TMEM250 (transmembrane protein 250)

Gene

• Entrez ID: 90120
• Gene name: Transmembrane protein 250
• Gene symbol: TMEM250
• Synonyms (NCBI Gene): C9orf69
• Chromosome: 9
• Chromosome location: 9q34.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT676038	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT676037	hsa-miR-1911-3p	HITS-CLIP	23824327
MIRT676036	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT676035	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT676034	hsa-miR-1226-3p	HITS-CLIP	23824327
MIRT676033	hsa-miR-4733-3p	HITS-CLIP	23824327
MIRT676032	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT676031	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT676030	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT676029	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT676028	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT676027	hsa-miR-3135b	HITS-CLIP	23824327
MIRT676026	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT676025	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT676024	hsa-miR-3652	HITS-CLIP	23824327
MIRT676023	hsa-miR-4430	HITS-CLIP	23824327
MIRT676022	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT676021	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT676020	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT676019	hsa-miR-5698	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21667337
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	21667337
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21667337
GO:0005737	Component	Cytoplasm	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	21667337
GO:0016020	Component	Membrane	IEA
GO:0048524	Process	Positive regulation of viral process	IDA	21667337

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: H0YL14
• Protein name: Transmembrane protein 250 (Herpes virus UL25-binding protein)
• Protein function: May play a role in cell proliferation by promoting progression into S phase. ; (Microbial infection) Promotes human herpes simplex virus 1/HHV-1 proliferation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17685	DUF5533	1 → 139	Family of unknown function (DUF5533)	Family

• Sequence:

  MPVMPIPRRVRSFHGPHTTCLHAACGPVRASHLARTKYNNFDVYIKTRWLYGFIRFLLYF
  SCSLFTAALWGALAALFCLQYLGVRVLLRFQRKLSVLLLLLGRRRVDFRLVNELLVYGIH
  VTMLLVGGLGWCFMVFVDM

• Sequence length: 139

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations