010	hsa-miR-1263	CLIP-seq
MIRT969011	hsa-miR-142-5p	CLIP-seq
MIRT969012	hsa-miR-154	CLIP-seq
MIRT969013	hsa-miR-17	CLIP-seq
MIRT969014	hsa-miR-200b	CLIP-seq
MIRT969015	hsa-miR-200c	CLIP-seq
MIRT969016	hsa-miR-2054	CLIP-seq
MIRT969017	hsa-miR-20a	CLIP-seq
MIRT969018	hsa-miR-20b	CLIP-seq
MIRT969019	hsa-miR-21	CLIP-seq
MIRT969020	hsa-miR-2116	CLIP-seq
MIRT969021	hsa-miR-214	CLIP-seq
MIRT969022	hsa-miR-23a	CLIP-seq
MIRT969023	hsa-miR-23b	CLIP-seq
MIRT969024	hsa-miR-23c	CLIP-seq
MIRT969025	hsa-miR-298	CLIP-seq
MIRT969026	hsa-miR-302a	CLIP-seq
MIRT969027	hsa-miR-302b	CLIP-seq
MIRT969028	hsa-miR-302c	CLIP-seq
MIRT969029	hsa-miR-302d	CLIP-seq
MIRT969030	hsa-miR-302e	CLIP-seq
MIRT969031	hsa-miR-3074-5p	CLIP-seq
MIRT969032	hsa-miR-3125	CLIP-seq
MIRT969033	hsa-miR-3140-3p	CLIP-seq
MIRT969034	hsa-miR-3163	CLIP-seq
MIRT969035	hsa-miR-3200-5p	CLIP-seq
MIRT969036	hsa-miR-323-5p	CLIP-seq
MIRT969037	hsa-miR-340	CLIP-seq
MIRT969038	hsa-miR-34b	CLIP-seq
MIRT969039	hsa-miR-3609	CLIP-seq
MIRT969040	hsa-miR-3614-5p	CLIP-seq
MIRT969041	hsa-miR-3616-5p	CLIP-seq
MIRT969042	hsa-miR-3619-5p	CLIP-seq
MIRT969043	hsa-miR-3620	CLIP-seq
MIRT969044	hsa-miR-3622a-3p	CLIP-seq
MIRT969045	hsa-miR-3622b-3p	CLIP-seq
MIRT969046	hsa-miR-3647-5p	CLIP-seq
MIRT969047	hsa-miR-3656	CLIP-seq
MIRT969048	hsa-miR-3675-3p	CLIP-seq
MIRT969049	hsa-miR-3682-3p	CLIP-seq
MIRT969050	hsa-miR-369-3p	CLIP-seq
MIRT969051	hsa-miR-370	CLIP-seq
MIRT969052	hsa-miR-372	CLIP-seq
MIRT969053	hsa-miR-373	CLIP-seq
MIRT969054	hsa-miR-374a	CLIP-seq
MIRT969055	hsa-miR-374b	CLIP-seq
MIRT969056	hsa-miR-380	CLIP-seq
MIRT969057	hsa-miR-3916	CLIP-seq
MIRT969058	hsa-miR-409-3p	CLIP-seq
MIRT969059	hsa-miR-4263	CLIP-seq
MIRT969060	hsa-miR-4282	CLIP-seq
MIRT969061	hsa-miR-429	CLIP-seq
MIRT969062	hsa-miR-4291	CLIP-seq
MIRT969063	hsa-miR-4293	CLIP-seq
MIRT969064	hsa-miR-4433	CLIP-seq
MIRT969065	hsa-miR-4455	CLIP-seq
MIRT969066	hsa-miR-4459	CLIP-seq
MIRT969067	hsa-miR-4477a	CLIP-seq
MIRT969068	hsa-miR-4495	CLIP-seq
MIRT969069	hsa-miR-450b-3p	CLIP-seq
MIRT969070	hsa-miR-452	CLIP-seq
MIRT969071	hsa-miR-4666-5p	CLIP-seq
MIRT969072	hsa-miR-4670-3p	CLIP-seq
MIRT969073	hsa-miR-4676-3p	CLIP-seq
MIRT969074	hsa-miR-4719	CLIP-seq
MIRT969075	hsa-miR-4742-5p	CLIP-seq
MIRT969076	hsa-miR-4768-3p	CLIP-seq
MIRT969077	hsa-miR-4777-5p	CLIP-seq
MIRT969078	hsa-miR-4793-3p	CLIP-seq
