SAMD1 (sterile alpha motif domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 90378
• Gene name: Sterile alpha motif domain containing 1
• Gene symbol: SAMD1
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19p13.12

miRNA Show/Hide all (19)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031219	hsa-miR-19b-3p	Sequencing	20371350
MIRT642881	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT642880	hsa-miR-132-5p	HITS-CLIP	23824327
MIRT642879	hsa-miR-3119	HITS-CLIP	23824327
MIRT642878	hsa-miR-623	HITS-CLIP	23824327
MIRT642877	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT642876	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT642874	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT642875	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT642873	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT642881	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT642880	hsa-miR-132-5p	HITS-CLIP	23824327
MIRT642879	hsa-miR-3119	HITS-CLIP	23824327
MIRT642878	hsa-miR-623	HITS-CLIP	23824327
MIRT642877	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT642876	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT642874	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT642875	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT642873	hsa-miR-4446-5p	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	33980486
GO:0005515	Function	Protein binding	IPI	33980486
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	ISS
GO:0005634	Component	Nucleus	IDA	33980486
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0030169	Function	Low-density lipoprotein particle binding	ISS
GO:0034439	Process	Lipoprotein lipid oxidation	ISS
GO:0051260	Process	Protein homooligomerization	IDA	33980486
GO:0090077	Process	Foam cell differentiation	ISS
GO:0160217	Process	Negative regulation of transcription initiation-coupled chromatin remodeling	IDA	33980486

Other IDs

• MIM: 620206
• HGNC: 17958
• e!Ensembl: ENSG00000141858

Protein

• UniProt ID: Q6SPF0
• Protein name: Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)
• Protein function: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to m
• PDB: 6LUI , 6LUJ , 6LUK , 8Y77
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00536	SAM_1	460 → 523	SAM domain (Sterile alpha motif)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in atherosclerotic lesions, not in normal intima. Expressed in foam cells. {ECO:0000269|PubMed:16159594}.
• Sequence:

  MAGPPALPPPETAAAATTAAAASSSAASPHYQEWILDTIDSLRSRKARPDLERICRMVRR
  RHGPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPAPPRAPRGAPA
  AAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAP
  PPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAV
  RAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRG
  DRPGRAPPAASARPSRSKRGGEERVLEKEEEEDDDEDEDEEDDVSEGSEVPESDRPAGAQ
  HHQLNGERGPQSAKERVKEWTPCGPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGTASVA
  TGPDSPSPVPLPPGKPALPGADGTPFGCPPGRKEKPSDPVEWTVMDVVEYFTEAGFPEQA
  TAFQEQEIDGKSLLLMQRTDVLTGLSIRLGPALKIYEHHIKVLQQGHFEDDDPDGFLG

• Sequence length: 538

Related Genes

No strongly related genes found yet for SAMD1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SAMD1.