Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9045
Gene name	Ribosomal protein L14
Gene symbol	RPL14
Synonyms (NCBI Gene)	CAG-ISL-7CTG-B33L14RL14eL14hRL14
Chromosome	3
Chromosome location	3p22.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031990	hsa-miR-16-5p	Proteomics	18668040
MIRT048582	hsa-miR-100-5p	CLASH	23622248
MIRT047311	hsa-miR-181a-5p	CLASH	23622248
MIRT045056	hsa-miR-186-5p	CLASH	23622248
MIRT039154	hsa-miR-769-5p	CLASH	23622248
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	19536157
MIRT721211	hsa-miR-4479	HITS-CLIP	19536157
MIRT721210	hsa-miR-3960	HITS-CLIP	19536157
MIRT721209	hsa-miR-8072	HITS-CLIP	19536157
MIRT721208	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT721207	hsa-miR-6894-3p	HITS-CLIP	19536157
MIRT700070	hsa-miR-548an	HITS-CLIP	23313552
MIRT700069	hsa-miR-6768-3p	HITS-CLIP	23313552
MIRT700068	hsa-miR-4484	HITS-CLIP	23313552
MIRT700067	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT700066	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT700065	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT700064	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT700063	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT700062	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT700061	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT700060	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT700059	hsa-miR-3910	HITS-CLIP	23313552
MIRT700058	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT700057	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT700056	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT700055	hsa-miR-302e	HITS-CLIP	23313552
MIRT700054	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT700053	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT700052	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT700051	hsa-miR-520b	HITS-CLIP	23313552
MIRT700050	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT700049	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT700048	hsa-miR-520e	HITS-CLIP	23313552
MIRT700047	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT700046	hsa-miR-520h	HITS-CLIP	23313552
MIRT700045	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT700044	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT700043	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT700041	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT700042	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT700040	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT700039	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT700038	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT539902	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT539901	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT031990	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT539900	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT539899	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT539898	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT539896	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT654135	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT654133	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT654131	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT654132	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654130	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT654128	hsa-miR-4473	HITS-CLIP	23824327
MIRT539902	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT539901	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031990	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT539900	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT539899	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT539898	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT539896	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT539897	hsa-miR-624-5p	PAR-CLIP	21572407
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	19536157
MIRT721211	hsa-miR-4479	HITS-CLIP	19536157
MIRT721210	hsa-miR-3960	HITS-CLIP	19536157
MIRT721209	hsa-miR-8072	HITS-CLIP	19536157
MIRT721208	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT721207	hsa-miR-6894-3p	HITS-CLIP	19536157
MIRT700070	hsa-miR-548an	HITS-CLIP	23313552
MIRT700069	hsa-miR-6768-3p	HITS-CLIP	23313552
MIRT700068	hsa-miR-4484	HITS-CLIP	23313552
MIRT700067	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT700066	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT700065	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT700064	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT700063	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT700062	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT700061	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT700060	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT700059	hsa-miR-3910	HITS-CLIP	23313552
MIRT700058	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT700057	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT700056	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT700055	hsa-miR-302e	HITS-CLIP	23313552
MIRT700054	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT700053	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT700052	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT700051	hsa-miR-520b	HITS-CLIP	23313552
MIRT700050	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT700049	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT700048	hsa-miR-520e	HITS-CLIP	23313552
MIRT700047	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT700046	hsa-miR-520h	HITS-CLIP	23313552
MIRT700045	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT700044	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT700043	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT700041	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT700042	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT700040	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT700039	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT700038	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT539902	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT539901	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT031990	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT539900	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT539899	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT539898	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT539896	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT654135	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT654133	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT654131	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT654132	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654130	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT654128	hsa-miR-4473	HITS-CLIP	23824327
MIRT539902	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT539901	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031990	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT539900	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT539899	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT539898	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT539896	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT539897	hsa-miR-624-5p	PAR-CLIP	21572407
MIRT1315987	hsa-miR-3064-3p	CLIP-seq
MIRT1315988	hsa-miR-4715-3p	CLIP-seq
MIRT1315989	hsa-miR-556-3p	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	9480843
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	9480843
GO:0005515	Function	Protein binding	IPI	11369516, 24725412, 28514442, 30021884, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	9480843
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	9480843
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	18697920
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
617414	10305	ENSG00000188846

P50914

Protein name

Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01929	Ribosomal_L14e	46 → 120	Ribosomal protein L14	Family

Sequence

MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDF
ILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN
RIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPA
QKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA

Sequence length

215

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, RENAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUPUS ERYTHEMATOSUS, SYSTEMIC	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (25)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33305312	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	9920051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromophobe Renal Cell Carcinoma	Chromophobe Carcinoma	CTD_human_DG	23797736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Collecting Duct Carcinoma of the Kidney	Renal Carcinoma	CTD_human_DG	23797736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	23797736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	8549859		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	8549859		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	8549859		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17786358		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	9920051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	34057029	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	9920051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	9920051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	34057029	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	39744943	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16316724, 17701052		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	9920051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary Renal Cell Carcinoma	Papillary Renal Carcinoma	CTD_human_DG	23797736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	CTD_human_DG	18353766		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	23797736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcomatoid Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	23797736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	16316724		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	9920051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33305312	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPL14 (ribosomal protein L14)