MIRT969079	hsa-miR-4793-5p	CLIP-seq
MIRT969080	hsa-miR-495	CLIP-seq
MIRT969081	hsa-miR-5095	CLIP-seq
MIRT969082	hsa-miR-5096	CLIP-seq
MIRT969083	hsa-miR-512-3p	CLIP-seq
MIRT969084	hsa-miR-513a-3p	CLIP-seq
MIRT969085	hsa-miR-519d	CLIP-seq
MIRT969086	hsa-miR-520a-3p	CLIP-seq
MIRT969087	hsa-miR-520b	CLIP-seq
MIRT969088	hsa-miR-520c-3p	CLIP-seq
MIRT969089	hsa-miR-520d-3p	CLIP-seq
MIRT969090	hsa-miR-520e	CLIP-seq
MIRT969091	hsa-miR-548a-5p	CLIP-seq
MIRT969092	hsa-miR-548ab	CLIP-seq
MIRT969093	hsa-miR-548ah	CLIP-seq
MIRT969094	hsa-miR-548ak	CLIP-seq
MIRT969095	hsa-miR-548b-5p	CLIP-seq
MIRT969096	hsa-miR-548c-5p	CLIP-seq
MIRT969097	hsa-miR-548d-5p	CLIP-seq
MIRT969098	hsa-miR-548h	CLIP-seq
MIRT969099	hsa-miR-548i	CLIP-seq
MIRT969100	hsa-miR-548j	CLIP-seq
MIRT969101	hsa-miR-548k	CLIP-seq
MIRT969102	hsa-miR-548l	CLIP-seq
MIRT969103	hsa-miR-548n	CLIP-seq
MIRT969104	hsa-miR-548t	CLIP-seq
MIRT969105	hsa-miR-548w	CLIP-seq
MIRT969106	hsa-miR-548y	CLIP-seq
MIRT969107	hsa-miR-552	CLIP-seq
MIRT969108	hsa-miR-559	CLIP-seq
MIRT969109	hsa-miR-562	CLIP-seq
MIRT969110	hsa-miR-564	CLIP-seq
MIRT969111	hsa-miR-570	CLIP-seq
MIRT969112	hsa-miR-573	CLIP-seq
MIRT969113	hsa-miR-576-5p	CLIP-seq
MIRT969114	hsa-miR-577	CLIP-seq
MIRT969115	hsa-miR-583	CLIP-seq
MIRT969116	hsa-miR-590-5p	CLIP-seq
MIRT969117	hsa-miR-633	CLIP-seq
MIRT969118	hsa-miR-640	CLIP-seq
MIRT969119	hsa-miR-653	CLIP-seq
MIRT969120	hsa-miR-658	CLIP-seq
MIRT969121	hsa-miR-758	CLIP-seq
MIRT969122	hsa-miR-761	CLIP-seq
MIRT969123	hsa-miR-769-3p	CLIP-seq
MIRT969124	hsa-miR-873	CLIP-seq
MIRT969125	hsa-miR-876-3p	CLIP-seq
MIRT969126	hsa-miR-890	CLIP-seq
MIRT969127	hsa-miR-922	CLIP-seq
MIRT969128	hsa-miR-93	CLIP-seq
MIRT1987194	hsa-miR-1225-3p	CLIP-seq
MIRT1987195	hsa-miR-1233	CLIP-seq
MIRT1987196	hsa-miR-1238	CLIP-seq
MIRT1987197	hsa-miR-1271	CLIP-seq
MIRT1987198	hsa-miR-1294	CLIP-seq
MIRT1987199	hsa-miR-182	CLIP-seq
MIRT1987200	hsa-miR-1827	CLIP-seq
MIRT1987201	hsa-miR-196a	CLIP-seq
MIRT1987202	hsa-miR-196b	CLIP-seq
MIRT969014	hsa-miR-200b	CLIP-seq
MIRT969015	hsa-miR-200c	CLIP-seq
MIRT1987203	hsa-miR-203	CLIP-seq
MIRT1987204	hsa-miR-205	CLIP-seq
MIRT969044	hsa-miR-3622a-3p	CLIP-seq
MIRT969045	hsa-miR-3622b-3p	CLIP-seq
MIRT1987205	hsa-miR-3973	CLIP-seq
MIRT1987206	hsa-miR-4266	CLIP-seq
MIRT969061	hsa-miR-429	CLIP-seq
MIRT1987207	hsa-miR-4316	CLIP-seq
MIRT1987208	hsa-miR-4422	CLIP-seq
MIRT969066	hsa-miR-4459	CLIP-seq
MIRT1987209	hsa-miR-4635	CLIP-seq
MIRT1987210	hsa-miR-4677-3p	CLIP-seq
MIRT1987211	hsa-miR-4679	CLIP-seq
MIRT1987212	hsa-miR-4694-3p	CLIP-seq
MIRT1987213	hsa-miR-4695-5p	CLIP-seq
MIRT969074	hsa-miR-4719	CLIP-seq
MIRT1987214	hsa-miR-4736	CLIP-seq
MIRT1987215	hsa-miR-4759	CLIP-seq
MIRT1987216	hsa-miR-4779	CLIP-seq
MIRT1987217	hsa-miR-501-3p	CLIP-seq
MIRT1987218	hsa-miR-502-3p	CLIP-seq
MIRT1987219	hsa-miR-526b	CLIP-seq
MIRT969104	hsa-miR-548t	CLIP-seq
MIRT969114	hsa-miR-577	CLIP-seq
MIRT969118	hsa-miR-640	CLIP-seq
MIRT969120	hsa-miR-658	CLIP-seq
MIRT1987220	hsa-miR-665	CLIP-seq
MIRT1987221	hsa-miR-9	CLIP-seq
MIRT1987222	hsa-miR-940	CLIP-seq
MIRT1987223	hsa-miR-96	CLIP-seq
MIRT2221654	hsa-miR-1	CLIP-seq
MIRT1987196	hsa-miR-1238	CLIP-seq
MIRT2221655	hsa-miR-1245	CLIP-seq
MIRT2221656	hsa-miR-128	CLIP-seq
MIRT2221657	hsa-miR-151-5p	CLIP-seq
MIRT2221658	hsa-miR-151b	CLIP-seq
MIRT1987200	hsa-miR-1827	CLIP-seq
MIRT969014	hsa-miR-200b	CLIP-seq
MIRT969015	hsa-miR-200c	CLIP-seq
MIRT969016	hsa-miR-2054	CLIP-seq
MIRT2221659	hsa-miR-206	CLIP-seq
MIRT2221660	hsa-miR-224	CLIP-seq
MIRT2221661	hsa-miR-27a	CLIP-seq
MIRT2221662	hsa-miR-27b	CLIP-seq
MIRT2221663	hsa-miR-31	CLIP-seq
MIRT2221664	hsa-miR-3131	CLIP-seq
MIRT2221665	hsa-miR-3151	CLIP-seq
MIRT2221666	hsa-miR-3173-3p	CLIP-seq
MIRT2221667	hsa-miR-3188	CLIP-seq
MIRT2221668	hsa-miR-326	CLIP-seq
MIRT2221669	hsa-miR-330-5p	CLIP-seq
MIRT969038	hsa-miR-34b	CLIP-seq
MIRT969040	hsa-miR-3614-5p	CLIP-seq
MIRT969044	hsa-miR-3622a-3p	CLIP-seq
MIRT969045	hsa-miR-3622b-3p	CLIP-seq
MIRT2221670	hsa-miR-3658	CLIP-seq
MIRT2221671	hsa-miR-3663-5p	CLIP-seq
MIRT2221672	hsa-miR-3664-3p	CLIP-seq
MIRT2221673	hsa-miR-3673	CLIP-seq
MIRT969048	hsa-miR-3675-3p	CLIP-seq
MIRT2221674	hsa-miR-3929	CLIP-seq
MIRT2221675	hsa-miR-4265	CLIP-seq
MIRT969061	hsa-miR-429	CLIP-seq
MIRT969063	hsa-miR-4293	CLIP-seq
MIRT2221676	hsa-miR-4296	CLIP-seq
MIRT2221677	hsa-miR-4322	CLIP-seq
MIRT2221678	hsa-miR-4419b	CLIP-seq
MIRT969064	hsa-miR-4433	CLIP-seq
MIRT2221679	hsa-miR-4447	CLIP-seq
MIRT969066	hsa-miR-4459	CLIP-seq
MIRT2221680	hsa-miR-4472	CLIP-seq
MIRT2221681	hsa-miR-4478	CLIP-seq
MIRT2221682	hsa-miR-4649-3p	CLIP-seq
MIRT2221683	hsa-miR-4662a-3p	CLIP-seq
MIRT1987213	hsa-miR-4695-5p	CLIP-seq
MIRT969076	hsa-miR-4768-3p	CLIP-seq
MIRT969078	hsa-miR-4793-3p	CLIP-seq
MIRT2221684	hsa-miR-485-5p	CLIP-seq
MIRT2221685	hsa-miR-486-3p	CLIP-seq
MIRT2221686	hsa-miR-490-5p	CLIP-seq
MIRT2221687	hsa-miR-491-5p	CLIP-seq
MIRT2221688	hsa-miR-510	CLIP-seq
MIRT2221689	hsa-miR-512-5p	CLIP-seq
MIRT2221690	hsa-miR-515-5p	CLIP-seq
MIRT2221691	hsa-miR-516a-5p	CLIP-seq
MIRT2221692	hsa-miR-584	CLIP-seq
MIRT2221693	hsa-miR-593	CLIP-seq
MIRT2221694	hsa-miR-611	CLIP-seq
MIRT2221695	hsa-miR-613	CLIP-seq
MIRT969118	hsa-miR-640	CLIP-seq
MIRT969120	hsa-miR-658	CLIP-seq
MIRT1987204	hsa-miR-205	CLIP-seq
MIRT969044	hsa-miR-3622a-3p	CLIP-seq
MIRT969045	hsa-miR-3622b-3p	CLIP-seq
MIRT969066	hsa-miR-4459	CLIP-seq
MIRT1987213	hsa-miR-4695-5p	CLIP-seq
MIRT2448939	hsa-miR-3065-5p	CLIP-seq
MIRT2448940	hsa-miR-371-5p	CLIP-seq
MIRT2448941	hsa-miR-548ae	CLIP-seq
MIRT2448942	hsa-miR-548aj	CLIP-seq
MIRT2448943	hsa-miR-548am	CLIP-seq
MIRT2448944	hsa-miR-548x	CLIP-seq
MIRT1987194	hsa-miR-1225-3p	CLIP-seq
MIRT1987195	hsa-miR-1233	CLIP-seq
MIRT2525250	hsa-miR-124	CLIP-seq
MIRT1987197	hsa-miR-1271	CLIP-seq
MIRT2525251	hsa-miR-1283	CLIP-seq
MIRT1987198	hsa-miR-1294	CLIP-seq
MIRT2525252	hsa-miR-135a	CLIP-seq
MIRT2525253	hsa-miR-135b	CLIP-seq
MIRT2525254	hsa-miR-181a	CLIP-seq
MIRT2525255	hsa-miR-181b	CLIP-seq
MIRT2525256	hsa-miR-181c	CLIP-seq
MIRT2525257	hsa-miR-181d	CLIP-seq
MIRT1987199	hsa-miR-182	CLIP-seq
MIRT1987200	hsa-miR-1827	CLIP-seq
MIRT2525258	hsa-miR-186	CLIP-seq
MIRT2525259	hsa-miR-18a	CLIP-seq
MIRT2525260	hsa-miR-18b	CLIP-seq
MIRT2525261	hsa-miR-1914	CLIP-seq
MIRT1987201	hsa-miR-196a	CLIP-seq
MIRT1987202	hsa-miR-196b	CLIP-seq
MIRT969016	hsa-miR-2054	CLIP-seq
MIRT2525262	hsa-miR-208a	CLIP-seq
MIRT2525263	hsa-miR-208b	CLIP-seq
MIRT969019	hsa-miR-21	CLIP-seq
MIRT969020	hsa-miR-2116	CLIP-seq
MIRT969022	hsa-miR-23a	CLIP-seq
MIRT969023	hsa-miR-23b	CLIP-seq
MIRT969024	hsa-miR-23c	CLIP-seq
MIRT2525264	hsa-miR-24	CLIP-seq
MIRT2221663	hsa-miR-31	CLIP-seq
MIRT969032	hsa-miR-3125	CLIP-seq
MIRT2525265	hsa-miR-3137	CLIP-seq
MIRT2221665	hsa-miR-3151	CLIP-seq
MIRT2221666	hsa-miR-3173-3p	CLIP-seq
MIRT2221667	hsa-miR-3188	CLIP-seq
MIRT969035	hsa-miR-3200-5p	CLIP-seq
MIRT2525266	hsa-miR-339-3p	CLIP-seq
MIRT2525267	hsa-miR-33a	CLIP-seq
MIRT2525268	hsa-miR-33b	CLIP-seq
MIRT969038	hsa-miR-34b	CLIP-seq
MIRT969040	hsa-miR-3614-5p	CLIP-seq
MIRT969041	hsa-miR-3616-5p	CLIP-seq
MIRT2525269	hsa-miR-3617	CLIP-seq
MIRT969044	hsa-miR-3622a-3p	CLIP-seq
MIRT969045	hsa-miR-3622b-3p	CLIP-seq
MIRT969046	hsa-miR-3647-5p	CLIP-seq
MIRT2525270	hsa-miR-3662	CLIP-seq
MIRT2221672	hsa-miR-3664-3p	CLIP-seq
MIRT2525271	hsa-miR-3667-3p	CLIP-seq
MIRT969048	hsa-miR-3675-3p	CLIP-seq
MIRT2525272	hsa-miR-3685	CLIP-seq
MIRT2525273	hsa-miR-3714	CLIP-seq
MIRT2448940	hsa-miR-371-5p	CLIP-seq
MIRT969054	hsa-miR-374a	CLIP-seq
MIRT969055	hsa-miR-374b	CLIP-seq
MIRT2525274	hsa-miR-3910	CLIP-seq
MIRT969057	hsa-miR-3916	CLIP-seq
MIRT2525275	hsa-miR-3926	CLIP-seq
MIRT2221674	hsa-miR-3929	CLIP-seq
MIRT969058	hsa-miR-409-3p	CLIP-seq
MIRT2525276	hsa-miR-421	CLIP-seq
MIRT2525277	hsa-miR-4262	CLIP-seq
MIRT2221675	hsa-miR-4265	CLIP-seq
MIRT1987206	hsa-miR-4266	CLIP-seq
MIRT2525278	hsa-miR-4272	CLIP-seq
MIRT2525279	hsa-miR-4284	CLIP-seq
MIRT2221676	hsa-miR-4296	CLIP-seq
MIRT2525280	hsa-miR-4297	CLIP-seq
MIRT2525281	hsa-miR-4303	CLIP-seq
MIRT2525282	hsa-miR-4307	CLIP-seq
MIRT1987207	hsa-miR-4316	CLIP-seq
MIRT2221677	hsa-miR-4322	CLIP-seq
MIRT2525283	hsa-miR-4325	CLIP-seq
MIRT2221678	hsa-miR-4419b	CLIP-seq
MIRT969064	hsa-miR-4433	CLIP-seq
MIRT2221679	hsa-miR-4447	CLIP-seq
MIRT969066	hsa-miR-4459	CLIP-seq
MIRT2221680	hsa-miR-4472	CLIP-seq
MIRT2525284	hsa-miR-4477b	CLIP-seq
MIRT2221681	hsa-miR-4478	CLIP-seq
MIRT2525285	hsa-miR-4506	CLIP-seq
MIRT2525286	hsa-miR-450b-5p	CLIP-seq
MIRT2525287	hsa-miR-4633-5p	CLIP-seq
MIRT2525288	hsa-miR-4645-3p	CLIP-seq
MIRT2221682	hsa-miR-4649-3p	CLIP-seq
MIRT2525289	hsa-miR-4663	CLIP-seq
MIRT969071	hsa-miR-4666-5p	CLIP-seq
MIRT2525290	hsa-miR-4668-3p	CLIP-seq
MIRT969072	hsa-miR-4670-3p	CLIP-seq
MIRT1987210	hsa-miR-4677-3p	CLIP-seq
MIRT1987211	hsa-miR-4679	CLIP-seq
MIRT1987213	hsa-miR-4695-5p	CLIP-seq
MIRT2525291	hsa-miR-4700-3p	CLIP-seq
MIRT2525292	hsa-miR-4709-5p	CLIP-seq
MIRT2525293	hsa-miR-4720-3p	CLIP-seq
MIRT2525294	hsa-miR-4735-3p	CLIP-seq
MIRT1987214	hsa-miR-4736	CLIP-seq
MIRT1987215	hsa-miR-4759	CLIP-seq
MIRT2525295	hsa-miR-4761-5p	CLIP-seq
MIRT969076	hsa-miR-4768-3p	CLIP-seq
MIRT2525296	hsa-miR-4773	CLIP-seq
MIRT969077	hsa-miR-4777-5p	CLIP-seq
MIRT1987216	hsa-miR-4779	CLIP-seq
MIRT2525297	hsa-miR-4795-3p	CLIP-seq
MIRT2525298	hsa-miR-4804-3p	CLIP-seq
MIRT2221684	hsa-miR-485-5p	CLIP-seq
MIRT2221685	hsa-miR-486-3p	CLIP-seq
MIRT2221687	hsa-miR-491-5p	CLIP-seq
MIRT969080	hsa-miR-495	CLIP-seq
MIRT2525299	hsa-miR-499-5p	CLIP-seq
MIRT1987217	hsa-miR-501-3p	CLIP-seq
MIRT1987218	hsa-miR-502-3p	CLIP-seq
MIRT2525300	hsa-miR-506	CLIP-seq
MIRT2525301	hsa-miR-507	CLIP-seq
MIRT2221688	hsa-miR-510	CLIP-seq
MIRT2221689	hsa-miR-512-5p	CLIP-seq
MIRT2525302	hsa-miR-532-5p	CLIP-seq
MIRT2525303	hsa-miR-541	CLIP-seq
MIRT2525304	hsa-miR-548aa	CLIP-seq
MIRT2448941	hsa-miR-548ae	CLIP-seq
MIRT2448942	hsa-miR-548aj	CLIP-seq
MIRT2448943	hsa-miR-548am	CLIP-seq
MIRT2448944	hsa-miR-548x	CLIP-seq
MIRT2525305	hsa-miR-557	CLIP-seq
MIRT2525306	hsa-miR-561	CLIP-seq
MIRT969110	hsa-miR-564	CLIP-seq
MIRT969112	hsa-miR-573	CLIP-seq
MIRT2525307	hsa-miR-586	CLIP-seq
MIRT969116	hsa-miR-590-5p	CLIP-seq
MIRT2525308	hsa-miR-610	CLIP-seq
MIRT2525309	hsa-miR-641	CLIP-seq
MIRT969119	hsa-miR-653	CLIP-seq
MIRT2525310	hsa-miR-654-5p	CLIP-seq
MIRT969120	hsa-miR-658	CLIP-seq
MIRT1987220	hsa-miR-665	CLIP-seq
MIRT2525311	hsa-miR-671-5p	CLIP-seq
MIRT1987221	hsa-miR-9	CLIP-seq
MIRT1987222	hsa-miR-940	CLIP-seq
MIRT1987223	hsa-miR-96	CLIP-seq
MIRT1987194	hsa-miR-1225-3p	CLIP-seq
MIRT1987195	hsa-miR-1233	CLIP-seq
MIRT1987197	hsa-miR-1271	CLIP-seq
MIRT2525251	hsa-miR-1283	CLIP-seq
MIRT1987198	hsa-miR-1294	CLIP-seq
MIRT2525252	hsa-miR-135a	CLIP-seq
MIRT2525253	hsa-miR-135b	CLIP-seq
MIRT1987199	hsa-miR-182	CLIP-seq
MIRT1987200	hsa-miR-1827	CLIP-seq
MIRT2525258	hsa-miR-186	CLIP-seq
MIRT1987201	hsa-miR-196a	CLIP-seq
MIRT1987202	hsa-miR-196b	CLIP-seq
MIRT969016	hsa-miR-2054	CLIP-seq
MIRT2525262	hsa-miR-208a	CLIP-seq
MIRT2525263	hsa-miR-208b	CLIP-seq
MIRT969022	hsa-miR-23a	CLIP-seq
MIRT969023	hsa-miR-23b	CLIP-seq
MIRT969024	hsa-miR-23c	CLIP-seq
MIRT2221663	hsa-miR-31	CLIP-seq
MIRT969032	hsa-miR-3125	CLIP-seq
MIRT969035	hsa-miR-3200-5p	CLIP-seq
MIRT2525269	hsa-miR-3617	CLIP-seq
MIRT969044	hsa-miR-3622a-3p	CLIP-seq
MIRT969045	hsa-miR-3622b-3p	CLIP-seq
MIRT2525270	hsa-miR-3662	CLIP-seq
MIRT2221672	hsa-miR-3664-3p	CLIP-seq
MIRT2525271	hsa-miR-3667-3p	CLIP-seq
MIRT969048	hsa-miR-3675-3p	CLIP-seq
MIRT2525272	hsa-miR-3685	CLIP-seq
MIRT2448940	hsa-miR-371-5p	CLIP-seq
MIRT969057	hsa-miR-3916	CLIP-seq
MIRT2525275	hsa-miR-3926	CLIP-seq
MIRT2221674	hsa-miR-3929	CLIP-seq
MIRT2525276	hsa-miR-421	CLIP-seq
MIRT2525280	hsa-miR-4297	CLIP-seq
MIRT2525281	hsa-miR-4303	CLIP-seq
MIRT1987207	hsa-miR-4316	CLIP-seq
MIRT2221678	hsa-miR-4419b	CLIP-seq
MIRT969064	hsa-miR-4433	CLIP-seq
MIRT969066	hsa-miR-4459	CLIP-seq
MIRT2221681	hsa-miR-4478	CLIP-seq
MIRT2525285	hsa-miR-4506	CLIP-seq
MIRT2525287	hsa-miR-4633-5p	CLIP-seq
MIRT2525288	hsa-miR-4645-3p	CLIP-seq
MIRT2221682	hsa-miR-4649-3p	CLIP-seq
MIRT969071	hsa-miR-4666-5p	CLIP-seq
MIRT2525290	hsa-miR-4668-3p	CLIP-seq
MIRT1987210	hsa-miR-4677-3p	CLIP-seq
MIRT1987211	hsa-miR-4679	CLIP-seq
MIRT1987213	hsa-miR-4695-5p	CLIP-seq
MIRT2525292	hsa-miR-4709-5p	CLIP-seq
MIRT1987214	hsa-miR-4736	CLIP-seq
MIRT969076	hsa-miR-4768-3p	CLIP-seq
MIRT2221684	hsa-miR-485-5p	CLIP-seq
MIRT2525299	hsa-miR-499-5p	CLIP-seq
MIRT1987217	hsa-miR-501-3p	CLIP-seq
MIRT1987218	hsa-miR-502-3p	CLIP-seq
MIRT2221688	hsa-miR-510	CLIP-seq
MIRT2221689	hsa-miR-512-5p	CLIP-seq
MIRT2525302	hsa-miR-532-5p	CLIP-seq
MIRT2448941	hsa-miR-548ae	CLIP-seq
MIRT2448942	hsa-miR-548aj	CLIP-seq
MIRT2448943	hsa-miR-548am	CLIP-seq
MIRT2448944	hsa-miR-548x	CLIP-seq
MIRT969110	hsa-miR-564	CLIP-seq
MIRT2525307	hsa-miR-586	CLIP-seq
MIRT2525308	hsa-miR-610	CLIP-seq
MIRT2525309	hsa-miR-641	CLIP-seq
MIRT969120	hsa-miR-658	CLIP-seq
MIRT1987220	hsa-miR-665	CLIP-seq
MIRT1987221	hsa-miR-9	CLIP-seq
MIRT1987222	hsa-miR-940	CLIP-seq
MIRT1987223	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-RNA exonuclease activity	IBA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IEA
GO:0000460	Process	Maturation of 5.8S rRNA	IMP	37352860
GO:0000467	Process	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	23329046, 23804756
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	16912046
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	16912046
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006364	Process	RRNA processing	IEA
GO:0008408	Function	3'-5' exonuclease activity	IDA	14536070, 16912046
GO:0016787	Function	Hydrolase activity	IEA
GO:0019843	Function	RRNA binding	ISS
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031125	Process	RRNA 3'-end processing	ISS
GO:0043022	Function	Ribosome binding	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0071044	Process	Histone mRNA catabolic process	IMP	18172165
GO:0071204	Component	Histone pre-mRNA 3'end processing complex	ISS
GO:0071207	Function	Histone pre-mRNA stem-loop binding	ISS

Other IDs

• MIM: 608739
• HGNC: 23994
• e!Ensembl: ENSG00000104626

Protein

• UniProt ID: Q8IV48
• Protein name: 3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO)
• Protein function: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487, PubMed:37352860). A 2' and 3'-hyd
• PDB: 1W0H, 1ZBH, 1ZBU, 4L8R, 4QOZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02037	SAP	76 → 110	SAP domain	Family
  PF00929	RNase_T	131 → 306	Exonuclease	Family

• Sequence:

  MEDPQSKEPAGEAVALALLESPRPEGGEEPPRPSPEETQQCKFDGQETKGSKFITSSASD
  FSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKES
  NFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLLNTHTLEIEDTFQQYVRPEINT
  QLSDFCISLTGITQDQVDRADTFPQVLKKVIDWMKLKELGTKYKYSLLTDGSWDMSKFLN
  IQCQLSRLKYPPFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHCGLDDSK
  NIARIAVRMLQDGCELRINEKMHAGQLMSVSSSLPIEGTPPPQMPHFRK

• Sequence length: 349

Pathways

Reactome:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Abnormal finger morphology	Likely pathogenic	rs1563322318	RCV000714292	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Coarse facial features	Likely pathogenic	rs1563322318	RCV000714292	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
ERI1-associated disorder	Likely pathogenic	rs766625084	RCV001254154	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Global developmental delay	Likely pathogenic	rs1563322318	RCV000714292	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hoxha-Aliu syndrome	Likely pathogenic; Pathogenic	rs2486218891, rs1221141256, rs2486243611, rs766625084	RCV003459873 RCV003459879 RCV003985062 RCV003462836	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Spondyloepimetaphyseal dysplasia, Guo-Campeau type	Likely pathogenic; Pathogenic	rs2486219481, rs2486309230, rs2486219940, rs1433280953, rs982911729, rs2486175152	RCV003464411 RCV003464412 RCV003459874 RCV003459875 RCV003459876 RCV003459877 RCV003459878	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Unilateral renal agenesis	Likely pathogenic	rs1563322318	RCV000714292	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ERI1-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Global developmental delay	Developmental Delay	CLINVAR_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Intellectual Disability	Mental retardation	BEFREE	28488351		★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only
Unilateral agenesis of kidney	Renal aplasia	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only